TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Molecular endocrinology and gene expression. Functional organization of the estrogen receptor and its involvement in mammary carcinogenesis. Estrogens and estrogen antagonists represent a group of clinically useful hormones and drugs that act through a nuclear receptor to modulate the transcriptional activity of a set of genes involved most notably in female reproductive physiology. The receptor for estrogens belongs to a superfamily of intracellular receptors that mediate the effects of the other gonadal and adrenal steroids, retinoids, thyroid hormones, and vitamin D. Common features shared by the intracellular receptors include organization into discrete functional domains responsible for ligand recognition, sequence-specific DNA binding, nuclear localization, and activation of transcription.  1, record 1, English, - sequence%20specific%20DNA%20binding%20ligand

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Les profils ou patterns compositionnels des génomes des vertébrés. Histogrammes montrant les quantités relatives, les densités de flottaison modales et les niveaux des GC des composants majeurs de l'ADN chez le xénope, le poulet, la souris et l'homme, estimés après le fractionnement d'ADN par centrifugation préparative en gradient de densité en présence de ligands séquence-spécifiques.  1, record 1, French, - ligand%20s%C3%A9quence%2Dsp%C3%A9cifique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.  3, record 2, English, - Nuclear%20receptor%20Co%2DRepressor

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

N-Cor et SMRT sont des corépresseurs transcriptionnels des récepteurs des hormones thyroïdiennes et de l'acide rétinoïque.  1, record 2, French, - facteur%20N%2DCor

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

The immediate-early gene NGFI-B encodes an orphan nuclear receptor that binds DNA as a monomer and activates transcription through a canonical response element(NBRE). NGFI-B is expressed under basal conditions and in response to external stimuli in many mammalian tissues. In particular, NGFI-B expression is dramatically elevated in the adrenal cortex in response to stress and in Y1 adrenocortical cells in response to adrenocorticotropin. NGFI-B activates transcription through a NBRE of the gene encoding 21-hydroxylase(P450c21) in Y1 cell.  2, record 3, English, - orphan%20nuclear%20receptor

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

La grande famille des récepteurs nucléaires inclut les récepteurs des hormones stéroïdiennes et thyroïdiennes, et des dérivés actifs des vitamines A et D. Cette famille comprend également un très grand nombre de membres dont les ligands demeurent inconnus. Ces protéines, considérées comme des récepteurs potentiels, sont donc appelées orphelins. L'identification des fonctions biologiques et des ligands associés aux récepteurs nucléaires orphelins aura non seulement un impact considérable sur nos connaissances des phénomènes biologiques impliqués dans le développement et l'homéostasie, mais elle ouvrira des perspectives prometteuses dans la mise au point de nouveaux agents thérapeutiques pour le traitement des maladies diverses telles que le diabète et certains types de cancer.  1, record 3, French, - r%C3%A9cepteur%20nucl%C3%A9aire%20orphelin

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

A very original set of experiments carried out by the Unit of Molecular Biology of Gene Expression concerns another protein essential for mouse development that is also a transcription factor. This factor known as KBF2 or RBP-Jk is homologous to a Drosophila gene product, Su(H)(Suppressor of Hairless), which belongs to the Notch signal transduction cascade involved in regulating the competence of a cell to respond to specific developmental cues. A likely function of the Su(H) protein is to serve as an anchor on DNA for non DNA-binding transcriptional activators. This function is conserved in the Notch pathway : the activation of this transmembrane receptor likely involves a proteolytic cleavage step which releases its intracellular domain; following nuclear translocation, it activates its target genes by binding to the Su(H) protein, which is already bound to several sites in the target promoters.  2, record 4, English, - Su%28H%29%20protein

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

La protéine Su(H), impliquée dans l'activité de transmission de ce signal, semble capable de s'associer à la région intracellulaire de Notch. C'est un facteur de transcription qui se lie à certaines séquences localisées dans les promoteurs de plusieurs des gènes cibles de Notch.  1, record 4, French, - prot%C3%A9ine%20Su%28H%29

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

With the charcoal method non-specific binding may not be recognized as readily as with the sucrose gradient method, nor does it distinguish receptor that sediments at 8S and 4S, a distinction considered important by some workers(Jensen, 1977). If cytoplasmic estrogen receptor is transferred to nuclear sites, it is inaccessible for assay using conventional techniques(McGuire, 1977a).  1, record 5, English, - sucrose%20gradient%20method

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 OBS

Méthode utilisée dans le dépistage du -- du -- en dosant les récepteurs hormonaux.  1, record 5, French, - technique%20de%20purification%20par%20centrifugation%20sur%20gradient%20de%20sucrose

Record 5,  Textual support,  Spanish