TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

... a new drug for which the purpose and conditions of use recommended by the manufacturer relate to a condition that is described in the List of Conditions that Threaten Public Health...  2, record 1, English, - public%20health%20emergency%20drug

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Drogue nouvelle dont les fins et le mode d'emploi recommandés par le fabricant ont trait à une affection décrite dans la Liste d'affections qui menacent la santé publique.  1, record 1, French, - drogue%20pour%20urgence%20de%20sant%C3%A9%20publique

Record number: 1, Textual support number: 1 OBS

drogue pour urgence de santé publique : Le terme «drogue» peut désigner un médicament uniquement dans le contexte de la Loi sur les aliments et drogues et de son application.  3, record 1, French, - drogue%20pour%20urgence%20de%20sant%C3%A9%20publique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Pharmacoproteomics enables the examination of drug mechanisms at the proteome level, allowing for the exploration of toxicity, resistance, and the identification of possible new therapeutic targets at the early stage of drug development.  2, record 2, English, - pharmacoproteomics

Record number: 2, Textual support number: 2 CONT

Pharmacoproteomics involves the comprehensive analysis of proteins in biological samples such as cells, tissues, and body fluids. The analysis can be done using various techniques such as mass spectrometry, protein microarrays, and bioinformatics.  3, record 2, English, - pharmacoproteomics

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 OBS

Il s'agit notamment de l'application de l'analyse protéomique à la découverte et au développement de nouveaux médicaments ainsi qu'à l'étude des effets des médicaments sur le protéome.  2, record 2, French, - pharmacoprot%C3%A9omique

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

In some cases, a foreign manufacturer may want to import a drug into Canada for pre-positioning before a health care practitioner makes a request through SAP [Special Access Program]. To pre-position a drug, a manufacturer must : provide information about the medical emergency and how the new drug being imported will be used[;] give a rationale as to why the product needs to be pre-positioned[;] explain the urgency of having the product in Canada, including if the drug requires timely administration[;] specify the quantity of drug to be pre-positioned[;] identify the Canadian importer who will pre-position the drug in a Canadian facility(must hold an establishment licence in Canada) [. ]  2, record 3, English, - pre%2Dposition

Record number: 3, Textual support number: 1 PHR

pre-position a drug  3, record 3, English, - pre%2Dposition

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Dans certains cas, un fabricant étranger peut vouloir importer un médicament au Canada pour son prépositionnement avant qu'un professionnel de la santé ne fasse une demande au moyen du PAS [Programme d'accès spécial]. Pour prépositionner un médicament, le fabricant doit : fournir des renseignements sur l'urgence médicale et sur la façon dont le nouveau médicament importé sera utilisé; expliquer pourquoi le produit doit être prépositionné; expliquer l'urgence de faire entrer le produit au Canada, par exemple le fait que le médicament doit être administré en temps opportun; préciser la quantité de médicament à prépositionner; nommer l'importateur canadien qui prépositionnera le médicament dans une installation canadienne (doit détenir une licence d'établissement au Canada).  1, record 3, French, - pr%C3%A9positionner

Record number: 3, Textual support number: 1 PHR

prépositionner un médicament  3, record 3, French, - pr%C3%A9positionner

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

A composite primary endpoint is used when a study has a fairly rare primary endpoint. Rare events may require a very large, expensive trial in order to get statistically significant results. Let's say a study is investigating a new drug for anaphylaxis(a severe allergic reaction which can lead to death). If "death" is the endpoint, a trial could need about a million people to record one death. A composite primary endpoint might be "any non-fatal or fatal allergic reaction"—which would require much smaller numbers(thousands, or possibly hundreds).  2, record 4, English, - composite%20primary%20endpoint

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Le critère de jugement principal composite était la mortalité d'origine cardiovasculaire ou l'aggravation d'une insuffisance cardiaque, définie par une hospitalisation pour insuffisance cardiaque, et/ou l'administration de diurétiques intra-veineux.  4, record 4, French, - crit%C3%A8re%20de%20jugement%20principal%20composite

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Drug approval refers to a process that is under the jurisdiction of the Therapeutics Products Program, a division of Health Canada that reviews the safety and efficacy data for each new drug submission. If a new drug submission is found to be acceptable on the basis of clinical trial efficacy and toxicity data, the Therapeutics Products Program issues a notice of compliance and the associated product labelling. The drug is then approved and may be prescribed by physicians and dispensed by pharmacies in Canada. However, such approval does not mean that provincial drug plans or other third-party payers will pay for the approved drug. The decision regarding who pays is made by each province.  1, record 5, English, - approved%20drug

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Le gouvernement fédéral a la responsabilité d'évaluer la sécurité, l'efficacité, la qualité et la justesse du prix des médicaments. Les fabricants doivent obtenir un avis de conformité de Santé Canada avant de pouvoir commercialiser leur produit. Cependant, les provinces ne sont pas obligées de fournir à leurs citoyens tous les médicaments approuvés par Santé Canada.  1, record 5, French, - m%C3%A9dicament%20approuv%C3%A9

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

... the Taiwan Food and Drug Administration(TFDA) designed a pathway to EUA [emergency use authorization] for all local vaccine candidates [against severe acute respiratory syndrome coronavirus 2] based on immunobridging, which compares the immune response of a vaccine candidate with an approved vaccine... It is assumed that a part of the immune response—such as binding or neutralizing antibodies—will correlate with other important components of the immune response... In the absence of efficacy data, immunobridging can be adopted as an approach to infer the likelihood of a vaccine's protective effect by translating immunogenicity to vaccine efficacy. The inference is based on the comparison of immunogenicity of a new vaccine with a comparator vaccine with an established protective effect...  2, record 6, English, - immunobridging

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Procédure de mise au point d'un vaccin qui est fondée sur l'évaluation de la production d'anticorps.  2, record 6, French, - %C3%A9valuation%20immunologique

Record number: 6, Textual support number: 1 OBS

évaluation immunologique : désignation et définition publiées au Journal officiel de la République française le 19 juin 2024.  3, record 6, French, - %C3%A9valuation%20immunologique

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 OBS

CDSW is a drug early warning system that helps... monitor, predict, and respond to the rise of new and emerging psychoactive substances.  1, record 7, English, - Canadian%20Drug%20and%20Substance%20Watch

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

Le SCSDS est un système d'alerte rapide qui [...] aide à surveiller, à prévoir et à réagir face à l'apparition de substances psychoactives nouvelles et émergentes.  1, record 7, French, - Syst%C3%A8me%20canadien%20de%20surveillance%20des%20drogues%20et%20des%20substances

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 OBS

... a new Chemical Precursor Risk Management Unit [will] increase oversight over precursor chemicals and monitor emerging illegal drug trends, enhance monitoring and surveillance, and enable timely law enforcement action.  2, record 8, English, - Chemical%20Precursor%20Risk%20Management%20Unit

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 OBS

[...] une nouvelle Unité de gestion des risques liés aux produits chimiques précurseurs [permettra] d'accroître la surveillance des produits chimiques précurseurs et de surveiller les tendances émergentes liées aux drogues illicites, d'améliorer la surveillance et la vigilance, et de permettre une action policière rapide.  1, record 8, French, - Unit%C3%A9%20de%20gestion%20des%20risques%20li%C3%A9s%20aux%20produits%20chimiques%20pr%C3%A9curseurs

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Syringe access programs operate with the primary goal of providing injection drug users with new, sterile injection equipment as a means of reducing the spread of blood-borne viruses and other injection-related infections. In addition, there has traditionally been an emphasis placed on simultaneously removing used injection equipment from circulation through a process of exchanging old syringes for new ones.  8, record 9, English, - used%20drug%20injection%20paraphernalia

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

[...] certaines situations qui surviennent dans la trajectoire de consommation peuvent provoquer l'utilisation de matériel d'injection usagé.  4, record 9, French, - mat%C3%A9riel%20d%27injection%20de%20drogue%20usag%C3%A9

Record number: 9, Textual support number: 1 OBS

Le matériel d'injection comprend les seringues et les aiguilles, ainsi que les filtres, de l'eau stérile et les contenants pour dissoudre et chauffer la drogue.  1, record 9, French, - mat%C3%A9riel%20d%27injection%20de%20drogue%20usag%C3%A9

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

The investigator's brochure(IB) is a comprehensive compilation of clinical and nonclinical data on the investigational product(drug, supplement, device or other product) maintained by a drug developer or investigator that contains the body of information about the investigational product obtained before and during a drug trial. The IB is a document of critical importance throughout the drug development process and is updated with new information as it becomes available.  3, record 10, English, - investigator%27s%20brochure

Record 10,  Textual support,  French

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

N-pyrrolidino protonitazene is a new synthetic opioid that has recently emerged on the drug scene. What sets it apart from other synthetic opioids is its alarming potency—approximately 25 times greater than that of fentanyl.... This new opioid is part of the nitazene analogue subclass and bears structural resemblance to both protonitazene and N-pyrrolidino etonitazene, two previously encountered nitazene analogues.  3, record 11, English, - protonitazepyne

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Le protonitazèpyne est préoccupant, car comme il est plus puissant [que le fentanyl], il est nécessaire d'administrer plusieurs doses de naloxone, l'antidote aux surdoses d'opioïdes, pour renverser une surdose déclenchée par cette drogue.  3, record 11, French, - protonitaz%C3%A8pyne

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

A knowledge of the fate of a drug, its disposition(absorption, distribution, metabolism, and excretion, known by the acronym ADME) and pharmacokinetics... plays a central role throughout pharmaceutical research and development. These studies aid in the discovery and selection of new chemical entities, support safety assessment, and are critical in defining conditions for safe and effective use in patients. ADME studies provide [a] basis for critical judgments from situations where the behavior of the drug is understood to those where it is unknown : this is most important in bridging from animal studies to the human situation.  3, record 12, English, - absorption%2C%20distribution%2C%20metabolism%20and%20excretion%20study

Record 12,  Textual support,  French

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

Amid the evolution of the pharmaceutical industry, and more recently catalyzed by [COVID-19] and its implications on drug demand, delivery and the supply chain, parenteral drugs are experiencing increased demand. Whether administered intravenously, intramuscularly, or subcutaneously, the format creates new and critical avenues for drug delivery thanks to some favorable attributes around safety and efficacy. For one, parenterals allow for a controlled release—either gradual or instantaneous—that an oral medication cannot always provide. This format is critical to providing immediate pain relief, such as with epidurals during childbirth, or for continuously managing fluid levels, such as with saline solutions delivered [intravenously. ]  6, record 13, English, - parenteral%20drug

Record number: 13, Textual support number: 1 OBS

parenteral: Taken into the body or administered in a manner other than through the digestive tract, as by intravenous or intramuscular injection.  7, record 13, English, - parenteral%20drug

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 OBS

parentéral : Qui s'administre par une voie autre que la voie digestive, généralement sous la forme d'injection intraveineuse, musculaire, sous-cutanée.  2, record 13, French, - m%C3%A9dicament%20parent%C3%A9ral

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 OBS

This policy applies to a New Drug Submission(NDS) or Supplemental New Drug Submission(S/NDS) for a serious, life-threatening or severely debilitating disease or condition for which there is substancial evidence of clinical effectiveness that the drug provides : effective treatment, prevention or diagnosis of a disease or condition for which no drug is presently marketed in Canada; or a significant increase in efficacy and/or significant decrease in risk such that the overall benefit/risk profile is improved over existing therapies, preventatives or diagnostic agents for a disease or condition that is not adequately managed by a drug marketed in Canada.  1, record 14, English, - Priority%20Review%20of%20Drug%20Submissions%20Policy

Record 14,  Textual support,  French

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 CONT

The general scheme of an add-on clinical trial is shown. Patients with newly diagnosed lupus nephritis(LN) or new flare of LN are given stand-of-care(SOC) therapy and randomized to receive either the experimental drug or placebo.  3, record 15, English, - add%2Don%20clinical%20trial

Record 15,  Textual support,  French

Record 15,  Textual support,  Spanish

Record number: 15, Textual support number: 1 CONT

España autoriza la última fase del ensayo clínico complementario para la vacuna de dos dosis contra la COVID-19 de Johnson & Johnson.  1, record 15, Spanish, - ensayo%20cl%C3%ADnico%20complementario

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 CONT

Gene expression microarrays provide a snapshot of all the transcriptional activity in a biological sample. Unlike most traditional molecular biology tools, which generally allow the study of a single gene or a small set of genes, microarrays facilitate the discovery of totally novel and unexpected functional roles of genes. The power of these tools has been applied to a range of applications, including discovering novel disease subtypes, developing new diagnostic tools, and identifying underlying mechanisms of disease or drug response.  2, record 16, English, - gene%20expression%20microarray

Record 16,  Textual support,  French

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 CONT

Drug repositioning can reduce the time, costs and risks of drug development by identifying new therapeutic effects for known drugs. It is challenging to reposition drugs as pharmacological data is large and complex.  4, record 17, English, - reposition%20a%20drug

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 CONT

Compte tenu des coûts importants du développement clinique de nouvelles molécules et de la lenteur de la découverte de nouveaux traitements, repositionner un médicament «ancien» dans une nouvelle indication s'avère parfois une solution intéressante. Elle implique de réutiliser un composé dont la sécurité et la tolérance ont déjà été démontrées, avec potentiellement une réduction des délais et des budgets de développement, mais aussi une augmentation des chances de succès.  1, record 17, French, - repositionner%20un%20m%C3%A9dicament

Record 17,  Textual support,  Spanish

Record number: 17, Textual support number: 1 CONT

Muchos compuestos seguros, inicialmente pensados para curar una enfermedad principal, pueden ser útiles para tratar otras enfermedades. Esta metodología basada en reperfilar un medicamento se considera una de las fuentes más interesantes de compuestos para enfermedades que aún no tienen cura como el Alzheimer y la esclerosis múltiple.  1, record 17, Spanish, - reperfilar%20un%20medicamento

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 OBS

The CDSS will formally restore harm reduction as a key pillar of Canada's drug strategy alongside the existing pillars of prevention, treatment and enforcement. The inclusion of harm reduction as a pillar of Canada's drug policy will better enable the government to address the current opioid crisis, and to work toward preventing the emergence of new crises.  2, record 18, English, - Canadian%20Drugs%20and%20Substances%20Strategy

Record number: 18, Textual support number: 2 OBS

Health Canada.  3, record 18, English, - Canadian%20Drugs%20and%20Substances%20Strategy

Record number: 18, Textual support number: 3 OBS

Canadian Drugs and Substances Strategy: This strategy replaced the National Anti-Drug Strategy in 2016.  3, record 18, English, - Canadian%20Drugs%20and%20Substances%20Strategy

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 OBS

La [...] Stratégie canadienne sur les drogues et autres substances sera dirigée par la ministre de la Santé. Elle replacera la réduction des méfaits parmi les principaux piliers de la politique sur les drogues du Canada, aux côtés de la prévention, du traitement et de l'application de la loi. Le gouvernement sera ainsi mieux outillé pour régler la crise actuelle des opioïdes et pour prévenir l'émergence de nouvelles crises.  2, record 18, French, - Strat%C3%A9gie%20canadienne%20sur%20les%20drogues%20et%20autres%20substances

Record number: 18, Textual support number: 2 OBS

Santé Canada.  3, record 18, French, - Strat%C3%A9gie%20canadienne%20sur%20les%20drogues%20et%20autres%20substances

Record number: 18, Textual support number: 3 OBS

Stratégie canadienne sur les drogues et autres substances: Cette stratégie a remplacé la Stratégie nationale antidrogue en 2016.  3, record 18, French, - Strat%C3%A9gie%20canadienne%20sur%20les%20drogues%20et%20autres%20substances

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 OBS

The Transition Office will advance work on pharmacare-related initiatives and provide dedicated leadership and resources to support federal-provincial-territorial discussions. It will also engage provinces, territories and stakeholders in discussions on the creation of a new Canadian Drug Agency.  2, record 19, English, - Canadian%20Drug%20Agency%20Transition%20Office

Record number: 19, Textual support number: 2 OBS

Canadian Drug Agency Transition Office: office announced in the 2019 federal budget.  3, record 19, English, - Canadian%20Drug%20Agency%20Transition%20Office

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 OBS

Le Bureau de transition fera avancer les travaux liés aux initiatives d'assurance médicaments et fournira un leadership solide et des ressources afin de faciliter les discussions fédérales provinciales territoriales. Il impliquera également les provinces, les territoires et les intervenants dans des discussions portant sur la création de la nouvelle Agence canadienne des médicaments.  2, record 19, French, - Bureau%20de%20transition%20vers%20une%20Agence%20canadienne%20des%20m%C3%A9dicaments

Record number: 19, Textual support number: 2 OBS

Bureau de transition vers une Agence canadienne des médicaments : bureau annoncé dans le budget fédéral de 2019.  3, record 19, French, - Bureau%20de%20transition%20vers%20une%20Agence%20canadienne%20des%20m%C3%A9dicaments

Record 19,  Textual support,  Spanish

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 DEF

The process of identifying and validating a use not previously approved for an existing drug.  3, record 20, English, - drug%20repositioning

Record number: 20, Textual support number: 1 CONT

Drug reprofiling provides a chance for an established or a forgotten drug to move into a new area of therapy, whether related to the known effects or in a completely new area.  4, record 20, English, - drug%20repositioning

Record 20,  Textual support,  French

Record number: 20, Textual support number: 1 DEF

Approche visant à découvrir et à valider une utilisation qui n'a pas déjà été homologuée pour un médicament existant.  2, record 20, French, - repositionnement%20de%20m%C3%A9dicament

Record number: 20, Textual support number: 1 CONT

Le repositionnement de médicament consiste à utiliser des molécules déjà présentes sur le marché pour les appliquer à d'autres maladies qui ne relèvent pas de l'indication médicale d'origine.  3, record 20, French, - repositionnement%20de%20m%C3%A9dicament

Record 20,  Textual support,  Spanish

Record number: 20, Textual support number: 1 CONT

El reposicionamiento de medicamentos, por medio del cual los medicamentos se "reciclan" y se utilizan en el tratamiento de enfermedades distintas de aquellas para las que fueron desarrollados, se ha convertido en un modelo prometedor capaz de hacer frente a estos dos problemas: concretamente, aumentar la productividad de los medicamentos y, al mismo tiempo, generar nuevos tratamientos para enfermedades huérfanas y desatendidas.  1, record 20, Spanish, - reposicionamiento%20de%20medicamentos

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 DEF

Research [which may involve] testing of a new treatment for a disease, a new drug therapy or a new surgical procedure [on a human being].  2, record 21, English, - therapeutic%20research

Record number: 21, Textual support number: 1 OBS

The aim of therapeutic research is to benefit the individual research participant or patient by treating or curing their condition ... the aim of non-therapeutic research is to benefit people other than the research participant.  3, record 21, English, - therapeutic%20research

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 CONT

La recherche thérapeutique est réalisée sur l'homme par des chercheurs médecins et pharmaciens qui travaillent le plus souvent à l'hôpital. Elle fait suite à la recherche fondamentale et à l'expérimentation animale : la recherche fondamentale permet de comprendre les mécanismes de la maladie et de trouver des moyens (médicaments ou autres) pour bloquer ces mécanismes. C'est la recherche thérapeutique qui permet, ensuite, de savoir si ces moyens sont efficaces contre la maladie. L'expérimentation animale permet de «sélectionner», sur un temps assez court, des nouveaux médicaments efficaces et de «se débarrasser» des médicaments qui s'avèrent être trop toxiques. Seule la recherche thérapeutique permettra ensuite d'étudier chez l'homme les médicaments les plus efficaces et, a priori, les moins toxiques.  2, record 21, French, - recherche%20th%C3%A9rapeutique

Record 21,  Textual support,  Spanish

Record number: 21, Textual support number: 1 DEF

Conjunto de los estudios preclínicos y clínicos puestos en marcha para caracterizar la dosis, el régimen de administración, la actividad y la tolerancia del agente utilizado solo o en asociación [...] y la caracterización de nuevos métodos quirúrgicos.  2, record 21, Spanish, - investigaci%C3%B3n%20terap%C3%A9utica

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 DEF

An application submitted by a manufacturer to [the competent authorities] for approval to market a new drug(a new, non-biological molecular entity) for human use.  3, record 22, English, - new%20drug%20submission

Record number: 22, Textual support number: 1 OBS

new drug submission; new drug application; NDA : terms, abbreviation and definition standardized by the Health Technology Assessment(HTA) Glossary English Editorial Board and the Translation Bureau.  5, record 22, English, - new%20drug%20submission

Record 22,  Textual support,  French

Record number: 22, Textual support number: 1 DEF

Demande soumise par un fabricant [aux autorités compétentes] pour l'autorisation de commercialiser un nouveau médicament (une nouvelle entité moléculaire non biologique) pour usage chez l'humain.  1, record 22, French, - pr%C3%A9sentation%20de%20nouveau%20m%C3%A9dicament

Record number: 22, Textual support number: 1 OBS

Le terme «présentation de drogue nouvelle» (PDN) est à éviter, car «drogue» n'a pas le sens de «médicament» que le terme anglais «drug» peut avoir. En français, une drogue est soit une substance dont on fait un usage abusif à des fins non médicamenteuses, soit la matière première de certains médicaments. Toutefois, Santé Canada emploie «présentation de drogue nouvelle», et les fabricants peuvent être obligés de l'utiliser afin de se conformer aux exigences du Règlement sur les aliments et drogues.  1, record 22, French, - pr%C3%A9sentation%20de%20nouveau%20m%C3%A9dicament

Record number: 22, Textual support number: 2 OBS

présentation de nouveau médicament; PNM; dossier d'autorisation de mise sur le marché; dossier d'AMM; dossier de demande d'autorisation de mise sur le marché; dossier de demande d'AMM : termes et abréviation normalisés par l'Institut national d'excellence en santé et en services sociaux (INESSS) et le Bureau de la traduction.  3, record 22, French, - pr%C3%A9sentation%20de%20nouveau%20m%C3%A9dicament

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 OBS

The Food Safety Modernization Act(FSMA) was signed into law by President Barack Obama on January 4, 2011. The FSMA has given the Food and Drug Administration(FDA) new authorities to regulate the way foods are grown, harvested and processed.  1, record 23, English, - Food%20Safety%20Modernization%20Act

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 OBS

La règle de la loi FDA Food Safety Modernization Act (FSMA) [...] exige que les importateurs exécutent certaines activités [...] afin de vérifier que les denrées importées aux États-Unis ont été produites conformément aux normes américaines de sécurité applicables.  3, record 23, French, - Food%20Safety%20Modernization%20Act

Record 23,  Textual support,  Spanish

Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 OBS

In 2013, Canada's Centre for Drug Research and Development... partnered with top drug commercialization centres from five other countries to form the new Global Alliance of Leading Drug Discovery and Development Centres.  2, record 24, English, - Global%20Alliance%20of%20Leading%20Drug%20Discovery%20and%20Development%20Centres

Record 24,  Textual support,  French

Record 24,  Textual support,  Spanish

Record 25,  Textual support,  English

Record number: 25, Textual support number: 1 OBS

The Advanced Drug Investigative Techniques course is designed to [update] training in areas such as recent case law, agent led investigations, new drug trends, organized crime trends, assets investigations, and high risk operational planning.  1, record 25, English, - Advanced%20Drug%20Investigative%20Techniques

Record number: 25, Textual support number: 2 OBS

ADITC: a Canadian Police College course code.  2, record 25, English, - Advanced%20Drug%20Investigative%20Techniques

Record 25,  Textual support,  French

Record number: 25, Textual support number: 1 OBS

Le Cours de techniques d'enquêtes avancées relatives aux drogues [vise à actualiser] la formation dans des domaines comme la jurisprudence récente, les enquêtes menées par des agents, les nouvelles tendances en matière de drogues, les tendances du crime organisé, les enquêtes sur les actifs, et la planification des opérations à risque élevé.  1, record 25, French, - Cours%20de%20techniques%20d%27enqu%C3%AAtes%20avanc%C3%A9es%20relatives%20aux%20drogues

Record number: 25, Textual support number: 2 OBS

ADITC : code de cours du Collège canadien de police.  2, record 25, French, - Cours%20de%20techniques%20d%27enqu%C3%AAtes%20avanc%C3%A9es%20relatives%20aux%20drogues

Record 25,  Textual support,  Spanish

Record 26,  Textual support,  English

Record number: 26, Textual support number: 1 CONT

For the past three years the powerful crime cartel trucked heroin from the poppy fields of the Golden Triangle into China's notorious Fujian Province and shipped the drug west to be sold on the streets of Vancouver, Toronto, New York and other North American cities.  5, record 26, English, - crime%20cartel

Record number: 26, Textual support number: 2 CONT

... regardless of how criminal cartels are ultimately defined by statute, clients should consider undertaking a full cartel audit of their businesses before the draft bill becomes law ...  6, record 26, English, - crime%20cartel

Record 26,  Textual support,  French

Record number: 26, Textual support number: 1 CONT

Le troisième mode d'organisation auquel fait appel le cartel criminel est la parenté clanique, la structure ethnique.  4, record 26, French, - cartel%20criminel

Record 26,  Textual support,  Spanish

Record number: 26, Textual support number: 1 DEF

Organización ilícita vinculada al tráfico de drogas o de armas.  7, record 26, Spanish, - cartel

Record number: 26, Textual support number: 1 OBS

cartel criminal: Al contener la palabra cartel el significado de "organización ilícita", la construcción "cartel criminal" parece redundante.  3, record 26, Spanish, - cartel

Record number: 26, Textual support number: 2 OBS

cartel; cártel: La Fundación del Español Urgente (Fundéu BBVA), con el asesoramiento de la Real Academia Española, indica que tanto "cartel" como "cártel" son grafías adecuadas para referirse a una "organización ilícita vinculada al tráfico de drogas o de armas", conforme al Diccionario académico.  8, record 26, Spanish, - cartel

Record 27,  Textual support,  English

Record number: 27, Textual support number: 1 CONT

These occurrences include the introduction of new legislation requiring the special labeling of foods(including meat and poultry) produced by modern biotechnology(H. R. 3377, 1999) ;the spillover effects of the European debate about "Frankenstein" foods(Klee, 1999) and requisite European Union(EU) labeling requirements(EU, 1998) ;a suit against the Food and Drug Administration(FDA) demanding mandatory labeling, among other things(Alliance for Biointegrity v. Shalala, 1998) ;and three public hearings on the subject of biotech food labeling and other topics(FDA, 1999a).  6, record 27, English, - genetically%20modified%20food

Record 27,  Textual support,  French

Record number: 27, Textual support number: 1 CONT

[...] le conseiller scientifique du gouvernement britannique, le gouvernement lui-même, tous ont été singulièrement inefficaces et tous ont désastreusement sous-estimé les réactions du public à ce qui a fini par être connu, non sous le nom «aliments transgéniques», mais sous celui de «aliments Frankenstein».  2, record 27, French, - aliment%20g%C3%A9n%C3%A9tiquement%20modifi%C3%A9

Record 27,  Textual support,  Spanish

Record number: 27, Textual support number: 1 DEF

Alimento que contiene, está constituido o ha sido producido a partir de organismos cuyo material genético ha sido modificado.  5, record 27, Spanish, - alimento%20gen%C3%A9ticamente%20modificado

Record number: 27, Textual support number: 1 CONT

Los organismos genéticamente modificados (OGM) pueden definirse como organismos en los cuales el material genético (ADN) ha sido alterado de un modo artificial. [...] la tecnología de ADN recombinante [...] permite transferir genes seleccionados individuales de un organismo a otro, también entre especies no relacionadas. Dichos métodos se utilizan para crear vegetales GM que luego se utilizan para desarrollar cultivos de alimentos GM. [...] ¿Por qué se producen alimentos GM? Los alimentos GM se desarrollan y comercializan porque se percibe cierta ventaja tanto para los productores como para los consumidores de estos alimentos.  1, record 27, Spanish, - alimento%20gen%C3%A9ticamente%20modificado

Record 28,  Textual support,  English

Record number: 28, Textual support number: 1 CONT

... as a first step towards a more strategic, comprehensive and coordinated approach to pharmaceutical management, the new coordinated provincial approach to price setting for six widely used generic drugs should help maintain the recent trend in drug spending growth.  1, record 28, English, - price%20setting

Record 28,  Textual support,  French

Record 28,  Textual support,  Spanish

Record 29,  Textual support,  English

Record number: 29, Textual support number: 1 DEF

An application for approval of an unapproved drug or a drug previously approved for another use, submitted by the manufacturer to [the competent authorities] prior to human testing of that drug.  4, record 29, English, - investigational%20new%20drug%20submission

Record number: 29, Textual support number: 1 OBS

The term new drug submission is used in Canada and the term new drug application is used in the United States.  4, record 29, English, - investigational%20new%20drug%20submission

Record number: 29, Textual support number: 2 OBS

investigational new drug application; IND : term and abbreviation standardized by the Health Technology Assessment(HTA) Glossary English Editorial Board and the Translation Bureau.  7, record 29, English, - investigational%20new%20drug%20submission

Record 29,  Textual support,  French

Record number: 29, Textual support number: 1 DEF

Demande d’autorisation d’un médicament non approuvé, ou approuvé préalablement pour un autre usage, soumise par le fabricant [aux autorités compétentes] avant l’expérimentation de ce médicament chez l’humain.  1, record 29, French, - pr%C3%A9sentation%20de%20nouveau%20m%C3%A9dicament%20de%20recherche

Record number: 29, Textual support number: 1 OBS

Le terme «demande d'autorisation de drogue nouvelle de recherche» (DNR) est à éviter, car «drogue» n’a pas le sens de «médicament» que le terme anglais «drug» peut avoir. En français, une drogue est soit une substance dont on fait un usage abusif à des fins non médicamenteuses, soit la matière première de certains médicaments. Toutefois, Santé Canada emploie «demande d'autorisation de drogue nouvelle de recherche», et les fabricants peuvent être obligés de l’utiliser afin de se conformer aux exigences du Règlement sur les aliments et drogues.  1, record 29, French, - pr%C3%A9sentation%20de%20nouveau%20m%C3%A9dicament%20de%20recherche

Record number: 29, Textual support number: 2 OBS

présentation de nouveau médicament de recherche; PNMR : terme et abréviation normalisés par l'Institut national d'excellence en santé et en services sociaux (INESSS) et le Bureau de la traduction.  3, record 29, French, - pr%C3%A9sentation%20de%20nouveau%20m%C3%A9dicament%20de%20recherche

Record 29,  Textual support,  Spanish

Record 30,  Textual support,  English

Record number: 30, Textual support number: 1 CONT

MAOIs [monoamine oxidase inhibitors] tend to be underutilized in clinical practice, due in part to misinformation and mythology about their dietary and drug interactions. The new class of reversible monoamine oxidase inhibitors(RIMAs) has shown efficacy in depression, with safety and tolerability comparable to SSRIs [selective serotonin reuptake inhibitors].  1, record 30, English, - reversible%20monoamine%20oxidase%20inhibitor

Record 30,  Textual support,  French

Record number: 30, Textual support number: 1 CONT

On a rapporté des réactions graves, dont certaines ont été fatales, chez des patients ayant reçu [du] chlorhydrate de sertraline ([zoloft]) en association avec un inhibiteur de la monoamine oxydase (IMAO), y compris avec la sélégiline, un IMAO sélectif, le moclobémide, un IMAO réversible ou IRMAO (inhibiteur réversible de la monoamine oxydase) et le linézolide, un antibiotique et un IRMAO non sélectif.  2, record 30, French, - inhibiteur%20r%C3%A9versible%20de%20la%20monoamine%20oxydase

Record 30,  Textual support,  Spanish

Record 31,  Textual support,  English

Record number: 31, Textual support number: 1 CONT

Every drug receives three distinct names : the chemical name, the generic(or nonproprietary) name, and the brand(or proprietary or trademark) name.... The generic name is commonly used by health care professionals and is usually created when a new drug is ready to be marketed. Although the manufacturer or sponsor of the drug has exclusive right of manufacture during the 17 years of the drug's patent, it never owns the generic name.... In the United States, the generic name must first be approved by the U. S. Adopted Name(USAN) Council and then by the World Health Organization(WHO).... After approving the generic name, the Council submits the name to WHO, which has final approval.... After being approved by WHO, the drug is assigned an international nonproprietary name.  6, record 31, English, - nonproprietary%20name

Record number: 31, Textual support number: 2 CONT

Once a chemical substance has become frequently cited in the literature, it will be identified with simplified nomenclature popularly known as a "generic" name. This nonproprietary name is preferred in database indexing over all other types of drug nomenclature. MEDLINE [registered trademark] cites the United States Adopted Name (USAN) as a standard, when available. USANs are officially approved designations adopted by the FDA for uniformity in labeling and regulatory references. EMBASE®, on the other hand, prefers International Nonproprietary Names (INNs), promulgated by the World Health Organization, as drug descriptors. Caution: the USAN and INN "generic" name for the same drug may differ. Other official nomenclature standards include: British Approved Name (BAN), Nordiska Farmakopenamden (NFN), and Dénomination Commune Francaise (DCF).  7, record 31, English, - nonproprietary%20name

Record 31,  Textual support,  French

Record number: 31, Textual support number: 1 DEF

Nom auquel ne s'attache aucun droit de propriété, tels les noms officiellement agréés, les noms de pharmacopée ou les dénominations libres.  3, record 31, French, - d%C3%A9nomination%20commune

Record 31,  Textual support,  Spanish

Record 32,  Textual support,  English

Record number: 32, Textual support number: 1 DEF

A difference in a single nucleotide at a particular DNA site [that is] used as [a] genomic [masker] for human (or other) populations.  1, record 32, English, - single%2Dnucleotide%20polymorphism

Record number: 32, Textual support number: 1 CONT

A tool is under way to catalogue genetic variations among single DNA bases, known as single nucleotide polymorphisms(SNPs, pronounced "snips"), which can be used in characterizing drug responses. The National Institutes of Health has launched a $36-million, three-year program to collect data on 50, 000 to 100, 000 SNPs, a new goal for its Human Genome Project.  3, record 32, English, - single%2Dnucleotide%20polymorphism

Record 32,  Textual support,  French

Record number: 32, Textual support number: 1 DEF

Différence génétique entre individus d'une même population, correspondant à la variation d'une seule base dans une séquence nucléotidique déterminée.  1, record 32, French, - polymorphisme%20mononucl%C3%A9otidique

Record number: 32, Textual support number: 1 CONT

Le but de cette coopération est de mettre au point par Nanogen une méthode pour cartographier les «polymorphismes de nucléotides simples» [...] Les SNP sont le type le plus fréquent de variations individuelles dans les séquences d'ADN humain.  2, record 32, French, - polymorphisme%20mononucl%C3%A9otidique

Record number: 32, Textual support number: 1 OBS

Il existe plus de trois millions de ces variations.  1, record 32, French, - polymorphisme%20mononucl%C3%A9otidique

Record number: 32, Textual support number: 2 OBS

polymorphisme mononucléotidique; snip : termes et définition publiés au Journal officiel de la République française le 6 septembre 2008.  6, record 32, French, - polymorphisme%20mononucl%C3%A9otidique

Record 32,  Textual support,  Spanish

Record number: 32, Textual support number: 1 DEF

Marcador genético resultante de la variación en una secuencia situada en una determinada posición dentro de una secuencia de ADN.  1, record 32, Spanish, - polimorfismo%20de%20un%20solo%20nucle%C3%B3tido

Record number: 32, Textual support number: 1 CONT

Los SNP provienen generalmente de cambios por transición (A [adenina] por G [guanina], T [timina] por C [citosina]), por transversión (G o A por T o C) o por deleción de una única base. Esta variación se encuentra en todos los genomas y tiene como ventaja específica el poder detectarla sin necesidad de emplear electroforesis en gel.  1, record 32, Spanish, - polimorfismo%20de%20un%20solo%20nucle%C3%B3tido

Record number: 32, Textual support number: 1 OBS

SNP por sus siglas en inglés.  2, record 32, Spanish, - polimorfismo%20de%20un%20solo%20nucle%C3%B3tido

Record 33,  Textual support,  English

Record number: 33, Textual support number: 1 OBS

Alcoholism and Drug Dependency Commission of New Brunswick.  1, record 33, English, - Campbellton%20Treatment%20Centre

Record 33,  Textual support,  French

Record number: 33, Textual support number: 1 OBS

Commission de l'alcoolisme et de la pharmacodépendance du Nouveau-Brunswick.  1, record 33, French, - Centre%20de%20traitement%20de%20Campbellton

Record 33,  Textual support,  Spanish

Record 34,  Textual support,  English

Record number: 34, Textual support number: 1 CONT

DNA dog tag or genetic ID? The US Army began collecting blood and tissue samples from new recruits... that will allow pathologists to identify the smallest tissue specimens by cross-matching to genetic samples stored on file. The samples will be treated as medical specimens in accordance with privacy statutes, and will not be tested for AIDS, drug use or anything else. In a criminal investigation however, authorities would be forced to comply.  2, record 34, English, - genetic%20ID%20card

Record 34,  Textual support,  French

Record number: 34, Textual support number: 1 DEF

Système expert miniaturisé identifiant l'empreinte génétique d'une personne (les caractéristiques de son ADN photographié et interprété après l'analyse des corps fluides ou solides de son organisme).  2, record 34, French, - carte%20d%27identit%C3%A9%20g%C3%A9n%C3%A9tique

Record number: 34, Textual support number: 2 DEF

Caractéristique génétique individuelle, définie par les groups tissulaires HLA (Human Leucocyte Antigen) dont le système est une sorte de «cerveau immunologique» qui commande la défense biologique de l'organisme.  3, record 34, French, - carte%20d%27identit%C3%A9%20g%C3%A9n%C3%A9tique

Record number: 34, Textual support number: 1 CONT

Un jeune Ghanéen qui désirait rejoindre sa mère résidant au Royaume-Uni se vit refuser le droit d'entrée par les services britanniques d'immigration. Les examens habituels de groupe sanguin, des facteur rhésus et autres «marqueurs» du sang n'avaient pas permis de conclure si l'enfant était le fils ou le neveu de la femme prétendant être sa mère. Seule l'analyse directe de l'information génétique, contenue dans la molécule d'ADN, de l'un et de l'autre, permit d'établir la filiation sans ambiguïté. L'autorisation d'immigration fut alors donnée. [...] Cet exemple illustre une réalité : l'établissement de la carte d'identité génétique d'un individu est devenu possible.  4, record 34, French, - carte%20d%27identit%C3%A9%20g%C3%A9n%C3%A9tique

Record number: 34, Textual support number: 2 CONT

Sans la découverte des groupes tissulaires HLA (Human Leucocyte Antigen, 1958), les greffes d'organes seraient impossibles. Le système HLa a aussi prouvé le caractère unique de chaque homme, qui dispose d'une véritable «carte d'identité génétique».  5, record 34, French, - carte%20d%27identit%C3%A9%20g%C3%A9n%C3%A9tique

Record 34,  Textual support,  Spanish

Record 35,  Textual support,  English

Record number: 35, Textual support number: 1 CONT

Although, the drug delivery system(DDS) concept is not new, great progress has recently been made in the treatment of a variety of diseases. Targeting delivery of drugs to the diseased lesions is one of the most important aspects of DDS. To convey a sufficient dose of drug to the lesion, suitable carriers of drugs are needed. Nano and microparticle carriers have important potential applications for the administration of therapeutic molecules.  1, record 35, English, - drug%20delivery%20system

Record 35,  Textual support,  French

Record number: 35, Textual support number: 1 DEF

Dispositif et mode d'administration d'un médicament qui permettent la libération d'un principe actif selon un profil donné après introduction dans l'organisme.  7, record 35, French, - syst%C3%A8me%20de%20lib%C3%A9ration%20de%20m%C3%A9dicaments

Record number: 35, Textual support number: 1 OBS

système de délivrance de médicaments; système de délivrance : Ces termes sont d'usage fréquent pour désigner la notion. Néanmoins, le terme «délivrance» n'a jamais eu en français le sens d'administration et il n'a plus celui de libération. De plus, il peut porter à confusion parce que la «délivrance d'un médicament» (drug dispensing) est ce que fait un pharmacien lorsqu'il remet un médicament à un patient.  7, record 35, French, - syst%C3%A8me%20de%20lib%C3%A9ration%20de%20m%C3%A9dicaments

Record number: 35, Textual support number: 2 OBS

Selon certains auteurs, «delivery system» n'a pas d'équivalent en français. Ce terme se traduit soit par «dispositif d'administration», soit par «mode d'administration» selon le contexte. D'autres auteurs estiment que «système de libération» recouvre tous les traits sémantiques de «delivery system», et qu'il est donc un équivalent acceptable.  7, record 35, French, - syst%C3%A8me%20de%20lib%C3%A9ration%20de%20m%C3%A9dicaments

Record 35,  Textual support,  Spanish

Record 36,  Textual support,  English

Record number: 36, Textual support number: 1 OBS

The Centre for Policy and Regulatory Affairs(CPRA) is responsible for regulatory policy development and evaluation, submission management, and health promotion support(including public involvement) to all areas of the Biologics and Genetic Therapies Directorate. Specifically, it is responsible for developing new and updating existing policies, standards, guidelines, directives and other legislative/regulatory instruments as it relates to biologics and genetic therapies. It also screens drug submissions and clinical trial applications(CTAs) for vaccines, biotherapeutics, radiopharmaceuticals and blood, tissues and organs(as outlined in Schedules C and D of the Food and Drugs Act), to ensure the completeness and accuracy of submissions received from the industry for review by BGTD, and that the final Notice of Compliance(NOC) package reflects the clinical, chemistry and manufacturing data that has been reviewed and found to be safe, efficacious and of good quality.  1, record 36, English, - Centre%20for%20Policy%20and%20Regulatory%20Affairs

Record 36,  Textual support,  French

Record number: 36, Textual support number: 1 OBS

Le Centre des politiques et des affaires réglementaires (CPAR) est chargé d'élaborer et d'évaluer les politiques réglementaires, de gérer les présentations et de fournir un soutien à la promotion de la santé (y compris la participation du public) dans tous les secteurs d'activités de la Direction des produits biologiques et des thérapies génétiques. En particulier, le Centre est responsable de l'élaboration de nouvelles politiques, normes, lignes directrices et directives ainsi que de nouveaux instruments législatifs et réglementaires, de même que de la mise à jour de ceux en vigueur, dans la mesure où ils traitent des produits biologiques et des thérapies génétiques. Il a également pour responsabilité de présélectionner les présentations de drogues et les demandes d'essais cliniques (DEC) pour les vaccins, les produits biothérapeutiques, les produits radiopharmaceutiques, le sang, les tissus et les organes (comme le stipulent brièvement les annexes C et D de la Loi sur les aliments et drogues ) afin d'assurer l'état complet et l'exactitude des présentations que soumet l'industrie à la DPBTG aux fins d'examen, et afin de s'assurer que l'avis de conformité (AC) final reflète les données cliniques chimiques et celles sur le processus de fabrication qui ont été examinées et déclarées sécuritaires, efficaces et de bonne qualité.  1, record 36, French, - Centre%20des%20politiques%20et%20des%20affaires%20r%C3%A9glementaires

Record 36,  Textual support,  Spanish

Record 37,  Textual support,  English

Record number: 37, Textual support number: 1 CONT

Trimebutine is so far the only drug that has been shown in clinical trials to be effective against irritable bowel. However, a unique drug called Fedotozine, a new opioid receptor ligand is undergoing a multicenter clinical trial in Canada.  1, record 37, English, - opioid%20receptor%20ligand

Record 37,  Textual support,  French

Record number: 37, Textual support number: 1 OBS

Ligand: Toute molécule capable de s'attacher à un récepteur cellulaire.  1, record 37, French, - ligand%20du%20r%C3%A9cepteur%20opio%C3%AFde

Record 37,  Textual support,  Spanish

Record 38,  Textual support,  English

Record number: 38, Textual support number: 1 CONT

The goal of the drug pusher is to extract everything he can from his existing clients, while locating new clients to replace his existing ones.  6, record 38, English, - drug%20pusher

Record number: 38, Textual support number: 1 OBS

A petty seller of drugs, e.g. on the street.  7, record 38, English, - drug%20pusher

Record number: 38, Textual support number: 2 OBS

dealer: not to be confused with "cartel dealer."  7, record 38, English, - drug%20pusher

Record 38,  Textual support,  French

Record number: 38, Textual support number: 1 CONT

Au Québec, un nombre important de prostituées travailleraient sous le contrôle d'un proxénète. Le vendeur de drogue tient aussi souvent le rôle de proxénète, tout comme les propriétaires de studios de massage, d'agences d'escortes et de bars de danseuses nues, dont 80 % offrent des services sexuels.  4, record 38, French, - revendeur%20de%20drogue

Record number: 38, Textual support number: 2 CONT

Le nouveau proxénète est le «pusher» (ou revendeur de drogue).  5, record 38, French, - revendeur%20de%20drogue

Record number: 38, Textual support number: 1 OBS

[Le revendeur de drogue] ne doit pas être confondu avec le trafiquant, véritable grossiste de la drogue.  6, record 38, French, - revendeur%20de%20drogue

Record 38,  Textual support,  Spanish

Record 39,  Textual support,  English

Record number: 39, Textual support number: 1 OBS

The Scientific Advisory Committee on HIV-Therapies(SAC-HIV-T) provides advice to the Therapeutic Products Directorate(TPD) at Health Canada on emerging issues related to HIV infections, therapies, or research. The committee advises on post-marketing requirements for new drugs, ethical and policy issues regarding drug approval and use, and issues related to the efficacy, toxicity and clinically relevant interactions of HIV therapies, as required.  1, record 39, English, - Scientific%20Advisory%20Committee%20on%20HIV%2DTherapies

Record 39,  Textual support,  French

Record number: 39, Textual support number: 1 OBS

Le Comité consultatif scientifique sur les thérapies anti-VIH (CCS-T-VIH) fournit des conseils à la Direction des produits thérapeutiques (DPT) de Santé Canada sur les nouvelles questions relatives aux infections à VIH ainsi qu'aux traitements et aux recherches connexes. Le Comité formule également des avis sur les exigences après-vente des nouveaux médicaments, les questions éthiques et stratégiques qui touchent l'approbation et l'utilisation de médicaments ainsi que les questions liées à l'efficacité, à la toxicité et aux interactions cliniques significatives des traitements des infections à VIH, le cas échéant.  1, record 39, French, - Comit%C3%A9%20consultatif%20scientifique%20sur%20les%20th%C3%A9rapies%20anti%2DVIH

Record 39,  Textual support,  Spanish

Record 40,  Textual support,  English

Record number: 40, Textual support number: 1 DEF

A semisynthetic macrolide antibiotic [member of the avermectin group] which is also a new antifilarial drug that can be given in a single oral dose.  2, record 40, English, - ivermectin

Record number: 40, Textual support number: 1 OBS

A major recent addition to the broadspectrum anthelmintics; prepared from avermectins.  3, record 40, English, - ivermectin

Record 40,  Textual support,  French

Record number: 40, Textual support number: 1 DEF

Lactose macrocyclique indiqué dans le traitement de l'onchocercose à «Onchocerca volvulus».  2, record 40, French, - ivermectine

Record number: 40, Textual support number: 1 OBS

Vermifuge antiparasitaire.  3, record 40, French, - ivermectine

Record 40,  Textual support,  Spanish

Record number: 40, Textual support number: 1 CONT

Un medicamento de administración oral llamado ivermectin es más efectivo en la eliminación de los piojos que el tratamiento normal con la crema malathion.  2, record 40, Spanish, - ivermectin

Record 41,  Textual support,  English

Record number: 41, Textual support number: 1 OBS

Of the new drug.  1, record 41, English, - processing

Record 41,  Textual support,  French

Record number: 41, Textual support number: 1 OBS

De la drogue nouvelle. Source : Règlement sur les aliments et drogues C.08.002 d).  1, record 41, French, - conditionnement

Record 41,  Textual support,  Spanish

Record 42,  Textual support,  English

Record number: 42, Textual support number: 1 OBS

Human Safety Division evaluates data on new drugs to assess any potential hazards to human health resulting from the use of veterinary pharmaceuticals in animals used for food, and conducts health risk assessments at the request of the Canadian Food Inspection Agency(CFIA). The Division establishes mandatory withdrawal periods and sets maximum residue limits for residues of veterinary drugs in food derived from animals and develops WARNING statements for veterinary drug labels. In addition, the Human Safety Division develops policies relating to the human safety of veterinary drugs, including antimicrobial resistance, and maintains a close working relationship with CFIA on matters of food safety.  2, record 42, English, - Human%20Safety%20Division

Record 42,  Textual support,  French

Record number: 42, Textual support number: 1 OBS

La Division de l'innocuité pour les humains examine les données sur les nouveaux médicaments pour évaluer les éventuels risques pour la santé des humains reliés à l'administration de médicaments aux animaux destinés à l'alimentation. Elle effectue aussi des évaluations des risques pour la santé à la demande de l'Agence canadienne d'inspection des aliments (ACIA). La Division établit des délais d'attente obligatoires, fixe des limites maximales en matière de résidus de médicaments vétérinaires dans les aliments d'origine animale et rédige des AVERTISSEMENTS pour les étiquettes des médicaments vétérinaires. De plus, la Division de l'innocuité pour les humains élabore des politiques relative à l'innocuité pour les humains des médicaments vétérinaires, y compris la résistance aux antimicrobiens, et entretient des relations de travail étroites avec l'ACIA en ce qui a trait à la salubrité des aliments.  1, record 42, French, - Division%20de%20l%27innocuit%C3%A9%20pour%20les%20humains

Record 42,  Textual support,  Spanish

Record 43,  Textual support,  English

Record number: 43, Textual support number: 1 CONT

Protein Structure-Function Relationships-Cloning and Structural Studies on Receptors and Enzymes Molecular biology of drug receptors and the advent of reverse pharmacology. A structural basis of proteinase-protein inhibitor interaction Detection of new enzymes and receptors by hybridization technique :new approaches to isolation, expression and molecular modelling of proteases.  1, record 43, English, - reverse%20pharmacology

Record 43,  Textual support,  French

Record number: 43, Textual support number: 1 CONT

Aujourd'hui, on voit émerger de nouveaux concepts, basés sur la connaissance intime de la cible que devra atteindre le médicament. De manière plus rationnelle que par le passé, on peut espérer ainsi créer des pharmacophores, véritables têtes de série de nouvelles familles chimiques. En intégrant la biologie structurale, cette pharmacologie, dite inverse, devient une approche majeure pour concevoir de nouveaux médicaments.  1, record 43, French, - pharmacologie%20inverse

Record 43,  Textual support,  Spanish

Record 44,  Textual support,  English

Record number: 44, Textual support number: 1 DEF

[A drug] designed to block viral genetic instructions, marking them for destruction by cellular enzymes, in order to prevent the building of new virus or the infection of new cells.  1, record 44, English, - antisense%20drug

Record 44,  Textual support,  French

Record number: 44, Textual support number: 1 DEF

Médicament constitué par un enchaînement de bases choisies pour bloquer électivement les éléments d'un gène spécifique (ADN) ou de l'ARN messager correspondant.  1, record 44, French, - m%C3%A9dicament%20antisens

Record 44,  Textual support,  Spanish

Record number: 44, Textual support number: 1 DEF

Compuesto que interfiere tanto en el acoplamiento como en el desacoplamiento del ARN viral en el ADN de la célula.  1, record 44, Spanish, - compuesto%20antisentido

Record number: 44, Textual support number: 1 OBS

Actúan en macrófagos y linfocitos.  1, record 44, Spanish, - compuesto%20antisentido

Record 45,  Textual support,  English

Record number: 45, Textual support number: 1 OBS

Source : The Structure of Veterinary New Drug Submission.  1, record 45, English, - resuspendability

Record 45,  Textual support,  French

Record number: 45, Textual support number: 1 OBS

Source : La structure d'une présentation d'un nouveau médicament à usage vétérinaire.  2, record 45, French, - resuspensibilit%C3%A9

Record 45,  Textual support,  Spanish

Record 46,  Textual support,  English

Record number: 46, Textual support number: 1 DEF

A person who deals in illegal drugs.  5, record 46, English, - drug%20trafficker

Record number: 46, Textual support number: 1 CONT

Adapting to stepped-up pressure from law enforcement, a new breed of Colombian drug trafficker has abandoned the model of the huge narcotics cartel and is shunning the high-profile lifestyle. Out are bodyguards and armor-plated Toyota Landcruisers. In are taxis and conservative business suits.  6, record 46, English, - drug%20trafficker

Record 46,  Textual support,  French

Record number: 46, Textual support number: 1 DEF

Personne qui trafique des drogues, des produits illicites ou dopants.  4, record 46, French, - narcotrafiquant

Record number: 46, Textual support number: 1 CONT

Parce que la réussite de certains narcotrafiquants est érigée en modèle, leurs comportements - recours systématique à la violence, consommation ostentatoire, mépris des lois, etc. - sont imités et cela contribue au délitement des normes sociales.  5, record 46, French, - narcotrafiquant

Record number: 46, Textual support number: 2 CONT

Les autorités mexicaines ont annoncé hier avoir arrêté à Mexico le narcotraficant Ricardo García Urquiza, alias le «Docteur», lors d'une opération policière menée voilà 10 jours.  6, record 46, French, - narcotrafiquant

Record number: 46, Textual support number: 1 OBS

narcotrafiquant; narcotraficant; trafiquant de drogue : Ces termes s'appliquent notamment aux barons des cartels.  4, record 46, French, - narcotrafiquant

Record 46,  Textual support,  Spanish

Record 47,  Textual support,  English

Record number: 47, Textual support number: 1 OBS

Every year, dozens of new drug products come on the market in Canada. For many of the new drugs made available to the public, we have to decide if the medication should be added to the Pharmacare drug benefit program. Before a new drug is considered for Pharmacare coverage, the manufacturer must send a drug submission to the Manitoba Drug Standards and Therapeutics Committee. This information includes reviews of scientific literature, comparable drug therapies, anticipated drug costs, and therapeutic benefits.  1, record 47, English, - Manitoba%20Drug%20Standards%20and%20Therapeutics%20Committee

Record 47,  Textual support,  French

Record number: 47, Textual support number: 1 OBS

Chaque année, des dizaines de nouveaux produits pharmaceutiques sont introduits sur le marché canadien. Pour la plupart de ceux offerts au public, la question se pose : faut-il ajouter ce nouveau produit à la liste des médicaments admissibles du Régime d'assurance-médicaments? Avant qu'un nouveau produit puisse être couvert par la Régime d'assurance-médicaments, le fabricant doit présenter une demande au Comité responsable du choix des médicaments et des normes pharmaceutiques du Manitoba. Celle-ci doit fournir les renseignements suivants : les études publiées dans la littérature scientifique, les thérapies comparables, les coûts à prévoir ainsi que les bienfaits thérapeutiques du produit.  2, record 47, French, - Comit%C3%A9%20responsable%20du%20choix%20des%20m%C3%A9dicaments%20et%20des%20normes%20pharmaceutiques%20du%20Manitoba

Record 47,  Textual support,  Spanish

Record 48,  Textual support,  English

Record number: 48, Textual support number: 1 OBS

The New Drug Pipeline Monitor was prepared by the Patented Medicine Prices Review Board(PMPRB) under the provisions and conditions of the National Prescription Drug Utilization Information System(NPDUIS). The report was produced with the invaluable assistance of the NPDUIS Steering Committee.  1, record 48, English, - New%20Drug%20Pipeline%20Monitor

Record 48,  Textual support,  French

Record number: 48, Textual support number: 1 OBS

L'Observateur des médicaments émergents (OMÉ) a été préparé par le Conseil d'examen du prix des médicaments brevetés (CEPMB) au titre du Système national d'information sur les médicaments prescrits (SNIUMP). Le rapport a été produit en collaboration avec les membres du Comité directeur du SNIUMP.  1, record 48, French, - L%27Observateur%20des%20m%C3%A9dicaments%20%C3%A9mergents

Record 48,  Textual support,  Spanish

Record 49,  Textual support,  English

Record number: 49, Textual support number: 1 CONT

The Circuit Attorney's office was successful in receiving a renewal of its drug prosecution grant and has also been awarded a new drug prosecution grant that will provide additional prosecutors soley for the purpose of prosecuting crimes involving the use of guns.  2, record 49, English, - drug%20prosecution

Record 49,  Textual support,  French

Record number: 49, Textual support number: 1 OBS

Source(s) : Lexique Economic Union and Distribution of Powers.  1, record 49, French, - poursuite%20contre%20les%20trafiquants%20de%20drogue

Record 49,  Textual support,  Spanish