TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Sickle cell retinopathy is present in some patients with sickle cell disease. In sickle cell retinopathy, blockage of blood vessels in the retina and choroid... results in abnormal blood vessel growth and thinning of the retina.... Sickle cell maculopathy, which affects the center part of the retina, occurs when there is decreased blood flow to this part of the eye. This abnormal blood flow causes patches of retinal thinning... Patients will sometimes note blind spots as a result.  3, record 1, English, - sickle%20cell%20maculopathy

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

La drépanocytose est une maladie systémique hématologique induisant la survenue d'événements vaso-occlusifs de divers organes cibles. Sur le plan oculaire, l'atteinte rétinienne se caractérise par des occlusions préférentiellement artérielles et de la vascularisation terminale, pouvant se compliquer de néovascularisation périphérique. Longtemps ignorée, la maculopathie drépanocytaire est désormais bien caractérisée grâce à l'imagerie multimodale[. Une] étude de cas suggère que la maculopathie drépanocytaire, caractérisée par des amincissements rétiniens focaux, proviendrait d'une ischémie du plexus capillaire rétinien profond, à l'origine d'une atrophie tissulaire séquellaire.  2, record 1, French, - maculopathie%20dr%C3%A9panocytaire

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Chronic conditions are ongoing, long-term or recurring conditions that can have a significant impact on people’s lives.  5, record 2, English, - chronic%20medical%20condition

Record number: 2, Textual support number: 2 CONT

Chronic medical conditions that present in youth include but are not limited to asthma, diabetes, epilepsy/seizures, obesity, cystic fibrosis, allergies, sickle cell anemia, irritable bowel diseases(e. g., ulcerative colitis, Crohn's disease), migraines/headaches, juvenile arthritis, congenital heart defect, traumatic brain injury/spinal injury, and organ transplant...  6, record 2, English, - chronic%20medical%20condition

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Pour déterminer la présence de problèmes de santé chroniques, les participants se sont vus demander s'ils avaient «des problèmes de santé de longue durée», soit un état qui persiste ou qui devrait persister six mois ou plus, qui ont été diagnostiqués par un professionnel de la santé. Une liste de problèmes de santé leur a été lue, problèmes parmi lesquels les suivants ont été pris en considération dans [l']analyse : l'asthme, l'arthrite ou le rhumatisme, les maux de dos (autres que ceux dus à l'arthrite), la bronchite ou l'emphysème, le diabète, les maladies cardiaques, le cancer, les séquelles d'un accident vasculaire cérébral, l'incontinence urinaire, et le glaucome ou les cataractes.  4, record 2, French, - probl%C3%A8me%20de%20sant%C3%A9%20chronique

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Sickle cell hemoglobin(HbS) is a hemoglobin(Hb) variant characterized by point mutation causing replacement of glutamic acid by valine at position 6 of the β globin chain, which results in sickling phenomenon in low oxygen states, acidosis, and dehydration.  1, record 3, English, - sickle%20cell%20hemoglobin

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

La production d'une hémoglobine mutée appelée hémoglobine S (HbS) est à l'origine de nombreuses complications. Cette HbS a la particularité de polymériser en conditions désoxygénées engendrant la falciformation des globules rouges.  3, record 3, French, - h%C3%A9moglobine%20dr%C3%A9panocytaire

Record number: 3, Textual support number: 1 OBS

hémoglobine S : Dans cette désignation, l'abréviation «S» provient du mot anglais «sickle» qui signifie «faucille».  4, record 3, French, - h%C3%A9moglobine%20dr%C3%A9panocytaire

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

Any of the diseases associated with the presence of hemoglobin S and sickle cells ...  7, record 4, English, - sickle%20cell%20disease

Record number: 4, Textual support number: 1 OBS

[It includes] sickle cell anemia, sickle cell-hemoglobin C disease, sickle cell-hemoglobin D disease, and sickle cell-thalassemia disease.  7, record 4, English, - sickle%20cell%20disease

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Les altérations cellulaires sont une constante de la maladie drépanocytaire. En effet, dans sa forme désoxygénée l'HbS [hémoglobine S] polymérise et déforme le globule rouge qui devient fragile et rigide. Ce dernier prend alors la forme d’une faucille d'où le nom de falciformation donné à ce phénomène.  5, record 4, French, - maladie%20falciforme

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

People who inherit one sickle cell gene and one normal gene have sickle cell trait(SCT). People with SCT usually do not have any of the symptoms of sickle cell disease(SCD), but they can pass the trait on to their children.  2, record 5, English, - sickle%20cell%20trait

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Le trait drépanocytaire caractérise l'individu qui a hérité d'un seul gène d'hémoglobine S d'un de ses parents. Le trait ne peut pas évoluer en anémie à cellules falciformes.  4, record 5, French, - trait%20dr%C3%A9panocytaire

Record 5,  Textual support,  Spanish

Record number: 5, Textual support number: 1 DEF

Forma heterocigótica de la anemia drepanocítica, caracterizada por la presencia a la vez de hemoglobina S y hemoglobina A en los hematíes.  1, record 5, Spanish, - rasgo%20drepanoc%C3%ADtico

Record number: 5, Textual support number: 1 OBS

No se produce anemia ni otros signos de la anemia drepanocítica. Las personas que tienen ese rasgo son informadas y aconsejadas en relación con la posibilidad de tener un niño con drepanocitosis si ambos padres lo presentan.  1, record 5, Spanish, - rasgo%20drepanoc%C3%ADtico

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Sickle cell anemia is an inherited disorder of the globin chains that causes hemolysis and chronic organ damage. Sickle cell anemia is the most common form of sickle cell disease(SCD), with a lifelong affliction of hemolytic anemia requiring blood transfusions, pain crises, and organ damage.  5, record 6, English, - sickle%20cell%20anemia

Record number: 6, Textual support number: 1 OBS

... sickle cell anaemia is the main form of SCD [sickle cell disease], in which the person inherits the gene encoding sickle haemoglobin(HbS) from both biological parents.  6, record 6, English, - sickle%20cell%20anemia

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Pour qu'un enfant soit atteint d'anémie à hématies falciformes, il faut que ses deux parents lui aient transmis le gène de l'hémoglobine S. Si un seul parent lui transmet le gène, l'enfant sera lui aussi porteur du gène fautif, mais il ne souffrira pas de cette maladie.  1, record 6, French, - an%C3%A9mie%20%C3%A0%20h%C3%A9maties%20falciformes

Record number: 6, Textual support number: 1 OBS

drépanocytose : Bien que la désignation «drépanocytose» désigne l'ensemble des maladies causées par la présence d'hémoglobine S, certains auteurs l'utilisent comme synonyme de la désignation «anémie à hématies falciformes» qui correspond à la forme homozygote de la maladie falciforme.  6, record 6, French, - an%C3%A9mie%20%C3%A0%20h%C3%A9maties%20falciformes

Record 6,  Textual support,  Spanish

Record number: 6, Textual support number: 1 CONT

La anemia falciforme es una anemia hemolítica severa con alto índice de mortalidad y es hereditaria con patrón de herencia autosómica recesiva.  1, record 6, Spanish, - anemia%20falciforme

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 OBS

The Sickle Cell Foundation of Alberta(SCFA) is a volunteer-based organization dedicated to creating awareness about SCD [sickle cell disease] and providing support services to patients living in Alberta... The SCFA teaches patients coping skills for pain management, advocates for funding of SCD research and provides its members with access to the most current scientific research and information.  2, record 7, English, - Sickle%20Cell%20Foundation%20of%20Alberta

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

Organisme bénévole voué à la sensibilisation à la drépanocytose, [la] Sickle Cell Foundation of Alberta (SCFA) se consacre à offrir des services de soutien aux patients vivant en Alberta. [Les] patients atteints de drépanocytose [se font enseigner] les habiletés d'adaptation leur permettant de faire face à leur douleur […]  1, record 7, French, - Sickle%20Cell%20Foundation%20of%20Alberta

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

The production of fibroblasts; cells of the fibrous tissue.  2, record 8, English, - fibroplasia

Record number: 8, Textual support number: 1 CONT

Diabetic retinopathy affects largely the posterior pole of the eye. The retinopathy of prematurity(previously known as retrolental fibroplasia) and sickle cell disease have their major impact on the peripheral retina.  1, record 8, English, - fibroplasia

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Formation de fibroblastes; cellules du tissu fibreux.  2, record 8, French, - fibroplasie

Record number: 8, Textual support number: 1 CONT

Fibroplasie rétrolentale.  1, record 8, French, - fibroplasie

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

Any inherited disorder caused by abnormalities of hemoglobin, resulting in conditions such as sickle cell anemia, hemolytic anemia, or thalassemia.  1, record 9, English, - hemoglobinopathy

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

Groupe de maladies caractérisées par une anomalie de l'hémoglobine.  2, record 9, French, - h%C3%A9moglobinopathie

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

In severe congenital hemolytic anemias, marked new bone formation perpendicular to the tables of the skull, producing a radial hair-on-end appearance. Although most commonly seen in patients with thalassemia, the hair-on-end pattern may also be produced in patients with sickle cell disease or spherocytosis, as well as in some persons with iron-deficiency anemia. [From EISER, 1984, p. 339. ]  2, record 10, English, - hair%2Don%2Dend%20appearance

Record number: 10, Textual support number: 1 OBS

hair-on-end appearance (of the skull)  2, record 10, English, - hair%2Don%2Dend%20appearance

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 DEF

Aspect radiologique strié de la voûte crânienne observé au cours de certaines anémies hémolytiques constitutionnelles et notamment dans la thalassémie.  1, record 10, French, - cr%C3%A2ne%20en%20poils%20de%20brosse

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

Priapism, an unwanted painful erection, affects nearly two thirds of males with sickle cell disease and strikes most commonly between the ages of 5 and 13 years and 21 and 29 years.  1, record 11, English, - priapism

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Érection prolongée douloureuse apparaissant sans excitation sexuelle.  2, record 11, French, - priapisme

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.  1, record 12, English, - whole%20blood%20exchange%20transfusion

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 DEF

Technique consistant à substituer au sang circulant du malade une quantité équivalente de sang provenant de donneurs compatibles.  1, record 12, French, - exsanguinotransfusion

Record number: 12, Textual support number: 1 OBS

L'Académie de Médecine a proposé de remplacer ler terme d'exsanguinotransfusion par transfusion d'échange.  1, record 12, French, - exsanguinotransfusion

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 DEF

The development of sickle cells in the blood, as in sickle cell anemia.  2, record 13, English, - sickling

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 CONT

[L']anémie à hématie falciforme est une maladie héréditaire due à la présence d'une hémoglobine anormale S dans le globule rouge. Au cours de l'appauvrissement de l'organisme en oxygène, cette hémoglobine S devenue fibreuse durcit dans un certain nombre de globules rouges auxquels elle donne la forme d'une faucille : c'est la falciformation.  2, record 13, French, - falciformation

Record 13,  Textual support,  Spanish

Record number: 13, Textual support number: 1 PHR

Falciformación de los hematíes.  1, record 13, Spanish, - falciformaci%C3%B3n

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 DEF

An erythrocyte shaped like a sickle or crescent, the abnormal shape caused by the presence of varying proportions of hemoglobin S.  1, record 14, English, - sickle%20cell

Record number: 14, Textual support number: 1 OBS

When a person with sickle cell anemia is exposed to dehydration, infection, or low oxygen supply, their fragile red blood cells form liquid crystals and assume a crescent shape causing red cell destruction and thickening of the blood.  1, record 14, English, - sickle%20cell

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 CONT

La drépanocytose [...] la polymérisation de l'Hb [l'hémoglobine] en de longues fibres [déforme le globule rouge] en lui donnant l'aspect d'une faucille (drépanocyte).  2, record 14, French, - dr%C3%A9panocyte

Record 14,  Textual support,  Spanish

Record number: 14, Textual support number: 1 DEF

Hematíe maduro en forma de hoz, debido a la presencia de una hemoglobina anormal.  2, record 14, Spanish, - drepanocito

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 CONT

... the effects of pH variation on the in vitro oxygen affinity of whole blood from persons with sickle cell anemia...  3, record 15, English, - pH%20variation

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 CONT

Les variations du pH du sang sont donc très importantes en physiologie et en pathologie; toutefois sa mesure est délicate, et on se contente en général, en clinique, de la mesure de la réserve alcaline.  1, record 15, French, - variation%20du%20pH

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 OBS

Said of a type of anemia  2, record 16, English, - drepanocytic

Record number: 16, Textual support number: 1 CONT

Sickel cell disease(drepanocytic anemia) is an hemolytic anemia with RBC assuming characteristic sickle cell shape(drepanocytes) due to abnormal B globin subunit(substitution of valine for glutamic acid at the 6th position from the N-terminus). Roughly 8% of American blacks are heterozygous for the trait.  3, record 16, English, - drepanocytic

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 DEF

Se dit d'une personne atteinte d'anémie falciforme (ou drépanocytose).  1, record 16, French, - dr%C3%A9panocytaire

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 DEF

Destruction of the red cell membrane causing release of hemoglobin.  2, record 17, English, - hemolysis

Record number: 17, Textual support number: 1 CONT

Hemolysis of sickle cells is both extravascular and intravascular. The former is due to the effects of unstable Hb [hemoglobin] S and recurrent sickling on causing oxidative damage to cell membranes.  3, record 17, English, - hemolysis

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 DEF

Destruction des globules rouges provoquant la libération de l'hémoglobine.  2, record 17, French, - h%C3%A9molyse

Record number: 17, Textual support number: 1 CONT

hémolyse intra-vasculaire.  3, record 17, French, - h%C3%A9molyse

Record 17,  Textual support,  Spanish

Record number: 17, Textual support number: 1 DEF

Destrucción de glóbulos rojos.  3, record 17, Spanish, - hem%C3%B3lisis

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 CONT

monogenic diseases : genetic diseases associated with a single gene(e. g. sickle cell anemia).  2, record 18, English, - monogenic

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 CONT

Les progrès réalisés dans ce domaine ont déjà permis d'isoler des gènes associés à des maladies tant monogéniques que multifactorielles (cancers familiaux du sein et du côlon, obésité, maladie de Hungtington, syndrome de Menkes, ataxie-télangiactasie, etc.).  2, record 18, French, - monog%C3%A9nique

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 CONT

Scientists report in Wednesday's edition of the journal Nature Genetics that they have created the first functioning, artificial human chromosome. The new technology, developed by researchers from Case Western Reserve University and Athersys Inc., may eventually provide a way to cure inherited diseases by altering the cell' s genetic structure. Athersys officials say they would like to use artificial chromosomes as a way to package treatments for diseases affecting the immune system, such as AIDS, as well as blood disorders such as sickle cell anemia.  2, record 19, English, - artificial%20human%20chromosome

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 CONT

La synthèse d'un chromosome humain artificiel constitue un autre événement majeur de cette année 1997 dans le domaine de la génétique. Grâce à ces molécules fabriquées par des chercheurs américains, les généticiens disposent désormais de remarquables outils pour mieux comprendre les mécanismes qui régissent la conservation et les remaniements du patrimoine génétique humain. Depuis des années, on sait que ces mécanismes interviennent dans l'apparition de cancers et de nombreuses autres maladies graves. Selon les chercheurs, les chromosomes humains artificiels pourraient se révéler d'excellents vecteurs pour assurer le transfert de gènes « normaux » dans l'organisme de personnes atteintes de pathologies génétiques.  1, record 19, French, - chromosome%20humain%20artificiel

Record 19,  Textual support,  Spanish

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 CONT

The degree of difficulty in finding a disease gene of interest depends largely on what information is already known about the gene and, especially, on what kind of DNA alterations cause the disease. Spotting the disease gene is very difficult when disease results from a single altered DNA base; sickle cell anemia is an example of such a case, as are probably most major human inherited diseases.  1, record 20, English, - disease%20gene

Record 20,  Textual support,  French

Record 20,  Textual support,  Spanish

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 CONT

Allogenic B. M. T. has been investigated as a curative treatment of anemia in S. C. D. [sickle cell disease]. Furthermore, correction of functional asplenia has been observed after B. M. T. ;it remains to be determined if such a treatment may reserve other organ damage and particularly bone abnormalities and osteonecrosis frequently associated with S. C. hemoglobinopathies.  3, record 21, English, - allogenic%20bone%20marrow%20transplantation

Record number: 21, Textual support number: 1 OBS

Bone Marrow transplantation(B. M. T.) and correction of bone abnormalities associated with sickle cell disease(S. C. D.)  3, record 21, English, - allogenic%20bone%20marrow%20transplantation

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 CONT

Évolution du tissu osseux après allogreffe de moelle osseuse chez l'adolescent drépanocytaire  1, record 21, French, - allogreffe%20de%20moelle%20osseuse

Record 21,  Textual support,  Spanish

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 DEF

Recurrent painful swelling of the hands and feet occurring in infants and young children with sickle cell anemia.  1, record 22, English, - hand%2Dand%2Dfoot%20syndrome

Record 22,  Textual support,  French

Record number: 22, Textual support number: 1 DEF

Syndrome associant une fièvre, une pâleur et un gonflement brutal, diffus, symétrique, douloureux des deux mains, voire des pieds, spontanément régressif en 1 à 3 semaines. Il survient chez un tiers des sujets atteints de thalassémie symptomatique pendant les deux premières années de la vie.  2, record 22, French, - syndrome%20d%27enflure%20douloureuse%20des%20mains%20et%20des%20pieds

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 CONT

Haemoglobin sickle cell disease is characterized by emboli formation.  1, record 23, English, - haemoglobin%20sickle%20cell%20disease

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 CONT

L'hémoglobinopathie à hématies falciformes se caractérise par la formation d'emboles.  1, record 23, French, - h%C3%A9moglobinopathie%20%C3%A0%20h%C3%A9maties%20falciformes

Record 23,  Textual support,  Spanish

Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 OBS

October-the Canadian Sickle Cell Society.  1, record 24, English, - Sickle%20Cell%20Disease%20Month

Record 24,  Textual support,  French

Record number: 24, Textual support number: 1 OBS

Octobre - La Société de l'anémie falciforme du Canada.  1, record 24, French, - Mois%20de%20l%27an%C3%A9mie%20falciforme

Record 24,  Textual support,  Spanish