TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

Regulation of enzyme activity. Enzymes may be regulated at two levels :(1) at the level of gene expression and protein synthesis through induction and repression;(2) at the enzyme level through enzyme inhibition or activation as a result of the binding of effector molecules at allosteric sites on the enzyme.  2, record 1, English, - enzyme%20regulation

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Deux mécanismes majeurs sont à la base de la régulation de l'activité enzymatique : le contrôle génétique et le contrôle de la catalyse. Le contrôle génétique fait intervenir un changement dans la quantité totale de molécules enzymatiques. Les exemples les plus connus de cette forme de régulation sont l'induction enzymatique et la répression chez les micro-organismes [...]. Le contrôle de la catalyse fait intervenir un changement dans l'activité enzymatique sans que change la quantité totale de l'enzyme synthétisée.  1, record 1, French, - r%C3%A9gulation%20de%20l%27activit%C3%A9%20enzymatique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

Any of a mixture of glycopeptide antibiotics produced by a strain of Streptomyces verticillus, designated A₁ to A₆, A_2’, and B₁ to B₆, that bind to DNA causing chain scission and removal of purine and pyrimidine bases, resulting in inhibition of DNA synthesis and, to a lesser extent, RNA and protein synthesis and also accumulation of cells in the G₂ phase of the cell cycle.  2, record 2, English, - bleomycin

Record number: 2, Textual support number: 1 OBS

... used ... for treatment of squamous cell carcinomas ...  2, record 2, English, - bleomycin

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Nom générique d'un groupe d'antibiotiques de nature glucidique et peptidique, extraits de Streptomyces verticillatus et utilisés en chimiothérapie anticancéreuse.  1, record 2, French, - bl%C3%A9omycine

Record number: 2, Textual support number: 1 CONT

Les bléomycines [...] provoquent une inhibition de la division cellulaire en fractionnant les chaînes d'A.D.N. en A.D.N. de plus faible poids moléculaire.  1, record 2, French, - bl%C3%A9omycine

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Fármaco antibiótico antineoplásico.  2, record 2, Spanish, - bleomicina

Record number: 2, Textual support number: 1 OBS

[...] utilizado en el tratamiento de tumores germinales, osteosarcoma, enfermedad de Hodgkin, sarcoma de Kaposi y carcinoma de cabeza y cuello, pene y cérvix.  2, record 2, Spanish, - bleomicina

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Inhibition of protein synthesis during CNS myelination produces focal accumulations of membrane vesicles in oligodendrocytes.  3, record 3, English, - inhibition%20of%20protein%20synthesis

Record number: 3, Textual support number: 2 CONT

Protein synthesis inhibition induces cytoresistance in cultured human proximal tubular(hk-2) cells.  4, record 3, English, - inhibition%20of%20protein%20synthesis

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

L'action anticoagulante des antivitamines K présente [des] caractéristiques essentielles [qui] s'expliquent par le mécanisme d'action des AVK [antivitamines K]. Elles inhibent compétitivement la K-époxide réductase et la K-NADH réductase, responsables de la régénération de la vitamine K (KH2) à partir de la vitamine K oxydée sous forme d'époxide KO. Il en résulte une inhibition de la synthèse des protéines vitamines K-dépendantes actives dont la concentration plasmatique chute. La rapidité de leur décroissance dépend du degré d'inhibition de leur synthèse et surtout de leur demi-vie.  6, record 3, French, - inhibition%20de%20la%20synth%C3%A8se%20prot%C3%A9ique

Record number: 3, Textual support number: 2 CONT

Le plomb libre ionisé exerce ses effets cytotoxiques par plusieurs mécanismes : altération fonctionnelle de nombreuses protéines possédant des groupements thiol et inhibition de la synthèse protéique [...]  7, record 3, French, - inhibition%20de%20la%20synth%C3%A8se%20prot%C3%A9ique

Record number: 3, Textual support number: 1 OBS

inhibition : Diminution d'activité d'une enzyme, due à un composé chimique de structure voisine de celle du substrat, qui se combine à l'enzyme aux lieu et place de ce dernier.  8, record 3, French, - inhibition%20de%20la%20synth%C3%A8se%20prot%C3%A9ique

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Glyphosate is recognized for its effectiveness against perennial, deep-rooted, grass and broad-leaf weeds, as well as woody brush problems in crop and noncrop areas. It is a translocated, foliar-applied herbicide that can be applied at any stage of plant growth or at any time of year, with most types of application equipment, including the new wick, roller, and wiper devices. Its mechanism of action appears to be the inhibition of the synthesis of aromatic amino acids, which results in the inhibition of nucleic acid metabolism and protein synthesis.  2, record 4, English, - roller%20applicator

Record number: 4, Textual support number: 1 OBS

Used in Integrated Pest Management.  3, record 4, English, - roller%20applicator

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

Terme utilisé en «Lutte intégrée».  2, record 4, French, - applicateur%20%C3%A0%20rouleaux

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

There are some questions as to methodology [concerning research in molecular and developmental genetics] Things such as possible difficulties with interpretation of data from using heterologous biochemical assays and correlating in vitro protein phosphorylation sites with in vivo sites of phosphorylation could have been better addressed ....  1, record 5, English, - protein%20phosphorylation

Record number: 5, Textual support number: 2 CONT

Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells... Agents which activate protein kinase C or otherwise enhance protein phosphorylation caused a substantial decrease in A beta production in vitro... The muscarinic inhibition of cyclic AMP(cAMP) mediated contractile effects may not only be the result of a reduction in cAMP levels, but may also involve cAMP linked protein phosphorylation in the heart... Recent studies in Alzheimer brains have shown aberrant protein phosphorylation, suggesting an alteration in protein kinases and/or phosphoprotein phosphatases... [Source : PASCAL database].  2, record 5, English, - protein%20phosphorylation

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

L'exemple le plus ancien et le plus célèbre des régulations par phosphorylation de protéines est celui de la glycogène phosphorylase, déjà rencontrée comme protéine allostérique. Nous savons qu'un 2e mécanisme règle l'activité de la protéine puisqu'elle peut passer par phosphorylation d'une forme b peu active à une forme a très active. Une seule phosphorylation sur chaque sous-unité du dimère suffit [...]  1, record 5, French, - phosphorylation%20de%20prot%C3%A9ines

Record 5,  Textual support,  Spanish