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TRH [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2004-01-20

English

Subject field(s)
  • Hormones
  • The Thyroid
DEF

A peptide hormone secreted by the anterior pituitary [which] promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland.

CONT

The hypothalamus generates thyroid-releasing hormone(TRH) to energize pituitary thyroid-stimulating hormone(TSH). TSH, in turn, stimulates thyroid hormonal output, which feeds back on both hypothalamus and pituitary to complete the regulatory circle.

Key term(s)
  • thyroid stimulating hormone

French

Domaine(s)
  • Hormones
  • Thyroïde
CONT

La sécrétion d'hormones thyroïdiennes (T3 - T4) est sous la dépendance d'une hormone hypophysaire : la thyréostimuline (TSH).

Spanish

Campo(s) temático(s)
  • Hormonas
  • Glándula tiroides
DEF

Hormona segregada por la hipófisis que controla la actividad de la glándula tiroidea.

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Record 2 2001-04-20

English

Subject field(s)
  • Endocrine System and Metabolism
CONT

In most patient with growth hormone(GH) secreting pituitary adenomas and clinically nonfunctioning pituitary tumors(NFPT) the intravenous injection of thyrotropin releasing hormone(TRH) augments the secretion of GH and subunits of gonatropin hormones respectively. Similar hormone responses to TRH have been detected in rat pituitary cell lines and primary human pituitary tumor cultures in vitro. Nevertheless the TRH effect on tumor hormonal secretion has not been well characterized. In the present study we examined TRH-induced hormone secretion in GH secreting tumors and in NFPT in vitro. Cultured cells secreted betaFSH secretion at 60 to 90 min, with no further increase at 34 h. TRH-stimulated GH secretion peaked at 90-120 min, and decreased after 3 h, but a secondary rise occurred after 24 h of incubation. Chronic daily exposure to TRH followed by an acute TRH challenge resulted in a further increase of GH secretion after one hour.

OBS

TRH is a tonic secretagogue in growth hormone secreting but not in nonfunctioning pituitary tumors.

French

Domaine(s)
  • Systèmes endocrinien et métabolique
CONT

L'injection intra-veineuse de TRH (Thyrotropin-Releasing-Hormone), 200ug/IV entraîne une réponse de TRH avec un maximum à 30 minutes. Le test TRH apprécie la réactivité thyréotrope antéhypophysaire qui dépend de l'intégrité des cellules thyréotropes hypophysaires; du niveau d'hormonémie thyroidienne.

Spanish

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