TERMIUM Plus®

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MAXIMALLY TOLERATED DOSE [1 record]

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Record 1 1995-04-07

English

Subject field(s)
  • Scientific Research
  • Medication
CONT

Doxazosin crosses the placental barrier. Studies in rabbits and rats at daily oral doses of up to 40 and 20 mg/kg respectively have revealed no evidence of teratogenic effect. The rabbit study however, was compromised by the failure to use a maximally tolerated dose of doxazosin.

French

Domaine(s)
  • Recherche scientifique
  • Médicaments
CONT

La doxazosine traverse la barrière placentaire. Des études effectuées sur des lapins et des rats auxquels on avait administré des doses quotidiennes orales atteignant 40 et 20 mg/kg respectivement n'ont pas mis d'effet tératogène en évidence. La validité des résultats de l'étude sur les lapins a toutefois été compromise par le fait que l'on avait omis d'administrer la dose maximale tolérée de doxazosine.

Spanish

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