TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

A serotonin-noradrenalin reuptake inhibitor which promotes satiety and supports the effects of diet and exercise on weight loss.  4, record 1, English, - 1%2D%5B1%2D%284%2Dchlorophenyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrimethylbutan%2D1%2Damine

Record number: 1, Textual support number: 1 CONT

Sibutramine has been shown to reduce body weight by dual actions : reduction of food intake through enhancement of satiety, and increase of energy expenditure by induction of thermogenesis. Sibutramine produces its therapeutic effects primarily by serotonin and norepinephrine reuptake inhibition.  5, record 1, English, - 1%2D%5B1%2D%284%2Dchlorophenyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrimethylbutan%2D1%2Damine

Record number: 1, Textual support number: 1 OBS

1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine: form recommended by the IUPAC (International Union of Pure and Applied Chemistry) for the systematic name corresponding to the CAS number indicated on the present record.  3, record 1, English, - 1%2D%5B1%2D%284%2Dchlorophenyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrimethylbutan%2D1%2Damine

Record number: 1, Textual support number: 2 OBS

alpha: This word must be replaced by the corresponding Greek letter or italicized.  3, record 1, English, - 1%2D%5B1%2D%284%2Dchlorophenyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrimethylbutan%2D1%2Damine

Record number: 1, Textual support number: 3 OBS

N: This capital letter must be italicized.  3, record 1, English, - 1%2D%5B1%2D%284%2Dchlorophenyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrimethylbutan%2D1%2Damine

Record number: 1, Textual support number: 4 OBS

sibutramine: international nonproprietary name (INN).  3, record 1, English, - 1%2D%5B1%2D%284%2Dchlorophenyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrimethylbutan%2D1%2Damine

Record number: 1, Textual support number: 5 OBS

Medaria; Meridia; Reductil; Sibutral: (Abbott): Names under which the active ingredient is sold.  6, record 1, English, - 1%2D%5B1%2D%284%2Dchlorophenyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrimethylbutan%2D1%2Damine

Record number: 1, Textual support number: 6 OBS

Chemical formula: C₁₇H₂₆ClN  6, record 1, English, - 1%2D%5B1%2D%284%2Dchlorophenyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrimethylbutan%2D1%2Damine

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Substance médicamenteuse qui agit sur le cerveau, où elle augmente l'effet de la sérotonine et de la noradrénaline, et est utilisée comme anorexigène dans le traitement de l'obésité.  3, record 1, French, - 1%2D%5B1%2D%284%2Dchloroph%C3%A9nyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrim%C3%A9thylbutan%2D1%2Damine

Record number: 1, Textual support number: 1 CONT

La sibutramine fait perdre du poids par deux mécanismes complémentaires : [...] Elle augmente le seuil de satiété. [...] Elle augmente la thermogenèse, c'est-à-dire la production de chaleur par l'organisme.  4, record 1, French, - 1%2D%5B1%2D%284%2Dchloroph%C3%A9nyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrim%C3%A9thylbutan%2D1%2Damine

Record number: 1, Textual support number: 1 OBS

1-[1-(4-chlorophényl)cyclobutyl]-N,N,3- triméthylbutan-1-amine : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée) pour le nom systématique correspondant au numéro CAS indiqué sur la présente fiche.  1, record 1, French, - 1%2D%5B1%2D%284%2Dchloroph%C3%A9nyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrim%C3%A9thylbutan%2D1%2Damine

Record number: 1, Textual support number: 2 OBS

alpha : Ce mot doit être remplacé par la lettre grecque correspondante ou s'écrire en italique.  1, record 1, French, - 1%2D%5B1%2D%284%2Dchloroph%C3%A9nyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrim%C3%A9thylbutan%2D1%2Damine

Record number: 1, Textual support number: 3 OBS

N : Cette lettre majuscule s'écrit en italique.  1, record 1, French, - 1%2D%5B1%2D%284%2Dchloroph%C3%A9nyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrim%C3%A9thylbutan%2D1%2Damine

Record number: 1, Textual support number: 4 OBS

sibutramine: dénomination commune internationale (DCI).  1, record 1, French, - 1%2D%5B1%2D%284%2Dchloroph%C3%A9nyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrim%C3%A9thylbutan%2D1%2Damine

Record number: 1, Textual support number: 5 OBS

Medaria; Meridia; Reductil; Sibutral (Abbott) : Noms sous lesquels le principe actif est commercialisé.  3, record 1, French, - 1%2D%5B1%2D%284%2Dchloroph%C3%A9nyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrim%C3%A9thylbutan%2D1%2Damine

Record number: 1, Textual support number: 6 OBS

Formule chimique : C₁₇H₂₆ClN  3, record 1, French, - 1%2D%5B1%2D%284%2Dchloroph%C3%A9nyl%29cyclobutyl%5D%2DN%2CN%2C3%2Dtrim%C3%A9thylbutan%2D1%2Damine

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

SSRIs treat depression by increasing levels of serotonin in the brain. Serotonin is one of the chemical messengers(neurotransmitters) that carry signals between brain nerve cells(neurons). SSRIs block the reabsorption(reuptake) of serotonin into neurons. This makes more serotonin available to improve transmission of messages between neurons. SSRIs are called selective because they mainly affect serotonin, not other neurotransmitters. SSRIs may also be used to treat conditions other than depression, such as anxiety disorders.  4, record 2, English, - selective%20serotonin%20reuptake%20inhibitor

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Les ISRS, en inhibant la recapture de la 5-HT [sérotonine] dans la synapse, augmentent sa concentration et donc son efficacité sur les récepteurs sérotoninergiques synaptiques.  3, record 2, French, - inhibiteur%20s%C3%A9lectif%20de%20la%20recapture%20de%20la%20s%C3%A9rotonine

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

MAOIs [monoamine oxidase inhibitors] tend to be underutilized in clinical practice, due in part to misinformation and mythology about their dietary and drug interactions. The new class of reversible monoamine oxidase inhibitors(RIMAs) has shown efficacy in depression, with safety and tolerability comparable to SSRIs [selective serotonin reuptake inhibitors].  1, record 3, English, - reversible%20monoamine%20oxidase%20inhibitor

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

On a rapporté des réactions graves, dont certaines ont été fatales, chez des patients ayant reçu [du] chlorhydrate de sertraline ([zoloft]) en association avec un inhibiteur de la monoamine oxydase (IMAO), y compris avec la sélégiline, un IMAO sélectif, le moclobémide, un IMAO réversible ou IRMAO (inhibiteur réversible de la monoamine oxydase) et le linézolide, un antibiotique et un IRMAO non sélectif.  2, record 3, French, - inhibiteur%20r%C3%A9versible%20de%20la%20monoamine%20oxydase

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 OBS

The Scientific Advisory Panel(SAP) on Selective Serotonin Reuptake Inhibitors(SSRI) and Serotonin/Norepinephrine Reuptake Inhibitors(SNRI) acts as a forum of advice and a sounding board for management and scientists of Health Canada(HC). The SAP will primarily be consulted on the issue concerning the use of SSRI/SNRI in children under 18 years of age having major depressive disorders, but the decision-making responsibility remains with HC.  1, record 4, English, - Scientific%20Advisory%20Panel%20on%20Selective%20Serotonin%20Reuptake%20Inhibitors%20and%20Serotonin%2FNorepinephrine%20Reuptake%20Inhibitors

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

Le Groupe consultatif scientifique (CCS) des inhibiteurs sélectifs de la recaptation de la sérotonine (ISRS) et des inhibiteurs sélectifs de la recaptation de la sérotonine/norépinéphrine (ISRSN) a pour mandat de conseiller et d'informer les membres de la direction et les scientifiques de Santé Canada (SC). On consultera le CCS principalement dans le domaine de l'utilisation des ISRS/ISRSN chez les enfants de moins de 18 ans atteints de troubles dépressifs majeurs, mais la responsabilité des décisions incombe à SC.  1, record 4, French, - Groupe%20consultatif%20scientifique%20des%20inhibiteurs%20s%C3%A9lectifs%20de%20la%20recaptation%20de%20la%20s%C3%A9rotonine%20et%20des%20inhibiteurs%20s%C3%A9lectifs%20de%20la%20recaptation%20de%20la%20s%C3%A9rotonine%2Fnor%C3%A9pin%C3%A9phrine

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

A chemical product which has the property of blocking the reuptake of the neurotransmitter serotonin and which is therefore used as an antidepressant.  4, record 5, English, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Dazepin%2D5%2Dyl%29%2DN%2CN%2Ddimethylpropan%2D1%2Damine

Record number: 5, Textual support number: 1 OBS

3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine: The capital letters "H" and "N" and the small letters "b" and "f" between brackets must be italicized; form recommended by the IUPAC (International Union of Pure and Applied Chemistry).  1, record 5, English, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Dazepin%2D5%2Dyl%29%2DN%2CN%2Ddimethylpropan%2D1%2Damine

Record number: 5, Textual support number: 2 OBS

imipramine: International nonproprietary name (INN) of the World Health Organization (WHO).  1, record 5, English, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Dazepin%2D5%2Dyl%29%2DN%2CN%2Ddimethylpropan%2D1%2Damine

Record number: 5, Textual support number: 3 OBS

Also known under a large number of commercial and trade names, such as: Dimipressin; Dynaprin; Dyna-Zina; Eupramin; G-22355; Imidobenzyle; Imizin; Intalpram; Iramil; Melipramine; Nelipramin; Prazepine; Promiben; Surplix; Timolet.  4, record 5, English, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Dazepin%2D5%2Dyl%29%2DN%2CN%2Ddimethylpropan%2D1%2Damine

Record number: 5, Textual support number: 4 OBS

Chemical formula: C₁₉H₂₄N₂  4, record 5, English, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Dazepin%2D5%2Dyl%29%2DN%2CN%2Ddimethylpropan%2D1%2Damine

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Produit chimique capable d'inhiber la réabsorption de la sérotonine et que, par conséquent, l'on utilise comme antidépresseur.  4, record 5, French, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Daz%C3%A9pin%2D5%2Dyl%29%2DN%2CN%2Ddim%C3%A9thylpropan%2D1%2Damine

Record number: 5, Textual support number: 1 OBS

3-(10,11-dihydro-5H-dibenzo[b,f]azépin-5-yl)-N,N-diméthylpropan-1-amine : Les lettres majuscules «H» et «N» de même que les lettres minuscules «b» et «f» entre crochets s'écrivent en italique; forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée).  1, record 5, French, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Daz%C3%A9pin%2D5%2Dyl%29%2DN%2CN%2Ddim%C3%A9thylpropan%2D1%2Damine

Record number: 5, Textual support number: 2 OBS

imipramine : Dénomination commune internationale (DCI) de l'Organisation mondiale de la santé (OMS).  1, record 5, French, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Daz%C3%A9pin%2D5%2Dyl%29%2DN%2CN%2Ddim%C3%A9thylpropan%2D1%2Damine

Record number: 5, Textual support number: 3 OBS

Formule chimique : C₁₉H₂₄N₂  4, record 5, French, - 3%2D%2810%2C11%2Ddihydro%2D5H%2Ddibenzo%5Bb%2Cf%5Daz%C3%A9pin%2D5%2Dyl%29%2DN%2CN%2Ddim%C3%A9thylpropan%2D1%2Damine

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Zimeldine is a selective 5-HT reuptake inhibitor based on the "chemical lead" of brompheniramine-an antihistamine with some 5-HT reuptake inhibitory properties.(Source : Acta Psychiatrica Scandinavica(Supplement), 1983, vol. 308, pp. 19-24).  2, record 6, English, - zimeldine

Record 6,  Textual support,  French

Record 6,  Textual support,  Spanish