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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Sickle cell retinopathy is present in some patients with sickle cell disease. In sickle cell retinopathy, blockage of blood vessels in the retina and choroid... results in abnormal blood vessel growth and thinning of the retina.... Sickle cell maculopathy, which affects the center part of the retina, occurs when there is decreased blood flow to this part of the eye. This abnormal blood flow causes patches of retinal thinning... Patients will sometimes note blind spots as a result.  3, record 1, English, - sickle%20cell%20maculopathy

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

La drépanocytose est une maladie systémique hématologique induisant la survenue d'événements vaso-occlusifs de divers organes cibles. Sur le plan oculaire, l'atteinte rétinienne se caractérise par des occlusions préférentiellement artérielles et de la vascularisation terminale, pouvant se compliquer de néovascularisation périphérique. Longtemps ignorée, la maculopathie drépanocytaire est désormais bien caractérisée grâce à l'imagerie multimodale[. Une] étude de cas suggère que la maculopathie drépanocytaire, caractérisée par des amincissements rétiniens focaux, proviendrait d'une ischémie du plexus capillaire rétinien profond, à l'origine d'une atrophie tissulaire séquellaire.  2, record 1, French, - maculopathie%20dr%C3%A9panocytaire

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Chronic conditions are ongoing, long-term or recurring conditions that can have a significant impact on people’s lives.  5, record 2, English, - chronic%20medical%20condition

Record number: 2, Textual support number: 2 CONT

Chronic medical conditions that present in youth include but are not limited to asthma, diabetes, epilepsy/seizures, obesity, cystic fibrosis, allergies, sickle cell anemia, irritable bowel diseases(e. g., ulcerative colitis, Crohn's disease), migraines/headaches, juvenile arthritis, congenital heart defect, traumatic brain injury/spinal injury, and organ transplant...  6, record 2, English, - chronic%20medical%20condition

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Pour déterminer la présence de problèmes de santé chroniques, les participants se sont vus demander s'ils avaient «des problèmes de santé de longue durée», soit un état qui persiste ou qui devrait persister six mois ou plus, qui ont été diagnostiqués par un professionnel de la santé. Une liste de problèmes de santé leur a été lue, problèmes parmi lesquels les suivants ont été pris en considération dans [l']analyse : l'asthme, l'arthrite ou le rhumatisme, les maux de dos (autres que ceux dus à l'arthrite), la bronchite ou l'emphysème, le diabète, les maladies cardiaques, le cancer, les séquelles d'un accident vasculaire cérébral, l'incontinence urinaire, et le glaucome ou les cataractes.  4, record 2, French, - probl%C3%A8me%20de%20sant%C3%A9%20chronique

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

Any of the diseases associated with the presence of hemoglobin S and sickle cells ...  7, record 3, English, - sickle%20cell%20disease

Record number: 3, Textual support number: 1 OBS

[It includes] sickle cell anemia, sickle cell-hemoglobin C disease, sickle cell-hemoglobin D disease, and sickle cell-thalassemia disease.  7, record 3, English, - sickle%20cell%20disease

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Les altérations cellulaires sont une constante de la maladie drépanocytaire. En effet, dans sa forme désoxygénée l'HbS [hémoglobine S] polymérise et déforme le globule rouge qui devient fragile et rigide. Ce dernier prend alors la forme d’une faucille d'où le nom de falciformation donné à ce phénomène.  5, record 3, French, - maladie%20falciforme

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

People who inherit one sickle cell gene and one normal gene have sickle cell trait(SCT). People with SCT usually do not have any of the symptoms of sickle cell disease(SCD), but they can pass the trait on to their children.  2, record 4, English, - sickle%20cell%20trait

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Le trait drépanocytaire caractérise l'individu qui a hérité d'un seul gène d'hémoglobine S d'un de ses parents. Le trait ne peut pas évoluer en anémie à cellules falciformes.  4, record 4, French, - trait%20dr%C3%A9panocytaire

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Forma heterocigótica de la anemia drepanocítica, caracterizada por la presencia a la vez de hemoglobina S y hemoglobina A en los hematíes.  1, record 4, Spanish, - rasgo%20drepanoc%C3%ADtico

Record number: 4, Textual support number: 1 OBS

No se produce anemia ni otros signos de la anemia drepanocítica. Las personas que tienen ese rasgo son informadas y aconsejadas en relación con la posibilidad de tener un niño con drepanocitosis si ambos padres lo presentan.  1, record 4, Spanish, - rasgo%20drepanoc%C3%ADtico

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Sickle cell anemia is an inherited disorder of the globin chains that causes hemolysis and chronic organ damage. Sickle cell anemia is the most common form of sickle cell disease(SCD), with a lifelong affliction of hemolytic anemia requiring blood transfusions, pain crises, and organ damage.  5, record 5, English, - sickle%20cell%20anemia

Record number: 5, Textual support number: 1 OBS

... sickle cell anaemia is the main form of SCD [sickle cell disease], in which the person inherits the gene encoding sickle haemoglobin(HbS) from both biological parents.  6, record 5, English, - sickle%20cell%20anemia

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Pour qu'un enfant soit atteint d'anémie à hématies falciformes, il faut que ses deux parents lui aient transmis le gène de l'hémoglobine S. Si un seul parent lui transmet le gène, l'enfant sera lui aussi porteur du gène fautif, mais il ne souffrira pas de cette maladie.  1, record 5, French, - an%C3%A9mie%20%C3%A0%20h%C3%A9maties%20falciformes

Record number: 5, Textual support number: 1 OBS

drépanocytose : Bien que la désignation «drépanocytose» désigne l'ensemble des maladies causées par la présence d'hémoglobine S, certains auteurs l'utilisent comme synonyme de la désignation «anémie à hématies falciformes» qui correspond à la forme homozygote de la maladie falciforme.  6, record 5, French, - an%C3%A9mie%20%C3%A0%20h%C3%A9maties%20falciformes

Record 5,  Textual support,  Spanish

Record number: 5, Textual support number: 1 CONT

La anemia falciforme es una anemia hemolítica severa con alto índice de mortalidad y es hereditaria con patrón de herencia autosómica recesiva.  1, record 5, Spanish, - anemia%20falciforme

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 OBS

The Sickle Cell Foundation of Alberta(SCFA) is a volunteer-based organization dedicated to creating awareness about SCD [sickle cell disease] and providing support services to patients living in Alberta... The SCFA teaches patients coping skills for pain management, advocates for funding of SCD research and provides its members with access to the most current scientific research and information.  2, record 6, English, - Sickle%20Cell%20Foundation%20of%20Alberta

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 OBS

Organisme bénévole voué à la sensibilisation à la drépanocytose, [la] Sickle Cell Foundation of Alberta (SCFA) se consacre à offrir des services de soutien aux patients vivant en Alberta. [Les] patients atteints de drépanocytose [se font enseigner] les habiletés d'adaptation leur permettant de faire face à leur douleur […]  1, record 6, French, - Sickle%20Cell%20Foundation%20of%20Alberta

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

The production of fibroblasts; cells of the fibrous tissue.  2, record 7, English, - fibroplasia

Record number: 7, Textual support number: 1 CONT

Diabetic retinopathy affects largely the posterior pole of the eye. The retinopathy of prematurity(previously known as retrolental fibroplasia) and sickle cell disease have their major impact on the peripheral retina.  1, record 7, English, - fibroplasia

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Formation de fibroblastes; cellules du tissu fibreux.  2, record 7, French, - fibroplasie

Record number: 7, Textual support number: 1 CONT

Fibroplasie rétrolentale.  1, record 7, French, - fibroplasie

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

In severe congenital hemolytic anemias, marked new bone formation perpendicular to the tables of the skull, producing a radial hair-on-end appearance. Although most commonly seen in patients with thalassemia, the hair-on-end pattern may also be produced in patients with sickle cell disease or spherocytosis, as well as in some persons with iron-deficiency anemia. [From EISER, 1984, p. 339. ]  2, record 8, English, - hair%2Don%2Dend%20appearance

Record number: 8, Textual support number: 1 OBS

hair-on-end appearance (of the skull)  2, record 8, English, - hair%2Don%2Dend%20appearance

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Aspect radiologique strié de la voûte crânienne observé au cours de certaines anémies hémolytiques constitutionnelles et notamment dans la thalassémie.  1, record 8, French, - cr%C3%A2ne%20en%20poils%20de%20brosse

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Priapism, an unwanted painful erection, affects nearly two thirds of males with sickle cell disease and strikes most commonly between the ages of 5 and 13 years and 21 and 29 years.  1, record 9, English, - priapism

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

Érection prolongée douloureuse apparaissant sans excitation sexuelle.  2, record 9, French, - priapisme

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 OBS

Said of a type of anemia  2, record 10, English, - drepanocytic

Record number: 10, Textual support number: 1 CONT

Sickel cell disease(drepanocytic anemia) is an hemolytic anemia with RBC assuming characteristic sickle cell shape(drepanocytes) due to abnormal B globin subunit(substitution of valine for glutamic acid at the 6th position from the N-terminus). Roughly 8% of American blacks are heterozygous for the trait.  3, record 10, English, - drepanocytic

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 DEF

Se dit d'une personne atteinte d'anémie falciforme (ou drépanocytose).  1, record 10, French, - dr%C3%A9panocytaire

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

The degree of difficulty in finding a disease gene of interest depends largely on what information is already known about the gene and, especially, on what kind of DNA alterations cause the disease. Spotting the disease gene is very difficult when disease results from a single altered DNA base; sickle cell anemia is an example of such a case, as are probably most major human inherited diseases.  1, record 11, English, - disease%20gene

Record 11,  Textual support,  French

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

Allogenic B. M. T. has been investigated as a curative treatment of anemia in S. C. D. [sickle cell disease]. Furthermore, correction of functional asplenia has been observed after B. M. T. ;it remains to be determined if such a treatment may reserve other organ damage and particularly bone abnormalities and osteonecrosis frequently associated with S. C. hemoglobinopathies.  3, record 12, English, - allogenic%20bone%20marrow%20transplantation

Record number: 12, Textual support number: 1 OBS

Bone Marrow transplantation(B. M. T.) and correction of bone abnormalities associated with sickle cell disease(S. C. D.)  3, record 12, English, - allogenic%20bone%20marrow%20transplantation

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

Évolution du tissu osseux après allogreffe de moelle osseuse chez l'adolescent drépanocytaire  1, record 12, French, - allogreffe%20de%20moelle%20osseuse

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

Haemoglobin sickle cell disease is characterized by emboli formation.  1, record 13, English, - haemoglobin%20sickle%20cell%20disease

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 CONT

L'hémoglobinopathie à hématies falciformes se caractérise par la formation d'emboles.  1, record 13, French, - h%C3%A9moglobinopathie%20%C3%A0%20h%C3%A9maties%20falciformes

Record 13,  Textual support,  Spanish