TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

Enzyme which converts a zymogen to the active enzyme form.  2, record 1, English, - kinase

Record number: 1, Textual support number: 1 CONT

A somewhat different type of regulation of enzyme activity is the enzyme-catalyzed activation of inactive precursors of enzymes(zymogens) to yield the catalytically active forms. The classical examples are the digestive enzymes pepsin, trypsin, and chymotrypsin which are synthesized as the inactive zymogens pepsinogen, trypsinogen, and chymotrypsinogen, respectively. When these enzymes are secreted into the gastrointestinal tract, they are converted into their active forms by the selective hydrolytic cleavage of one or more specific peptide bonds in the zymogen molecule.... Trypsinogen is converted into active trypsin by removal of a hexapeptide from the N-terminal end, through the action of... kinase.  3, record 1, English, - kinase

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Nom d'ensemble des enzymes dont la présence est nécessaire pour rendre active une autre enzyme. Ex.: l'entérokinase pancréatique permet la transformation du trypsinogène en trypsine.  2, record 1, French, - kinase

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

Enzyme that is interconverted between active and inactive forms by the action of other enzymes. Some of these also respond to noncovalent allosteric modulators.  2, record 2, English, - covalently%20modulated%20enzyme

Record number: 2, Textual support number: 1 CONT

Covalently modulated enzymes... are responsive to alterations in the metabolic state of a cell or tissue on a relatively short time scale... within minutes.... The classical examples are the digestive enzymes pepsin, trypsin, and chymotrypsin, which are synthesized as the inactive zymogens pepsinogen, trypsinogen, and chymotrypsinogen, respectively. When these enzymes are secreted into the gastrointestinal tract, they are converted into their active forms by the selective hydrolytic cleavage or one or more specific peptide bonds in the zymogen molecule.  1, record 2, English, - covalently%20modulated%20enzyme

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Enzyme régulateur dans lequel les formes active et inactive sont interconverties par des modifications covalentes de leur structure, catalysées par d'autres enzymes. L'exemple type de ce genre d'enzyme régulateur est la glycogène phosphorylase des tissus animaux qui catalyse la décomposition du polysaccharide de réserve, le glycogène, un polymère du glucose, pour donner le glucose 1-phosphate.  2, record 2, French, - enzyme%20modul%C3%A9%20de%20fa%C3%A7on%20covalente

Record number: 2, Textual support number: 1 CONT

Les enzymes modulés de façon convalente [...] répondent à des changements de métabolisme d'une cellule ou d'un tissu, en un temps relativement court : quelques [...] minutes.  1, record 2, French, - enzyme%20modul%C3%A9%20de%20fa%C3%A7on%20covalente

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

.... the single peptide chain of the inactive zymogen is converted to the three-chain active chymotrypsin....  2, record 3, English, - inactive

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

De nombreux enzymes sont en effet inactifs à l'état oxydé [...] mais ils redeviennent actifs lorsque par réduction ils récupèrent leurs groupements.  2, record 3, French, - inactif

Record 3,  Textual support,  Spanish