TERMIUM Plus®

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FACTORS ASSAY [3 records]

Record 1 2011-11-01

English

Subject field(s)
  • Biochemistry
  • Biotechnology
  • Cancers and Oncology
DEF

A protein secreted by transformed cells that can stimulate growth of normal cells.

CONT

A number of transforming growth factors have been isolated from media conditioned by tumor cells. Two of these were purified on the basis of their synergistic actions in stimulating the growth of fibroblasts in soft agar, an assay often used as an index of cell "transformation. "Since cancer cells grow in soft agar, the growth factors were first thought to be mitogens involved in tumorigenesis and were called tumor growth factors. However their main role appear to be in embryonic development and in tissue repair.

French

Domaine(s)
  • Biochimie
  • Biotechnologie
  • Cancers et oncologie
CONT

Or Todaro et coll. avaient observé que les fibroblastes en culture, transformés par certains rétrovirus porteurs d'oncogènes, secrétaient dans le milieu de culture des substances capables d'imprimer à des cellules normales un comportement phénotypique proche de cellules transformées. Ces facteurs que l'on a appelés facteur de croissance transformant (TGF) ont été isolés et caractérisés chimiquement.

Spanish

Campo(s) temático(s)
  • Bioquímica
  • Biotecnología
  • Tipos de cáncer y oncología
DEF

Proteína segregada por un tumor que estimula la multiplicación de las células cancerígenas.

Save record 1

Record 2 2000-03-30

English

Subject field(s)
  • Blood
DEF

In hematology, the quantitative determination of the percentage concentration of individual clotting factors.

French

Domaine(s)
  • Sang

Spanish

Save record 2

Record 3 1991-07-18

English

Subject field(s)
  • Genetics
CONT

A human glioma cell lines(YKGI), which was positively identified for glial fibrillary acidic(GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. Chromosome analysis of the cells revealed a homogeneously staining region(HSR) on a marker chromosome. The assay for transforming growth factors(TGFs) in the conditioned medium of the cell line revealed that it contained high levels of alpha-and beta-type TGFs, which might regulate the growth of glioblastoma and influence on the peritumoral tissues.

OBS

Tiré de: Acta Neuropathologica, 1989, 79 (1), 30-36.

French

Domaine(s)
  • Génétique
CONT

L'amplification d'ADN peut parfois être visualisée en cytogénétique sous deux formes différentes. La première, extrachromosomique, correspond aux chromosomes minutes. (...) L'autre forme visible est constituée par les HSR (homogeneously staining region) ou ECR (expanded chromosome region), régions intrachromosomiques étendues d'ADN amplifié, dont la ségrégation se fait normalement à chaque mitose, et qui sont donc conservées de manière relativement stable, même si la sélection n'est plus appliquée.

Spanish

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