TERMIUM Plus®

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BETA FIBROBLAST GROWTH FACTOR [2 records]

Record 1 1994-01-19

English

Subject field(s)
  • Biochemistry
CONT

Surgical biopsies from 10 head and neck squamous cell carcinomas were labeled in vitro with bromodeoxyuridine. In histological sections, bromodeoxyuridine-positive nuclei and beta-fibroblast growth factor(beta-FGF) were stained using immunohistochemistry. In clearly discernible clusters of tumor cells, the cytoplasm shows strong positive beta-FGF staining, whereas other tumor regions are completely beta-FGF negative... Three classes of mesoderm-inducing factor(MIF) that might be responsible for... interaction in vivo... These are members of the transforming growth factor type beta(TGF-beta), fibroblast growth factor(FGF) and Wnt families... Six well-characterized human growth factors were chosen for detailed investigation by topical application to standardized skin wounds in swine : epidermal growth factor(EGF), transforming growth factors alpha and beta(TGF-alpha and TGF-beta), fibroblast growth factor(FGF), insulin-like growth factor-1(IGF-l), and platelet-derived growth factor(PDGf). [Source : PASCAL database].

French

Domaine(s)
  • Biochimie
OBS

Source : base de données PASCAL.

Spanish

Save record 1

Record 2 1991-07-17

English

Subject field(s)
  • Cytology
CONT

Recently, several mesoderm-inducing factors(MIFs) have been discovered. These cause isolated Xenopus animal caps to form mesodermal cell types such as muscle, instead of their normal fate of epidermis. The MIFs fall into two classes. One comprises members of the fibroblast growth factor(FGF) family, and the other members of the transforming growth factor type beta(TGF-beta) family. Of the latter group, the most potent is XTC-MIF, a protein produced by Xenopus XTC cells. Here we show that XTC-MIF is the homologue of mammalian activin A.

OBS

Tiré du périodique londonien: Nature, 1990, 345 (6277), pp. 729-731.

French

Domaine(s)
  • Cytologie
CONT

Les activines, des inducteurs du mésoderme axial chez le xénope et le poulet. Nous avons rapporté, dans une brève récente, que l'inducteur mésodermique XTC-MIF (mesoderm inducing factor dérivé de la lignée de xénope XTC), appartenant à la famille TGF B, était l'équivalent de l'activine chez Xenopus.

Spanish

Save record 2

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