TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Desalkylgidazepam, or bromonordiazapam, is a newly emerging designer benzodiazepine that is structurally related to nordiazepam... It is the active metabolite of gidazepam, an anxiolytic prescribed in Ukraine and Russia, but is also being manufactured illicitly as a drug on its own.  3, record 1, English, - desalkylgidazepam

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

Le désalkylgidazépam est une benzodiazépine de synthèse dont la structure est semblable à celle du nordiazépam. Il s'agit du métabolite actif du gidazépam.  2, record 1, French, - d%C3%A9salkylgidaz%C3%A9pam

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Norfludiazepam is a BZD [benzodiazepine], structurally related to the internationally controlled substance diazepam... It is the active metabolite of flurazepam and fludiazepam and is used in the synthesis of midazolam...  3, record 2, English, - norfludiazepam

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Le norfludiazépam [...] est une benzodiazépine de synthèse à longue demi-vie [...]  1, record 2, French, - norfludiaz%C3%A9pam

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

A negative sample, meaning the drug is not contained in the urine,... has limitations of interpretation. Since drugs have different clearance rates in urine, it is possible that a negative test could result from not sampling soon enough after drug consumption. It is also possible that the dose of the drug taken was not large enough to result in sufficient quantities of drug metabolites to be detected with the current cut-off levels of the laboratory tests. It could also be that the drugs were not used chronically. Intermittent drug use will result in periods of time where no drug or metabolite is contained in the sample.  3, record 3, English, - negative

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

L'interprétation d'un échantillon négatif, c'est-à-dire d'un échantillon qui ne renferme pas la drogue recherchée, présente [...] des limites. Comme les drogues ont différents taux d'élimination dans l'urine, il est possible qu'un résultat négatif soit attribuable au fait que l'échantillon n'a pas été prélevé assez rapidement après la consommation de la drogue. Il se peut également que la dose consommée n'ait pas été assez forte pour produire des quantités suffisantes de métabolites de drogues qui peuvent être détectés à l'aide des seuils actuels des tests en laboratoire. La drogue peut aussi ne pas avoir été consommée régulièrement. La consommation intermittente d'une drogue aboutit à des périodes où l'échantillon ne renferme ni drogue ni métabolite.  1, record 3, French, - n%C3%A9gatif

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

A method for the measurement in plasma, blood and urine of progabide, its main acid metabolite, and the corresponding benzophenone is described. This assay allows the determination of progabide and its acid metabolite for therapeutic drug monitoring...  1, record 4, English, - acid%20metabolite

Record number: 4, Textual support number: 1 PHR

Arachidonic, carboxylic, folic, terfenadine acid metabolite.  2, record 4, English, - acid%20metabolite

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

L'ébastine est rapidement absorbée après prise orale et subit un effet de premier passage intestinal et hépatique très important. Elle est presque entièrement transformée en son métabolite acide pharmacologiquement actif, la carébastine.  2, record 4, French, - m%C3%A9tabolite%20acide

Record number: 4, Textual support number: 1 PHR

Métabolite acide carboxylique.  3, record 4, French, - m%C3%A9tabolite%20acide

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

The mixed-cell raceway … was designed … to integrate the beneficial characteristics of raceways(e. g. grading, harvesting, efficient use of space) with those of circular tanks(e. g. self-cleaning design, elimination of metabolite concentration gradients, more homogenous hydraulics) by hydraulically segregating a conventional raceway into a series of counter-rotating mixed cells … Mixed-cell raceways offer the added advantage of being able to be operated as either partial re-use or intensive recirculation systems.  2, record 5, English, - mixed%2Dcell%20raceway

Record 5,  Textual support,  French

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

[The] residue derived from the covalent binding of the parent drug or a metabolite of the drug and a cellular biological soluble or insoluble macromolecule.  1, record 6, English, - bound%20residue

Record number: 6, Textual support number: 1 OBS

[Bound] residue is not extractable from the macromolecule by exhaustive extraction, denaturation or solubilization techniques. It does not result from the incorporation of metabolized, radiolabelled fragments of the drug into endogenous compounds, or the same macromolecule by normal biosynthetic pathways.  1, record 6, English, - bound%20residue

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Résidu dérivé de la liaison covalente du médicament souche ou d'un métabolite de celui-ci avec un produit biologique cellulaire soluble ou une macromolécule insoluble.  1, record 6, French, - r%C3%A9sidu%20li%C3%A9

Record number: 6, Textual support number: 1 OBS

[Le résidu lié] n'est pas extractible de la macromolécule par des techniques de dénaturation, de solubilisation ou d'extraction exhaustive. Il ne résulte pas de l'incorporation de fragments métabolisés radio-étiquetés du médicament dans des composés endogènes, ou de la même molécule par voies biosynthétiques normales.  1, record 6, French, - r%C3%A9sidu%20li%C3%A9

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

7-KETO(3-acetyl-7-oxo-dehydroepiandrosterone) is a naturally occurring metabolite(breakdown product) of the hormone dehydroepiandrosterone(DHEA). DHEA is the most abundant of the adrenal steroid hormones and serves as a precursor for sex hormones, such as estrogen and testosterone.... 7-KETO is available as a dietary supplement.  3, record 7, English, - 7%2Dketo%20DHEA

Record number: 7, Textual support number: 2 CONT

The invention concerns the use of a DHEA derivative selected among 7-hydroxy DHEA and/or 7-keto DHEA in or for preparing a composition for preventing or treating disorders related to excessive 5$g(a)-reductase activity such as acne and/or seborrhoea and/or hirsutism and/or androgenetic alopecia.  4, record 7, English, - 7%2Dketo%20DHEA

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

La 7-Keto DHEA est un métabolite naturel récemment identifié de la déshydroépiandrostérone (DHEA); elle est à la fois beaucoup plus efficace et plus sûre que celle ci car elle ne se convertit ni en testostérone ni en œstrogènes dans l'organisme.  4, record 7, French, - 7%2Dc%C3%A9to%20DHEA

Record number: 7, Textual support number: 2 CONT

L'invention se rapporte à l'utilisation d'un dérivé de DHEA choisi parmi la 7-hydroxy DHEA et/ou la 7-céto DHEA dans ou pour la préparation d'une composition destinée à la prévention ou au traitement des désordres liés à une suractivité de la 5$g(a)-réductase tels que l'acné et/ou la séborrhée et/ou l'hirsutisme et/ou l'alopécie androgéno-dépendante.  5, record 7, French, - 7%2Dc%C3%A9to%20DHEA

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 OBS

Metabolite of nicotine(a component of tobacco smoke).  2, record 8, English, - cotinine

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

La cotinine, premier métabolite de la nicotine, est le meilleur marqueur du tabagisme actif ou environnemental.  2, record 8, French, - cotinine

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

The major ochratoxin component.  3, record 9, English, - ochratoxin%20A

Record number: 9, Textual support number: 1 CONT

Ochratoxin A(OTA) is a toxic metabolite formed by Aspergillus ochraceus, Penicillium verrucosum and other mould species. It is one of the most commonly occurring mycotoxins in improperly stored food. OTA has been found in corn, peanuts and decaying vegetation. It has also been found in mouldy cereals such as wheat, rye, barley, oats, and other commodities, including bread, flour, beans, peas, rice, and coffee and in samples of meat where the slaughtered animal may have consumed feed contaminated with OTA.  2, record 9, English, - ochratoxin%20A

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

L'ochratoxine A (OTA) est un métabolite toxique produit par Aspergillus ochraceus, Penicillium verrucosum et d'autres espèces de moisissures. C'est l'une des mycotoxines les plus fréquentes dans les aliments mal conservés. L'OTA se trouve dans le maïs, les arachides et la végétation en décomposition. Elle est aussi observée dans des céréales moisies comme le blé, le seigle, l'orge, l'avoine et dans d'autres denrées, notamment le pain, la farine, les haricots, les pois, le riz, le café et dans des échantillons de viande issus d'animaux ayant consommé des aliments contaminés à l'OTA.  2, record 9, French, - ochratoxine%20A

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

Metabolomics is the scientific study of chemical processes involving metabolites. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind, "the study of their small-molecule metabolite profiles.  3, record 10, English, - metabolomics

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 DEF

[Science] qui étudie l'ensemble des métabolites (sucres, acides aminés, acides gras, etc.) présents dans une cellule, un organe, un organisme.  2, record 10, French, - m%C3%A9tabolomique

Record number: 10, Textual support number: 1 OBS

métabolomique : terme publié au Journal officiel de la République française le 15 septembre 2013.  3, record 10, French, - m%C3%A9tabolomique

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

A primary metabolite is a kind of metabolite that is directly involved in normal growth, development, and reproduction. It usually performs a physiological function in the organism(i. e. an intrinsic function).  2, record 11, English, - primary%20metabolite

Record number: 11, Textual support number: 1 OBS

Primary metabolites are essential for the survival of the plant and include sugars, proteins and amino acids.  3, record 11, English, - primary%20metabolite

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

[...] les métabolites primaires sont des molécules qui existent dans toutes les cellules végétales et sont nécessaires à la vie de la plante. Les sucres simples, les acides aminés, les protéines et les acides nucléiques sont des exemples de métabolites primaires.  1, record 11, French, - m%C3%A9tabolite%20primaire

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

Secondary metabolites have no recognizable function in the physiology of the producing organism. The antibiotic function, for example, is usually derived from compounds excreted too late in the producing organism's life cycle to confer any ecological advantage. There are, however, a few secondary metabolites which may have some physiological significance to the producing organism. Commercially, the most important secondary metabolites are the antibiotics. Of these, penicillin is produced in the greatest quantity, at a rate of 10⁷ kg per annum. Other important antibiotics produced by fermentation are the aminoglycosides, cephalosporins, polyenes, non-polyene macrolides and the tetracyclines. Toxins and alkaloids account for the remainder of the secondary metabolites of industrial importance. Secondary metabolite is not formed as a direct result of the metabolism that keeps the cells alive. Hence the accumulation of a secondary metabolite in a reactor vessel lags behind the growth of the cells that produce it.  2, record 12, English, - secondary%20metabolite

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

De tous les produits classiques fabriqués par fermentation, les métabolites secondaires sont les plus importants pour la santé humaine. Ce groupe comprend non seulement les antibiotiques, mais aussi les toxines, les alcaloïdes et les facteurs de croissance des végétaux. Leur structure est très variée : chacun d'eux n'est produit que par une seule ou un petit nombre d'espèces microbiennes et se présente souvent sous la forme d'un mélange de substances très voisines (des analogues).  1, record 12, French, - m%C3%A9tabolite%20secondaire

Record 12,  Textual support,  Spanish

Record number: 12, Textual support number: 1 DEF

Producto del metabolismo secundario.  1, record 12, Spanish, - metabolito%20secundario

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

Brewery workers working for 1 day with ear protection and 1 day without excrete significantly more norepinephrine(NE) and its metabolite vanillylmandelic acid in urine under the noise stress condition.  6, record 13, English, - 2%2D%284%2Dhydroxy%2D3%2Dmethoxyphenyl%29%2D2%2Dhydroxyacetic%20acid

Record number: 13, Textual support number: 1 OBS

2-(4-hydroxy-3-methoxyphenyl)-2-hydroxyacetic acid: form recommended by the IUPAC (International Union of Pure and Applied Chemistry).  1, record 13, English, - 2%2D%284%2Dhydroxy%2D3%2Dmethoxyphenyl%29%2D2%2Dhydroxyacetic%20acid

Record number: 13, Textual support number: 2 OBS

The word "alpha" must be replaced by the corresponding Greek letter or italicized.  7, record 13, English, - 2%2D%284%2Dhydroxy%2D3%2Dmethoxyphenyl%29%2D2%2Dhydroxyacetic%20acid

Record number: 13, Textual support number: 3 OBS

Chemical formula: C₉H₁₀O₅  7, record 13, English, - 2%2D%284%2Dhydroxy%2D3%2Dmethoxyphenyl%29%2D2%2Dhydroxyacetic%20acid

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 CONT

L'excrétion urinaire des catécholamines et de l'acide vanillylmandelique au cours de la spasmophilie.  6, record 13, French, - acide%202%2D%284%2Dhydroxy%2D3%2Dm%C3%A9thoxyph%C3%A9nyl%29%2D2%2Dhydroxyac%C3%A9tique

Record number: 13, Textual support number: 1 OBS

acide 2-(4-hydroxy-3-méthoxyphényl)-2-hydroxyacétique : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée).  1, record 13, French, - acide%202%2D%284%2Dhydroxy%2D3%2Dm%C3%A9thoxyph%C3%A9nyl%29%2D2%2Dhydroxyac%C3%A9tique

Record number: 13, Textual support number: 2 OBS

Le mot «alpha» doit être remplacé par la lettre grecque correspondante ou s'écrire en italique.  7, record 13, French, - acide%202%2D%284%2Dhydroxy%2D3%2Dm%C3%A9thoxyph%C3%A9nyl%29%2D2%2Dhydroxyac%C3%A9tique

Record number: 13, Textual support number: 3 OBS

Formule chimique : C₉H₁₀O₅  7, record 13, French, - acide%202%2D%284%2Dhydroxy%2D3%2Dm%C3%A9thoxyph%C3%A9nyl%29%2D2%2Dhydroxyac%C3%A9tique

Record 13,  Textual support,  Spanish

Record number: 13, Textual support number: 1 OBS

Fórmula química: C₉H₁₀O₅  2, record 13, Spanish, - %C3%A1cido%20vanillilmand%C3%A9lico

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 DEF

A toxic metabolite of some strains of Aspergillus flavus.  1, record 14, English, - aflatoxin

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 DEF

Toxine produite par un champignon microscopique, Aspergillus flavus.  1, record 14, French, - aflatoxine

Record number: 14, Textual support number: 1 OBS

Ce champignon peut se développer dans certains aliments mal conservés, qui sont généralement des fourrages moisis, de la farine de maïs ou d'arachide avariée, dont l'ingestion par des animaux (bovins, porcs, volailles...) va provoquer une intoxication plus ou moins grave selon la quantité de toxine absorbée.  1, record 14, French, - aflatoxine

Record 14,  Textual support,  Spanish

Record number: 14, Textual support number: 1 DEF

Toxina producida por algunas cepas del hongo Aspergillus flavus, que constituye el más potente cancerígeno descubierto.  2, record 14, Spanish, - aflatoxina

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 DEF

An enzyme that possesses properties that specifically endows it with regulatory roles in metabolism.  2, record 15, English, - regulatory%20enzyme

Record number: 15, Textual support number: 1 CONT

Regulatory enzymes occupy key positions in metabolic pathways. The structural elements needed to make a regulatory enzyme are used with great selectivity and imposed only on those enzymes with which it will result in the maximum economy of the cell’s resources. An understanding of a particular multienzyme pathway usually suggests which enzymes might make attractive candidates for regulation. For example, many biosynthetic pathways involve a long chain of single chemical steps, each carried out by a discrete enzyme. ... It is obviously most economical for the first enzyme of the pathway to be inhibited once sufficient end product is present.  3, record 15, English, - regulatory%20enzyme

Record number: 15, Textual support number: 1 OBS

There are two major types of such enzymes :(1) allosteric enzymes, whose catalytic activity is modulated through the noncovalent binding of a specific metabolite at a site on the protein other than the catalytic site, and(2) covalently modulated enzymes, which are interconverted between active and inactive forms by the action of other enzymes.  2, record 15, English, - regulatory%20enzyme

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 DEF

Enzyme qui joue un rôle important dans la régulation des processus métaboliques de la cellule vivante.  2, record 15, French, - enzyme%20de%20r%C3%A9gulation

Record number: 15, Textual support number: 1 CONT

Il existe dans les principales voies métaboliques une ou plusieurs étapes catalysées par une enzyme régulatrice. Ces enzymes régulatrices, qui sont généralement allostériques, sont précisément les enzymes sur lesquelles agissent les signaux. Ces signaux activeront ou inhiberont ces enzymes et ainsi canaliseront les métabolites vers les voies satisfaisantes pour les besoins de la cellule.  4, record 15, French, - enzyme%20de%20r%C3%A9gulation

Record number: 15, Textual support number: 1 OBS

Il en existe deux principaux types : (1) les enzymes allostériques dont l'activité est modulée grâce à l'attachement non covalent d'un métabolite spécifique sur un autre site protéique que le site catalytique; (2) les enzymes modulées de façon covalente dont la forme inactive est activée par une transformation réalisée par une autre enzyme.  2, record 15, French, - enzyme%20de%20r%C3%A9gulation

Record 15,  Textual support,  Spanish

Record number: 15, Textual support number: 1 OBS

Tradicionalmente, la Real Academia Española (RAE) admitía únicamente el género femenino para el sustantivo enzima; así fue hasta 1984, fecha en que pasó a considerarlo de género ambiguo, que puede funcionar por igual como masculino y como femenino. El uso, no obstante, parece haberse decantado claramente en español por el femenino, que hoy se emplea en el 90% de los casos [...]  2, record 15, Spanish, - enzima%20reguladora

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 CONT

Allosteric enzymes function through reversible, noncovalent binding of a regulatory metabolite called a modulator. They have other shapes or conformations induced by the binding of modulators. An example is feedback inhibition. An allosteric effect is described as a variation in proteins activity through the interaction of another molecule at a site on the protein which is distinct from the "active" site.(Ex. Hb and BPG.)  2, record 16, English, - allosteric%20enzyme

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 CONT

[...] les enzymes allostériques reconnaissent en s'y associant un substrat spécifique, et active sa conversion en produits. Mais en outre, ces enzymes ont la propriété de reconnaître électivement un ou plusieurs autres composés dont l'association (stéréospécifique) avec la protéine a pour effet de modifier, c'est-à-dire, selon le cas, d'accroître ou d'inhiber son activité à l'égard du substrat.  2, record 16, French, - enzyme%20allost%C3%A9rique

Record 16,  Textual support,  Spanish

Record number: 16, Textual support number: 1 OBS

Tradicionalmente, la Real Academia Española (RAE) admitía únicamente el género femenino para el sustantivo enzima; así fue hasta 1984, fecha en que pasó a considerarlo de género ambiguo, que puede funcionar por igual como masculino y como femenino. El uso, no obstante, parece haberse decantado claramente en español por el femenino, que hoy se emplea en el 90% de los casos [...]  2, record 16, Spanish, - enzima%20alost%C3%A9rica

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 OBS

A type of metabolite.  2, record 17, English, - 2%2C4%2Ddichlorophenol

Record 17,  Textual support,  French

Record 17,  Textual support,  Spanish

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 DEF

Delayed degradation or excretion of a drug(or of its active metabolite) brought about by concurrent administration of another substance.  1, record 18, English, - extender%20effect

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 DEF

Ralentissement de la dégradation ou de l'excrétion d'un médicament (ou de son métabolite actif) par administration concomitante d'une autre substance.  1, record 18, French, - effet%2Dretard

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 DEF

A crystalline, biologically inactive dehydroxy derivative of progesterone and its chief urinary metabolite.  1, record 19, English, - pregnanediol

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 DEF

Métabolite héxalydrogéné principal de la progestérone, qui est éliminé dans les urines sous forme de glycoconjugué.  2, record 19, French, - pr%C3%A9gnandiol

Record 19,  Textual support,  Spanish

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 DEF

A metabolite of the omega-3 fatty acid alpha-linolenic acid.  4, record 20, English, - docosahexanoic%20acid

Record 20,  Textual support,  French

Record number: 20, Textual support number: 1 CONT

[Des spécialistes] ont mesuré la concentration de deux acides gras oméga-3 dans le sang de 426 Inuits du Nunavik. Ces deux composés, l'EPA (acide eicosapentanoïque) et le DHA (acide docosahexanoïque) abondent dans les poissons et les mammifères marins qui font partie de l'alimentation traditionnelle de ce peuple.  3, record 20, French, - acide%20docosahexano%C3%AFque

Record number: 20, Textual support number: 2 CONT

L'acide docosahexaénoïque (ADH). L’ADH est également présent dans les produits marins, plus particulièrement dans certains poissons gras. Il joue un rôle fondamental dans le développement du cerveau et de la rétine ainsi que dans la formation et la motilité des spermatozoïdes.  7, record 20, French, - acide%20docosahexano%C3%AFque

Record number: 20, Textual support number: 1 OBS

ADH : abréviation non officielle; ne pas l'utiliser seule, pour éviter tout risque de confusion. DHA : abréviation anglaise.  2, record 20, French, - acide%20docosahexano%C3%AFque

Record 20,  Textual support,  Spanish

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 DEF

A major metabolite of testosterone and androstenedione, found in the plasma and urine of men and women.  1, record 21, English, - androsterone

Record number: 21, Textual support number: 1 OBS

Chemical formula: C₁₉H₃₀O₂  2, record 21, English, - androsterone

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 OBS

Hormone sexuelle secondaire, d'origine corticosurrénalienne.  1, record 21, French, - androst%C3%A9rone

Record number: 21, Textual support number: 2 OBS

Formule chimique : C₁₉H₃₀O₂  2, record 21, French, - androst%C3%A9rone

Record 21,  Textual support,  Spanish

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 OBS

Cilazapril is used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.  2, record 22, English, - cilazapril

Record number: 22, Textual support number: 2 OBS

Active ingredient commonly sold under the name Justor.  3, record 22, English, - cilazapril

Record number: 22, Textual support number: 3 OBS

Chemical formula: C₂₂H₃₃N₃O₆  3, record 22, English, - cilazapril

Record 22,  Textual support,  French

Record number: 22, Textual support number: 1 CONT

Le cilazapril est actif à tous les stades de l'hypertension artérielle : légère, modérée ou sévère; on observe une réduction des pressions artérielles systolique et diastolique, en décubitus et en orthostatisme.  2, record 22, French, - cilazapril

Record number: 22, Textual support number: 1 OBS

Principe actif couramment commercialisé sous le nom de Justor.  3, record 22, French, - cilazapril

Record number: 22, Textual support number: 2 OBS

Formule chimique : C₂₂H₃₃N₃O₆  3, record 22, French, - cilazapril

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 DEF

Allosteric enzyme that is stimulated or inhibited by an effector or modulator molecule other than its substrate. For the enzyme threonine dehydratase the substrate is threonine and modulator is L-isoleucine. In many cases the effectors are end products of a metabolic pathway, and when they inhibit (which is usually the case) these effectors are called end product or feedback inhibitors. Kinetically feedback inhibitors are usually partially competitive in that they can be partially overcome by high concentrations of the substrate.  2, record 23, English, - heterotropic%20enzyme

Record number: 23, Textual support number: 1 OBS

A great many(if not most) allosteric enzymes are of mixed homotropic-heterotropic type, in which both the substrate and some other metabolite(s) may function as modulators.  3, record 23, English, - heterotropic%20enzyme

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 DEF

Enzyme allostérique stimulé ou inhibé par un effecteur ou un modulateur autre que leur substrat. Pour l'enzyme thréonine déshydratase, le substrat est la thréonine et le modulateur la L-isoleucine.  1, record 23, French, - enzyme%20h%C3%A9t%C3%A9rotrope

Record 23,  Textual support,  Spanish

Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 DEF

Major metabolite of norepinephrine...  3, record 24, English, - 1%2D%284%2Dhydroxy%2D3%2Dmethoxyphenyl%29ethane%2D1%2C2%2Ddiol

Record number: 24, Textual support number: 1 OBS

1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol: form recommended by the IUPAC (International Union of Pure and Applied Chemistry).  1, record 24, English, - 1%2D%284%2Dhydroxy%2D3%2Dmethoxyphenyl%29ethane%2D1%2C2%2Ddiol

Record number: 24, Textual support number: 2 OBS

MHPG: This might be an in-house or a non-recognized abbreviation; not to be used alone, to avoid any risk of confusion.  1, record 24, English, - 1%2D%284%2Dhydroxy%2D3%2Dmethoxyphenyl%29ethane%2D1%2C2%2Ddiol

Record number: 24, Textual support number: 3 OBS

Chemical formula: C₉H₁₂O₄  6, record 24, English, - 1%2D%284%2Dhydroxy%2D3%2Dmethoxyphenyl%29ethane%2D1%2C2%2Ddiol

Record 24,  Textual support,  French

Record number: 24, Textual support number: 1 DEF

Métabolite de la noradrénaline issue de la norépinéphrine (noradrénaline).  3, record 24, French, - 1%2D%284%2Dhydroxy%2D3%2Dm%C3%A9thoxyph%C3%A9nyl%29%C3%A9thane%2D1%2C2%2Ddiol

Record number: 24, Textual support number: 1 OBS

1-(4-hydroxy-3-méthoxyphényl)éthane-1,2-diol : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée).  1, record 24, French, - 1%2D%284%2Dhydroxy%2D3%2Dm%C3%A9thoxyph%C3%A9nyl%29%C3%A9thane%2D1%2C2%2Ddiol

Record number: 24, Textual support number: 2 OBS

Formule chimique : C₉H₁₂O₄  4, record 24, French, - 1%2D%284%2Dhydroxy%2D3%2Dm%C3%A9thoxyph%C3%A9nyl%29%C3%A9thane%2D1%2C2%2Ddiol

Record 24,  Textual support,  Spanish

Record 25,  Textual support,  English

Record number: 25, Textual support number: 1 CONT

Zestril(lisinopril dihydrate), a synthetic peptide derivative, is an oral long-acting angiotensin converting enzyme inhibitor. It is a lysine analogue of enalaprilat(active metabolite of enalapril). Lisinopril dihydrate is a white to off-white, crystalline powder, with a molecular weight of 441. 53.... Zestril tablets also contain mannitol, calcium hydrogen phosphate, maize starch, pregelatinised maize starch, magnesium stearate and iron oxide red CI77491.  6, record 25, English, - lisinopril%20dihydrate

Record number: 25, Textual support number: 1 OBS

Zestril (lisinopril dihydrate) is a leading angiotensin converting enzyme (ACE) inhibitor for hypertension, congestive heart failure, acute myocardial infarction, and renal and retinal complications of diabetes. Zestril is sold under licence from Merck & Co, Inc. in all major territories worldwide.  6, record 25, English, - lisinopril%20dihydrate

Record number: 25, Textual support number: 2 OBS

{N²-[(S)-(1-carboxy-3-phenylpropyl)]-L-lysyl}-L-proline dihydrate: The capital letters "N" and "S" are italicized; the letter "L" is a small capital; form recommended by the IUPAC (International Union of Pure and Applied Chemistry) and by the IUBMB (International Union of Biochemistry and Molecular Biology).  2, record 25, English, - lisinopril%20dihydrate

Record number: 25, Textual support number: 3 OBS

(S)-1-[N²-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate: The capital letters "S" and "N" are italicized; the letter "L" is a small capital; CAS name.  2, record 25, English, - lisinopril%20dihydrate

Record number: 25, Textual support number: 4 OBS

Also known under a large number of commercial or trade names, such as: Acerbon; Alapril; Carace; Coric; MK-521; Novatec; Prinil; Tensopril; Vivatec.  7, record 25, English, - lisinopril%20dihydrate

Record number: 25, Textual support number: 5 OBS

Chemical formula: C₂₁H₃₁N₃O₅·2H₂O  7, record 25, English, - lisinopril%20dihydrate

Record 25,  Textual support,  French

Record number: 25, Textual support number: 1 OBS

Produit chimique agissant comme inhibiteur de l'enzyme responsable de la conversion de l'angiotensine 1 (inactive) en angiotensine 2 (active), utilisé dans le traitement de l'hypertension artérielle et de l'insuffisance cardiaque.  4, record 25, French, - lisinopril%20dihydrate

Record number: 25, Textual support number: 2 OBS

{N²-[(S)-(1-carboxy-3-phénylpropyl)]-L-lysyl}-L-proline dihydrate : Les lettres majuscules «N» et «S» s'écrivent en italique; la lettre «L» est une petite capitale; forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée) et par l'UIBBM (Union internationale de biochimie et de biologie moléculaire).  1, record 25, French, - lisinopril%20dihydrate

Record number: 25, Textual support number: 3 OBS

lisinopril dihydraté; dihydrate de lisinopril : Les hydrates sont des composés d'addition, formés par deux ou plusieurs composés distincts qui ne se combinent pas pour former un nouveau composé. Les hydrates sont ainsi composés d'un composé, le lisinopril dans le cas présent, et d'un certain nombre de molécules d'eau (2 ici); l'eau peut se trouver sous forme d'eau de cristallisation ou sous n'importe quelle forme. Le terme hydrate est une exception à la règle de nomenclature qui veut que la terminaison en «ate» désigne un anion : le terme hydrate désigne une molécule d'eau et non l'ion OH_- qui est nommé «hydroxide». Dans un nom de composé d'addition, les molécules d'eau sont toujours citées en dernier lieu. Une molécule d'eau est signalée par le terme «monohydrate»; les préfixes multiplicatifs «di-», «tri-», «tétra-», etc., sont utilisés pour indiquer le nombre de molécules d'eau (2,3,4, etc.). Le nom «lisinopril dihydrate» est conforme à l'usage. L'adjectif «hydraté» a été proposé, sans succès. Le terme «(di)hydrate de lisinopril» est à bannir, car cette forme n'indique plus qu'il s'agit d'un composé d'addition, mais laisse entendre que ce serait un composé équivalent à un sel, comme dans «chlorhydrate de...».  1, record 25, French, - lisinopril%20dihydrate

Record number: 25, Textual support number: 4 OBS

Le lisinopril dihydrate entre dans la composition de la marque Zestril, il en constitue l'ingrédient actif.  4, record 25, French, - lisinopril%20dihydrate

Record number: 25, Textual support number: 5 OBS

Formule chimique : C₂₁H₃₁N₃O₅·2H₂O  4, record 25, French, - lisinopril%20dihydrate

Record 25,  Textual support,  Spanish

Record 26,  Textual support,  English

Record number: 26, Textual support number: 1 CONT

A comparison of cocaine and its metabolite norcocaine : effects on locomotor activity.  1, record 26, English, - norcocaine

Record 26,  Textual support,  French

Record 26,  Textual support,  Spanish

Record 27,  Textual support,  English

Record number: 27, Textual support number: 1 OBS

N-[4-chloro-2-fluoro-5-({[(isopropylamino)sulfonyl]amino}carbonyl)phenyl]urea: form recommended by the IUPAC (International Union of Pure and Applied Chemistry).  2, record 27, English, - N%2D%5B4%2Dchloro%2D2%2Dfluoro%2D5%2D%28%7B%5B%28isopropylamino%29sulfonyl%5Damino%7Dcarbonyl%29phenyl%5Durea

Record number: 27, Textual support number: 2 OBS

IUPAC name of saflufenacil metabolite.  1, record 27, English, - N%2D%5B4%2Dchloro%2D2%2Dfluoro%2D5%2D%28%7B%5B%28isopropylamino%29sulfonyl%5Damino%7Dcarbonyl%29phenyl%5Durea

Record number: 27, Textual support number: 3 OBS

N: This capital letter must be italicized.  2, record 27, English, - N%2D%5B4%2Dchloro%2D2%2Dfluoro%2D5%2D%28%7B%5B%28isopropylamino%29sulfonyl%5Damino%7Dcarbonyl%29phenyl%5Durea

Record 27,  Textual support,  French

Record number: 27, Textual support number: 1 OBS

N-[4-chloro-2-fluoro-5-({[(isopropylamino) sulfonyl]amino}carbonyl)phényl]urée : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée).  1, record 27, French, - N%2D%5B4%2Dchloro%2D2%2Dfluoro%2D5%2D%28%7B%5B%28isopropylamino%29sulfonyl%5Damino%7Dcarbonyl%29ph%C3%A9nyl%5Dur%C3%A9e

Record number: 27, Textual support number: 2 OBS

Nom UICPA du métabolite du saflufénacil.  1, record 27, French, - N%2D%5B4%2Dchloro%2D2%2Dfluoro%2D5%2D%28%7B%5B%28isopropylamino%29sulfonyl%5Damino%7Dcarbonyl%29ph%C3%A9nyl%5Dur%C3%A9e

Record number: 27, Textual support number: 3 OBS

N : Cette lettre majuscule s'écrit en italique.  1, record 27, French, - N%2D%5B4%2Dchloro%2D2%2Dfluoro%2D5%2D%28%7B%5B%28isopropylamino%29sulfonyl%5Damino%7Dcarbonyl%29ph%C3%A9nyl%5Dur%C3%A9e

Record 27,  Textual support,  Spanish

Record 28,  Textual support,  English

Record number: 28, Textual support number: 1 OBS

An antilipemic agent and the biologically active metabolite of clofibrate.  3, record 28, English, - clofibric%20acid

Record number: 28, Textual support number: 2 OBS

Chemical formula: C₁₀H₁₁ClO₃  4, record 28, English, - clofibric%20acid

Record 28,  Textual support,  French

Record number: 28, Textual support number: 1 OBS

Agent hypolipémiant. C'est le métabolite actif du clofibrate.  2, record 28, French, - acide%20clofibrique

Record number: 28, Textual support number: 2 OBS

Formule chimique : C₁₀H₁₁ClO₃  3, record 28, French, - acide%20clofibrique

Record 28,  Textual support,  Spanish

Record number: 28, Textual support number: 1 OBS

Fórmula química: C₁₀H₁₁ClO₃  2, record 28, Spanish, - %C3%A1cido%20clof%C3%ADbrico

Record 29,  Textual support,  English

Record number: 29, Textual support number: 1 DEF

Fermentation vessel or bioreactor in which steady-state growth is maintained by providing the cells with a constant input of nutrients. The rate of growth can be regulated by the level of a specific nutrient and the dilution rate (rate of removal of organisms from the vessel) matched to the cell growth rate.  1, record 29, English, - chemostat

Record number: 29, Textual support number: 1 CONT

Both mathematical models of the action of a chemostat and experimental studies show that a single-stage chemostat of practical size cannot yield a high concentration of a product and low concentrations of unconsumed raw materials. The inefficiency is particularly great in the synthesis of products such as penicillin, which is a secondary metabolite : it is made by living cells but its synthesis does not arise in the course of the metabolism that keeps the cells alive and growing. It is characteristic of the industrial production of a secondary metabolite that the proliferation of the organism precedes the accumulation of the metabolite by a significant margin.  2, record 29, English, - chemostat

Record 29,  Textual support,  French

Record number: 29, Textual support number: 1 DEF

Type de réacteur dans lequel on contrôle la réaction par l'intermédiaire du flux entrant. On fixe la concentration d'une substance nutritive critique à une valeur telle que les autres substances nutritives se trouvent en excès. La substance nutritive critique impose alors une limite à la prolifération des micro-organismes.  2, record 29, French, - chemostat

Record number: 29, Textual support number: 1 CONT

Pour la production industrielle, il est nécessaire de réaliser des cultures de micro-organismes en très grandes quantités dans des récipients, adaptés aux différents types de fabrication, nommés fermenteurs, dont le volume peut atteindre plusieurs centaines de litres. Ils doivent être thermostatés avec précision. [...] La tendance actuelle est une automatisation de plus en plus poussée, avec un développement ininterrompu des cultures (technique du «chemostat»).  3, record 29, French, - chemostat

Record 29,  Textual support,  Spanish

Record 30,  Textual support,  English

Record number: 30, Textual support number: 1 DEF

[A] secondary metabolite produced by a plant in response to infection by microorganisms.  2, record 30, English, - phytoalexin

Record 30,  Textual support,  French

Record number: 30, Textual support number: 1 DEF

Substance qui inhibe la croissance de certains micro-organismes et qui est produite par les plantes supérieures en réponse à des stimulations biologiques, physiques ou chimiques.  2, record 30, French, - phytoalexine

Record number: 30, Textual support number: 1 OBS

phytoalexine : terme publié au Journal officiel de la République française le 6 juillet 2008.  3, record 30, French, - phytoalexine

Record 30,  Textual support,  Spanish

Record 31,  Textual support,  English

Record number: 31, Textual support number: 1 CONT

Citreoviridin is a toxic secondary metabolite isolated from several Penicillium species... Citreoviridin has a close structural similarity to the aurovertins... which have been shown to be potent inhibitors of the mitochondrial ATP synthetase system...  2, record 31, English, - citreoviridin

Record 31,  Textual support,  French

Record number: 31, Textual support number: 1 CONT

La citréoviridine, neurotoxine puissante, provoque une paralysie des extrémités, des convulsions et la mort par arrêt respiratoire.  2, record 31, French, - citr%C3%A9oviridine

Record 31,  Textual support,  Spanish

Record 32,  Textual support,  English

Record number: 32, Textual support number: 1 DEF

A carcinogenic metabolite of the foodborne carcinogen aflatoxin B1 previously known only as a bioreduction product in vitro...  2, record 32, English, - aflatoxicol

Record 32,  Textual support,  French

Record number: 32, Textual support number: 1 DEF

Produit du métabolisme de l'aflatoxine [...]  3, record 32, French, - aflatoxicol

Record 32,  Textual support,  Spanish

Record 33,  Textual support,  English

Record number: 33, Textual support number: 1 CONT

Ditiocarb [is a] chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of disulfiram.  3, record 33, English, - diethyldithiocarbamate

Record number: 33, Textual support number: 2 CONT

Imuthiol (also called diethyldithiocarbamate, ditiocarb, or DTC) was ... withdrawn by its sponsor, Institut Merieux of Lyon, France, after disappointing results from a preliminary analysis of a large clinical trial in France ...  2, record 33, English, - diethyldithiocarbamate

Record 33,  Textual support,  French

Record 33,  Textual support,  Spanish

Record number: 33, Textual support number: 1 DEF

Medicamento empleado para estimular el sistema inmunitario, induciendo al hígado a producir hepatosin. Su nombre comercial es Imuthiol y sus principales efectos secundarios indeseables son sabor metálico que perdura uno o dos días, molestias abdominales, fatiga, náusea y reducción de la agudeza mental.  1, record 33, Spanish, - DTC

Record 34,  Textual support,  English

Record number: 34, Textual support number: 1 CONT

At least since the 1940s fluoroacetate is known as one of the most toxic substances anywhere... Compound 1080 is sodium fluoroacetate.... Fluoroacetate is also a metabolite of many other fluorinated pesticides and other organic fluoride compounds, such as those used in anesthetics(i. e. halothane, evoflurane, etc), or 5-fluorouracil, an agent given in cancer(chemotherapy) treatment, etc.... Its use has been investigated and employed even in chemical warfare agents. It is the toxic breakdown product of organophosphates.  3, record 34, English, - fluoroacetate

Record 34,  Textual support,  French

Record number: 34, Textual support number: 1 OBS

Composé connu depuis longtemps pour être un violent poison cardiotoxique et neurotoxique.  1, record 34, French, - fluoroac%C3%A9tate

Record 34,  Textual support,  Spanish

Record 35,  Textual support,  English

Record number: 35, Textual support number: 1 DEF

A metabolite that, when bound to an allosteric enzyme, alters the catalytic activity of the enzyme. It generally alters either the Michaelis constant of the enzyme or the maximum velocity of the reaction.  2, record 35, English, - effector

Record 35,  Textual support,  French

Record number: 35, Textual support number: 1 DEF

Petite molécule organique qui intervient dans les processus de régulation du métabolisme cellulaire [...] au niveau de l'activité des enzymes, en se combinant avec une enzyme dont il modifie l'affinité pour le substrat.  2, record 35, French, - effecteur

Record 35,  Textual support,  Spanish

Record 36,  Textual support,  English

Record number: 36, Textual support number: 1 CONT

"Soy is rich in isoflavones" and estrogenic activity, continues Hasler.  2, record 36, English, - isoflavone

Record number: 36, Textual support number: 2 CONT

All plants make a class of secondary metabolite known as flavonoids. Most legumes-the plant family that includes peas, beans, clover, alfalfa and lupines-make a sub-class of flavonoid called isoflavones.  3, record 36, English, - isoflavone

Record 36,  Textual support,  French

Record number: 36, Textual support number: 1 CONT

L'isoflavone est un phytoestrogène.  2, record 36, French, - isoflavone

Record 36,  Textual support,  Spanish

Record 37,  Textual support,  English

Record number: 37, Textual support number: 1 DEF

Conversion of an open-chain organic compound into one having a closed ring structure. [Definition standardized by ISO.]  3, record 37, English, - cyclization

Record number: 37, Textual support number: 1 CONT

M3 was the major metabolite in the liver, unchanged dimethenamid was the major radiocarbon in fat. Metabolism was via glutathione conjugation, reductive dechlorination, hydroxylation, and ring cyclization.  2, record 37, English, - cyclization

Record number: 37, Textual support number: 1 OBS

cyclization: term standardized by ISO.  4, record 37, English, - cyclization

Record 37,  Textual support,  French

Record number: 37, Textual support number: 1 DEF

Transformation d'un composé organique à chaîne ouverte en un autre à structure cyclique. [Définition normalisée par l'ISO.]  2, record 37, French, - cyclisation

Record number: 37, Textual support number: 1 OBS

cyclisation : terme normalisé par l'ISO.  3, record 37, French, - cyclisation

Record number: 37, Textual support number: 2 OBS

Voir aussi les fiches TERMIUM pour les termes suivants : «cycle», «noyau» et «structure cyclique» (en chimie).  4, record 37, French, - cyclisation

Record 37,  Textual support,  Spanish

Record 38,  Textual support,  English

Record number: 38, Textual support number: 1 CONT

Vitamin D3(cholecalciferol) must be metabolized in the liver and the kidneys before it is fully active on its target tissues. Calcitriol(1, 25-dihydroxycholecalciferol) is the major active metabolite.  1, record 38, English, - calcitriol

Record 38,  Textual support,  French

Record number: 38, Textual support number: 1 CONT

La vitamine D3 (cholécalciférol) doit être métabolisée dans le foie et le rein avant de pouvoir exercer pleinement son action sur les tissus cibles. Le calcitriol (1,25-dihydroxycholécalciférol) est le métabolite actif.  1, record 38, French, - calcitriol

Record number: 38, Textual support number: 2 CONT

[Le] calcitriol est une forme active de la vitamine D3 qui fait courir un risque d'effets indésirables sur le métabolisme du calcium. Par contre le calcipotriol est un analogue de la vitamine D3 et paraît plus efficace que le valérate de bétaméthasone.  2, record 38, French, - calcitriol

Record 38,  Textual support,  Spanish

Record 39,  Textual support,  English

Record number: 39, Textual support number: 1 CONT

At the conclusion of this module, a student will be expected to have gained an up-to-date knowledge and understanding, and developed a critical appreciation of the following aspects of biochemical diagnosis of disease :(1) the role of enzyme and metabolite assays in the diagnosis and monitoring of diseases with a biochemical parthogenesis,(2) the role of immunoassays in the diagnosis and monitoring of endocrine diseases,(3) the application of DNA-based methods to the diagnosis of cancer, genetic diseases and infectious diseases,(4) ethical, social, legal and economic aspects of modern diagnostics.  1, record 39, English, - biochemical%20diagnosis

Record 39,  Textual support,  French

Record number: 39, Textual support number: 1 CONT

Diagnostic biochimique. À l'heure actuelle, seuls les diagnostics génétiques ont une sensibilité suffisante pour permettre un diagnostic à partir d'une cellule unique. Cependant, certaines équipes tentent de développer des techniques biochimiques pour réaliser un diagnostic génétique préimplantatoire.  1, record 39, French, - diagnostic%20biochimique

Record number: 39, Textual support number: 1 OBS

Technique susceptible d'améliorer le diagnostic génétique préimplantatoire.  2, record 39, French, - diagnostic%20biochimique

Record 39,  Textual support,  Spanish

Record 40,  Textual support,  English

Record number: 40, Textual support number: 1 CONT

The conversion of these nitrates to gaseous nitrogen implies a further denitrification stage. There are several possible ways of achieving this :... changing the state of the mixed liquor from aerobiosis to anaerobiosis before clarification, passing it through a shallow lagoon where algae develop, using this form of nitrogen as a metabolite.  2, record 40, English, - nitrogen%20gas

Record 40,  Textual support,  French

Record number: 40, Textual support number: 1 CONT

La transformation de ces nitrates en azote gazeux implique un stade de dénitrification complémentaire. Pour cela plusieurs schémas sont possibles : [...] passage de la liqueur mixte en anoxybiontie avant clarification, passage dans une lagune de faible profondeur, où des algues se développent, utilisant cette forme d'azote comme métabolite.  1, record 40, French, - azote%20gazeux

Record 40,  Textual support,  Spanish

Record 41,  Textual support,  English

Record number: 41, Textual support number: 1 CONT

The rodent AUCs and metabolite profiles may be determined from separate steady-state pharmacokinetic studies, as part of the subchronic toxicity studies, or dose-ranging studies.  1, record 41, English, - steady%2Dstate%20pharmacokinetic%20study

Record 41,  Textual support,  French

Record number: 41, Textual support number: 1 CONT

Lors d'une étude pharmacocinétique à l'état d'équilibre menée sur l'administration simultanée de furosémide et de fosinopril, l'aire sous la courbe et les concentrations maximales du fosinoprilate ont augmenté de 26% et de 25% respectivement.  1, record 41, French, - %C3%A9tude%20pharmacocin%C3%A9tique%20%C3%A0%20l%27%C3%A9tat%20d%27%C3%A9quilibre

Record 41,  Textual support,  Spanish

Record 42,  Textual support,  English

Record number: 42, Textual support number: 1 CONT

Lorazepan was chosen as the comparison drug because of its well documented behavioral effects and because it has a short metabolic half-life and no active metabolite, which eliminates the possible confounding effects of drug accumulation.(The journal of pharmacology and experimental therapeutics, 1993. 264(3) page 1218-1226).  1, record 42, English, - comparison%20drug

Record 42,  Textual support,  French

Record 42,  Textual support,  Spanish

Record 43,  Textual support,  English

Record number: 43, Textual support number: 1 CONT

Desogestrel is transformed in two steps to its active metabolite 3 keto-desogestrel(ll-methylene-levonorgestrel).  1, record 43, English, - 3%2Dketo%2Ddesogestrel

Record 43,  Textual support,  French

Record number: 43, Textual support number: 1 CONT

Le progestatif utilisé a été le 3-kéto-désogestrel (k-DOG). Il exerce un important effet progestatif sur l'appareil génital, mais a peu d'effets systématiques androgènes secondaires à son action métabolique. (Relevé dans Contracept. Fertil. Sex. - 1992 - Vol. 20, no 1, p. 18).  1, record 43, French, - 3%2Dk%C3%A9to%2Dd%C3%A9sogestrel

Record 43,  Textual support,  Spanish

Record 44,  Textual support,  English

Record number: 44, Textual support number: 1 DEF

A major metabolite of thyroxine having little or no calorigenic activity....  1, record 44, English, - reverse%20triiodothyronine

Record number: 44, Textual support number: 1 OBS

The metabolism of thyroxine to reverse T3 ... represents a mechanism that potentially can respond to the energy needs of the body in a variety of different physiologic states.  1, record 44, English, - reverse%20triiodothyronine

Record 44,  Textual support,  French

Record number: 44, Textual support number: 1 OBS

triiodothyronine (t3).  2, record 44, French, - triiodothyronine%20inverse

Record 44,  Textual support,  Spanish

Record 45,  Textual support,  English

Record number: 45, Textual support number: 1 CONT

An example of feedforward enzyme activation is found in the activation of glycogen synthetase by glucose 6-phosphate, i. e. a metabolite activates an enzyme concerned in its utilization. Enzyme induction is a positive feedforward process.  1, record 45, English, - feedforward%20enzyme%20activation

Record number: 45, Textual support number: 1 OBS

See "enzyme induction"  2, record 45, English, - feedforward%20enzyme%20activation

Record 45,  Textual support,  French

Record number: 45, Textual support number: 1 CONT

Principaux modes de régulation de l'activité enzymatique : - La rétroinhibition. (...) - L'activation d'un enzyme par un précurseur du substrat ou par le substrat lui-même. - L'activation par un produit de dégradation du métabolite terminal, permettant d'élever à nouveau la concentration de ce métabolite (qui peut être une substance à haut potentiel énergétique par exemple). - L'activation d'un enzyme d'une suite métabolique conduisant à un métabolite A par un métabolite B, qui est synthétisé par une suite indépendante, lorsque A et B sont tous deux nécessaires à la synthèse des mêmes macromolécules, ce qui permet une production coordonnée des précurseurs.  1, record 45, French, - activation

Record 45,  Textual support,  Spanish

Record 46,  Textual support,  English

Record number: 46, Textual support number: 1 CONT

It is possible that many inherited defects, which need not be congenital, are due to inheritance of a higher requirement of a specific metabolite than normal, the so-called "genetotrophic" diseases.  1, record 46, English, - genetotrophic%20disease

Record 46,  Textual support,  French

Record number: 46, Textual support number: 1 CONT

Il est possible que beaucoup de défectuosités et anomalies héréditaires, lesquelles n'ont pas besoin d'être congénitales, soient sous la dépendance de la transmission héréditaire d'un besoin en un métabolite donné, besoin supérieur à la normale de l'espèce : c'est dans ce cas que l'on parle de "maladies génotrophiques".  1, record 46, French, - maladie%20g%C3%A9notrophique

Record 46,  Textual support,  Spanish

Record 47,  Textual support,  English

Record number: 47, Textual support number: 1 CONT

Falcon Disposable Roller Bottles. Ideal for large-scale requirements of viral vaccine and cellular metabolite production. Extra-large surface area means greater efficiency, better utilization of roller rack space, reduced risk of contamination and savings of time, labor and media.  1, record 47, English, - roller%20bottle

Record 47,  Textual support,  French

Record number: 47, Textual support number: 1 CONT

Bouteilles Falcon pour agitateurs rotatifs (...). Bouteilles idéales pour la production industrielle de vaccins contre les maladies virales et de métabolites cellulaires. Leur surface extra-grande signifie production haut de gamme, utilisation maximale de l'espace sur l'agitateur, risques de contamination très peu élevés, économie de temps, de travail, de milieux.  1, record 47, French, - bouteille%20pour%20agitateur%20rotatif

Record 47,  Textual support,  Spanish

Record 48,  Textual support,  English

Record number: 48, Textual support number: 1 CONT

The major metabolite identified in blood and urine [in the case of isotretinoin] was 4-oxo-isotretinoin. Tretinoin and 4-oxo-tretinoin were also observed.  1, record 48, English, - 4%2Doxo%2Disotretinoin

Record 48,  Textual support,  French

Record number: 48, Textual support number: 1 CONT

Le principal métabolite identifié dans le sang et l'urine [dans le cas de l'isotrétinoine] fut la 4-oxo-isotrétinoine. On a aussi observé de la trétinoine et de la 4-oxo-trétinoine.  1, record 48, French, - 4%2Doxo%2Disotr%C3%A9tinoine

Record 48,  Textual support,  Spanish

Record 49,  Textual support,  English

Record number: 49, Textual support number: 1 CONT

The major metabolite identified in blood and urine [in the case of isotretinoin] was 4-oxo-isotretinoin. Tretinoin and 4-oxo-tretinoin were also observed.  1, record 49, English, - 4%2Doxo%2Dtretinoin

Record 49,  Textual support,  French

Record number: 49, Textual support number: 1 CONT

Le principal métabolite identifié dans le sang et l'urine [dans le cas de l'isotrétinoine] fut la 4-oxo-isotrétinoine. On a aussi observé de la trétinoine et de la 4-oxo-trétinoine.  1, record 49, French, - 4%2Doxo%2Dtr%C3%A9tinoine

Record 49,  Textual support,  Spanish

Record 50,  Textual support,  English

Record number: 50, Textual support number: 1 OBS

We have post-antibiotic effects with cefotaxime. We may have a bonus from a metabolite effect but all of these things together add up to post-dosing where at the midpoint the serum level crossed the MIC(concentration maximale inhibitrice).  1, record 50, English, - post%2Ddosing

Record 50,  Textual support,  French

Record 50,  Textual support,  Spanish

Record 51,  Textual support,  English

Record number: 51, Textual support number: 1 CONT

Mixed culture fermentations. It is becoming increasingly clear that the concurrent growth of two or more microbial species can confer advantages and properties not characteristic of monocultures of the constituent organisms. Applications of mixed culture technology can be found in traditional and novel food/feed production, metabolite synthesis, metal recovery and detoxification.  1, record 51, English, - mixed%20culture%20fermentation

Record 51,  Textual support,  French

Record number: 51, Textual support number: 1 CONT

Les fermentations en culture mixte. Il apparaît de plus en plus évident que la culture conjointe de deux ou plusieurs espèces microbiennes peut présenter des avantages et des propriétés qui ne se manifestent pas dans les monocultures des organismes considérés. Les techniques de culture mixte peuvent trouver à s'appliquer dans la production de denrées alimentaires traditionnelles et nouvelles, pour l'être humain et pour les animaux, dans la synthèse de métabolites, dans la récupération des métaux et dans la détoxication.  1, record 51, French, - fermentation%20en%20culture%20mixte

Record 51,  Textual support,  Spanish

Record 52,  Textual support,  English

Record number: 52, Textual support number: 1 CONT

The conversion of these nitrates to gaseous nitrogen implies a further denitrification stage. There are several possible ways of achieving this :... changing the state of the mixed liquor from aerobiosis to anaerobiosis before clarification, passing it through a shallow lagoon where algae develop, using this form of nitrogen as a metabolite.  1, record 52, English, - denitrification%20stage

Record 52,  Textual support,  French

Record number: 52, Textual support number: 1 CONT

La transformation de ces nitrates en azote gazeux implique un stade de dénitrification complémentaire. Pour cela plusieurs schémas sont possibles : [...] passage de la liqueur mixte en anoxybiontie avant clarification, passage dans une lagune de faible profondeur, où des algues se développent, utilisant cette forme d'azote comme métabolite.  1, record 52, French, - stade%20de%20d%C3%A9nitrification

Record 52,  Textual support,  Spanish