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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 OBS

A synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.  2, record 1, English, - nalidixic%20acid

Record number: 1, Textual support number: 2 OBS

Chemical formula: C₁₂H₁₂N₂O₃  3, record 1, English, - nalidixic%20acid

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

Agent antibactérien de synthèse (1,8-naphthyridine) qui possède un spectre bactéricide limité. C'est un inhibiteur de la sous-unité A de l'ADN gyrase bactérienne.  1, record 1, French, - acide%20nalidixique

Record number: 1, Textual support number: 2 OBS

Formule chimique : C₁₂H₁₂N₂O₃  2, record 1, French, - acide%20nalidixique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

Any one of the fluorinated quinolones, a class of antibiotic drugs, often used as growth promoters or to control disease in poultry, cattle and other livestock.  3, record 2, English, - fluoroquinolone

Record number: 2, Textual support number: 1 CONT

Ciprofloxacin, a synthetic fluoroquinolone, has a bactericidal mode of action. This action is achieved through inhibition of DNA gyrase, an essential component of the bacterial DNA replication system.  4, record 2, English, - fluoroquinolone

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Les quinolones non fluorées (acide oxolinique, fluméquine, acide pipémidique) sont issues de l'acide nalidixique. Elles sont indiquées dans les infections urinaires courantes (cystite secondaire à des bactéries à Gram négatif). [...] Les quinolones fluorées appelées également fluoroquinolones (quinolone de deuxième génération) possèdent un spectre d'action plus large que les précédentes. Ce sont : la ciprofloxacine, l'ofloxacine, la péfloxacine. Cette variété d'antibiotiques est utilisée dans les infections sévères, pour les germes sensibles touchant les organes respiratoires, digestifs, cutanés et les méninges.  3, record 2, French, - fluoroquinolone

Record number: 2, Textual support number: 2 CONT

Peu après l'homologation et l'utilisation de la fluoroquinolone en élevage aviaire, molécule appartenant à une nouvelle classe puissante d'antimicrobiens, l'isolement de salmonelles et de Campylobacter résistants à la fluoroquinolone est devenu plus courant d'abord chez l'animal puis, peu après, chez l'homme.  4, record 2, French, - fluoroquinolone

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Replication of plasmid pIP501 is regulated at a step subsequent to transcription initiation by an antisense RNA(RNAIII) and transcriptionally by a repressor protein, CopR... We suggest that, in the absence of CopR, the increased(derepressed) RNAII transcription interferes, in cis, with initiation of transcription of RNAIII(convergent transcription), resulting in a lower RNAIII/plasmid ration. When CopR is present, the pII promoter is repressed to >90%, so that convergent transcription is mostly abolished and RNAIII/plasmid ratios are high. The hypothesis that RNAII transcription influences promoter pIII through induced changes in DNa supercoiling is supported by the finding that the gyrase inhibitor novobiocin affects the accumulation of both sense and antisense RNA. The dual role of CopR in repression of RNAII transcription and in prevention of convergent transcription is discussed in the context of replication control of pIP501.  1, record 3, English, - convergent%20transcription

Record 3,  Textual support,  French

Record 3,  Textual support,  Spanish