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HEDGEHOG SIGNAL [2 records]

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Alphabetical list of terms

Record 1 2010-04-20

English

Subject field(s)
  • Genetics
CONT

Sending and receiving the Hedgehog signal : control by the Drosophila Gli protein cubitus interruptus.

CONT

The ptc gene encodes a transmembrane protein that in Drosophila acts in opposition to the Hedgehog signaling protein, controlling cell fates, patterning, and growth in numerous tissues. The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression.

French

Domaine(s)
  • Génétique
CONT

[...] le système de transmission du signal Hedgehog est à l'honneur. Son régulateur négatif, Patched, est déficient dans le syndrome de Gorlin et des épithéliomas baso-cellulaires sporadiques. L'une des cibles du signal Hedgehog est le facteur Wingless/Wnt1, lui même impliqué dans la régulation de la prolifération et de la morphogénèse. Ce facteur agit en contrôlant la quantité et l'activité de la ß-caténine [...]

Spanish

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Record 2 2010-04-20

English

Subject field(s)
  • Genetics
CONT

The protein Sonic Hedgehog (Shh) controls patterning growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Ptc can form a physical complex with w newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly.

CONT

Sequence analysis of the smoothened transcription reveals a single open reading frame encoding a protein with seven putative transmembrane domains. This structure is typical of G-protein-coupled receptors, suggesting that the Smoothened protein may act as a receptor for the Hegdgehog ligand.

CONT

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal.

French

Domaine(s)
  • Génétique
CONT

Le signal Hedgehog et sa pathologie. Le précurseur de Sonic Hedgehog subit une maturation autoprotéolytique par liaison au cholestérol. La partie amino-terminale de Sonic Hedgehog se fixe au récepteur «patched» complexé à la protéine Smoothened.

Spanish

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