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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

One of the important modifications of the ISH [in situ hybridization] technique is genomic in situ hybridization(GISH). GISH is a genomic painting technique which allows parental genomes in interspecific hybrids to be distinguished.  2, record 1, English, - genomic%20in%20situ%20hybridization

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Nous avons également analysé leur comportement méiotique et leur composition chromosomique, au moyen de techniques cytogénétiques et d’analyses GISH (hybridation génomique in situ).  2, record 1, French, - hybridation%20g%C3%A9nomique%20in%20situ

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Breast cancer progression is determined by a complex pattern of multiple genetic aberrations the association of which with patient prognosis is unknown. In this study, we have undertaken a genome-wide screening to detect genetic changes associated with clinical outcome in node-negative breast cancer. Comparative genomic hybridization was used to screen for DNA sequence gains and losses across all human chromosomes in 23 tumors...  1, record 2, English, - genomic%20hybridization

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

La séquence FISH (hybridation en fluorescence in situ) et le développement des techniques fondées sur son principe sont en train de modifier radicalement les méthodes d'analyse de la génétique. Parmi celles-ci, l'hybridation génomique comparative (CGH) constitue un outil performant d'exploration du génome.  1, record 2, French, - hybridation%20g%C3%A9nomique%20comparative

Record number: 2, Textual support number: 2 CONT

La CGH est une méthode permettant d'évaluer une modification du nombre de copies d'ADN dans un génome pathologique [...] Son principe est fondé sur la compétition, lors de l'hybridation, entre un ADN génomique normal et un ADN génomique pathologique.  1, record 2, French, - hybridation%20g%C3%A9nomique%20comparative

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Two strategies have been used to clone specific sequences of eukaryotic, genomic DNA in bacteriophage lambda vectors. The first involved cloning of DNA preparations that had been highly enriched for the sequences of interest. Total genomic DNA was digested to completion with a restriction endonuclease and the resulting fragments were separated by preparative gel electrophoresis, reverse-phase column chromatography, or both. The fractions containing the DNA sequences of interest were identified by hybridization to appropriate probes and cloned in bacteriophage lambda vectors. Because these fractionation procedures may yield an overall enrichment of as much as 100-fold to 300-fold, the number of recombinant bacteriophages that had to be generated and screened for the DNA sequences of interest could be significantly reduced. Subsequently, the development of efficient in vitro packaging systems and in situ hybridization techniques eliminated the need to enrich the starting DNA for the sequences of interest.  1, record 3, English, - reverse%20phase%20column%20chromatography

Record 3,  Textual support,  French

Record 3,  Textual support,  Spanish