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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

The timing of the administration of a drug to reflect the circadian or other bioperiodic rhythm, which may affect the receptor number on a membrane, biomolecular conformation and rate-limiting steps in metabolic pathways.  2, record 1, English, - chronesthesy

Record 1,  Textual support,  French

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

The attachment or clumping of platelets together.  2, record 2, English, - platelet%20aggregation

Record number: 2, Textual support number: 1 CONT

In Glanzmann's thrombocytopenia, two membrane glycoproteins(GPIIb-IIIa) that normally serve as the receptor for fibrinogen in activated platelets are markedly deficient. Fibrinogen binding to platelets is required for platelet aggregation.  1, record 2, English, - platelet%20aggregation

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Processus par lequel des thrombocytes se fixent les uns aux autres de façon à former un agrégat (collection).  2, record 2, French, - agr%C3%A9gation%20plaquettaire

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

The protein Sonic Hedgehog (Shh) controls patterning growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Ptc can form a physical complex with w newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly.  4, record 3, English, - Smoothened

Record number: 3, Textual support number: 2 CONT

Sequence analysis of the smoothened transcription reveals a single open reading frame encoding a protein with seven putative transmembrane domains. This structure is typical of G-protein-coupled receptors, suggesting that the Smoothened protein may act as a receptor for the Hegdgehog ligand.  5, record 3, English, - Smoothened

Record number: 3, Textual support number: 3 CONT

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal.  3, record 3, English, - Smoothened

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Le signal Hedgehog et sa pathologie. Le précurseur de Sonic Hedgehog subit une maturation autoprotéolytique par liaison au cholestérol. La partie amino-terminale de Sonic Hedgehog se fixe au récepteur «patched» complexé à la protéine Smoothened.  1, record 3, French, - prot%C3%A9ine%20Smoothened

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

(...) a thin tube [exuded by the acrosome] that extends to the egg surface and fuses with the egg plasma membrane (...) The tubule thus formed establishes continuity between the egg and the spermatozoon and provides a way for the spermatozoal nucleus to reach the interior of the egg.  1, record 4, English, - acrosomal%20tubule

Record number: 4, Textual support number: 1 CONT

for "acrosomal process" : In invertebrates such as the sea urchin the acrosome simultaneously undergoes a remarkable structural change: it exudes a thin filament called the acrosomal process that attaches itself to the vitelline layer of the egg, a thin membrane underlying the jelly coat.  2, record 4, English, - acrosomal%20tubule

Record number: 4, Textual support number: 2 CONT

for "acrosomal process" : Once the tip of the acrosomal process has interacted with the receptor site, it perforates the vitelline layer and fuses with the underlying plasma membrane of the egg. The plasma membranes of the two cells then become continuous, forming a bridge that progressively enlarges until the entire sperm is surrounded by the egg plasma membrane and is incorporated into the egg.  2, record 4, English, - acrosomal%20tubule

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Chez les invertébrés comme les oursins, la structure de l'acrosome est modifiée au même moment et de façon tout à fait remarquable: l'acrosome sécrète un mince filament appelé tube acrosomial qui s'attache à la membrane sous-jacente à la gangue gélatineuse. (...) Quand l'extrémité du tube acrosomial a réagi avec le site récepteur de l'ovule, elle perfore la membrane vitelline et fusionne avec la membrane plasmique sous-jacente. Les membranes plasmiques des deux cellules sont alors reliées entre elles par un pont qui s'agrandit progressivement jusqu'à ce que la membrane de l'ovule recouvre le spermatozoïde et que celui-ci soit incorporé à l'ovule.  2, record 4, French, - tube%20acrosomial

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

A peripheral nervous system membrane protein binding the inhibitory ß-subunit of the motor neural glycine receptor to tubulin in the cytosqueleton.  1, record 5, English, - gephyrin

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Protéine membranaire des neurones, de masse moléculaire 93 kDa [kilodaltons], qui est associée au récepteur de la glycine et qui se lie à la tubuline.  1, record 5, French, - g%C3%A9phyrine

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

E-rosette assay. An assay for human T lymphocytes based on the existence of a specific receptor on T cells for a sheep red blood cell membrane antigen. Peripheral blood lymphocytes are incubated with sheep red cells. T cells are surrounded by a ring of red cells-an E erythrocyte rosette-and are counted using a hemacytometer.  1, record 6, English, - E%20rosette

Record number: 6, Textual support number: 2 CONT

E Rosette. Human T cells have receptors for sheep erythrocytes (E) and so may be isolated by mixing with the sheep cells and separating the rosettes produced.  2, record 6, English, - E%20rosette

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Lorsqu'on les met en présence d'érythrocytes de mouton à 4°C, 60 à 80 pour 100 des lymphocytes du sang humain forment des rosettes E. Les récepteurs responsables de la formation des rosettes E ne reconnaissent pas les antigènes érythrocytaires, mais les molécules d'adhésion LFA-3 de la surface des hématies, distinctes des antigènes du globule rouge. [...] L'intérêt de ces phénomènes de rosettes tient à ce que les «rosettes mouton» ne se forment qu'autour des lymphocytes T, alors que les «rosettes souris» se forment autour des lymphocytes B.  1, record 6, French, - rosette%20E

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

Signal reception. Most signal receptors are plasma membrane proteins. The signal protein matches the shape of a specific site on the receptor protein. The signal protein acts as ligand, a small protein that specifically binds to large one. The binding of the signal protein causes a conformational change in the receptor protein, which in turn can now activate another molecule. Most signal proteins are water soluble and too large to pass through the plasma membrane.  2, record 7, English, - signal%20protein

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

protéine signal : terme retenu par le réseau Entraide Traduction Santé.  2, record 7, French, - prot%C3%A9ine%20signal

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

The Iribhn is a pioneer in cloning and studying membrane receptors, the targets of over 70% of today's medicines. It has notably cloned receptors for adenosine and nociceptin and the thyrotropin receptor of the thyroid, further showing that mutations in the latter receptor can cause thyroid tumour.  1, record 8, English, - nociceptin

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Polypeptide présent dans le cerveau et responsable d'une hypersensibilité à la douleur.  2, record 8, French, - nociceptine

Record number: 8, Textual support number: 1 CONT

En bloquant l'action de la nociceptine, il serait possible d'obtenir de nouveaux types d'analgésiques sans effets secondaires.  3, record 8, French, - nociceptine

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Neurotransmitter receptors are proteins that span the neuronal membrane. These proteins have ligand binding regions that are accessible to extracellular messengers and other regions involved in transducing the binding interaction into an intercellular effect. The reversible binding of the neurotransmitter to the receptor causes a conformational change that triggers the transmembrane signaling event.  1, record 9, English, - binding

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Études du site de liaison du récepteur delta par modélisation et mutagénèse dirigée : l'implication de résidus transmembranaires du récepteur dans la reconnaissance d'une douzaine d'opiacés, structuralement et fonctionnellement distincts, a été évaluée. Un domaine général de fixation a été identifié, avec une contribution particulière de chacun des résidus pour chacun des ligands étudiés. Les interactions récepteur-ligand semblent être de nature non ionique.  2, record 9, French, - liaison

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

There are multiple signal transduction pathways : cascade of information from plasma membrane to nucleus in response to an extracellular stimulus in living organisms. Extracellular signal molecule binds specific intracellular receptor, and initiates the signaling pathway. Now, there is a large amount of information about the signaling pathway which controls the gene expression and cellular proliferation.  2, record 10, English, - signal%20molecule

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

Les molécules «signal». La leptine est fréquemment considérée comme une hormone permettant de diminuer la masse du tissu adipeux. Elle agit sur la prise alimentaire à la fois grâce à ses propriétés anorexigènes, et/ou en augmentant la dépense énergétique. Cependant, il est possible que l'action principale de la leptine ne soit pas de diminuer la masse adipeuse mais qu'elle représente plutôt un signal permettant de préserver un stock suffisant d'énergie sous forme de graisse.  1, record 10, French, - mol%C3%A9cule%20signal

Record 10,  Textual support,  Spanish