TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Chronic conditions are ongoing, long-term or recurring conditions that can have a significant impact on people’s lives.  5, record 1, English, - chronic%20medical%20condition

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Chronic medical conditions that present in youth include but are not limited to asthma, diabetes, epilepsy/seizures, obesity, cystic fibrosis, allergies, sickle cell anemia, irritable bowel diseases(e. g., ulcerative colitis, Crohn's disease), migraines/headaches, juvenile arthritis, congenital heart defect, traumatic brain injury/spinal injury, and organ transplant...  6, record 1, English, - chronic%20medical%20condition

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Pour déterminer la présence de problèmes de santé chroniques, les participants se sont vus demander s'ils avaient «des problèmes de santé de longue durée», soit un état qui persiste ou qui devrait persister six mois ou plus, qui ont été diagnostiqués par un professionnel de la santé. Une liste de problèmes de santé leur a été lue, problèmes parmi lesquels les suivants ont été pris en considération dans [l']analyse : l'asthme, l'arthrite ou le rhumatisme, les maux de dos (autres que ceux dus à l'arthrite), la bronchite ou l'emphysème, le diabète, les maladies cardiaques, le cancer, les séquelles d'un accident vasculaire cérébral, l'incontinence urinaire, et le glaucome ou les cataractes.  4, record 1, French, - probl%C3%A8me%20de%20sant%C3%A9%20chronique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

Any of the diseases associated with the presence of hemoglobin S and sickle cells ...  7, record 2, English, - sickle%20cell%20disease

Record number: 2, Textual support number: 1 OBS

[It includes] sickle cell anemia, sickle cell-hemoglobin C disease, sickle cell-hemoglobin D disease, and sickle cell-thalassemia disease.  7, record 2, English, - sickle%20cell%20disease

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Les altérations cellulaires sont une constante de la maladie drépanocytaire. En effet, dans sa forme désoxygénée l'HbS [hémoglobine S] polymérise et déforme le globule rouge qui devient fragile et rigide. Ce dernier prend alors la forme d’une faucille d'où le nom de falciformation donné à ce phénomène.  5, record 2, French, - maladie%20falciforme

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Sickle cell anemia is an inherited disorder of the globin chains that causes hemolysis and chronic organ damage. Sickle cell anemia is the most common form of sickle cell disease(SCD), with a lifelong affliction of hemolytic anemia requiring blood transfusions, pain crises, and organ damage.  5, record 3, English, - sickle%20cell%20anemia

Record number: 3, Textual support number: 1 OBS

... sickle cell anaemia is the main form of SCD [sickle cell disease], in which the person inherits the gene encoding sickle haemoglobin (HbS) from both biological parents.  6, record 3, English, - sickle%20cell%20anemia

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Pour qu'un enfant soit atteint d'anémie à hématies falciformes, il faut que ses deux parents lui aient transmis le gène de l'hémoglobine S. Si un seul parent lui transmet le gène, l'enfant sera lui aussi porteur du gène fautif, mais il ne souffrira pas de cette maladie.  1, record 3, French, - an%C3%A9mie%20%C3%A0%20h%C3%A9maties%20falciformes

Record number: 3, Textual support number: 1 OBS

drépanocytose : Bien que la désignation «drépanocytose» désigne l'ensemble des maladies causées par la présence d'hémoglobine S, certains auteurs l'utilisent comme synonyme de la désignation «anémie à hématies falciformes» qui correspond à la forme homozygote de la maladie falciforme.  6, record 3, French, - an%C3%A9mie%20%C3%A0%20h%C3%A9maties%20falciformes

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 CONT

La anemia falciforme es una anemia hemolítica severa con alto índice de mortalidad y es hereditaria con patrón de herencia autosómica recesiva.  1, record 3, Spanish, - anemia%20falciforme

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

Any inherited disorder caused by abnormalities of hemoglobin, resulting in conditions such as sickle cell anemia, hemolytic anemia, or thalassemia.  1, record 4, English, - hemoglobinopathy

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Groupe de maladies caractérisées par une anomalie de l'hémoglobine.  2, record 4, French, - h%C3%A9moglobinopathie

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

In severe congenital hemolytic anemias, marked new bone formation perpendicular to the tables of the skull, producing a radial hair-on-end appearance. Although most commonly seen in patients with thalassemia, the hair-on-end pattern may also be produced in patients with sickle cell disease or spherocytosis, as well as in some persons with iron-deficiency anemia. [From EISER, 1984, p. 339. ]  2, record 5, English, - hair%2Don%2Dend%20appearance

Record number: 5, Textual support number: 1 OBS

hair-on-end appearance (of the skull)  2, record 5, English, - hair%2Don%2Dend%20appearance

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Aspect radiologique strié de la voûte crânienne observé au cours de certaines anémies hémolytiques constitutionnelles et notamment dans la thalassémie.  1, record 5, French, - cr%C3%A2ne%20en%20poils%20de%20brosse

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.  1, record 6, English, - whole%20blood%20exchange%20transfusion

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Technique consistant à substituer au sang circulant du malade une quantité équivalente de sang provenant de donneurs compatibles.  1, record 6, French, - exsanguinotransfusion

Record number: 6, Textual support number: 1 OBS

L'Académie de Médecine a proposé de remplacer ler terme d'exsanguinotransfusion par transfusion d'échange.  1, record 6, French, - exsanguinotransfusion

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

An erythrocyte shaped like a sickle or crescent, the abnormal shape caused by the presence of varying proportions of hemoglobin S.  1, record 7, English, - sickle%20cell

Record number: 7, Textual support number: 1 OBS

When a person with sickle cell anemia is exposed to dehydration, infection, or low oxygen supply, their fragile red blood cells form liquid crystals and assume a crescent shape causing red cell destruction and thickening of the blood.  1, record 7, English, - sickle%20cell

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

La drépanocytose [...] la polymérisation de l'Hb [l'hémoglobine] en de longues fibres [déforme le globule rouge] en lui donnant l'aspect d'une faucille (drépanocyte).  2, record 7, French, - dr%C3%A9panocyte

Record 7,  Textual support,  Spanish

Record number: 7, Textual support number: 1 DEF

Hematíe maduro en forma de hoz, debido a la presencia de una hemoglobina anormal.  2, record 7, Spanish, - drepanocito

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

The development of sickle cells in the blood, as in sickle cell anemia.  2, record 8, English, - sickling

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

[L']anémie à hématie falciforme est une maladie héréditaire due à la présence d'une hémoglobine anormale S dans le globule rouge. Au cours de l'appauvrissement de l'organisme en oxygène, cette hémoglobine S devenue fibreuse durcit dans un certain nombre de globules rouges auxquels elle donne la forme d'une faucille : c'est la falciformation.  2, record 8, French, - falciformation

Record 8,  Textual support,  Spanish

Record number: 8, Textual support number: 1 PHR

Falciformación de los hematíes.  1, record 8, Spanish, - falciformaci%C3%B3n

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

... the effects of pH variation on the in vitro oxygen affinity of whole blood from persons with sickle cell anemia...  3, record 9, English, - pH%20variation

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Les variations du pH du sang sont donc très importantes en physiologie et en pathologie; toutefois sa mesure est délicate, et on se contente en général, en clinique, de la mesure de la réserve alcaline.  1, record 9, French, - variation%20du%20pH

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 OBS

Said of a type of anemia  2, record 10, English, - drepanocytic

Record number: 10, Textual support number: 1 CONT

Sickel cell disease(drepanocytic anemia) is an hemolytic anemia with RBC assuming characteristic sickle cell shape(drepanocytes) due to abnormal B globin subunit(substitution of valine for glutamic acid at the 6th position from the N-terminus). Roughly 8% of American blacks are heterozygous for the trait.  3, record 10, English, - drepanocytic

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 DEF

Se dit d'une personne atteinte d'anémie falciforme (ou drépanocytose).  1, record 10, French, - dr%C3%A9panocytaire

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

monogenic diseases : genetic diseases associated with a single gene(e. g. sickle cell anemia).  2, record 11, English, - monogenic

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Les progrès réalisés dans ce domaine ont déjà permis d'isoler des gènes associés à des maladies tant monogéniques que multifactorielles (cancers familiaux du sein et du côlon, obésité, maladie de Hungtington, syndrome de Menkes, ataxie-télangiactasie, etc.).  2, record 11, French, - monog%C3%A9nique

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

Scientists report in Wednesday's edition of the journal Nature Genetics that they have created the first functioning, artificial human chromosome. The new technology, developed by researchers from Case Western Reserve University and Athersys Inc., may eventually provide a way to cure inherited diseases by altering the cell' s genetic structure. Athersys officials say they would like to use artificial chromosomes as a way to package treatments for diseases affecting the immune system, such as AIDS, as well as blood disorders such as sickle cell anemia.  2, record 12, English, - artificial%20human%20chromosome

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

La synthèse d'un chromosome humain artificiel constitue un autre événement majeur de cette année 1997 dans le domaine de la génétique. Grâce à ces molécules fabriquées par des chercheurs américains, les généticiens disposent désormais de remarquables outils pour mieux comprendre les mécanismes qui régissent la conservation et les remaniements du patrimoine génétique humain. Depuis des années, on sait que ces mécanismes interviennent dans l'apparition de cancers et de nombreuses autres maladies graves. Selon les chercheurs, les chromosomes humains artificiels pourraient se révéler d'excellents vecteurs pour assurer le transfert de gènes « normaux » dans l'organisme de personnes atteintes de pathologies génétiques.  1, record 12, French, - chromosome%20humain%20artificiel

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

The degree of difficulty in finding a disease gene of interest depends largely on what information is already known about the gene and, especially, on what kind of DNA alterations cause the disease. Spotting the disease gene is very difficult when disease results from a single altered DNA base; sickle cell anemia is an example of such a case, as are probably most major human inherited diseases.  1, record 13, English, - disease%20gene

Record 13,  Textual support,  French

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 CONT

Allogenic B. M. T. has been investigated as a curative treatment of anemia in S. C. D. [sickle cell disease]. Furthermore, correction of functional asplenia has been observed after B. M. T. ;it remains to be determined if such a treatment may reserve other organ damage and particularly bone abnormalities and osteonecrosis frequently associated with S. C. hemoglobinopathies.  3, record 14, English, - allogenic%20bone%20marrow%20transplantation

Record number: 14, Textual support number: 1 OBS

Bone Marrow transplantation (B.M.T.) and correction of bone abnormalities associated with sickle cell disease (S.C.D.)  3, record 14, English, - allogenic%20bone%20marrow%20transplantation

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 CONT

Évolution du tissu osseux après allogreffe de moelle osseuse chez l'adolescent drépanocytaire  1, record 14, French, - allogreffe%20de%20moelle%20osseuse

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 DEF

Recurrent painful swelling of the hands and feet occurring in infants and young children with sickle cell anemia.  1, record 15, English, - hand%2Dand%2Dfoot%20syndrome

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 DEF

Syndrome associant une fièvre, une pâleur et un gonflement brutal, diffus, symétrique, douloureux des deux mains, voire des pieds, spontanément régressif en 1 à 3 semaines. Il survient chez un tiers des sujets atteints de thalassémie symptomatique pendant les deux premières années de la vie.  2, record 15, French, - syndrome%20d%27enflure%20douloureuse%20des%20mains%20et%20des%20pieds

Record 15,  Textual support,  Spanish