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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Heterologous, or recombinant, proteins are produced when recombinant DNA technology is used to ensure the expression of a gene product in an organism in which it would not normally be made.  2, record 1, English, - recombinant%20protein

Record 1,  Textual support,  French

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Proteína codificada por un gen clonado.  1, record 1, Spanish, - prote%C3%ADna%20recombinante

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Pronuclear injection is used to generate animals that express gene sequences under the control of a heterologous promoter.  2, record 2, English, - heterologous%20promoter

Record number: 2, Textual support number: 1 OBS

Heterologous(meaning ’derived from a different organism’) refers to the fact that often the transferred protein was initially cloned from or derived from a different cell type or a different species from the recipient.  3, record 2, English, - heterologous%20promoter

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

L'injection pronucléaire est utilisée pour produire des animaux qui expriment les séquences de gènes sous le contrôle d'un promoteur hétérologue.  1, record 2, French, - promoteur%20h%C3%A9t%C3%A9rologue

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

The DNA that has been derived from a source organism and has been integrated into a host cell.  3, record 3, English, - heterologous%20DNA

Record number: 3, Textual support number: 1 CONT

The situation of expressing heterologous DNA(DNA from a different species) in E. coli [Escherichia coli] has been discussed and it is clear that the well investigated genetic system of E. coli has enabled much valuable information to be gathered.  1, record 3, English, - heterologous%20DNA

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Fragment, plus ou moins long, d'ADN qui provient d'un organisme étranger ou externe et qui est intégré dans une cellule hôte.  4, record 3, French, - ADN%20h%C3%A9t%C3%A9rologue

Record number: 3, Textual support number: 1 CONT

Les données relatives à l'expression d'un ADN hétérologue (ADN d'une espèce différente) dans E. coli [Escherichia coli] ont été examinées et il est manifeste que le système génétique bien étudié d'E. coli a permis de rassembler un grand nombre d'informations précieuses.  1, record 3, French, - ADN%20h%C3%A9t%C3%A9rologue

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

ADN que proviene de un organismo y que se introduce en una célula de otro organismo de una especie diferente.  2, record 3, Spanish, - ADN%20ex%C3%B3geno

Record number: 3, Textual support number: 1 CONT

Transfección de ADN: introducción en una célula en cultivo [...] permeable al ADN, de moléculas [...] de ADN extrañas (heterólogas) insertadas en un vector. [...] La transformación requiere la integración del ADN exógeno en el cromosoma bacteriano mientras que la transfección usualmente no la requiere. El ADN extraño se asocia con el del cromosoma del huésped y se expresa como un fenotipo identificable.  3, record 3, Spanish, - ADN%20ex%C3%B3geno

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

An antibody directed against lymphocyte surface antigens. Such antibodies are produced by immunization of experimental animals with heterologous lymphocytes and are used... for example in organ transplantation.  1, record 4, English, - antilymphocyte%20globulin

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Immunoglobuline (anticorps) d'origine animale (lapin, chèvre ou cheval) générée en réponse à l'immunisation (de l'animal en question) par des lymphocytes humains.  1, record 4, French, - globuline%20antilymphocytaire

Record number: 4, Textual support number: 1 OBS

La globuline anti-lymphocytaire (ou sérum anti-lymphocytaire ou anti-thymocyte) est [...] utilisée, en association avec la cortisone et la cyclosporine-A, comme traitement de première instance dans les aplasies médullaires. [...] Lorsqu'injecté chez l'homme, ce sérum (ou globuline) peut détruire les lymphocytes auto-réactifs responsables de l'aplasie et ainsi contribuer à la correction de la maladie.  1, record 4, French, - globuline%20antilymphocytaire

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Primary malignant lymphoma of the brain : an immunohistochemical study of eight cases using a panel of monoclonal and heterologous antibodies.  1, record 5, English, - panel

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Analyse de la différenciation leucémique myélomonocytaire par un panel de marqueurs cellulaires de surface comprenant une lectine provenant de lotus tétragonolobus et liant le fucose.  1, record 5, French, - panel

Record number: 5, Textual support number: 1 OBS

Il s'agit d'une méthode de détection des anticorps.  2, record 5, French, - panel

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

Disease caused by the formation of immune complexes in tissues or by the deposition of circulating immune-complexes in tissues resulting in acute or chronic inflammation.  1, record 6, English, - immune%2Dcomplex%20disease

Record number: 6, Textual support number: 1 OBS

Deposition of circulating immune complexes is generally associated with glomerulonephritis, vasculitis, synovitis, endocarditis, neuritis, and dermatitis. Locally formed complexes are involved in the pathogenesis of some autoimmune diseases. Circulating complexes may result from administration of heterologous antigens(as in serum sickness)....  1, record 6, English, - immune%2Dcomplex%20disease

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Le choc allergique [...] Classification de Gell et Coombs : classification des accidents allergiques en 4 classes. [...] Type III: Maladie des complexes immuns avec dépôt de complexes Ig-Ag dans les organes (reins, poumons).  1, record 6, French, - maladie%20des%20complexes%20immuns

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

A heteropolymeric protein, consisting of an ordered association of functionally and structurally different enzymes, which catalyse successive steps in a chain of metabolic reactions.  4, record 7, English, - multienzyme%20complex

Record number: 7, Textual support number: 1 CONT

The multienzyme complex is an example of heterologous protein-protein interaction in a functional complex. The known multienzyme complexes consist of 2-7 different catalytic units associated noncovalently, with no associated lipids, nucleic acids or enzymatically inactive protein.  4, record 7, English, - multienzyme%20complex

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

Les enzymes ne sont pas distribuées au hasard dans la cellule. Elles sont localisées dans divers compartiments cellulaires et fréquemment elles sont disposées de façon ordonné dans le réseau macromoléculaire de la cellule et des organites cellulaires pour former ce qu'on appelle un système multi-enzymatique.  3, record 7, French, - complexe%20multienzymatique

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 OBS

heterologous : Derived from a different species.  2, record 8, English, - heterologous%20antigen

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 OBS

hétérologue : Qui provient d'une autre espèce.  2, record 8, French, - antig%C3%A8ne%20h%C3%A9t%C3%A9rologue

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

A method for enhancing the secretion of heterologous proteins in Escherichia coli by optimizing, as opposed to simply maximizing, the translational level of a given protein is described. Random alteration of the translational initiation region(TIR) of the Heat-Stable Enterotoxin II(STII) signal sequence resulted in a library of vectors with varied translational strenghts.  1, record 9, English, - translational%20initiation%20region

Record 9,  Textual support,  French

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

There are some questions as to methodology [concerning research in molecular and developmental genetics] Things such as possible difficulties with interpretation of data from using heterologous biochemical assays and correlating in vitro protein phosphorylation sites with in vivo sites of phosphorylation could have been better addressed....  1, record 10, English, - protein%20phosphorylation

Record number: 10, Textual support number: 2 CONT

Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells ... Agents which activate protein kinase C or otherwise enhance protein phosphorylation caused a substantial decrease in A beta production in vitro ... The muscarinic inhibition of cyclic AMP (cAMP) mediated contractile effects may not only be the result of a reduction in cAMP levels, but may also involve cAMP linked protein phosphorylation in the heart ... Recent studies in Alzheimer brains have shown aberrant protein phosphorylation, suggesting an alteration in protein kinases and/or phosphoprotein phosphatases ... [Source: PASCAL database].  2, record 10, English, - protein%20phosphorylation

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

L'exemple le plus ancien et le plus célèbre des régulations par phosphorylation de protéines est celui de la glycogène phosphorylase, déjà rencontrée comme protéine allostérique. Nous savons qu'un 2e mécanisme règle l'activité de la protéine puisqu'elle peut passer par phosphorylation d'une forme b peu active à une forme a très active. Une seule phosphorylation sur chaque sous-unité du dimère suffit [...]  1, record 10, French, - phosphorylation%20de%20prot%C3%A9ines

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

This non-specificity extends as far as heterologous antibodies. For example, antibodies against salmonella cholerae suis in horse serum are capable of passing through the intestinal wall of the new-born pig.  1, record 11, English, - heterologous%20antibody

Record number: 11, Textual support number: 1 OBS

heterologous. Derived from a different species.  2, record 11, English, - heterologous%20antibody

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Cette non-spécificité s'étend jusqu'à la possibilité d'absorption d'anticorps hétérologues. C'est ainsi que des anticorps contre Salmonella cholerae suis dans le sérum de cheval peuvent fort bien passer au travers de la paroi intestinale de porcs nouveau-nés.  1, record 11, French, - anticorps%20h%C3%A9t%C3%A9rologue

Record number: 11, Textual support number: 1 OBS

hétérologue. Qui provient d'une autre espèce. Un sérum hétérologue est un sérum provenant d'une autre espèce que le sujet auquel on l'injecte.  1, record 11, French, - anticorps%20h%C3%A9t%C3%A9rologue

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

although E. coli is known for its ability to express genes from B. subtilis, in contrast B. subtilis strongly discriminates against the expression of E. coli genes but expresses genes from other Gram-positive bacteria such as Staphylococcus aureus. This apparent asymmetry in the expression of heterologous genes between E. coli and B. subtilis is under active investigation...  1, record 12, English, - heterologous%20gene

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

si E. coli est connu pour son aptitude à exprimer des gènes de B. subtilis, B. subtilis en revanche manifeste une forte résistance à l'expression des gènes d'E. coli, mais exprime des gènes d'autres bactéries Gram-positives comme Staphylococcus aureus. Cette asymétrie apparente dans l'expression de gènes hétérologues entre E. coli et B. subtilis fait l'objet d'études poussées (...).  1, record 12, French, - g%C3%A8ne%20h%C3%A9t%C3%A9rologue

Record 12,  Textual support,  Spanish