TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Fibrin glues(also known as fibrin sealants) are widely used in surgery mainly as adjuncts to achieve hemostasis but also as surgical sealants, surgical glues, and as promoters of wound healing. They are based on two blood plasma-derived proteins, fibrinogen and thrombin. During surgical application of fibrin glue, a solution containing the fibrinogen component is mixed with a solution containing the thrombin component. At the site of application, thrombin catalyzes the conversion of fibrinogen to fibrin finally resulting in the formation of a tissue adhering hydrogel, the fibrin clot.  4, record 1, English, - fibrin%20glue

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Colle de fibrine (fibrinogène plus thrombine) [...]  2, record 1, French, - colle%20de%20fibrine

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Selected analysis of the placentas showed them to be thinner and to contain more subchorionic thrombin than those of women who did not smoke.  1, record 2, English, - subchorionic%20thrombin

Record number: 2, Textual support number: 1 OBS

thrombin : An enzyme that acts on fibrinogen in blood causing it to clot.  2, record 2, English, - subchorionic%20thrombin

Record number: 2, Textual support number: 2 OBS

subchorionic: Situated beneath the chorion.  3, record 2, English, - subchorionic%20thrombin

Record number: 2, Textual support number: 3 OBS

chorion: The outermost of the two fetal membranes (the amnion is the innermost) which together surround the embryo. The chorion develops villi (vascular fingers) and gives rise to the placenta.  4, record 2, English, - subchorionic%20thrombin

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 OBS

[La thrombine est une] enzyme possédant la capacité de transformer le fibrinogène en fibrine. Le fibrinogène est le précurseur de nature protéique de la fibrine synthétisé par le foie. La fibrine est une protéine qui n'est pas soluble et qui est à l'origine du caillot sanguin. C'est le résultat de la scission du fibrinogène sous l'action de la thrombine, au cours de la coagulation sanguine.  2, record 2, French, - thrombine%20sous%2Dchoriale

Record number: 2, Textual support number: 2 OBS

sous-chorial(e) : situé dessous le chorion.  1, record 2, French, - thrombine%20sous%2Dchoriale

Record number: 2, Textual support number: 3 OBS

chorion : Membrane externe de l'œuf, issue de la réunion du trophoblaste et du mésoblaste au début de la grossesse.  3, record 2, French, - thrombine%20sous%2Dchoriale

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

An enzyme with proteolytic activity that catalyzes the conversion of fibrinogen to fibrin during the clotting of blood. It is formed from an inactive precursor, prothrombin, in the presence of blood platelets, calcium ions and thromboplastin.  2, record 3, English, - thrombin

Record number: 3, Textual support number: 1 CONT

Under the action of thrombin, which splits off a small peptide from fibrinogen, fibrinogen is activated and starts to interact with other monomers. The end-to-end association forms long fibrin fibrils, but apparently there is also some lateral staggering and cross-linking with other fibers to form a network. As clotting progresses, aided by the blood platelets, fibrin retracts, squeezing out the serum, and the blood clot is completed.  2, record 3, English, - thrombin

Record number: 3, Textual support number: 1 OBS

Fibrinogenase and thrombase are obsolete terms.  3, record 3, English, - thrombin

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Enzyme catalysant l'hydrolyse de la fibrinogène en fibrine, provoquant ainsi la coagulation du sang.  2, record 3, French, - thrombine

Record number: 3, Textual support number: 1 CONT

L'ensemble du processus de coagulation du sang est fort complexe. Il met en jeu des ions calcium et une dizaine de facteurs protéiques qui font l'objet d'une activation en cascade, le plus souvent par des réactions de protéolyse partielle. C'est ainsi que la thrombine, qui transforme le fibrinogène, provient elle-même de l'activation d'une glycoprotéine plasmatique, la prothrombine.  3, record 3, French, - thrombine

Record number: 3, Textual support number: 1 OBS

Thrombose, plasmase, thrombosine et fibrine-ferment sont des termes vieillis à éviter.  2, record 3, French, - thrombine

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

Enzima proteolítica que hidroliza específicamente enlaces peptídicos con L-arginina. Convierte fibrinógeno en fibrina y se forma a partir del precursor inactivo protrombina.  2, record 3, Spanish, - trombina

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Using the natural protein hirudin as a model, a novel class of synthetic peptide inhibitors were recently designed. These inhibitors, ’hirulogs’, retain the carboxy terminal Hir53-64 domain that interacts with the anion binding exosite of thrombin, connected via an oligoglycyl spacer unit to a catalytic site-directed moiety modeled on the sequence(d) Phe-Pro-Arg-X.  1, record 4, English, - hirulog

Record 4,  Textual support,  French

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Decrease in frequency of anginal episodes by control of thrombin generation with low-dose heparin : a controlled cross-over randomized study.  2, record 5, English, - randomized%20study

Record 5,  Textual support,  French

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

Oligo-RNA, oligo-DNA, or a protein-oligo-RNA complex that can specifically bind a particular protein or other molecule, e. g., a thrombin-binding aptamer will inhibit the action of thrombin in blood clotting and thus prevent the formation of blood clots.  2, record 6, English, - aptamer

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

[...] classe d'ARN [ou d'ADN] de petites tailles (25 à 40 nucléotides) qui possèdent une structure tridimensionnelle extrêmement fine et organisée.  2, record 6, French, - aptam%C3%A8re

Record number: 6, Textual support number: 1 OBS

[Les aptamères] sont capables de se lier à une cible protéique avec une affinité comparable à celle obtenue lors de la formation d'un complexe antigène/anticorps et d'invalider la fonction de leur cible.  2, record 6, French, - aptam%C3%A8re

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

ZymoGenetics is developing recombinant human thrombin(rhThrombin) as a stand-alone product for use as a topical hemostat to control surgical bleeding. Currently, only thrombin derived from bovine blood is available in the US as a stand-alone thrombin product. The bovine-derived product has been used for more than thirty years to control blood loss in a variety of surgical settings.  2, record 7, English, - bovine%2Dderived%20product

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

[...] aucun produit d'origine bovine, ovine ou caprine destiné à la consommation humaine ou à l'alimentation des animaux ne quitte l'abattoir avant que l'autorité compétente n'ait reçu et accepté les résultats des tests effectués sur la totalité des animaux abattus potentiellement contaminés si l'ESB [encéphalopathie spongiforme bovine] était confirmée dans l'un d'eux [...]  2, record 7, French, - produit%20d%27origine%20bovine

Record 7,  Textual support,  Spanish

Record number: 7, Textual support number: 1 CONT

[...] con base en información establecida por la Organización Mundial de Sanidad Animal (OIE) los productos y subproductos de origen bovino consistentes en lengua, hígado, corazón, riñón y labios de bovino no representan riesgos para la salud humana y animal por Encefalopatía Espongiforme Bovina (EEB).  2, record 7, Spanish, - producto%20de%20origen%20bovino

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

A plasma protein produced in the liver in the presence of vitamin K and converted into thrombin in the clotting of blood.  5, record 8, English, - prothrombin

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Une protéine qui se trouve dans la circulation sanguine et qui joue un rôle important dans le processus de la coagulation. Le facteur Xa, une autre protéine sanguine, transforme la prothrombine (facteur II) en thrombine. La thrombine, en retour, assure la continuité de la réaction en chaîne de la coagulation. Sans prothrombine, le processus s'interrompt.  3, record 8, French, - prothrombine

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 OBS

prothrombin : A glycoprotein present in the plasma that is converted into thrombin...  2, record 9, English, - prothrombin%20report

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 OBS

La prothrombine est absorbable par les sels minéraux dont on peut l'éluer par le citrate de sodium.  1, record 9, French, - rapport%20de%20prothrombine

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

A protein which forms an insoluble network, thus producing a blood clot.  2, record 10, English, - fibrin

Record number: 10, Textual support number: 2 DEF

the insoluble protein formed from fibrinogen by the proteolytic action of thrombin during normal clotting of blood. Fibrin forms the essential portion of the blood clot.  3, record 10, English, - fibrin

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 DEF

Substance protidique filamenteuse, blanchâtre et élastique qui enserre les globules du sang, de la lymphe, au cours de la coagulation.  2, record 10, French, - fibrine

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 DEF

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages : stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.  3, record 11, English, - blood%20coagulation

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Transformation du sang liquide en une masse solide, le coagulum.  3, record 11, French, - coagulation%20sanguine

Record number: 11, Textual support number: 1 CONT

Au cours de la coagulation du sang, le fibrinogène, protéine soluble dans le plasma, se transforme en un réseau fibreux insoluble de fibrine, le caillot. Celui-ci laisse exsuder le sérum. La transformation du fibrinogène est catalysée par la thrombine et par des facteurs provenant des plaquettes sanguines.  4, record 11, French, - coagulation%20sanguine

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

The time needed for a fibrin clot to form after the addition of thrombin to citrated plasma.  1, record 12, English, - thrombin%20time

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

Temps de thrombine (TT) [...] temps de coagulation d'un plasma recueilli sur citrate et additionné d'une solution de thrombine en quantité suffisante pour obtenir un temps voisin de 20 secondes pour un plasma témoin. (la thrombine agit directement sur le fibrinogène pour le transformer en fibrine).  1, record 12, French, - temps%20de%20thrombine

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

Soluble fibrin complexes can indicate recent thrombin degradation, and fibrin generation products reflect recent plasmin generation.  1, record 13, English, - fibrin%20degradation%20product

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 CONT

Dégradation de la fibrine par la plasmine: La fibrine non stabilisée subit la même dégradation par la plasmine que le fibrinogène. Les produits de dégradation obtenus sont presque similaires. Par contre, les PDF obtenus à partir de la fibrine stabilisée ont une structure différente.  3, record 13, French, - produit%20de%20d%C3%A9gradation%20de%20la%20fibrine

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 DEF

a spongy form of denatured gelatin used as a hemostatic, especially when wet with thrombin.  1, record 14, English, - gelatin%20sponge

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 CONT

les éponges de gélatine ou Spongel (...) sont stériles et résorbables. Elles jouent un double rôle hémostatique: par leur forte adhésivité sur les plaies, elles assurent une hémostase de type mécanique; grâce à leur pouvoir de rétention élevé des liquides, elles servent de support aux solutions hémostatiques, quelles qu'elles soient, de thrombine en particulier.  1, record 14, French, - %C3%A9ponge%20de%20g%C3%A9latine

Record number: 14, Textual support number: 1 OBS

Voir D10 du fascicule 23760 de ENSTO.  2, record 14, French, - %C3%A9ponge%20de%20g%C3%A9latine

Record 14,  Textual support,  Spanish