TERMIUM Plus®

From: Translation Bureau

On social media

Consult the Government of Canada’s terminology data bank.

NUCLEOSIDE ANALOGUE [4 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2014-04-07

English

Subject field(s)
  • Medication
CONT

Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity.

OBS

A pyrimidine nucleoside analogue of cytidine with antineoplastic activity.

OBS

Active ingredient sold under a number of commercial (trade) names, among which: Vidaza.

French

Domaine(s)
  • Médicaments
CONT

L’azacitidine est un analogue pyrimidine. Elle possède deux principaux mécanismes d’action antinéoplasique : 1) cytotoxicité directe sur les cellules hématopoïétiques anormales dans la moelle osseuse et; 2) hypométhylation de l’ADN, permettant de rétablir le fonctionnement normal des gènes indispensables à la différenciation et à la prolifération des cellules de la moelle osseuse.

OBS

Principe actif commercialisé, entre autres, sous le nom de Vidaza.

Spanish

Campo(s) temático(s)
  • Medicamentos
Save record 1

Record 2 2006-08-30

English

Subject field(s)
  • Medication
CONT

Stavudine [is] a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

OBS

ZERIT(R) is the brand name for stavudine(d4T), a synthetic thymidine nucleoside analogue, active against the human immunodeficiency virus(HIV).

French

Domaine(s)
  • Médicaments
CONT

[La] stavudine [est] un analogue du didéoxynucléoside qui inhibe la transcriptase inverse et qui a une activité antiVIH in vitro.

OBS

Le d4T, connu également sous le nom de stavudine et la marque commerciale Zerit, appartient au groupe de médicaments antirétroviraux appelés inhibiteurs nucléosidiques de la transcriptase inverse, ou analogues nucléosidiques.

Spanish

Save record 2

Record 3 2006-05-24

English

Subject field(s)
  • Medication
OBS

HIVID is the Hoffmann-La Roche brand of zalcitabine [formerly called 2’, 3’-dideoxycytidine(ddC) ], a synthetic pyrimidine nucleoside analogue active against the human immunodeficiency virus(HIV). HIVID is available as film-coated tablets for oral administration in strengths of 0. 375 mg and 0. 750 mg.

French

Domaine(s)
  • Médicaments
OBS

La zalcitabine est un analogue de synthèse d'un nucléoside naturel, la 2'-désoxycytidine, dont le groupement hydroxyde en position 3' a été remplacé par un atome d'hydrogène. Dans la cellule, la zalcitabine est convertie par un système enzymatique en son métabolite actif, le didésoxycytidine-5'-triphosphate (ddCTP), qui remplace le substrat naturel, le désoxycytidine-triphosphate (dCTP), de la transcriptase inverse du VIH et qui inhibe la réplication in vitro du VIH-1 en inhibant la synthèse de l'ADN viral.

OBS

Zalcitabine. (anciennement appelée didésoxycytidine (ddC)).

Spanish

Campo(s) temático(s)
  • Medicamentos
OBS

Principio activo del ddC, cuyo nombre comercial es Hivid.

Save record 3

Record 4 2003-10-09

English

Subject field(s)
  • Medication
DEF

An anti-viral agent.

OBS

A synthetic nucleoside analogue of guanosine that interferes with biosynthesis of guanylic acid nucleotides. Active against DNA and RNA viruses including influenza, murine hepatitis and Lassa fever viruses. As good in vitro as cytarabine hydrochloride, andenine arabinoside, and idoxuridine against influenza virus A, A2 and B, and parainfluenza virus and adenovirus; specially indicated for treatment of severe lower respiratory tract RSV infections in patients with an underlying compromising condition(prematurity, bronchopulmonary dysplasia and other chronic lung conditions, congenital heart disease, immunodeficiency, immunosupression), and recent transplant recipients.(From sources a and b).

French

Domaine(s)
  • Médicaments
CONT

La ribavirine, est un analogue de la guanosine et un agent antiviral à large spectre actif sur le V.I.H. (From sources d et e).

Spanish

Campo(s) temático(s)
  • Medicamentos
Save record 4

Copyright notice for the TERMIUM Plus® data bank

© Public Services and Procurement Canada, 2026
TERMIUM Plus®, the Government of Canada's terminology and linguistic data bank
A product of the Translation Bureau

Display options

Change the order of display of the official languages of Canada
Option to display the non-official languages (Spanish or Portuguese)
Display definitions, contexts, etc., on records

Features

GCtranslate (available on the Government of Canada network only)

Use this artificial intelligence prototype to translate Government of Canada content up to and including Protected B. Available to employees of selected departments and agencies only.

Writing tools

The Language Portal’s writing tools have a new look! Easy to consult, they give you access to a wealth of information that will help you write better in English and French.

Glossaries and vocabularies

Access Translation Bureau glossaries and vocabularies.

Date Modified: