TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

"Skin popping" is a method of injecting illicit drugs, especially opiates, cocaine, and barbiturates, into the dermis or subcutaneous tissue with the goal of achieving slower absorption, decreased risk of overdose, or easier administration than with intravenous drug administration.  3, record 1, English, - skin%20popping

Record 1,  Textual support,  French

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

A knowledge of the fate of a drug, its disposition(absorption, distribution, metabolism, and excretion, known by the acronym ADME) and pharmacokinetics... plays a central role throughout pharmaceutical research and development. These studies aid in the discovery and selection of new chemical entities, support safety assessment, and are critical in defining conditions for safe and effective use in patients. ADME studies provide [a] basis for critical judgments from situations where the behavior of the drug is understood to those where it is unknown : this is most important in bridging from animal studies to the human situation.  3, record 2, English, - absorption%2C%20distribution%2C%20metabolism%20and%20excretion%20study

Record 2,  Textual support,  French

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

The three basic routes of drug administration are enteral, parenteral, and topical.... The enteral route uses the gastrointestinal(GI) tract for the ingestion and absorption of drugs. The most common method of administering drugs through the enteral route is orally. The enteral route also includes drugs that are administered through a nasogastric(NG) or a gastronomy(G) tube.  1, record 3, English, - enteral%20route

Record 3,  Textual support,  French

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

The most common mechanism of absorption for drugs is passive diffusion. This process can be explained through the Fick law of diffusion, in which the drug molecule moves according to the concentration gradient from a higher drug concentration to a lower concentration until equilibrium is reached. Passive diffusion can occur in an aqueous or lipid environment.  2, record 4, English, - passive%20diffusion

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

La diffusion passive est le mécanisme qui assure le passage transplacentaire de la plupart des médicaments. La membrane placentaire est lipoprotéique et se comporte comme une membrane semi-perméable. La vitesse à laquelle les molécules sont transférées par diffusion passive répond à la loi de Fick.  2, record 4, French, - diffusion%20passive

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

ADME is the abbreviation for absorption, distribution, metabolism and excretion. ADME studies are designed to investigate how a chemical(e. g. a drug compound) is processed by a living organism.  2, record 5, English, - absorption%2C%20distribution%2C%20metabolism%20and%20excretion

Record 5,  Textual support,  French

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Systemic administration refers to administration of the drug where the drug is distributed in the systemic circulation. Example: An oral antibiotic tablet for an infected wound.  2, record 6, English, - systemic%20administration

Record number: 6, Textual support number: 1 OBS

Administration can take place via enteral administration(absorption of the drug through the gastrointestinal tract)... or parenteral administration(generally injection, infusion, or implantation).  3, record 6, English, - systemic%20administration

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

L'administration d'un produit anticancéreux se fait soit par voie générale, soit par voie locale ou régionale. L'administration par voie générale peut être faite sous forme orale (comprimés) ou sous forme injectable.  3, record 6, French, - administration%20par%20voie%20g%C3%A9n%C3%A9rale

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

To date, contracts have been awarded using the Project BioShield special reserve fund for the purchase of anthrax therapeutics, anthrax vaccines, botulism antitoxin, a pediatric formulation of potassium iodide(a drug that blocks absorption of radioactive iodide in the thyroid gland), and Calcium-and Zinc-DTPA(two forms of a decorporation agent to remove transuranic radionuclides from the body).  1, record 7, English, - decorporation%20agent

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

[...] substance chimique utilisée dans [un] traitement visant à éliminer de l'organisme [...] des éléments radioactifs ou toxiques qui ont été incorporés.  1, record 7, French, - d%C3%A9corporant

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

Since absorption rates, volumes of distribution and elimination rates differ greatly among the benzodiazepine derivatives... Two half-lives can be described : the alpha half-life, the rate of decline in plasma concentrations due to the process of drug redistribution from the central to the peripheral compartment, and the beta half-life, the rate of decline due to the process of drug elimination due to metabolism.  1, record 8, English, - alpha%20half%2Dlife

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Dexrazoxane chlorhydrate. [...] Demi-Vie. Après administration intraveineuse, la demi-vie d'élimination est biphasique : - la demi-vie alpha se situe entre 10 et 20 minutes, - la demi-vie bêta se situe entre 2 et 3 heures. Elle peut être allongée en cas d'insuffisance rénale.  1, record 8, French, - demi%2Dvie%20alpha

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

A tablet that delays the release of a drug from a dosage form, for example, by promoting absorption in the intestine instead of the stomach.  2, record 9, English, - delayed%2Daction%20tablet

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

[Comprimé dont] le principe actif est libéré [...] à un moment ou à un lieu différent par rapport à une forme conventionnelle, par exemple dans l'intestin au lieu de l'estomac.  2, record 9, French, - comprim%C3%A9%20%C3%A0%20lib%C3%A9ration%20diff%C3%A9r%C3%A9e

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  French

Record 10,  Textual support,  Spanish