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HEAVY-CHAIN DISEASE [2 records]

Record 1 2004-02-27

English

Subject field(s)
  • Cancers and Oncology
  • Cytology
DEF

A group of rare malignant neoplasms of lymphoplasmacytic cells that secrete an M component consisting of monoclonal immunoglobulin heavy chains or heavy chain fragments; they are classified according to heavy chain type.

Key term(s)
  • heavy chain disease

French

Domaine(s)
  • Cancers et oncologie
  • Cytologie
DEF

Entité qui englobe trois gammapathies monoclonales caractérisées par l'élaboration excessive d'une partie des chaînes lourdes d'une immunoglobine spécifique, comprenant habituellement le fragment Fc.

Spanish

Campo(s) temático(s)
  • Tipos de cáncer y oncología
  • Citología
DEF

Alteraciones linfoplasmacíticas poco frecuentes y caracterizadas por la proliferación de células secretoras de una porción de la molécula de inmunoglobulina.

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Record 2 2002-07-30

English

Subject field(s)
  • Endocrine System and Metabolism
  • Lymphatic System
CONT

The heavy-chain diseases(HCDs) are lymphoplasmacytic proliferative disorders characterized by the uncontrolled production of abnormal, often structurally incomplete, immunoglobulin heavy chains.... The most often studied HCD is gamma-HCD, or Franklin disease...

Key term(s)
  • gamma heavy chain disease
  • gamma HCD

French

Domaine(s)
  • Systèmes endocrinien et métabolique
  • Système lymphatique
DEF

Maladie des chaînes lourdes caractérisée par une prolifération lymphoplasmocytaire polymorphe, ganglionnaire, hépatosplénique et médullaire avec parfois érythème palatin et oedème de la luette.

Spanish

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