TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 OBS

Major histocompatibility complex (MHC) molecule expressed on the surface of human cells.  3, record 1, English, - human%20leukocyte%20antigen

Record number: 1, Textual support number: 1 CONT

In the case of allogeneic transplants, identifying a potential donor who can give their stem cells to another person involves analyzing the human leukocyte antigens(HLA), which are proteins found on the surface of the blood and in tissue cells. The HLA must be as closely matched as possible so that the transplant recipient's body can "accept" the new stem cells into their bone marrow. Just as important, matching at HLA will decrease the chance of the new marrow reacting against the patient, a reaction called graft versus host disease.  4, record 1, English, - human%20leukocyte%20antigen

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Dans le cas des allogreffes, il faut faire une analyse des antigènes leucocytaires humains (antigènes HLA) pour identifier une personne susceptible de donner des cellules souches à une autre personne. Ces antigènes sont des protéines présentes à la surface des cellules sanguines et dans les cellules des tissus. Les antigènes HLA doivent être les plus semblables possible pour que le corps du receveur «accepte» les nouvelles cellules souches dans sa moelle osseuse. La compatibilité HLA diminuera aussi les risques que la nouvelle moelle réagisse contre le patient, ce que l'on appelle «réaction du greffon contre l'hôte».  4, record 1, French, - antig%C3%A8ne%20leucocytaire%20humain

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Marca que identifica a la célula propia del organismo para prevenir que el sistema inmunitario la ataque.  1, record 1, Spanish, - ant%C3%ADgeno%20de%20los%20leucocitos%20humanos

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

The condition [or disease] that results when the immune cells of a transplant (usually of bone marrow) from a donor attack the tissues of the person receiving the transplant.  2, record 2, English, - graft%20versus%20host%20disease

Record number: 2, Textual support number: 1 CONT

In 1955, Barnes and Loutit first described graft versus host disease(GVHD) in mice. Simonsen introduced the term graft-versus-host reaction in 1958 to describe the direction of the immunological damage caused by introduction of immunologically competent cells into an immunocompromised host. In 1966, Billingham proposed 3 conditions required for the development of GVHD, as follows :(1) the graft must contain immunologically competent cells,(2) the host must possess important transplant alloantigens that are lacking in the donor graft so that the host appears foreign to the graft, and(3) the host itself must be incapable of mounting an effective immunological reaction against the graft. According to the accepted definition, the immunologic assault itself and its consequences are referred to as GVHD.  3, record 2, English, - graft%20versus%20host%20disease

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

La principale complication, en cas d'allogreffe, est la maladie du greffon contre l'hôte. [...] Il s'agit d'une réaction immunitaire des cellules du greffon contre les organes du receveur. Cette réaction peut être aiguë, dans les trois premiers mois suivant la greffe, ou chronique et constituer une vraie maladie.  2, record 2, French, - maladie%20du%20greffon%20contre%20l%27h%C3%B4te

Record number: 2, Textual support number: 1 OBS

Ne pas confondre avec : réaction du greffon contre l'hôte.  3, record 2, French, - maladie%20du%20greffon%20contre%20l%27h%C3%B4te

Record 2,  Textual support,  Spanish