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GRAMICIDIN [2 records]

Record 1 2009-07-10

English

Subject field(s)
  • Chemical Elements and Compounds
  • Medication
DEF

An antibiotic consisting of tyrocidine and gramicidin usually extracted from a soil bacillus(Bacillus brevis).

French

Domaine(s)
  • Éléments et composés chimiques
  • Médicaments

Spanish

Campo(s) temático(s)
  • Elementos y compuestos químicos
  • Medicamentos
CONT

En 1939 [René Jules Dubos] culminó su investigación con el aislamiento de Bacillus brevis, del que extrajo un agente antibacteriano al que llamó tirotricina. La tirotricina no era una enzima simple, sino que contenía dos polipéptidos, tirocidina y gramicidina.

Save record 1

Record 2 1980-09-01

English

Subject field(s)
  • Biochemistry
OBS

Ionophores, molecules that carry ions across [mitochondrial] membranes, are essential tools in the study of chemiosmotic mechanisms(...) The ionophore valinomy is a cyclic molecule that is soluble in membranes and selectively carries potassium ions(K+). Nigericin also transports potassium, but only in exchange for protons; it is insoluble in the membrane unless one ion or the other is bound. Gramicidin A forms a pore in the membrane, made up of two helical molecules, that is permeable to ions with one positive charge.

French

Domaine(s)
  • Biochimie
OBS

Les ionophores, molécules qui transportent les ions à travers les membranes (mitochondriales) sont des outils essentiels dans l'étude des mécanismes chimiosmotiques [...] La valinomycine est un ionophore; c'est une molécule cyclique qui est soluble dans les membranes et transporte sélectivement les ions potassium (K+). La nigécirine transporte aussi le potassium mais seulement en l'échangeant avec des protons; elle est insoluble dans la membrane sauf lorsqu'elle est liée à l'un de ces ions. Deux molécules hélicoïdales de gramicidine A forment un pore à travers la membrane perméable aux ions porteurs d'une seule charge positive.

Spanish

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