TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

Human actin-binding protein(ABP), also called filamin, crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton.  1, record 1, English, - filamin

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Protéine filamenteuse de masse moléculaire 280 kDa [kilodaltons] qui se lie à l'actine dans les structures du cytosquelette contractile.  1, record 1, French, - filamine

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

While all AKAPs contain a conserved RII binding domain, a second motif unique to each anchoring protein allows it to sequester the kinase to specific intracellular locations.  1, record 2, English, - anchoring%20protein

Record number: 2, Textual support number: 2 CONT

There are several endocytic pathways that can mediate the internalization of many different cargo proteins.  2, record 2, English, - anchoring%20protein

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Nous avons ensuite montré que la myosine VIIa est une protéine d'ancrage de la protéine kinase A.  1, record 2, French, - prot%C3%A9ine%20d%27ancrage

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

A secondary novel technology to which the Company has exclusive rights is that of antibody-targeted liposomes. This technology involves the incorporation of an antimyosin antibody into liposome membranes that serves to target the immunoliposome to cytoskeletal protein exposed by cellular membrane lesions. Upon anchoring the liposome to the cell via the antibody the liposome presumably fuses with the cell membrane and repairs the lesion. In vitro and animal model studies have shown that this methodology has been able to preserve cell and tissue viability under anoxic/ischemic conditions. This technology may be able to limit the extent of heart muscle damage during heart attacks and myocarditis.  1, record 3, English, - immunoliposome

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

...Afin d'augmenter la quantité de molécules du médicament pouvant être associées aux anticorps, l'équipe de Pardridge a suggéré d'associer au complexe anticorps/médicament des vecteurs lipidiques, qu'elle a nommé «immunoliposomes». Chaque liposome de 100 nanomètres de diamètre peut acheminer au moins 10 000 petites molécules du médicament.(J. Huwyler et al. (1996) Proc.Natl. Acad. Sci. USA 93, 14164-14169.)  1, record 3, French, - immunoliposome

Record 3,  Textual support,  Spanish