TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

[The process of] modifying the molecular structure of a protein.  1, record 1, English, - denaturation

Record number: 1, Textual support number: 1 OBS

Denaturation involves the breaking of many of the weak linkages, or bonds(e. g. hydrogen bonds), within a protein molecule that are responsible for the highly ordered structure of the protein in its natural(native) state. Denatured proteins have a looser, more random structure; most are insoluble.  1, record 1, English, - denaturation

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

En biochimie, la dénaturation est une altération de la structure moléculaire d'une protéine qui rend celle-ci non fonctionnelle. Elle est un changement structurel des protéines ou des acides nucléiques où ils perdent leur structure native et, de cette manière, leur fonctionnement optimal et modifient parfois leurs propriétés physico-chimiques.  1, record 1, French, - d%C3%A9naturation

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

The three types of protein fibre - collagen, reticular and elastic - are embedded in the matrix and between cells ... Their function is to strengthen and support connective tissues.  2, record 2, English, - protein%20fibre

Record number: 2, Textual support number: 2 CONT

The aggregation of protein molecules into long fibrils is a property of many proteins when they become damaged or denatured. Such aggregates are formed as part of the pathology of many diseases, including Alzheimer's Disease and Parkinson's Disease. It is very important therefore to understand the fundamental reasons why proteins form such structures. Such understanding may eventually lead to therapies based upon interfering with the growth of the protein fibres.  3, record 2, English, - protein%20fibre

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 OBS

Les protéines peuvent former des tubes ou des filaments qui s'assemblent pour former des fibres très résistantes, plus résistantes que l'acier bien souvent (pour un même poids). Elles forment des structures aussi diverses que les tendons et les ligaments, l'armature interne des cellules, les toiles d'araignées, les cornes, les poils et les plumes, les fibres des caillots sanguins ou les membranes donnant de la résistance à la plupart des organes.  2, record 2, French, - fibre%20prot%C3%A9ique

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

The return by slow conversion of a denatured... protein to its "native" configuration.  1, record 3, English, - renaturation

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Restauration de l'activité biologique d'une protéine dénaturée, c'est-à-dire ayant perdu sa structure native sous l'effet de conditions extrêmes de milieu.  1, record 3, French, - renaturation

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

[Vuelta] de una proteína a su conformación tridimensional, permitiendo que recupere el funcionamiento normal.  1, record 3, Spanish, - renaturalizaci%C3%B3n%20de%20prote%C3%ADna

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

Protein that lost its natural configuration by exposure to a destabilizing agent such as heat.  1, record 4, English, - denatured%20protein

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Protéine qui a perdu sa configuration moléculaire interne à cause par exemple de la chaleur.  2, record 4, French, - prot%C3%A9ine%20d%C3%A9natur%C3%A9e

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Proteína cuya conformación in vivo se ha modificado al tratarla con calor o sales, perdiendo su actividad biológica.  2, record 4, Spanish, - prote%C3%ADna%20desnaturalizada

Record number: 4, Textual support number: 1 CONT

Al contrario que el ADN, las proteínas desnaturalizadas difícilmente vuelven a renaturalizarse.  2, record 4, Spanish, - prote%C3%ADna%20desnaturalizada

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

A technique used to identify and isolate the protein product of a cloned gene.  3, record 5, English, - hybrid%2Darrested%20translation

Record number: 5, Textual support number: 1 OBS

The cloned double-stranded DNA is denatured and annealed to a mixture of mRNAs known to contain mRNA [messenger RNA] : DNA hybrids are formed, which renders the relevant mRNA unavailable for translation. Translation of the annealed mixture in an in vitro translation system thus results in the absence of translation product of the test gene. Comparison with the translation products of an untreated sample can then identify the missing protein.  3, record 5, English, - hybrid%2Darrested%20translation

Record 5,  Textual support,  French

Record 5,  Textual support,  Spanish

Record number: 5, Textual support number: 1 DEF

Método utilizado para identificar la proteína o proteínas codificadas por una determinada secuencia de ADN clonado.  1, record 5, Spanish, - traducci%C3%B3n%20impedida%20por%20hibridaci%C3%B3n

Record number: 5, Textual support number: 1 OBS

Una preparación de todo el ARNm [ARN mensajero], que contiene diferentes ARNm, se hibrida con el ADN clonado, de manera que las moléculas de ARNm homólogas al ADN clonado se aparearán con él para formar heterodúplex de ADN/ARN. Las moléculas de ARNm no apareadas se traducen in vitro y el resultado se compara con los productos de la traducción de los ARNm sin tratar.  1, record 5, Spanish, - traducci%C3%B3n%20impedida%20por%20hibridaci%C3%B3n

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

In meiotic cells, a protein with broad phyletic distribution and unique cellular localization which shows a high binding efficiency for single-stranded DNA and the property of catalyzing the renaturation of thermally denatured DNA. The protein is assumed to play a role in meiotic recombination and to promote chromosome pairing and crossing over between homologous chromosomes. It is absent from somatic tissues.  1, record 6, English, - DNA%2Dbinding%20protein

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Le déroulement des deux biens de la molécule de DNA entraîne la formation de zones monocoténaires. Ces zones simple brin doivent être stabilisées (suppression du réappariement des deux brins de la molécule de DNA) et protégées de l'action des DNases. Ces fonctions semblent être assurées par une protéine appelée «DNA binding protein» qui se lie spécifiquement au DNA simple chaîne [...]. C'est le complexe formé par l'association entre le DNA monocoténaire et la protéine de liaison au DNA qui constitue en fait le substrat de la DNA polymérase III et des autres protéines qui jouent un rôle dans la réplication.  1, record 6, French, - prot%C3%A9ine%20de%20liaison%20au%20DNA

Record number: 6, Textual support number: 2 CONT

La régulation de l'expression d'un gène passe, entre autres mécanismes, par l'association de protéines à certaines des séquences d'acides nucléiques qui le constituent. L'analyse de ces séquences et celles des protéines régulatrices qui s'y fixent est donc d'une importance capitale pour la compréhension des mécanismes de régulation de l'expression des gènes.  2, record 6, French, - prot%C3%A9ine%20de%20liaison%20au%20DNA

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

A protein in its native conformation, i. e. one that has not been denatured.  2, record 7, English, - native%20protein

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

La conformation tridimensionnelle (structure primaire, secondaire, tertiaire et le cas échéant, quaternaire) est le propre d'une protéine native.  2, record 7, French, - prot%C3%A9ine%20native

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

One current proteomic tool for visualizing and quantitating all proteins expressed in a ological system at a given time is two-dimensional gel electrophoresis(2-DGE). As originally described by Patrick O’Farrell for analyzing Escherichia coli proteins in 1975, 2-DGE combines the electrophoretic separation of denatured proteins bysoelectric point charge differences in the first dimension with separation based on molecular size differences in the second dimension. The proteins, which can be detected using protein-specific stains, appear as constellations of spots in the 2-D space of the gel. Over the 20-year history of 2-DGE, numerous algorithms have been developed for comparing 2-DGE patterns and quantitatively analyzing protein abundance.  2, record 8, English, - two%2Ddimensional%20gel%20electrophoresis

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Le deuxième souffle de la protéomique a aussi pour moteur l'automatisation et l'amélioration de la sensibilité de l'électrophorèse sur gel à deux dimensions (2-DGE), technique de séparation des protéines contenues dans les extraits cellulaires, les perfectionnements des méthodes de spectrométrie de masse qui permettent d'identifier une protéine et ses modifications [...].  1, record 8, French, - %C3%A9lectrophor%C3%A8se%20sur%20gel%20%C3%A0%20deux%20dimensions

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

By more complete removal of the starch, products containing 75 and 85 percent protein are produced. When used in foods, the product is called "vital protein". When prepared for use in adhesive and other industrial products, it is made under less exacting conditions and called "denatured gluten". From Wheat to Flour, Wheat flour Institute, Chicago, 1966, p. 7.  2, record 9, English, - denatured%20gluten

Record number: 9, Textual support number: 1 OBS

Denature: To change the properties of a protein as to coagulate egg white.  3, record 9, English, - denatured%20gluten

Record 9,  Textual support,  French

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

A polypeptide chain with no particular configuration as, for example, in a denatured protein.  1, record 10, English, - crumpled%20chain

Record 10,  Textual support,  French

Record 10,  Textual support,  Spanish