TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

An enzyme that catalyzes the conversion of adenosine to the nucleoside inosine through the removal of an amino group.  4, record 1, English, - adenosine%20deaminase

Record number: 1, Textual support number: 1 OBS

A deficiency of ADA can lead to severe combined immunodeficiency syndrome.  4, record 1, English, - adenosine%20deaminase

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Enzyme qui catalyse une réaction d'hydrolyse de la fonction amine de l'adénosine la transformant en inosine.  2, record 1, French, - d%C3%A9saminase%20de%20l%27ad%C3%A9nosine

Record number: 1, Textual support number: 1 OBS

Le déficit en adénosine-désaminase peut être responsable d'un déficit immunitaire combiné sévère constitutionnel.  2, record 1, French, - d%C3%A9saminase%20de%20l%27ad%C3%A9nosine

Record number: 1, Textual support number: 2 OBS

désaminase de l'adénosine : désignation publiée au Journal officiel de la République française le 4 février 2021.  4, record 1, French, - d%C3%A9saminase%20de%20l%27ad%C3%A9nosine

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Enzima que cataliza la conversión de adenosina a inosina.  1, record 1, Spanish, - adenosina%20desaminasa

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Nucleoside-modified mRNA vaccines represent a new and highly efficacious category of mRNA vaccines.  5, record 2, English, - nucleoside%2Dmodified%20messenger%20ribonucleic%20acid%20vaccine

Record number: 2, Textual support number: 1 OBS

nucleoside-modified messenger ribonucleic acid; nucleoside-modified messenger RNA; nucleoside-modified mRNA; modRNA :... a synthetic messenger RNA(mRNA) in which some nucleosides are replaced by other naturally modified nucleosides or by synthetic nucleoside analogues.  6, record 2, English, - nucleoside%2Dmodified%20messenger%20ribonucleic%20acid%20vaccine

Record number: 2, Textual support number: 2 OBS

nucleoside : A compound(such as guanosine or adenosine) that consists of a purine or pyrimidine base combined with deoxyribose or ribose and is found especially in DNA or RNA [ribonucleic acid].  7, record 2, English, - nucleoside%2Dmodified%20messenger%20ribonucleic%20acid%20vaccine

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 OBS

nucléoside : Molécule composée d'une base de purine ou de pyrimidine et d'un sucre (ribose ou désoxyribose).  4, record 2, French, - vaccin%20%C3%A0%20acide%20ribonucl%C3%A9ique%20messager%20%C3%A0%20nucl%C3%A9oside%20modifi%C3%A9

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity.  2, record 3, English, - azacitidine

Record number: 3, Textual support number: 1 OBS

A pyrimidine nucleoside analogue of cytidine with antineoplastic activity.  2, record 3, English, - azacitidine

Record number: 3, Textual support number: 2 OBS

Active ingredient sold under a number of commercial (trade) names, among which: Vidaza.  3, record 3, English, - azacitidine

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

L’azacitidine est un analogue pyrimidine. Elle possède deux principaux mécanismes d’action antinéoplasique : 1) cytotoxicité directe sur les cellules hématopoïétiques anormales dans la moelle osseuse et; 2) hypométhylation de l’ADN, permettant de rétablir le fonctionnement normal des gènes indispensables à la différenciation et à la prolifération des cellules de la moelle osseuse.  2, record 3, French, - azacitidine

Record number: 3, Textual support number: 1 OBS

Principe actif commercialisé, entre autres, sous le nom de Vidaza.  3, record 3, French, - azacitidine

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

A nucleoside comprising adenine linked to D-ribose through a [beta]-glycosidic bond. Phosphorylated forms(AMP, ADP and ATP) are the major compounds involved in energy transfer in biological systems.  2, record 4, English, - adenosine

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Nucléoside purique résultant de la condensation de l'adénine et du D-ribose. Ses esters monophosphorique (A.M.P.), diphosphorique (A.D.P.) et triphosphorique (A.T.P.) jouent un rôle essentiel dans le transport de l'énergie biochimique.  2, record 4, French, - ad%C3%A9nosine

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Nucleósido de adenina.  2, record 4, Spanish, - adenosina

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

Nucleoside phosphate, other than adenosine, cytidine, guanosine or uridine, incorporated into tRNA molecules. These bases are important in establishing the unique spatial organization of the tRNA.  2, record 5, English, - rare%20base

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Base purique ou pyrimidique que l'on trouve uniquement dans certains acides nucléiques (notamment le tRNA) et en faibles quantités, d'où son nom. On en connaît une cinquantaine à l'heure actuelle.  2, record 5, French, - base%20rare

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

An enzyme of the transferase class that catalyzes the phosphorylation of hypoxanthine or guanine to its corresponding nucleoside monophosphate, a salvage mechanism for recovery of preformed purines, especially in the central nervous system.  3, record 6, English, - hypoxanthine%2Dguanine%2Dphosphoribosyltransferase

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Enzyme catalysant le transfert du radical phosphoribosyle du phosphoribosyl-pyrophosphate sur l'hypoxanthine ou sur la guanine, qu'il transforme respectivement en acide inosinique ou guanylique.  1, record 6, French, - hypoxanthine%2Dguanine%2Dphosphoribosyl%2Dtransf%C3%A9rase

Record number: 6, Textual support number: 1 OBS

Cet enzyme joue un rôle important dans le métabolisme des bases puriques dans le foie en permettant la récupération de ces bases libérées lors de la dégradation des nucléotides et d'éviter leur transformation en acide urique.  1, record 6, French, - hypoxanthine%2Dguanine%2Dphosphoribosyl%2Dtransf%C3%A9rase

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

An enzyme of the transferase class that acts as a DNA polymerase, specifically catalyzing the sequential addition of single deoxynucleotide residues, as nucleoside triphosphate, to the end of nucleotide chains.  3, record 7, English, - terminal%20deoxynucleotidyl%20transferase

Record number: 7, Textual support number: 1 CONT

Nearly every DNA polymerase characterized to date exclusively catalyzes the incorporation of mononucleotides into a growing primer using a DNA or RNA template as a guide to direct each incorporation event. There is, however, one unique DNA polymerase designated terminal deoxynucleotidyl transferase that performs DNA synthesis using only single-stranded DNA as the nucleic acid substrate.  6, record 7, English, - terminal%20deoxynucleotidyl%20transferase

Record number: 7, Textual support number: 1 OBS

The enzyme is often found in the blast cells of patients with acute lymphocytic leukemia; its presence is used in the differential diagnosis of this disease as well as to monitor response to treatment.  3, record 7, English, - terminal%20deoxynucleotidyl%20transferase

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Enzyme qui insère des nucléotides au niveau des jonctions entre des segments de gènes, en particulier au cours du réarrangement des éléments d’ADN lors de la différenciation des lymphocytes T.  1, record 7, French, - d%C3%A9soxyribonucl%C3%A9otidyl%2Dtransf%C3%A9rase%20terminale

Record number: 7, Textual support number: 1 OBS

Cet enzyme est actif dans le thymus, la moelle osseuse et les centres germinatifs. Il permet l’insertion de nucléotides de part et d’autre des segments génétiques D des locus TCRB [T cell receptor-beta], TCRD [T cell receptor delta], et IgH [immunoglobulin heavy]. Cet enzyme est par ailleurs utilisé pour fixer le dUTP [désoxyuridine triphosphate] sur les brins libres d’ADN dans les cellules en apoptose.  1, record 7, French, - d%C3%A9soxyribonucl%C3%A9otidyl%2Dtransf%C3%A9rase%20terminale

Record number: 7, Textual support number: 2 OBS

transférase terminale : terme publié au Journal officiel de la République française le 22 septembre 2000.  5, record 7, French, - d%C3%A9soxyribonucl%C3%A9otidyl%2Dtransf%C3%A9rase%20terminale

Record number: 7, Textual support number: 3 OBS

transférase-terminale : terme normalisé par l'AFNOR.  5, record 7, French, - d%C3%A9soxyribonucl%C3%A9otidyl%2Dtransf%C3%A9rase%20terminale

Record 7,  Textual support,  Spanish

Record number: 7, Textual support number: 1 DEF

Enzima que cataliza la adición de nucleótidos al extremo 3' de una molécula de ADN.  1, record 7, Spanish, - transferasa%20terminal

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

... a molecule(known as a nucleoside) that is formed when uracil is attached to a ribose ring(also known as a ribofuranose) via a ß-N₁-glycosidic bond.  2, record 8, English, - uridine

Record number: 8, Textual support number: 1 OBS

If uracil is attached to a deoxyribose ring, it is known as a deoxyuridine.  2, record 8, English, - uridine

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Ribonucléoside dont la base est l'uracile.  2, record 8, French, - uridine

Record 8,  Textual support,  Spanish

Record number: 8, Textual support number: 1 DEF

Ribonucleósido que resulta de la combinación de la base uracilo (U) y el azúcar D-ribosa.  2, record 8, Spanish, - uridina

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

A nucleoside having a purine or pyrimidine base bonded to deoxyribose.  1, record 9, English, - deoxyribonucleoside

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

Composé formé par l'union d'une base azotée et de désoxyribose.  1, record 9, French, - d%C3%A9soxyribonucl%C3%A9oside

Record 9,  Textual support,  Spanish

Record number: 9, Textual support number: 1 DEF

Nucleósido formado por la unión de una purina o de una pirimidina con 2-desoxirribosa.  1, record 9, Spanish, - desoxirribonucle%C3%B3sido

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 OBS

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules.  2, record 10, English, - inosine

Record number: 10, Textual support number: 2 OBS

Chemical formula: C₁₀H₁₂N₄O₅  3, record 10, English, - inosine

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 OBS

Formule chimique : C₁₀H₁₂N₄O₅  2, record 10, French, - inosine

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

Stavudine [is] a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.  2, record 11, English, - stavudine

Record number: 11, Textual support number: 1 OBS

ZERIT(R) is the brand name for stavudine(d4T), a synthetic thymidine nucleoside analogue, active against the human immunodeficiency virus(HIV).  3, record 11, English, - stavudine

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

[La] stavudine [est] un analogue du didéoxynucléoside qui inhibe la transcriptase inverse et qui a une activité antiVIH in vitro.  3, record 11, French, - stavudine

Record number: 11, Textual support number: 1 OBS

Le d4T, connu également sous le nom de stavudine et la marque commerciale Zerit, appartient au groupe de médicaments antirétroviraux appelés inhibiteurs nucléosidiques de la transcriptase inverse, ou analogues nucléosidiques.  2, record 11, French, - stavudine

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

Lamivudine, trade name Epivir(also known as 3TC), is an anti-HIV treatment in the class of drugs called Nucleoside Reverse Transcriptase Inhibitors(NRTIs).  1, record 12, English, - lamivudine

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 OBS

Antirétroviral, analogue nucléosidique, inhibiteur de la transcriptase inverse du VIH. Il est commercialisé sous le nom d'Epivir(R) dans la pathologie VIH. Également actif contre le VHB [virus à ADN responsable de l'hépatite B], il est alors commercialisé sous le nom de Zeffix (R).  1, record 12, French, - lamivudine

Record 12,  Textual support,  Spanish

Record number: 12, Textual support number: 1 DEF

Principio activo del 3TC o Epivir que es un nucleósido análogo, inhibidor de la acción de la transcriptasa inversa.  1, record 12, Spanish, - lamivudina

Record number: 12, Textual support number: 1 OBS

Principio activo de los fármacos antirretrovirales que se emplean para destruir o evitar la replicación de los retrovirus.  1, record 12, Spanish, - lamivudina

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 OBS

HIVID is the Hoffmann-La Roche brand of zalcitabine [formerly called 2’, 3’-dideoxycytidine(ddC) ], a synthetic pyrimidine nucleoside analogue active against the human immunodeficiency virus(HIV). HIVID is available as film-coated tablets for oral administration in strengths of 0. 375 mg and 0. 750 mg.  1, record 13, English, - zalcitabine

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 OBS

La zalcitabine est un analogue de synthèse d'un nucléoside naturel, la 2'-désoxycytidine, dont le groupement hydroxyde en position 3' a été remplacé par un atome d'hydrogène. Dans la cellule, la zalcitabine est convertie par un système enzymatique en son métabolite actif, le didésoxycytidine-5'-triphosphate (ddCTP), qui remplace le substrat naturel, le désoxycytidine-triphosphate (dCTP), de la transcriptase inverse du VIH et qui inhibe la réplication in vitro du VIH-1 en inhibant la synthèse de l'ADN viral.  2, record 13, French, - zalcitabine

Record number: 13, Textual support number: 2 OBS

Zalcitabine. (anciennement appelée didésoxycytidine (ddC)).  2, record 13, French, - zalcitabine

Record 13,  Textual support,  Spanish

Record number: 13, Textual support number: 1 OBS

Principio activo del ddC, cuyo nombre comercial es Hivid.  1, record 13, Spanish, - dideoxicitidina

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 CONT

4’-Azidothymidine(ADRT) is a... nucleoside analog, that selectively inhibits human immunodeficiency virus replication in human lymphocytes.  1, record 14, English, - 4%27%2DAzidothymidine

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 CONT

[Parmi les] analogues de nucléosides de «seconde génération», [...] on peut citer l'ADRT ou 4'-Azidothymidine [...]  1, record 14, French, - 4%27%2DAzidothymidine

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 DEF

Condition characterized by sensory loss, pain, muscle weakness, and wasting or muscle in the hands or legs and feet. It may start with burning or tingling sensations or numbness in the toes and fingers. In severe cases, paralysis may result.  2, record 15, English, - peripheral%20neuropathy

Record number: 15, Textual support number: 1 OBS

Peripheral neuropathy may arise from an HIV-related condition or be the side effect of certain drugs, some of the nucleoside analogs in particular.  2, record 15, English, - peripheral%20neuropathy

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 DEF

Dénomination générale pour indiquer l'existence d'une affection du système nerveux périphérique.  2, record 15, French, - neuropathie%20p%C3%A9riph%C3%A9rique

Record number: 15, Textual support number: 1 OBS

Elle peut être la conséquence d'une infection virale ou de la prise de certains médicaments, parmi lesquels les antirétroviraux.  2, record 15, French, - neuropathie%20p%C3%A9riph%C3%A9rique

Record 15,  Textual support,  Spanish

Record number: 15, Textual support number: 1 DEF

Trastorno del sistema nervioso periférico, que se manifiesta con pérdida de sensibilidad, entumecimiento, adormecimiento, hormigueo y dolor en las extremidades, sobre todo en manos y pies.  1, record 15, Spanish, - neuropat%C3%ADa%20perif%C3%A9rica

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 DEF

A compound consisting of a purine or pyrimidine base linked to D-ribose or D-deoxyribose.  2, record 16, English, - nucleoside

Record number: 16, Textual support number: 1 OBS

Deoxyribonucleosides or ribonucleosides are collectively called nucleosides. A nucleoside differs from a nucleotide in lacking a phosphate. Nucleosides are named according to the base(adenine, guanine, cytosine, uracil or thymine) they contain.  3, record 16, English, - nucleoside

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 DEF

Molécule formée d'un pentose, le ribose dans l'ARN ou le désoxyribose dans l'ADN, lié à une base nucléotidique.  2, record 16, French, - nucl%C3%A9oside

Record number: 16, Textual support number: 1 OBS

Un nucléoside est, en quelque sorte, un nucléotide sans groupe phosphate.  3, record 16, French, - nucl%C3%A9oside

Record 16,  Textual support,  Spanish

Record number: 16, Textual support number: 1 DEF

Molécula con que se construye el ADN y el ARN, forma cadenas que componen el genoma y [según] la secuencia que guarda, constituye los diversos organismos.  2, record 16, Spanish, - nucle%C3%B3sido

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 DEF

A pyrimidine nucleoside, C5H9O3C5H4N2O2, in which the base is thymine and the sugar desoxyribose, and which is obtained by the partial hydrolysis of DNA.  2, record 17, English, - thymidine

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 DEF

Désoxyribonucléoside qui contient comme base azotée la thymine spécifique de l'ADN.  2, record 17, French, - thymidine

Record 17,  Textual support,  Spanish

Record number: 17, Textual support number: 1 DEF

Una de las cuatro bases nitrogenadas que conforman el filamento ADN ó ARN.  2, record 17, Spanish, - timidina

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 DEF

An antiviral drug(a non nucleoside reverse transcriptase inhibitor) with anti-HIV activity.  4, record 18, English, - nevirapine

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 DEF

Agent inhibiteur de la réplication ayant la propriété de bloquer soit la copie du matériel génétique du VIH (la première) soit la synthèse de la protéine-enveloppe.  1, record 18, French, - n%C3%A9virapine

Record 18,  Textual support,  Spanish

Record number: 18, Textual support number: 1 DEF

Medicamento no nucleósido, inhibidor de la transcriptasa inversa. Se desconoce su interacción con los inhibidores de proteasa.  3, record 18, Spanish, - nevirapine

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 DEF

A nucleoside comprising guanine linked with D-ribose through a [beta]-glycosidic bond.  2, record 19, English, - guanosine

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 DEF

Nucléoside résultant de la condensation de la guanine et du ribose.  2, record 19, French, - guanosine

Record 19,  Textual support,  Spanish

Record number: 19, Textual support number: 1 DEF

Nucleósido constituido por guanina y ribasa [que constituye] uno de los elementos que conforman un filamento de ADN, los otros son adenina, citosina y timidina.  2, record 19, Spanish, - guanosina

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 DEF

An anti-viral agent.  4, record 20, English, - adenine%20arabinoside

Record number: 20, Textual support number: 1 OBS

Synthesized in 1960, it was subsequently found as a naturally occurring nucleoside in culture filtrates of streptomyces antibioticus. Mode of action nuclear but it probably inhibits viral DNA polymerase. It neither directly inactivates virus nor prevents attachment. It is active against herpesvirus and poxvirus; less so against adenovirus and papovirus. With the exception oncovirus the drug has no action against RNA viruses.  4, record 20, English, - adenine%20arabinoside

Record 20,  Textual support,  French

Record number: 20, Textual support number: 1 DEF

La principale substance utilisée, avant l'avènement de l'acyclovir, pour lutter contre les infections à herpèsvirus menaçant le pronostic vital, [et qui] agit également en l'absence de thymidine kinase.  2, record 20, French, - vidarabine

Record 20,  Textual support,  Spanish

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 DEF

A nucleoside comprising one cytosine molecule linked to a D-ribose sugar molecule. The derived nucleotides, cytidine mono-, di-, and triphosphate(CMP, CDP, and CTP respectively) participate in various biochemical reactions.  2, record 21, English, - cytidine

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 DEF

Nucléoside résultant de la condensation de la cytosine et du ribose.  2, record 21, French, - cytidine

Record 21,  Textual support,  Spanish

Record number: 21, Textual support number: 1 DEF

Nucleósido de citosina con ribosa o desoxirribosa.  2, record 21, Spanish, - citidina

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 DEF

An anti-viral agent.  4, record 22, English, - ribavirin

Record number: 22, Textual support number: 1 OBS

A synthetic nucleoside analogue of guanosine that interferes with biosynthesis of guanylic acid nucleotides. Active against DNA and RNA viruses including influenza, murine hepatitis and Lassa fever viruses. As good in vitro as cytarabine hydrochloride, andenine arabinoside, and idoxuridine against influenza virus A, A2 and B, and parainfluenza virus and adenovirus; specially indicated for treatment of severe lower respiratory tract RSV infections in patients with an underlying compromising condition(prematurity, bronchopulmonary dysplasia and other chronic lung conditions, congenital heart disease, immunodeficiency, immunosupression), and recent transplant recipients.(From sources a and b).  5, record 22, English, - ribavirin

Record 22,  Textual support,  French

Record number: 22, Textual support number: 1 CONT

La ribavirine, est un analogue de la guanosine et un agent antiviral à large spectre actif sur le V.I.H. (From sources d et e).  3, record 22, French, - ribavirine

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 CONT

Among the most effective treatment methods is highly active antiretroviral therapy(HAART). HAART currently consists of triple therapy, including two nucleoside analogues and a protease inhibitor.  1, record 23, English, - triple%20therapy

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 DEF

Traitement d'une affection à l'aide de trois médicaments.  1, record 23, French, - trith%C3%A9rapie

Record number: 23, Textual support number: 1 OBS

Dans le cas du traitement du VIH, une trithérapie consistera à prescrire deux inhibiteurs de reverse-transcriptase et un inhibiteur de protéase ou en combinant trois médicaments de classes différentes.  1, record 23, French, - trith%C3%A9rapie

Record 23,  Textual support,  Spanish

Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 DEF

Drug which inhibits production of viral DNA.  1, record 24, English, - reverse%20transcriptase%20inhibitor

Record number: 24, Textual support number: 1 OBS

Although there are two classes, nucleoside and mononucleoside analogues, RTI is often used to mean only the nucleoside analogues.  1, record 24, English, - reverse%20transcriptase%20inhibitor

Record 24,  Textual support,  French

Record number: 24, Textual support number: 1 DEF

[Médicament qui a] pour cible la reverse-transcriptase, enzyme du VIH, qui lui permet de s'intégrer à la cellule vivante.  1, record 24, French, - inhibiteur%20de%20la%20reverse%2Dtranscriptase

Record number: 24, Textual support number: 1 OBS

Parmi ces médicaments, le premier utilisé a été l'AZT.  1, record 24, French, - inhibiteur%20de%20la%20reverse%2Dtranscriptase

Record 24,  Textual support,  Spanish

Record 25,  Textual support,  English

Record number: 25, Textual support number: 1 CONT

Didanosine(ddI, Dideoxyinosine, Videx) is an antiretroviral(a nucleoside analog that inhibits replication of HIV), FDA approved 10/09/91 for treatment of adult and pediatric patients with advanced HIV who are intolerant to or deteriorating on AZT.(From sources a and b).  5, record 25, English, - dideoxyinosine

Record 25,  Textual support,  French

Record number: 25, Textual support number: 1 CONT

Au cours de l'infection à VIH, plusieurs traitements peuvent être mis en place selon le stade de l'infection. Les traitements antiviraux s'attaquent directement au VIH, en bloquant la transcriptase inverse après l'entrée du virus dans la cellule. Les principaux sont l'AZT, le ddl, le ddC. Ce sont des analogues des nucléotides entrant dans la constitution de la séquence d'ADN et qui en bloquent la synthèse. On les emploie seuls ou en association lorsque le taux de lymphocytes CD4 a commencé à diminuer.  3, record 25, French, - did%C3%A9oxyinosine

Record 25,  Textual support,  Spanish

Record 26,  Textual support,  English

Record number: 26, Textual support number: 1 CONT

The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl) adenine(PMEA) is a strong inducer of differentiation of several tumor cell lines. It is the prototype compound of a series of acyclic nucleoside phosphonate derivatives endowed with potent and selective anti-retroviral activity in vitro and in vivo.  1, record 26, English, - PMEA

Record 26,  Textual support,  French

Record number: 26, Textual support number: 1 CONT

Un autre type de composés bloquant la transcriptase reverse a été découvert en 1990 par la firme Janssen qui criblait «à l'aveugle» des anti-HIV : il s'agit de dérivés des benzodiazépines. Ces composés (TIBO et apparentés, HEPT, PMEA, BI-RG 578), lointains cousins des tranquillisants sont très actifs in vitro.  1, record 26, French, - PMEA

Record 26,  Textual support,  Spanish

Record 27,  Textual support,  English

Record number: 27, Textual support number: 1 CONT

Combined immunodeficiency secondary to enzyme deficiency. Two enzyme deficiency disorders have been found to cause severe combined immunodeficiency. These enzymes are necessary for the metabolism of purines : adenosine deaminase(ADA) and purine nucleoside phosphorylase(PNP). The enzyme deficiency is inherited as an autosomal recessive disorder. Deficiency of ADA or PNP leads to intracellular accumulation of deoxy-adenosine or deoxyguanine, respectively, resulting in inhibition of lymphocyte function.  1, record 27, English, - combined%20immunodeficiency%20secondary%20to%20enzyme%20deficiency

Record 27,  Textual support,  French

Record number: 27, Textual support number: 1 DEF

Déficit enzymatique qui touche (...) le métabolisme des purines (et qui) est responsable d'un défaut prédominant de l'immunité cellulaire. Les premiers signes infectieux apparaissent tardivement après l'âge d'un an.  1, record 27, French, - d%C3%A9ficit%20en%20purine%20nucl%C3%A9oside%20phosphorylase

Record 27,  Textual support,  Spanish

Record 28,  Textual support,  English

Record number: 28, Textual support number: 1 CONT

Combined immunodeficiency secondary to enzyme deficiency. Two enzyme deficiency disorders have been found to cause severe combined immunodeficiency. These enzymes are necessary for the metabolism of purines : adenosine deaminase(ADA) and purine nucleoside phosphorylase(PNP). The enzyme deficiency is inherited as an autosomal recessive disorder. Deficiency of ADA or PNP leads to intracellular accumulation of deoxy-adenosine or deoxyguanine, respectively, resulting in inhibition of lymphocyte function.  1, record 28, English, - combined%20immunodeficiency%20secondary%20to%20ADA%20enzyme%20deficiency

Record 28,  Textual support,  French

Record number: 28, Textual support number: 1 CONT

(...) le déficit immunitaire combiné sévère associé à un déficit en adénosine désaminase (ADA). L'affection est transmise de façon autosomique récessive (le gène de l'ADA est situé sur le chromosome 20). Elle est souvent associée à certaines anomalies du squelette.  1, record 28, French, - d%C3%A9ficit%20immunitaire%20combin%C3%A9%20s%C3%A9v%C3%A8re%20associ%C3%A9%20%C3%A0%20un%20d%C3%A9ficit%20en%20ad%C3%A9nosine%20d%C3%A9saminase

Record 28,  Textual support,  Spanish

Record 29,  Textual support,  English

Record number: 29, Textual support number: 1 OBS

(...) it is necessary to pass a sample of the products of the initial extension over a gel filtration column and thus to separate the relatively large extension chains attached to their template from the small individual nucleoside triphosphate building blocks that were not incorporated into new DNA.  1, record 29, English, - gel%20filtration%20column

Record 29,  Textual support,  French

Record number: 29, Textual support number: 1 OBS

(...) il est d'abord nécessaire de passer un échantillon des premiers produits d'élongation à travers une colonne de gel de filtration, de manière à séparer les chaînes relativement longues et attachées à leur modèle des éléments de base que sont les petits nucléosides triphosphates restant et qui n'ont pas été incorporés dans l'ADN nouvellement synthétisé.  1, record 29, French, - colonne%20de%20gel%20de%20filtration

Record 29,  Textual support,  Spanish

Record 30,  Textual support,  English

Record number: 30, Textual support number: 1 CONT

In the four plus systems, also designed to yield chains ending at defined positions, extension-product subsamples are incubated with only one nucleoside triphosphate instead of with three and with a different DNA polymerase, one that is manufactured by the bacterial virus designated T4.  1, record 30, English, - plus%20system

Record 30,  Textual support,  French

Record number: 30, Textual support number: 1 CONT

Dans les quatre systèmes "plus" qui sont aussi conçus pour donner des chaînes se terminant par un nucléotide déterminé, les échantillons sont incubés avec un seul nucléoside triphosphate au lieu de trois et avec une ADN-polymérase différente, fabriquée par le bactériophage T [4].  2, record 30, French, - syst%C3%A8me%20plus

Record 30,  Textual support,  Spanish