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HELPER/SUPPRESSOR RATIO [1 record]

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Record 1 2004-10-05

English

Subject field(s)
  • Immunology
CONT

Abnormalities in numbers of CD4+ and CD8+ T-cell subsets and the helper/suppressor ratio(CD4/CD8) were used very early in the AIDS epidemic to help define persons affected with AIDS before a screening test for HIV-1 was available. A low number of CD4+ lymphocytes alone or in combination with a decreased CD4 : CD8 ratio and total lymphocyte count can be useful as a predictor of HIV-1 seropositivity and progression of disease.

Key term(s)
  • T8/T4 ratio

French

Domaine(s)
  • Immunologie
CONT

Les CD4 ou T4 sont une sorte de globules blancs, des lymphocytes qui jouent un rôle capital dans le déclenchement d'une réaction immunitaire (de défense du corps) face à un "envahisseur". Ils sont aussi la cible privilégiée des VIH. [...] On utilise parfois [...] comme indicateur le rapport CD4/CD8, ces derniers étant les éléments qui assurent la clôture d'une réaction immunitaire.

Key term(s)
  • rapport T4/T8

Spanish

Campo(s) temático(s)
  • Inmunología
DEF

Correspondencia cuantitativa que se establece entre las células CD4 cooperadoras y las CD8 supresoras.

OBS

En condiciones normales, [la relación CD4/CD8] debe ser por arriba de uno, aproximadamente 2:1. En la mayoría de los casos de VIH, esta relación se encuentra invertida y es menor de uno.

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