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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions.  2, record 1, English, - drug%20interaction

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Modification des effets d'un médicament par un autre médicament ou par une substance donnée.  2, record 1, French, - interaction%20m%C3%A9dicamenteuse

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Influencia recíproca entre dos o más medicamentos administrados simultáneamente.  1, record 1, Spanish, - interacci%C3%B3n%20medicamentosa

Record number: 1, Textual support number: 1 OBS

El efecto puede ser un incremento o una [disminución de] la acción de cada fármaco, o puede consistir también en alteración de la absorción digestiva o del proceso hepático y aumento en los efectos tóxicos, disminución de su absorción o aceleramiento de su degradación.  1, record 1, Spanish, - interacci%C3%B3n%20medicamentosa

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

A drug-drug interaction(DDI) occurs when two or more drugs interact with each other in a way that affects their effectiveness, safety, or both.  3, record 2, English, - drug%2Ddrug%20interaction

Record 2,  Textual support,  French

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 OBS

An adverse event occurs during or after a treatment, but is not necessarily caused by the treatment itself.  2, record 3, English, - adverse%20event

Record number: 3, Textual support number: 2 OBS

It may involve the exacerbation of a pre-existing condition, intercurrent diseases, an accident, a drug interaction or a significant worsening of the disease.  3, record 3, English, - adverse%20event

Record number: 3, Textual support number: 3 OBS

adverse event: designation standardized by the Health Technology Assessment (HTA) Glossary English Editorial Board and the Translation Bureau.  4, record 3, English, - adverse%20event

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 OBS

Un événement indésirable survient pendant ou après un traitement, mais il n'est pas nécessairement causé par le traitement.  3, record 3, French, - %C3%A9v%C3%A9nement%20ind%C3%A9sirable

Record number: 3, Textual support number: 2 OBS

Il peut s'agir de l'exacerbation d'un problème préexistant, de maladies intercurrentes, d'un accident, d'une interaction médicamenteuse ou d'une aggravation importante de la maladie.  4, record 3, French, - %C3%A9v%C3%A9nement%20ind%C3%A9sirable

Record number: 3, Textual support number: 3 OBS

événement indésirable : désignation normalisée par l'Institut national d'excellence en santé et en services sociaux (INESSS) et le Bureau de la traduction.  2, record 3, French, - %C3%A9v%C3%A9nement%20ind%C3%A9sirable

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

[...] suceso médico [indeseable] que puede presentarse durante el tratamiento con un medicamento[, dispositivo médico o producto sanitario,] pero que no necesariamente tiene una relación causal con dicho tratamiento.  2, record 3, Spanish, - evento%20adverso

Record number: 3, Textual support number: 1 OBS

Las reacciones adversas y los eventos adversos no siempre son lo mismo. Un evento adverso es cualquier suceso indeseable experimentado por un paciente, independientemente de que se sospeche o no del medicamento administrado. Un ejemplo de un evento adverso es un paciente que sufre un accidente de tráfico mientras estaba con un tratamiento farmacológico específico. Mientras que una reacción adversa (RAM) es cualquier suceso indeseable que ha sucedido con el paciente mientras estaba utilizando un medicamento y existe la sospecha de que es causado por el medicamento.  4, record 3, Spanish, - evento%20adverso

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 OBS

[Non-extractable] residue is obtained by subtracting the extractable residues from the total residues and comprise : residue of the drug incorporated through normal metabolic pathways into endogenous compounds(e. g. amino acids, proteins, nucleic acid) and chemically-bound residue derived by interaction of residues of parent drug or its metabolites with macromolecules.  1, record 4, English, - non%2Dextractable%20residue

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

[Le] résidu [non extractible] représente la différence entre le total des résidus et les résidus extractibles, notamment: le résidu d'un médicament incorporé par des voies métaboliques normales dans des composés endogènes (acides aminés, protéines, acide nucléique, par ex.) et le résidu chimiquement lié et dérivé par l'interaction de résidus d'un médicament mère ou de ses métabolites avec des macromolécules.  1, record 4, French, - r%C3%A9sidu%20non%20extractible

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

[Herb]-drug combinations can produce untoward effects when the herbal product perturbs the activity of drug metabolizing enzymes and/or transporters. Despite increasing recognition of these types of herb-drug interactions, a standard system for interaction prediction and evaluation is nonexistent. Consequently, the mechanisms underlying herb-drug interactions remain an understudied area of pharmacotherapy.  2, record 5, English, - herb%2Ddrug%20interaction

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Selon les données probantes actuelles, l'utilisation de l'hydraste du Canada pourrait contribuer à des interactions plante-médicament, mais les données à ce sujet sont limitées et Santé Canada n'est au courant d'aucun cas d'interaction entre l'hydraste du Canada et des médicaments, que ce soit au Canada ou à l'étranger.  1, record 5, French, - interaction%20plante%2Dm%C3%A9dicament

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Adverse drug reactions can occur as a result of taking the wrong drug or having a drug-drug or drug-food interaction...  2, record 6, English, - drug%2Dfood%20interaction

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Souffre-t-il ou est-il susceptible de souffrir d'une baisse d'efficacité ou d'effets indésirables en raison d'une interaction médicament-médicament ou d'une interaction médicament-aliment?  2, record 6, French, - interaction%20m%C3%A9dicament%2Daliment

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

An interaction between two drugs that results in synergistic action which is greater than the combined individual responses to each drug if they were taken together but did not interact; as though 2 + 2=5.  2, record 7, English, - potentiation

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Synergie de médicaments administrés en association.  2, record 7, French, - potentialisation

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

The administration of naproxen may result in increased urinary values for 17-ketogenic steroids because of an interaction between the drug and/or its metabolites with m-dinitrobenzene used in this assay.  4, record 8, English, - 1%2C3%2Ddinitrobenzene

Record number: 8, Textual support number: 1 OBS

Also known under the following commercial designation: UN 1597.  5, record 8, English, - 1%2C3%2Ddinitrobenzene

Record number: 8, Textual support number: 2 OBS

1,3-dinitrobenzene: form recommended by the IUPAC (International Union of Pure and Applied Chemistry).  3, record 8, English, - 1%2C3%2Ddinitrobenzene

Record number: 8, Textual support number: 3 OBS

The prefixes "ortho-", "meta-" and "para-", along with their corresponding abbreviations ("o-", "m-" and "p-"), appear in italics and are ignored in alphabetizing. According to the actual chemical nomenclature rules in organic chemistry (in 2003), the numbers designating the positions of the disubstitution groups (1,2- for "ortho-", 1,3- for "meta-" and 1,4- for "para-") are to be preferred to the symbols "o-", "m-" and "p-". Furthermore, the prefixes "ortho-", "meta-" and "para-" should not be used anymore, and their corresponding abbreviations ("o-", "m-", and "p-") will soon be judged to be avoided, if not totally condemned.  3, record 8, English, - 1%2C3%2Ddinitrobenzene

Record number: 8, Textual support number: 4 OBS

Chemical formula: C₆H₄N₂O₄  5, record 8, English, - 1%2C3%2Ddinitrobenzene

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 OBS

1,3-dinitrobenzène : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée).  3, record 8, French, - 1%2C3%2Ddinitrobenz%C3%A8ne

Record number: 8, Textual support number: 2 OBS

Les préfixes de position «ortho-», «méta-» et «para-», tout comme les abréviations correspondantes «o-», «m-» et «p-», s'écrivent en italique et n'interviennent pas dans une classification par ordre alphabétique. Selon les règles de nomenclature de chimie organique en vigueur aujourd'hui (en 2003), il est recommandé d'utiliser les chiffres 1,2-, 1,3- et 1,4-, respectivement. Les préfixes «ortho-», «méta-» et «para-» ne doivent plus être utilisés. L'usage des symboles correspondants («o-», «m-» et «p-») sera bientôt fortement déconseillé, sans être exclu.  3, record 8, French, - 1%2C3%2Ddinitrobenz%C3%A8ne

Record number: 8, Textual support number: 3 OBS

Formule chimique : C₆H₄N₂O₄  4, record 8, French, - 1%2C3%2Ddinitrobenz%C3%A8ne

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Nearly every drug molecule works through a structural interaction with a "target" or "receptor" molecule or protein that plays key roles in all biological processes. In the most common model for this interaction, the drug molecule inserts itself into a functionally important crevice of its target protein, like a key in a lock. The molecule then binds there and either induces or, more commonly, inhibits the protein's normal function. This universal drug-target scheme suggests a powerful alternative approach to drug discovery : if it were possible to identify, in advance, the appropriate protein target for a given therapeutic need and if enough were known about the distinguishing structure of that target protein, it ought to be feasible to design the structure of an ideal drug to interact with it.  2, record 9, English, - target%20protein

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

La discipline [...] «Bio-informatique du médicament» recouvre les activités suivantes : analyser et exploiter les génomes pour identifier les classes structurales et fonctionnelles d'intérêt thérapeutique; [...] modéliser les protéines-cibles dont la structure n'est pas accessible expérimentalement [...]  1, record 9, French, - prot%C3%A9ine%2Dcible

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

Patterns of interaction, in this context, involve attenuation, no-effect and/or amplification by a third entity, the modulator, of the effect of an actor upon the reactor. Such feedsidewards lead to chronomodulation, a phenomenon accounting for qualitatively as well as quantitatively different modulatory effects of the same drug or other stimulus.  1, record 10, English, - chronomodulation

Record 10,  Textual support,  French

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

Protein Structure-Function Relationships-Cloning and Structural Studies on Receptors and Enzymes Molecular biology of drug receptors and the advent of reverse pharmacology. A structural basis of proteinase-protein inhibitor interaction Detection of new enzymes and receptors by hybridization technique : new approaches to isolation, expression and molecular modelling of proteases.  1, record 11, English, - reverse%20pharmacology

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Aujourd'hui, on voit émerger de nouveaux concepts, basés sur la connaissance intime de la cible que devra atteindre le médicament. De manière plus rationnelle que par le passé, on peut espérer ainsi créer des pharmacophores, véritables têtes de série de nouvelles familles chimiques. En intégrant la biologie structurale, cette pharmacologie, dite inverse, devient une approche majeure pour concevoir de nouveaux médicaments.  1, record 11, French, - pharmacologie%20inverse

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

The pharmacodynamic effect induced by a drug is the result of the interaction between the molecules of the drug and part of the molecules composing the biological object,(and) the chemical properties of the drug are decisive for its biological potentialities.  1, record 12, English, - structure%2Dactivity

Record number: 12, Textual support number: 1 CONT

Bisacodyl was introduced as a cathartic as a result of structure-activity studies of phenolphthalein-related compounds.  1, record 12, English, - structure%2Dactivity

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 DEF

L'activité d'une drogue est inhérente à sa structure propre [...] cette molécule agit dans un milieu biologique complexe au niveau d'un récepteur [...]  1, record 12, French, - structure%2Dactivit%C3%A9

Record number: 12, Textual support number: 1 CONT

À cause de leur ressemblance de structure avec les hydrocarbures polycycliques, la recherche d'une relation structure-activité s'est orientée vers la détermination de la configuration électronique des molécules.  1, record 12, French, - structure%2Dactivit%C3%A9

Record 12,  Textual support,  Spanish