TERMIUM Plus®

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HEMIZYGOUS [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2012-08-31

English

Subject field(s)
  • Genetics
  • Molecular Biology

French

Domaine(s)
  • Génétique
  • Biologie moléculaire
DEF

Se dit d'une cellule ou organisme diploïde ne possédant qu'un allèle à un locus donné (ou à une série de loci) pour cause d'absence de région homologue.

OBS

Par exemple, certains loci de l'hétérochromosome X ne sont pas présents sur le Y.

Spanish

Campo(s) temático(s)
  • Genética
  • Biología molecular
DEF

[Se dice de un] individuo, [organismo o célula] que posee un solo alelo para cada característica en su genotipo.

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Record 2 2012-06-01

English

Subject field(s)
  • Genetics
CONT

Since transgenic mice are being used to analyse somatic and germinal mutation rates in vivo, it is of interest to know to what extent these mice are normal or abnormal in any way. During experiments designed to compare the mutational response of the trasgene and an endogenous gene, Big Blue mice hemizygous for the transgene were bred to create a hybrid mouse in which the comparisons could be made. The fraction of these mice that inherited the transgene was 37% rather than the Mendelian expectation of 50%.

French

Domaine(s)
  • Génétique
CONT

Typiquement les gènes BRCA2, BRCA2, 53 ou MMR (mismatch repair) sont de type caretaker, leur altération conduisant à une instabilité génétique. Nous nous trouvons alors devant un paradoxe apparent, où les gènes de PHC n'induisent pas directement l'imitation tumorale. En revanche, ils créent une instabilité génétique avec hypermutation somatique dans les cellules, touchant plusieurs gènes dont des gatekeepers qui initieront alors le processus tumoral (mutation du deuxième allèle du caretaker, et mutation des deux allèles du gatekeeper).

Spanish

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