TERMIUM Plus®
The Government of Canada’s terminology and linguistic data bank.
DRUG FIRST SWITCH [2 records]
Record 1 - internal organization data 2018-06-11
Record 1, English
Record 1, Subject field(s)
- Psychoses
- Clinical Psychology
Record 1, Main entry term, English
- treatment-refractory schizophrenia
1, record 1, English, treatment%2Drefractory%20schizophrenia
correct
Record 1, Abbreviations, English
- TRS 1, record 1, English, TRS
correct
Record 1, Synonyms, English
- treatment-resistant schizophrenia 2, record 1, English, treatment%2Dresistant%20schizophrenia
correct
- TRS 3, record 1, English, TRS
correct
- TRS 3, record 1, English, TRS
- refractory schizophrenia 4, record 1, English, refractory%20schizophrenia
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Between one-third and one-half of the individuals who meet diagnostic criteria for schizophrenia remain actively ill despite optimal pharmacological treatment.... For patients who do not respond to the first prescribed antipsychotic drug, current clinical practice is to switch to a second and a third drug, and eventually to clozapine, the only antipsychotic drug proven to be effective in treatment-refractory schizophrenia(TRS). 1, record 1, English, - treatment%2Drefractory%20schizophrenia
Record 1, French
Record 1, Domaine(s)
- Psychoses
- Psychologie clinique
Record 1, Main entry term, French
- schizophrénie réfractaire
1, record 1, French, schizophr%C3%A9nie%20r%C3%A9fractaire
correct, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- schizophrénie résistante au traitement 2, record 1, French, schizophr%C3%A9nie%20r%C3%A9sistante%20au%20traitement
correct, feminine noun
- schizophrénie résistante 2, record 1, French, schizophr%C3%A9nie%20r%C3%A9sistante
correct, feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Schizophrénie dont les signes et symptômes ne sont pas soulagés par les traitements de premiers recours. 3, record 1, French, - schizophr%C3%A9nie%20r%C3%A9fractaire
Record number: 1, Textual support number: 1 CONT
Commercialisée au début des années 1970, [la clozapine] se positionne comme une troisième ligne dans l'algorithme de traitement après l'échec d'un traitement à l'aide de deux antipsychotiques, dont un atypique, en raison de la gravité de certains effets indésirables [...]. La clozapine permet une réponse clinique chez environ 30 à 60 % des patients atteints de schizophrénie réfractaire [...] 4, record 1, French, - schizophr%C3%A9nie%20r%C3%A9fractaire
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 1991-01-28
Record 2, English
Record 2, Subject field(s)
- Medication
Record 2, Main entry term, English
- drug of first switch
1, record 2, English, drug%20of%20first%20switch
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, French
Record 2, Domaine(s)
- Médicaments
Record 2, Main entry term, French
- médicament de premier relais
1, record 2, French, m%C3%A9dicament%20de%20premier%20relais
masculine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
- médicament de deuxième option 1, record 2, French, m%C3%A9dicament%20de%20deuxi%C3%A8me%20option
masculine noun
- médicament de deuxième intention 1, record 2, French, m%C3%A9dicament%20de%20deuxi%C3%A8me%20intention
masculine noun
Record 2, Textual support, French
Record 2, Spanish
Record 2, Textual support, Spanish
Copyright notice for the TERMIUM Plus® data bank
© Public Services and Procurement Canada, 2025
TERMIUM Plus®, the Government of Canada's terminology and linguistic data bank
A product of the Translation Bureau
Features
Language Portal of Canada
Access a collection of Canadian resources on all aspects of English and French, including quizzes.
Writing tools
The Language Portal’s writing tools have a new look! Easy to consult, they give you access to a wealth of information that will help you write better in English and French.
Glossaries and vocabularies
Access Translation Bureau glossaries and vocabularies.
- Date Modified: