TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

… a non-political, non-religious organization dedicated to scientific research in all fields of the cannabinoids [including] biochemical, chemical and physiological studies of the endogenous cannabinoid system [and] studies of the abuse potential of recreational cannabis.  3, record 1, English, - International%20Cannabinoid%20Research%20Society

Record number: 1, Textual support number: 1 OBS

The mission of the ICRS is to(1) foster cannabinoid research;(2) promote the exchange of scientific information and perspectives about cannabis, the cannabinoids, and endocannabinoids; …(3) serve as a source of reliable information regarding the chemistry, pharmacology, therapeutic uses, toxicology and the behavioral, psychological, and social effects of cannabis and its constituents, of synthetic and endogenous compounds that interact with cannabinoid receptors and of any compounds that target other components of the endocannabinoid system.  3, record 1, English, - International%20Cannabinoid%20Research%20Society

Record 1,  Textual support,  French

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Muscarinic acetylcholine receptors are members of rhodopsin-like G-protein coupled receptor family. They play several important roles; they mediate many of the effects of acetylcholine in the central and peripheral nervous system and modulate a variety of physiological functions, such as airway, eye and intestinal smooth muscle contraction, heart rate and glandular secretions. The receptors have a widespread tissue distribution and are a major drug target in human disease. They may be effective therapeutic targets in Alzheimer's disease, schizophrenia, Parkinson's disease and chronic obstructive pulmonary disease.  1, record 2, English, - muscarinic%20receptor

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Il y a deux grands types de récepteurs (cholinergiques) de l'acétylcholine, les récepteurs muscariniques et nicotiniques qui ont été identifiés à partir des réponses à différents agents chimiques. Les récepteurs nicotiniques sont activés par la nicotine du tabac et les récepteurs muscariniques le sont par le poison d'un champignon, la muscarine [...] Les récepteurs muscariniques sont situés dans la membrane des cellules effectrices (muscle cardiaque, muscles lisses, glandes) et sont stimulés par la liaison de l'acétylcholine libérée par les fibres postganglionnaires du système parasympathique.  2, record 2, French, - r%C3%A9cepteur%20muscarinique

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Research is on hairpin catalytic RNA, a catalytic RNA discovered and characterized here in my laboratory at Northern Illinois University. Hairpin catalytic RNA is a molecule which can be engineered to very efficiently cleave target RNA sequences in a unique and efficient reaction. The catalytic RNA can thus be used for the specific down regulation of gene expression since it can be designed to destroy mRNA. Current applications being developed are down regulation of selected genes, including those in the virus HIV-1. Thus it has potential as an AIDS therapeutic.  1, record 3, English, - catalytic%20RNA

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Macromolécule biologique d'acide ribonucléique susceptible d'agir comme une enzyme et de catalyser des réactions chimiques.  1, record 3, French, - ARN%20catalytique

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

Molécula de ARN [ácido ribonucleico] que puede catalizar la ruptura química de sí misma o de otras moléculas de ARN.  1, record 3, Spanish, - ARN%20catal%C3%ADtico

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Nearly every drug molecule works through a structural interaction with a "target" or "receptor" molecule or protein that plays key roles in all biological processes. In the most common model for this interaction, the drug molecule inserts itself into a functionally important crevice of its target protein, like a key in a lock. The molecule then binds there and either induces or, more commonly, inhibits the protein's normal function. This universal drug-target scheme suggests a powerful alternative approach to drug discovery : if it were possible to identify, in advance, the appropriate protein target for a given therapeutic need and if enough were known about the distinguishing structure of that target protein, it ought to be feasible to design the structure of an ideal drug to interact with it.  2, record 4, English, - target%20protein

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

La discipline [...] «Bio-informatique du médicament» recouvre les activités suivantes : analyser et exploiter les génomes pour identifier les classes structurales et fonctionnelles d'intérêt thérapeutique; [...] modéliser les protéines-cibles dont la structure n'est pas accessible expérimentalement [...]  1, record 4, French, - prot%C3%A9ine%2Dcible

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

[Alternative vector systems] include both viral and nonviral approaches to accomplish gene transfer. In both of these approaches, the goal is to develop a system that can deliver genes in vivo after systemic administration. This development is a step toward deriving a "targetable-injectable" vector-a vector that can deliver therapeutic genes selectively to target cells after direct, in vivo administration.  1, record 5, English, - vector

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Des vecteurs de synthèse pour la thérapie génique. [...] Les vecteurs envisagés actuellement sont des virus recombinants, rendus non pathogènes en remplaçant certaines séquences d'acide nucléique par celles à introduire dans la cellule.  1, record 5, French, - vecteur

Record 5,  Textual support,  Spanish

Record number: 5, Textual support number: 1 DEF

Medio móvil que sirve de transporte.  2, record 5, Spanish, - vector

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

A drug that speed up or slow down the central nervous system.  3, record 6, English, - central%20nervous%20system%20drug

Record number: 6, Textual support number: 1 CONT

[The] central nervous system agents [belong to] a class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e. g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use.  1, record 6, English, - central%20nervous%20system%20drug

Record number: 6, Textual support number: 1 OBS

central nervous system drug; central nervous system drug; CNS agent; CNS drug: Terms rarely used in the singular.  2, record 6, English, - central%20nervous%20system%20drug

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 OBS

médicament du système nerveux central; médicament agissant sur le système nerveux central; agent du système nerveux central; médicament du SNC; agent du SNC; médicament agissant sur le SNC : Termes rarement utilisés au singulier.  3, record 6, French, - m%C3%A9dicament%20du%20syst%C3%A8me%20nerveux%20central

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 OBS

Health Canada, Therapeutic Products Directorate. Guidelines regarding the nature of clinical studies and the target population studied.  2, record 7, English, - Studies%20in%20Support%20of%20Special%20Populations%3A%20Geriatrics%20%281994%29

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

Santé Canada, Direction des produits thérapeutiques. Lignes directrices portant sur les essais cliniques et les populations cibles.  2, record 7, French, - %C3%89tudes%20%C3%A0%20l%27appui%20des%20groupes%20sp%C3%A9ciaux%20%3A%20g%C3%A9riatrie%20%281994%29

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 OBS

Health Canada, Therapeutic Products Directorate. Guidelines regarding the nature of clinical studies and the target population studied.  2, record 8, English, - Dose%2DResponse%20Information%20to%20Support%20Drug%20Registration%20%281994%29

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 OBS

Santé Canada, Direction des produits thérapeutiques. Lignes directrices portant sur les essais cliniques et les populations cibles.  2, record 8, French, - Donn%C3%A9es%20relatives%20%C3%A0%20la%20relation%20dose%2Deffet%20%C3%A0%20l%27appui%20de%20l%27enregistrement%20des%20m%C3%A9dicaments%20%281994%29

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 OBS

Health Canada, Therapeutic Products Directorate. Guidelines regarding the nature of clinical studies and the target population studied.  2, record 9, English, - Clinical%20Safety%20Data%20Management%3A%20Definitions%20and%20Standards%20for%20Expedited%20Reporting%20%281995%29

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 OBS

Santé Canada, Direction des produits thérapeutiques. Lignes directrices portant sur les essais cliniques et les populations cibles.  2, record 9, French, - Gestion%20des%20donn%C3%A9es%20cliniques%20sur%20l%27innocuit%C3%A9%20des%20m%C3%A9dicaments%20%3A%20d%C3%A9finitions%20et%20normes%20relatives%20%C3%A0%20la%20d%C3%A9claration%20rapide%20%281995%29

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 OBS

Health Canada, Therapeutic Products Directorate. Guidelines regarding the nature of clinical studies and the target population studied.(draft 1997).  2, record 10, English, - Inclusion%20of%20Paediatric%20Subjects%20in%20Clinical%20Trials

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 OBS

Santé Canada, Direction des produits thérapeutiques. Lignes directrices portant sur les essais cliniques et les populations cibles. Ébauche 1997.  2, record 10, French, - Inclusion%20des%20patients%20p%C3%A9diatriques%20dans%20les%20essais%20cliniques

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

Multifunctional nano-devices based on dendritic polymer components will be developed that target neoplastic cells and sense the earliest signatures of cancer. The dendritic nano-devices will be designed to support the specific release of a therapeutic agent within a tumor, and analyze the effect of the therapeutic identifying evidence of residual disease.  2, record 11, English, - dendritic%20polymer

Record number: 11, Textual support number: 2 CONT

Dendritic polymers containing disulfide functional groups which are essentially inert under non-reducing conditions, but which form sulfhydryl groups upon being subjected to a reducing agent are prepared by synthesizing dendritic polymers having a core with a disulfide linkage or by reacting a dendritic polymer with a molecule containing a disulfide linkage and reactive terminal groups.  3, record 11, English, - dendritic%20polymer

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Polymère présentant une structure fractale formée de ramifications successives qui, en se développant à partir d'une molécule centrale, forme une sphérule.  1, record 11, French, - dendrim%C3%A8re

Record number: 11, Textual support number: 1 CONT

La surface extérieure des sphérules de dendrimères compte une infinité d'extrémités qui constituent autant de point d'ancrage. Cette particularité pourrait être utilisée pour améliorer les propriétés des lubrifiants, augmenter la transformabilité des plastiques, etc. De plus, les ramifications de la molécule ménagent des espaces pouvant abriter d'autres substances qui sont ensuite relâchées plus ou moins rapidement. C'est pourquoi on pense utiliser des dendrimères pour la libération contrôlée de médicaments. On a constaté aussi que l'ADN s'enroulait autour de certains dendrimères, qui pourraient ainsi servir au transport de gènes en thérapie génique.  1, record 11, French, - dendrim%C3%A8re

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 OBS

Health Canada, Therapeutic Products Directorate. Guidelines regarding the nature of clinical studies and the target population studied.  2, record 12, English, - Preclinical%20Safety%20Evaluation%20of%20Biotechnology%2DDerived%20Pharmaceuticals

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 OBS

Santé Canada, Direction des produits thérapeutiques. Lignes directrices portant sur les essais cliniques et les populations cibles.  2, record 12, French, - %C3%89valuation%20pr%C3%A9clinique%20de%20l%27innocuit%C3%A9%20des%20produits%20pharmaceutiques%20issus%20de%20la%20biotechnologie

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo. Perhaps this problem simply represents a special case of drug delivery in which the therapeutic gene constitutes the drug. But the relevance of traditional drug development to technological developments in gene therapy is questionable. Recombinant genes that can independently express a therapeutic RNA or protein are extraordinarily large and polar molecules--10, 000 times larger than traditional pharmaceutical agents. Moreover, the administration of genes as therapy requires vehicles--so-called vectors--that encapsulate the gene and guide it to the target cell. The binding of the gene to the cell, its internalization, the transport of the administered genome to the nucleus, and the expression of the gene all constitute potential limitations of this process.  1, record 13, English, - therapeutic%20gene

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 CONT

L'un des aspect essentiels du transfert de gènes à visée thérapeutique est la vectorisation de l'ADN par un transporteur jusqu'à la cellule cible [...] dans la plupart des cas, l'ADN doit être introduit dans la cellule, soit à l'aide d'une technique physique ou chimique fragilisant les membranes cellulaires, soit combiné à un vecteur.  1, record 13, French, - g%C3%A8ne%20%C3%A0%20vis%C3%A9e%20th%C3%A9rapeutique

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 CONT

For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo. Perhaps this problem simply represents a special case of drug delivery in which the therapeutic gene constitutes the drug. But the relevance of traditional drug development to technological developments in gene therapy is questionable. Recombinant genes that can independently express a therapeutic RNA or protein are extraordinarily large and polar molecules--10, 000 times larger than traditional pharmaceutical agents. Moreover, the administration of genes as therapy requires vehicles--so-called vectors--that encapsulate the gene and guide it to the target cell. The binding of the gene to the cell, its internalization, the transport of the administered genome to the nucleus, and the expression of the gene all constitute potential limitations of this process.  1, record 14, English, - therapeutic%20gene

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 CONT

Mais surtout, à côté de la pathologie, un fantastique domaine s'ouvre au transfert et à la thérapie génique, c'est celui du gène considéré comme médicament. La médecine utilise en effet toute une série de molécules d'origine protéique, comme les facteurs antihémophilliques, l'insuline, l'hormone de croissance, pour ne citer que les plus importantes. Le futur pourrait être la fabrication directe par l'organisme des molécules actives après transfert de gènes dans les cellules permissives. Mieux encore, on pourra vraisemblablement dams l'avenir injecter directement par voie intramusculaire par exemple, l'ADN génique, les cellules de l'organisme se comportant ensuite comme de mini-usines de fabrication et de mini-unités de distribution.  1, record 14, French, - g%C3%A8ne%20consid%C3%A9r%C3%A9%20comme%20m%C3%A9dicament

Record number: 14, Textual support number: 2 CONT

Ceci ne saurait s'effectuer en dehors d'un contexte réglementaire adapté à la complexité des différents niveaux d'intervention que nécessite le transfert de gènes à visée thérapeutique.  1, record 14, French, - g%C3%A8ne%20consid%C3%A9r%C3%A9%20comme%20m%C3%A9dicament

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 CONT

In the ideal world, the diseases would be cured for life by one treatment, with no side effects. And gene insertion into a chromosome in a target somatic cell would be site specific; in what is called homologous recombination, the healthy, or "therapeutic, "gene would exactly replace the damaged copy  1, record 15, English, - therapeutic%20gene

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 CONT

Des gènes marqueurs aux gènes thérapeutiques. De nombreux participants ont manifesté la volonté d'utiliser des approches de marquage avant d'aborder le problème du transfert génique en vue d'une action thérapeutique.  2, record 15, French, - g%C3%A8ne%20th%C3%A9rapeutique

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 CONT

For now most scientists interested in gene augmentation are planning to remove cells from patients, introduce a therapeutic gene and return the altered cells to the subject. Some day, however, physicians may directly inject patients with genes linked to substances that will deliver those genes to specific target cells.  1, record 16, English, - gene%20augmentation

Record 16,  Textual support,  French

Record 16,  Textual support,  Spanish