TERMIUM Plus^®

Record 1,  Textual support,  French

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A recombinant form of Human Interferon Beta made by Triton Biosciences designed to treat HIV infection and Kaposi’s Sarcoma. It is classified as: antineoplastic, antiviral, immunomodulator, antiretroviral.  1, record 2, English, - interferon%20beta%2D1b

Record number: 2, Textual support number: 1 CONT

BETASERON : Berlex Canada, interferon beta-1b is an immunomodulator used in ambulatory patients with relapsing-remitting multiple sclerosis. Betaseron is a highly purified, sterile, lyophilized protein product produced by recombinant DNA techniques and formulated for use by injection. It is manufactured by bacterial fermentation of a strain of E. coli that bears a genetically engineered plasmid containing the gene for human interferon betaser17. The native gene was obtained from human fibroblasts and altered in a way that substitutes serine for the cysteine residue found at position 17.  1, record 2, English, - interferon%20beta%2D1b

Record 2,  Textual support,  French

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

The pCOR plasmids are narrow-host range plasmid vectors for nonviral gene therapy. These plasmids contain a conditional origin of replication and must be propagated in a specifically engineered E. coli host strain, greatly reducing the potential for propagation in the environment or in treated patients.  3, record 3, English, - plasmid%20with%20a%20conditional%20origin%20of%20replication

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Afin d’améliorer la sécurité de notre vecteur non viral et notamment réduire le risque de dissémination du vecteur dans l’environnement et chez le patient, nous avons construit un nouveau plasmide doté d'une origine de réplication conditionnelle (pCOR). Cette plate-forme pCOR a été utilisée avec succès pour le transfert de gènes marqueurs et thérapeutiques (FGF-1, VEGFs) [...]  1, record 3, French, - plasmide%20dot%C3%A9%20d%27une%20origine%20de%20r%C3%A9plication%20conditionnelle

Record number: 3, Textual support number: 1 OBS

L'abréviation anglaise pCOR est largement utilisée en français.  3, record 3, French, - plasmide%20dot%C3%A9%20d%27une%20origine%20de%20r%C3%A9plication%20conditionnelle

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Shigella is closely related to Escherichia and is considered by some, to be another strain of E. coli. However, because Shigella is anaerogenic(does not produce gas from carbohydrates) and lactose(-), it is easily discernable from E. coli.  2, record 4, English, - anaerogenic

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Se dit d'un organisme ne produisant pas de gaz à partir d'un substrat donné.  1, record 4, French, - ana%C3%A9rog%C3%A8ne

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Purification of mutant enzymes is a prime requirement of biophysical and biochemical studies. Our investigations on the essential E. Coli enzyme glutaminyl-tRNA sybthetase demand mutant enzymes free of any wild-type protein contamination. However, as it is not possible to express non-complementing mutant enzymes in an E. Coli gInS-deletion strain, we developed a novel strategy to address these problems. Instead of following the common tactic of epitope-tagging the mutant protein of interest on an extrachromosomal genetic element, we fused a reporter epitope to the 5’ end of the chromosomal gInS-gene copy : this is referred as reverse epitope-tagging.  1, record 5, English, - reverse%20epitope%2Dtagging

Record 5,  Textual support,  French

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

A good example of the [DNA recombinant] technique comes from work carried out by ICI where a gene for an energy conserving nitrogen pathway taken from E. coli was transferred into their SCP(single-cell protein) organism Methylophilus methylotrophus strain AS1 where it substituted for the similar but energy consuming pathway possessed by the strain.  1, record 6, English, - nitrogen%20pathway

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Les travaux réalisés par ICI donnent un bon exemple de cette technique [de recombinaison de l'ADN] : un gène correspondant à une voie métabolique de l'azote économe en énergie a été prélevé dans E. coli et transféré dans l'organisme producteur de protéines d'organismes unicellulaires (POU) qu'utilise cette entreprise (souche AS1 de Methylophilus methylotrophus), où il a remplacé la voie métabolique analogue mais consommatrice d'énergie dont était dotée la souche.  1, record 6, French, - voie%20m%C3%A9tabolique%20de%20l%27azote

Record 6,  Textual support,  Spanish