TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 OBS

Histamine mediates its effects by interacting with either H1 or H2 receptors. [The] histamine-mediated axon flare response results in the liberation of neuropeptides, perhaps leading to more widespread airway involvement beyond the immediate microenvironment of the activated mast cell.  1, record 1, English, - axon%20flare%20response

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

L'injection d'histamine par voie dermique provoque [...] une zone de rubéfaction locale liée à une dilatation capillaire, entourée d'une rougeur diffuse, par vasodilatation artériolaire due au réflexe d'axone, et, enfin, une papule, réaction œdémateuse, au niveau de la zone primitive de rubéfaction locale.  1, record 1, French, - r%C3%A9flexe%20d%27axone

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A drug that blocks mast cell degranulation in response to antigen, which leads to decreased release of histamine, leukotrienes, and other inflammatory mast cell products.  4, record 2, English, - cromolyn%20sodium

Record number: 2, Textual support number: 1 OBS

Effective in preventing bronchoconstriction.  5, record 2, English, - cromolyn%20sodium

Record number: 2, Textual support number: 2 OBS

Active ingredient sold under a certain number of commercial (trade) names, among which: Intal, Opticrom, Gastrocom and Cromolyn.  6, record 2, English, - cromolyn%20sodium

Record number: 2, Textual support number: 3 OBS

Chemical formula: C₂₃H₁₄Na₂O₁₁  6, record 2, English, - cromolyn%20sodium

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

On commença alors un traitement préventif à base de gouttes oculaires contenant du cromoglycate de sodium, qui réussit à prévenir la conjonctivite allergique saisonnière.  5, record 2, French, - cromoglycate%20de%20sodium

Record number: 2, Textual support number: 1 OBS

[Le chromoglicate de sodium] s'oppose à la sécrétion des médiateurs mastocytaires par un mécanisme mal connu. Proposé dans la prévention [de diverses allergies].  2, record 2, French, - cromoglycate%20de%20sodium

Record number: 2, Textual support number: 2 OBS

cromoglicate : générique pour désigner les sels et les esters de l'acide cromoglicique.  6, record 2, French, - cromoglycate%20de%20sodium

Record number: 2, Textual support number: 3 OBS

Principe actif commercialisé, entre autres, sous les noms de Intal, Opticrom, Gastrocrom et Cromolyn.  7, record 2, French, - cromoglycate%20de%20sodium

Record number: 2, Textual support number: 4 OBS

Formule chimique : C₂₃H₁₄Na₂O₁₁  7, record 2, French, - cromoglycate%20de%20sodium

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

An inhibitor of the release of histamine and other mediators of immediate hypersensitivity from mast cells.  5, record 3, English, - cromoglicic%20acid

Record number: 3, Textual support number: 1 OBS

cromoglicic acid: International nonproprietary name (INN) of the World Health Organization (WHO).  6, record 3, English, - cromoglicic%20acid

Record number: 3, Textual support number: 2 OBS

cromolyn: United States Adopted Name (USAN).  6, record 3, English, - cromoglicic%20acid

Record number: 3, Textual support number: 3 OBS

Chemical formula: C₂₃H₁₆O₁₁  6, record 3, English, - cromoglicic%20acid

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Antiasthmatique de type chromone utilisé sous forme de sel de sodium (chromoglicate de sodium) en poudre pour inhalation (aérosol), au moyen d'un appareil permettant la synchronisation avec l'inspiration.  3, record 3, French, - acide%20cromoglicique

Record number: 3, Textual support number: 1 OBS

Cette bichromone exerce essentiellement une action préventive sur les asthmes d'origine allergique. Elle inhibe la dégranulation des mastocytes et la libération de médiateurs bronchoconstricteurs, pro-inflammatoires et chimiotactiques (histamine, prostaglandines, leucotriène). Elle ne semble pas empêcher le conflit antigène-anticorps; elle ne possède aucune action antiinflammatoire ou antihistaminique ou bronchodilatatrice.  3, record 3, French, - acide%20cromoglicique

Record number: 3, Textual support number: 2 OBS

acide cromoglicique : dénomination commune internationale (DCI) de l'Organisation mondiale de la santé (OMS).  4, record 3, French, - acide%20cromoglicique

Record number: 3, Textual support number: 3 OBS

Formule chimique : C₂₃H₁₆O₁₁  4, record 3, French, - acide%20cromoglicique

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

An agent that produces constriction of the bronchi.  1, record 4, English, - bronchoconstrictor%20agent

Record number: 4, Textual support number: 1 OBS

Examples include histamine, bradykinin, leukotrienes, certain prostaglandins and acetylcholine.  1, record 4, English, - bronchoconstrictor%20agent

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Qui entraîne une diminution du calibre des bronches.  2, record 4, French, - bronchoconstricteur

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

Denoting those responses by histamine receptors to histamine that are blocked by histamine antagonists(e. g. cimetidine).  2, record 5, English, - histaminergic

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Relatif à l'histaminergie : libération d'histamine ou de substances analogues servant de médiateurs chimiques à certains nerfs.  2, record 5, French, - histaminergique

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Bronchial hyperresponsiveness.... bronchial hyperreactivity to inhaled methacholine(is) present in many asthmatic persons during their symptom-free intervals.... The airways of asthmatic individuals react excessively not only to histamine and cholinergic agonists, but also to serotonin, bradykinin, SRS-A(slow-reacting substance of anaphylaxis), leukotrienes, prostaglandin F2d, cold air and sulphur dioxide.  1, record 6, English, - bronchial%20hyperresponsiveness

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Réaction bronchique plus forte que la normale à l'inhalation d'une grande variété de substances chimiques ou autres, et caractérisée sur le plan clinique par l'apparition de symptômes d'asthme.  1, record 6, French, - r%C3%A9action%20bronchique%20excessive

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

An enzyme widely distributed in the body that inactivates histamine.  2, record 7, English, - histaminase

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Enzyme impliquée dans la dégradation de l'histamine ayant un rôle de neurotransmetteur en plus d'être impliquée dans la réaction allergique.  2, record 7, French, - histaminase

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

... results suggest that the inhibitory effect of oxatomide on histamine release may be caused by a combination of(1) prevention of Ca uptake, which is highly selective toward mast cells;(2) inhibition of Ca2+ release from the intracellular Ca store, and(3) elevation of the cAMP [cyclic adenosine monophosphate] content in mast cells.  2, record 8, English, - oxatomide

Record number: 8, Textual support number: 1 OBS

Chemical formula: C₂₇H₃₀N₄O  3, record 8, English, - oxatomide

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

L'oxatomide inhibe la mobilisation du calcium intracellulaire. Le calcium est un des signaux indispensables à l'activation du mastocyte et au déclenchement de la réaction allergique. L'oxatomide inhibe les mécanismes secrétoires au niveau des mastocytes et des basophiles. Il inhibe la libération des médiateurs intragranulaires impliqués dans la phase précoce de l'allergie.  2, record 8, French, - oxatomide

Record number: 8, Textual support number: 1 OBS

Formule chimique : C₂₇H₃₀N₄O  3, record 8, French, - oxatomide

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Dimetindene. A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.  2, record 9, English, - dimetindene

Record number: 9, Textual support number: 1 OBS

Chemical formula: C₂₀H₂₄N₂  3, record 9, English, - dimetindene

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 OBS

Formule chimique : C₂₀H₂₄N₂  2, record 9, French, - dim%C3%A9tind%C3%A8ne

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

Lansoprazole is the second inhibitor of the gastric H+/K+-ATPase to be marketed for the treatment of peptic ulcer disease and reflux oesophagitis. Like omeprazole, lansoprazole is an acid-activated, non-competitive and highly specific inhibitor of the proton pump which causes profound and long-lasting inhibition of acid secretion. In controlled clinical trials, lansoprazole results in more rapid healing of duodenal and gastric ulcers than histamine H2 receptor antagonists.  1, record 10, English, - proton%20pump

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

Présence de cellules acidifiantes dans l'épididyme et le canal déférent: implication de la pompe à protons, H+-ATPase [...] La ATPase est une enzyme multimérique dont quelques sous-unités sont intimement imbriquées dans la membrane plasmique ou dans la membrane d'organites. Cette enzyme consomme de l'ATP pour transporter des protons de part et d'autre de la membrane et se trouve donc impliquée dans plusieurs processus d'acidification. Nous allons d'abord évoquer le rôle des cellules possédant une grande quantité de pompes à protons dans différents épithéliums, puis nous examinerons la contribution de ces cellules au processus d'acidification luminale dans l'épididyme et le canal déférent.  1, record 10, French, - pompe%20%C3%A0%20proton

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

The importance of the amino acid histidine lies in the fact that the body uses it to manufacture histamine, and histamine is responsible for a wide range of physiological processes. It is common knowledge that histamines cause the swelling and reddening in many inflammations and allergic reactions. Doctors therefore often prescribe antihistamines in the treatment of inflammations and infections, as well as allergies.  2, record 11, English, - histidine

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Acide aminé cristallin soluble comprenant 6 atomes de carbone, à partir duquel est élaborée l'histamine.  3, record 11, French, - histidine

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

A cytokine which triggers allergic reactions. It acts on basophils to release histamine.  2, record 12, English, - histamine%2Dreleasing%20factor

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 DEF

Cytokine qui induit la dégranulation des basophiles qui libèrent alors des médiateurs, dont l'histamine.  2, record 12, French, - facteur%20histaminolib%C3%A9rateur

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 DEF

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.  2, record 13, English, - cyproheptadine

Record number: 13, Textual support number: 1 OBS

Chemical formula: C₂₁H₂₁N  3, record 13, English, - cyproheptadine

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 OBS

Formule chimique : C₂₁H₂₁N  2, record 13, French, - cyproheptadine

Record 13,  Textual support,  Spanish

Record number: 13, Textual support number: 1 OBS

Fórmula química: C₂₁H₂₁N  2, record 13, Spanish, - ciproheptadina

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 DEF

The presence of histamine in the blood.  1, record 14, English, - histaminemia

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 DEF

Présence d'histamine dans le sang.  2, record 14, French, - histamin%C3%A9mie

Record number: 14, Textual support number: 1 CONT

Neuroleptiques. Quelques publications font état de réactions anaphylactiques au Droperidol parfois utilisé en anesthésiologie. Un autre mécanisme invoqué est celui d'une inhibition de l'histamine-N-méthyltransférase conduisant à une élévation de l'histaminémie.  1, record 14, French, - histamin%C3%A9mie

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 DEF

A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.  3, record 15, English, - meclizine

Record number: 15, Textual support number: 1 OBS

Active ingredient commonly sold under the name Agyrax.  4, record 15, English, - meclizine

Record number: 15, Textual support number: 2 OBS

Chemical formula: C₂₅H₂₇ClN₂  4, record 15, English, - meclizine

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 CONT

La méclozine est un antihistaminique H1. Elle est utilisée par voie orale dans le traitement symptomatique de la crise vertigineuse et dans le mal des transports.  2, record 15, French, - m%C3%A9clozine

Record number: 15, Textual support number: 1 OBS

Principe actif couramment commercialisé sous le nom d'Agyrax.  3, record 15, French, - m%C3%A9clozine

Record number: 15, Textual support number: 2 OBS

Formule chimique : C₂₅H₂₇ClN₂  3, record 15, French, - m%C3%A9clozine

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 CONT

In addition to the primary antigen-antibody reaction, these tests require an additional event, such as agglutination, precipitation, or hemolysis. Examples of secondary tests are immunodiffusion, complement fixation, and histamine release from leukocytes. These tests are less sensitive, as the secondary manifestation might not follow the primary interaction of antigen and antibody.  1, record 16, English, - secondary%20test

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 CONT

Classification des réactions antigènes-anticorps. - Les méthodes «secondaires» étudient des phénomènes qui sont la conséquence directe (mais non obligatoire) des interactions primaires. La précipitation en est un exemple : certains anticorps donnent lieu à des précipités mais tous les anticorps ne sont pas précipitants [...]. Réactions secondaires (in vitro) : précipitation, agglutination, neutralisation (toxines, virus, phages), réactions dépendant du complément : cytolyse, phagocytose (opsonisation), chimiotactisme.  2, record 16, French, - r%C3%A9action%20secondaire

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 OBS

Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.  2, record 17, English, - methapyrilene

Record number: 17, Textual support number: 2 OBS

Chemical formula: C₁₄H₁₉N₃S  3, record 17, English, - methapyrilene

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 OBS

Formule chimique : C₁₄H₁₉N₃S  2, record 17, French, - m%C3%A9thapyril%C3%A8ne

Record 17,  Textual support,  Spanish

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 DEF

Vasoactive amines : Products such as histamine and 5-hydroxytryptamine released by basophils, mast cells and platelets which act on the endothelium and smooth muscle of the local vasculature.  1, record 18, English, - vasoactive%20amine

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 DEF

amines vasoactives : Produits tels que l'histamine et la 5-hydroxytryptamine libérés par les basophiles, les mastocytes et les plaquettes et agissant sur l'endothélium et le muscle lisse des vaisseaux locaux.  1, record 18, French, - amine%20vasoactive

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 DEF

A drug that counteracts the action of histamine.  5, record 19, English, - antihistamine

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 DEF

[Substance] qui combat les effets de l'histamine.  3, record 19, French, - antihistaminique

Record 19,  Textual support,  Spanish

Record number: 19, Textual support number: 1 DEF

Sustancia sintética estructuralmente análoga a la histamina que, presente en muy pequeñas cantidades, previene la acción de un exceso de histamina formada en los tejidos del cuerpo como resultado de reacciones de tipo alérgico.  3, record 19, Spanish, - antihistamina

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 DEF

Counteracting the effects of histamine.  2, record 20, English, - antihistaminic

Record 20,  Textual support,  French

Record number: 20, Textual support number: 1 DEF

Qui combat les effets de l'histamine.  1, record 20, French, - antihistaminique

Record 20,  Textual support,  Spanish

Record number: 20, Textual support number: 1 DEF

[Dícese del fármaco] que sirve para neutralizar la histamina del organismo, usado para aliviar las reacciones alérgicas, gripe común, asma, urticaria y alergias a los medicamentos.  1, record 20, Spanish, - antihistam%C3%ADnico

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 DEF

The substance formed by decarboxylation of histidine [which] is released from mast cells during the allergic response.  2, record 21, English, - histamine

Record number: 21, Textual support number: 1 CONT

When a person is exposed to an allergen ... the bloodstream sends a crowd of circulating white blood cells to the site of contact. ... Some of those white cells, the basophils, release histamines, chemicals that increase local blood flow; cause leaks in small blood vessels; and spark a flood of more white cells.  3, record 21, English, - histamine

Record number: 21, Textual support number: 1 OBS

It stimulates the contraction of smooth muscle and increase vascular permeability.  2, record 21, English, - histamine

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 DEF

Produit chimique libéré dans le corps humain par l'interaction d'un allergène avec un anticorps fixé sur un mastocyte ou un basophile.  2, record 21, French, - histamine

Record number: 21, Textual support number: 1 CONT

L'histamine est le premier médiateur connu et peut entraîner toute une série de phénomènes inflammatoires caractéristiques de la réaction allergique immédiate.  2, record 21, French, - histamine

Record number: 21, Textual support number: 2 CONT

L'histamine est contenue à l'intérieur des mastocytes et des basophiles [...] L'histaminolibération survient principalement au cours des réactions d'hypersensibilité immédiate, lorsqu'un antigène, réintroduit dans l'organisme, réagit avec un anticorps fixé sur la membrane du mastocyte. [L]'histamine provoque une dilatation des capillaires avec augmentation de la perméabilité locale [...]  3, record 21, French, - histamine

Record 21,  Textual support,  Spanish

Record number: 21, Textual support number: 1 DEF

Sustancia orgánica presente en los tejidos vegetales y animales, que estimula secreciones e interviene en la actividad de los vasos sanguíneos. Está presente en las reacciones alérgicas.  2, record 21, Spanish, - histamina

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 CONT

Terfenadine has demonstrated antihistaminic effects by producing a marked and dose-related reduction of histamine wheals at single oral doses of 20 to 200 mg, with the maximum effect being obtained at 60 mg.  2, record 22, English, - terfenadine

Record 22,  Textual support,  French

Record number: 22, Textual support number: 1 CONT

L'effet antihistaminique de la terfénadine a été démontré par une nette réduction de l'urticaire causée par l'histamine à des doses orales uniques de 20 à 200 mg.  2, record 22, French, - terf%C3%A9nadine

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 CONT

Those mast cells, relatives of white blood cells, are common in the surface tissues of the body, where they wait for reexposure to the antigen like mines floating in a harbor. When the antigen returns and touches two or more IgE molecules, the mast cell pours out a cocktail of at least ten chemicals. Some are enzymes that attack any nearby cells; some activate platelets; some attract other white cells to the site; some can stimulate smooth muscle(thereby causing asthma). One, histamine, causes itching and swelling, unpleasant effects that can be blocked by antihistamines.  2, record 23, English, - mast%20cell

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 DEF

Cellule arrondie du tissu conjonctif [...]  2, record 23, French, - mastocyte

Record 23,  Textual support,  Spanish

Record number: 23, Textual support number: 1 DEF

Célula de tejidos que libera histamina y serotonina durante las inflamaciones y reacciones alérgicas.  2, record 23, Spanish, - mastocito

Record 24,  Textual support,  French

Record 24,  Textual support,  Spanish

Record 25,  Textual support,  French

Record 25,  Textual support,  Spanish

Record 26,  Textual support,  English

Record number: 26, Textual support number: 1 CONT

... the "Human Basophil Degranulation Test, "... Basophils contain granules which are made of histamine and other chemicals which can elicit symptoms of allergy when they are released or degranulated. A substance to which a person is allergic causes degranulation of the basophils. There are certain substances which will cause anybody's basophils to degranulate. IgE is a special type of antibody which causes the release/degranulation of basophils, and "anti-IgE" is an artificial(man-made) antibody that can have a similar effect as IgE.  1, record 26, English, - basophil%20degranulation

Record 26,  Textual support,  French

Record number: 26, Textual support number: 1 CONT

Les granulocytes basophiles sont impliqués essentiellement dans les phénomènes d'hypersensibilité immédiate, fonction liée aux substances chimiques contenues dans leurs granulations: la dégranulation des basophiles, après intervention d'immunoglobulines E (IgE), se produit par l'intermédiaire de vésicules d'exocytose, et s'accompagne d'une libération d'histamine et autres amines vasopressives responsables de réactions anaphylactiques.  1, record 26, French, - d%C3%A9granulation%20des%20basophiles

Record 26,  Textual support,  Spanish

Record 27,  Textual support,  English

Record number: 27, Textual support number: 1 DEF

A term once proposed to replace the term hormone and recently suggested as a general term for various physiologically active, endogenous substances(histamine, serotonin, angiotensin, prostaglandins, etc.) that do not yet fit into existing functional classifications.  2, record 27, English, - autacoid

Record number: 27, Textual support number: 2 DEF

autacoids : Substances with pronounced pharmacological activity that occur in(or at least are extractable from) tissues, and which do not appear to possess a neurotransmitter or endocrine hormone function in that tissue. Substances classed as autacoids include histamine, serotonin, eicosanoids, kinins, PAF-acether and purine nucleotides.  3, record 27, English, - autacoid

Record 27,  Textual support,  French

Record number: 27, Textual support number: 1 DEF

Substance spécifique formée par un organe et déversée dans la circulation pour produire sur d'autres organes des effets analogues à ceux des médicaments.  1, record 27, French, - autaco%C3%AFde

Record 27,  Textual support,  Spanish

Record 28,  Textual support,  English

Record number: 28, Textual support number: 1 DEF

Histamine originating within the body.(Training Manual Claritin, Schering Canada, 1987, p. 3. 1-5).  1, record 28, English, - endogenous%20histamine

Record 28,  Textual support,  French

Record number: 28, Textual support number: 1 DEF

Histamine qui provient de l'intérieur du corps. (Manuel de formation Claritine, Schering Canada, 1987, page 3.1-5).  1, record 28, French, - histamine%20endog%C3%A8ne

Record 28,  Textual support,  Spanish

Record 29,  Textual support,  English

Record number: 29, Textual support number: 1 OBS

Professor Bast graduated as a pharmacochemist from the Vrije Universiteit Amsterdam. He did his Ph. D. research at the Erasmus University in Rotterdam and the University of Utrecht, where he received his Ph. D. in 1981. In 1985 he joined the Department of Pharmacochemistry at the Vrije Universiteir Amsterdam. Current research interests involve both the role and pharmacological modulation of free radical processes in(patho-) physiology and the molecular pharmacology of histamine.  1, record 29, English, - pharmacochemist

Record 29,  Textual support,  French

Record number: 29, Textual support number: 1 CONT

La nature a offert aux pharmacochimistes quelques-uns des plus grands médicaments. Voilà une trentaine d'années, l'extraordinaire diversité de la faune et de la flore marine a incité les scientifiques à se mettre en quête de nouvelles molécules aux propriétés chimiques inédites [...]  1, record 29, French, - pharmacochimiste

Record 29,  Textual support,  Spanish

Record 30,  Textual support,  English

Record number: 30, Textual support number: 1 OBS

Histamine phosphate in one drop(1 : 1000) is placed on an area of normal skin of the patient and pricked with a needle. If the nerve is intact, there will be a weal and an erythematous flare showing that the nerve is intact.  1, record 30, English, - histamine%20test

Record 30,  Textual support,  French

Record number: 30, Textual support number: 1 DEF

Test qui consiste à piquer la peau à travers une goutte d'une solution à 1% d'histamine, ce qui provoque une vasodilatation intense des capillaires.  1, record 30, French, - test%20%C3%A0%20l%27histamine

Record 30,  Textual support,  Spanish

Record 31,  Textual support,  English

Record number: 31, Textual support number: 1 DEF

The cellular receptor site for histamine responsible for the dilation of blood vessels and the contraction of smooth muscle.  2, record 31, English, - H1%20receptor

Record 31,  Textual support,  French

Record number: 31, Textual support number: 1 DEF

Type de récepteur à l'histamine disséminé dans tout le corps.  1, record 31, French, - r%C3%A9cepteur%20H1

Record 31,  Textual support,  Spanish

Record 32,  Textual support,  English

Record number: 32, Textual support number: 1 DEF

The cellular receptor site for histamine responsible for the stimulation of heart rate and gastric secretion.  2, record 32, English, - H2%20receptor

Record 32,  Textual support,  French

Record number: 32, Textual support number: 1 DEF

Type de récepteur à l'histamine se trouvant dans l'estomac.  1, record 32, French, - r%C3%A9cepteur%20H2

Record 32,  Textual support,  Spanish

Record 33,  Textual support,  English

Record number: 33, Textual support number: 1 CONT

When lung fragments were challenged with high concentrations of 3 smooth muscle contractants(histamine, methacholine, and KCl), PGF2 alpha production was only 5 to 20% of that seen with optimal antigenic challenge of the same tissue.(In AM. REV. RESPIR. DIS.(USA), 1980, 121/6(911-920), cited in EMBASE data base.)  1, record 33, English, - smooth%20muscle%20contractant

Record 33,  Textual support,  French

Record number: 33, Textual support number: 1 OBS

action contracturante : relevé sous le terme «histamine» dans MANUILA, 1970, vol. 2, p. 410.  1, record 33, French, - agent%20ayant%20une%20action%20contracturante%20sur%20les%20muscles%20lisses

Record 33,  Textual support,  Spanish

Record 34,  Textual support,  French

Record 34,  Textual support,  Spanish

Record 35,  Textual support,  English

Record number: 35, Textual support number: 1 CONT

Terfenadine significantly reduced sneezing and the levels of histamine, kinins, TAME-esterase activity, and albumin seen after antigen challenge.  1, record 35, English, - TAME%2Desterase%20activity

Record number: 35, Textual support number: 2 CONT

Tryptase in nasal lavage fluid after local allergen challenge. Relationship to histamine levels and TAME-esterase activity.  2, record 35, English, - TAME%2Desterase%20activity

Record number: 35, Textual support number: 1 OBS

Second context extracted from PASCAL data base.  2, record 35, English, - TAME%2Desterase%20activity

Record 35,  Textual support,  French

Record number: 35, Textual support number: 1 OBS

Équivalent français tiré d'une liste de descripteurs d'un article de la base de données PASCAL.  1, record 35, French, - activit%C3%A9%20est%C3%A9rasique%20TAME

Record 35,  Textual support,  Spanish

Record 36,  Textual support,  French

Record 36,  Textual support,  Spanish

Record 37,  Textual support,  English

Record number: 37, Textual support number: 1 CONT

Primary mediators are released as a direct consequence of the interaction of antigen(allergen) with antibody. Histamine is the most important primary mediator in an allergic reaction. Other primary mediators released from mast cells and basophils include platelet activating factor(PAF), slow-reacting substance of anaphylaxis(LTC-4), and eosinophil chemotactic factor(ECF).  1, record 37, English, - primary%20mediator

Record number: 37, Textual support number: 1 OBS

Training Manual Claritin, Schering Canada, 1987, p. 1.2-13  1, record 37, English, - primary%20mediator

Record 37,  Textual support,  French

Record number: 37, Textual support number: 1 CONT

Le cromoglycate disodique (DSCG) utilisé depuis 1970 environ reste l'agent préventif le plus puissant. Son mode d'action intime n'est pas encore complètement élucidé, mais on sait qu'il agit comme stabilisateur de membrane : il inhibe la dégranulation des mastocytes et empêche de ce fait la libération dans le sang des médiateurs primaires de la réaction allergique (histamine et SRS-A en particulier).  1, record 37, French, - m%C3%A9diateur%20primaire

Record 37,  Textual support,  Spanish

Record 38,  Textual support,  English

Record number: 38, Textual support number: 1 CONT

Equipment for skin-prick testing includes alcohol swabs or tissues for skin preparation, a skin marker pen, appropriate allergen extracts with control solutions of saline and histamine, and skin lances(some operators prefer to use 25G needles).... A lance is introduced through the drop to a depth of about 1 mm into the skin, and pulled out, raising the skin in the process.  1, record 38, English, - skin%20lance

Record 38,  Textual support,  French

Record number: 38, Textual support number: 1 CONT

Le matériel utilisé pour le Prick-test cutané se compose de : cotons ou compresses alcoolisés pour la préparation cutanée, un stylo marqueur pour la peau, les extraits allergéniques appropriés plus du sérum physiologique et une solution d'histamine comme témoins et enfin des microlances dermatologiques (certains praticiens préfèrent employer des aiguilles 265G). [...] on marque les points de ponction puis on dépose une petite goutte de chaque solution allergénique au niveau des repères. On introduit ensuite une microlance dans la peau, à travers la gouttelette, jusqu'à une profondeur d'environ 1 mm, puis on la retire en soulevant la peau, sans jamais provoquer de saignement.  1, record 38, French, - microlance%20dermatologique

Record 38,  Textual support,  Spanish

Record 39,  Textual support,  English

Record number: 39, Textual support number: 1 CONT

This test indirectly determines specific IgE by measuring the histamine release from basophils challenged with allergens. As basophils and mast cells are fixed by IgE, allergens that react with specific IgE will crosslink two molecules of membrane-bound IgE and initiate mediator release from basophils or mast cells. Histamine is one of the mediators; hence by measuring the amount of histamine released, one has the overall assessment of the IgE-mediated mechanism, that is, quantity of histamine released correlates with the amount of membrane-bound specific IgE and the functioning properties of the basophils.  1, record 39, English, - leukocyte%20histamine%20release

Record 39,  Textual support,  French

Record number: 39, Textual support number: 1 DEF

Méthode de diagnostic allergologique qui consiste à mettre l'allergène en contact avec des basophiles supposés sensibilisés afin de vérifier s'ils vont libérer de l'histamine, ce qui argumenterait la responsabilité de cet allergène.  1, record 39, French, - test%20d%27histamino%2Dlib%C3%A9ration

Record 39,  Textual support,  Spanish

Record 40,  Textual support,  English

Record number: 40, Textual support number: 1 CONT

In each area involved in allergic responses, there is a late-phase allergic response involving successive waves of infiltrating polymorphonuclear leukocytes and mononuclear cells. These late-phase reactions are caused by mast cell mediators; they may induce recrudescence of mast cell histamine release because of factors generated from infiltrating cells; and they are thought to play an important part in allergic symptomatology.... Late-phase allergic reactions : symptoms elicited : congestion, nasal hyperirritability...  1, record 40, English, - late%2Dphase%20allergic%20reaction

Record number: 40, Textual support number: 1 OBS

second phase of the immediate allergic reaction: (J. Bousquet et al. in M. Kaliner (ed.), op. cit., p. 21).  2, record 40, English, - late%2Dphase%20allergic%20reaction

Record 40,  Textual support,  French

Record number: 40, Textual support number: 1 CONT

Phase tardive de la réponse à IgE. On a [...] montré que la phase immédiate de la réponse à IgE pouvait être suivie de manifestations inflammatoires locales débutant à la 6e - 12e heure et se prolongeant plusieurs heures. L'histologie cutanée montre à ce stade de l'oedème et l'infiltration du derme par différentes cellules, notamment polynucléaires neutrophiles, éosinophiles, basophiles, mais aussi cellules mononucléées; [...]. Au niveau bronchique, cette réponse tardive se traduit par une obstruction. La réponse tardive n'apparaît qu'à la suite de la dégranulation des mastocytes.  1, record 40, French, - phase%20tardive%20de%20la%20r%C3%A9ponse%20%C3%A0%20IgE

Record 40,  Textual support,  Spanish

Record 41,  Textual support,  English

Record number: 41, Textual support number: 1 CONT

Cross-linking of IgE receptors(under physiological conditions by antigen, under experimental conditions by antibodies to IgE, by antibodies to receptor, or by IgE aggregates) is required for receptor redistribution and for internalization of receptor. When receptor-bound IgE molecules bind to multivalent antigen they become indirectly cross-linked, they initiate histamine release from the cell, and the IgE molecules together with their receptors and their bound antigen are internalized... A number of biochemical events have been studied that occur immediately after the apposition(or "cross-linking") of adjacent IgE receptors.  1, record 41, English, - cross%2Dlinking

Record 41,  Textual support,  French

Record number: 41, Textual support number: 1 CONT

La formation de «patches» correspond à une agrégation passive des Ig de surface, probablement induite par la formation de réseaux d'Ig («cross-linking»), par les anticorps anti-Ig divalents (les anticorps monovalents ne donnant pas ce phénomène). Elle a lieu à 4°C. [...] Transduction du signal induit par la réticulation («cross-linking») des Ig de membrane.  2, record 41, French, - pontage

Record number: 41, Textual support number: 2 CONT

Plusieurs conditions doivent être réunies pour que la cellule B soit activée : la réticulation (ou pontage) des Ig de surface [...]  3, record 41, French, - pontage

Record 41,  Textual support,  Spanish

Record 42,  Textual support,  English

Record number: 42, Textual support number: 1 DEF

A rapidly occurring(within 30 min) antibody-mediated reaction arising from the release of histamine and other vasoactive substances. The antibody(an immunoglobulin, usually of IgE type) fixes to cells, especially mast cells. On contact with antigen, the cell is disrupted and vasoactive substances are released and produce anaphylaxis.  2, record 42, English, - immediate%20hypersensitivity%20reaction

Record 42,  Textual support,  French

Record number: 42, Textual support number: 1 CONT

Classification des réactions allergiques selon le délai d'apparition [...] deux catégories : 1) les réactions d'hypersensibilité de type immédiat qui surviennent très rapidement après le contact avec l'allergène. L'anaphylaxie cutanée survient en quelques minutes. La réaction d'Arthus, [...] atteint son maximum en 3 à 6 heures après le contact avec l'allergène [...]; 2) les réactions d'hypersensibilité du type retardé [...]  1, record 42, French, - r%C3%A9action%20d%27hypersensibilit%C3%A9%20du%20type%20imm%C3%A9diat

Record 42,  Textual support,  Spanish

Record 43,  Textual support,  English

Record 43,  Textual support,  French

Record number: 43, Textual support number: 1 CONT

[...] facteur stimulant la synthèse d'histamine ou HCSF, lymphokine produite au cours des réactions allogéniques [...]  1, record 43, French, - facteur%20stimulant%20la%20synth%C3%A8se%20d%27histamine

Record number: 43, Textual support number: 1 OBS

L'identité de l'interleukine 3 et de l'HCSF est suspectée mais non démontrée.  1, record 43, French, - facteur%20stimulant%20la%20synth%C3%A8se%20d%27histamine

Record 43,  Textual support,  Spanish

Record 44,  Textual support,  English

Record number: 44, Textual support number: 1 DEF

... a competitive inhibitor of histamine H2-receptors.  1, record 44, English, - Pepcid

Record 44,  Textual support,  French

Record number: 44, Textual support number: 1 OBS

Antagoniste des récepteurs histaminiques H2.  1, record 44, French, - Pepcid

Record 44,  Textual support,  Spanish

Record 45,  Textual support,  English

Record number: 45, Textual support number: 1 CONT

[Cimetidine] competitively inhibits the action of histamine at the histamine H2 receptors of the parietal cells and, thus, represents a new class of pharmacological agent, the histamine H2-receptor antagonist.  2, record 45, English, - histamine%20H2%2Dreceptor%20antagonist

Record 45,  Textual support,  French

Record number: 45, Textual support number: 1 CONT

Tagamet (...). Cimétidine. Antagoniste du récepteur H2 de l'histamine (...) : La cimétidine inhibe de façon compétitive l'action de l'histamine au niveau des récepteurs H2 des cellules pariétales de l'estomac.  1, record 45, French, - inhibiteur%20du%20r%C3%A9cepteur%20H2%20de%20l%27histamine

Record 45,  Textual support,  Spanish

Record 46,  Textual support,  French

Record 46,  Textual support,  Spanish