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HISTAMINE TEST [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2001-09-14

English

Subject field(s)
  • Cytology
  • Immunology
CONT

... the "Human Basophil Degranulation Test, "... Basophils contain granules which are made of histamine and other chemicals which can elicit symptoms of allergy when they are released or degranulated. A substance to which a person is allergic causes degranulation of the basophils. There are certain substances which will cause anybody's basophils to degranulate. IgE is a special type of antibody which causes the release/degranulation of basophils, and "anti-IgE" is an artificial(man-made) antibody that can have a similar effect as IgE.

French

Domaine(s)
  • Cytologie
  • Immunologie
CONT

Les granulocytes basophiles sont impliqués essentiellement dans les phénomènes d'hypersensibilité immédiate, fonction liée aux substances chimiques contenues dans leurs granulations: la dégranulation des basophiles, après intervention d'immunoglobulines E (IgE), se produit par l'intermédiaire de vésicules d'exocytose, et s'accompagne d'une libération d'histamine et autres amines vasopressives responsables de réactions anaphylactiques.

Spanish

Save record 1

Record 2 1993-03-24

English

Subject field(s)
  • Immunology
CONT

This test indirectly determines specific IgE by measuring the histamine release from basophils challenged with allergens. As basophils and mast cells are fixed by IgE, allergens that react with specific IgE will crosslink two molecules of membrane-bound IgE and initiate mediator release from basophils or mast cells. Histamine is one of the mediators; hence by measuring the amount of histamine released, one has the overall assessment of the IgE-mediated mechanism, that is, quantity of histamine released correlates with the amount of membrane-bound specific IgE and the functioning properties of the basophils.

French

Domaine(s)
  • Immunologie
DEF

Méthode de diagnostic allergologique qui consiste à mettre l'allergène en contact avec des basophiles supposés sensibilisés afin de vérifier s'ils vont libérer de l'histamine, ce qui argumenterait la responsabilité de cet allergène.

Spanish

Save record 2

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