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METABOLIZED DRUG [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2019-05-14

English

Subject field(s)
  • Agricultural Chemicals
  • Collaboration with the FAO
DEF

[The] residue derived from the covalent binding of the parent drug or a metabolite of the drug and a cellular biological soluble or insoluble macromolecule.

OBS

[Bound] residue is not extractable from the macromolecule by exhaustive extraction, denaturation or solubilization techniques. It does not result from the incorporation of metabolized, radiolabelled fragments of the drug into endogenous compounds, or the same macromolecule by normal biosynthetic pathways.

French

Domaine(s)
  • Agents chimiques (Agriculture)
  • Collaboration avec la FAO
DEF

Résidu dérivé de la liaison covalente du médicament souche ou d'un métabolite de celui-ci avec un produit biologique cellulaire soluble ou une macromolécule insoluble.

OBS

[Le résidu lié] n'est pas extractible de la macromolécule par des techniques de dénaturation, de solubilisation ou d'extraction exhaustive. Il ne résulte pas de l'incorporation de fragments métabolisés radio-étiquetés du médicament dans des composés endogènes, ou de la même molécule par voies biosynthétiques normales.

Spanish

Save record 1

Record 2 2003-05-13

English

Subject field(s)
  • Biochemistry
  • Biotechnology
DEF

Isotope that has a higher atomic weight than the usual (i.e. most abundant) natural isotope.

CONT

Studies of metabolism, drug utilization, and other reactions in living organisms are best done with stable isotopes like13C, 15N, 18O, and2H. Compounds are tagged by introducing a high concentration of the isotope into the molecular structure, and the metabolized products are studied using the mass spectrometer to measure the altered isotopic ratios.

French

Domaine(s)
  • Biochimie
  • Biotechnologie
DEF

Catégorie d'atomes contenant un nombre de neutrons supérieur à la normale et donc plus denses que l'isotope communément observé (par exemple15N et13C).

Spanish

Campo(s) temático(s)
  • Bioquímica
  • Biotecnología
Save record 2

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