TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Research is on hairpin catalytic RNA, a catalytic RNA discovered and characterized here in my laboratory at Northern Illinois University. Hairpin catalytic RNA is a molecule which can be engineered to very efficiently cleave target RNA sequences in a unique and efficient reaction. The catalytic RNA can thus be used for the specific down regulation of gene expression since it can be designed to destroy mRNA. Current applications being developed are down regulation of selected genes, including those in the virus HIV-1. Thus it has potential as an AIDS therapeutic.  1, record 1, English, - catalytic%20RNA

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Macromolécule biologique d'acide ribonucléique susceptible d'agir comme une enzyme et de catalyser des réactions chimiques.  1, record 1, French, - ARN%20catalytique

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Molécula de ARN [ácido ribonucleico] que puede catalizar la ruptura química de sí misma o de otras moléculas de ARN.  1, record 1, Spanish, - ARN%20catal%C3%ADtico

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

A real difference in pathogenicity between HIV-1 and HIV-2 could be significant, and it would be important to determine its molecular basis. The two viruses infect the same populations of cells, binding the same CD4 receptor, but there are some differences in their genetic material and therefore in proteins. One of the most obvious is the presence in HIV-1 of the vpu gene, which is absent in HIV-(and in SIV, for that matter). Perhaps the product of this gene, a small 16-kilodalton peptide, enpathogenicity. Similarly, HIV-2 and SIV contain the vpx gene; HIV-1 does not. If this gene's 12-kilodalton product somehow slows the proliferation or spread of the virus or reduces its ability cells, that too could help to explain why HIV-2 and SIV appear to be less regularly pathogenic than HIV-1.  1, record 2, English, - vpx%20gene

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

L'organisation du génome du HIV est plus complexe que celle des autres rétrovirus. En plus des gènes dits de structure, gag, pol et env, qui produisent les constituants de la particule virale, on trouve plusieurs gènes, plus petits situés entre les gènes pol et env. Cette région comporte le gène vif, qui est le plus grand de cette partie du génome, le gène vpr, et le gène vpx chez HIV-2 et SIV, les premiers segments des gènes encodant les protéines régulatrices Tat et Rev ainsi que dans certains isolats, le gène vpu. Un autre gène unique au virus du groupe HIV, nef, est situé dans la partie terminale du génome, après le gène env chevauchant le LTR de droite.  2, record 2, French, - g%C3%A8ne%20vpx

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 OBS

Term(s) taken from a Canadian laboratory-equipment company’s catalogue.  1, record 3, English, - HIV%2D1

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 OBS

Terme(s) tiré(s) du catalogue d'une compagnie canadienne d'équipement de laboratoire.  1, record 3, French, - VIH%2D1

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 OBS

Virus de la inmunodeficiencia humana que se presenta preponderantemente en América y Europa.  1, record 3, Spanish, - VIH%2D1

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

A real difference in pathogenicity between HIV-1 and HIV-2 could be significant, and it would be important to determine its molecular basis. The two viruses infect the same populations of cells, binding the same CD4 receptor, but there are some differences in their genetic material and therefore in proteins. One of the most obvious is the presence in HIV-1 of the vpu gene, which is absent in HIV-(and in SIV, for that matter).  1, record 4, English, - vpu%20gene

Record number: 4, Textual support number: 1 OBS

Upr stands for viral protein U.  2, record 4, English, - vpu%20gene

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

Le V.I.H.-1 présente des gènes régulateurs. Très récemment, deux nouveaux gènes ont été individualisés, les gènes vpr et vpu qui sont activés au cours de l'infection.  2, record 4, French, - g%C3%A8ne%20vpu

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

HIV-1 and macaque simian immunodeficiency virus(SIV_MAC) exhibit clearly distinct tropism for primate cells even if entry blocks are overcome by pseudotyping.  3, record 5, English, - macaque%20simian%20immunodeficiency%20virus

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

[...] il n'existe pas de modèle animal utilisant un virus humain et conduisant à une maladie de façon reproductible; l'infection du chimpanzé par le VIH-1 n'entraîne pas d'immunodéficience clinique ou biologique, et le seul modèle de maladie dont on dispose est l'infection du macaque par le virus de l'immunodéficience simienne (SIVmac).  2, record 5, French, - virus%20de%20l%27immunod%C3%A9ficience%20simienne%20du%20macaque

Record number: 5, Textual support number: 1 OBS

SIVmac : SIV_mac.  3, record 5, French, - virus%20de%20l%27immunod%C3%A9ficience%20simienne%20du%20macaque

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

The interaction of the HIV-1 Rev protein with its target, the Rev responsive element(RRE). The Rev regulatory protein of HIV Rev is modular protein with a N-terminal RNA binding motif and near C-terminal activation domain.  1, record 6, English, - Rev%20Responsive%20Element

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Chaque étape du cycle viral peut constituer une cible d'intervention antivirale. Les agent antiviraux en évaluation dans le monde sont: CD4 soluble, anticorps anti-Env intracellulaires ou secrétés, ribozymes, anticorps intracellulaires antiscriptase inverse (anti-RTase) IFN, leurres de séquence TAR, cible de TAT, inhibiteurs transdominants de TAT, leurres de la séquence RRE de réponse à REV, ARN antisens, inhibiteurs transdominants GAG, CD4 intracellulaires, anticorps anti-ENV "suicide-induit".  1, record 6, French, - s%C3%A9quence%20REE

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

The activity of the HIV-1 regulatory protein, Rev. depends on its binding to the Rev Responsive Element(RRE), located within viral mRNAs encoding key structural and regulatory proteins.... The Rev system's essential nature and treshold characteristics make it attractive target for a genetic anti-viral strategy.... To pursue this strategy, we have constructed AAV as in different combinations. These include anti-Rev single chain antibodies(anti-Rev SFV), an optimized RRE decoy, and RRE antisense oligonucleotide gene cassettes.  1, record 7, English, - decoy

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

Chaque étape du cycle viral peut constituer une cible d'intervention antivirale. Les agents antiviraux en évaluation dans le monde sont : CD4 soluble, anticorps anti-Env intracellulaires ou secrétés, ribozymes, anticorps intracellulaires antiscriptase inverse (anti-RTase) IFN, leurres de séquence TAR, cible de TAT, inhibiteurs transdominants de TAT, leurres de la séquence RRE de réponse à REV, ARN antisens, inhibiteurs transdominants GAG, CD4 intracellulaires, anticorps anti-ENV "suicide-induit".  1, record 7, French, - leurre

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

The glycoside of this herb [huang qin], baicalin, is a potent anti-inflammatory and antitumor agent. It inhibits tumor cell growth and suppresses carcinoma cell proliferation by inducing apoptosis and arresting it at the G0/G1 phase.  2, record 8, English, - baicalin

Record number: 8, Textual support number: 1 OBS

Baicalin inhhibits HIV-1 infection and replication by inhibiting HIV-1 RT.  3, record 8, English, - baicalin

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

[...] la baicaline (un flavonoïde utilisé par la médecine traditionnelle chinoise pour traiter l'allergie et l'inflammation) a été donnée par voie orale à des cochons d'Inde. Après le traitement par le flavonoïde, l'asthme a été chimiquement induit. Chez les animaux pré-traités avec le flavonoïde, les symptômes étaient beaucoup plus atténués que chez ceux qui ne l'avaient pas été.  2, record 8, French, - baicaline

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Two diterpenoid compounds, agastanol(1) and agastaquinone(2), were isolated from the roots of Agastache rugosa(Labiatae). Compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1(HIV-1) protease activity with IC50 values of 360 and 87 microM, respectively.  2, record 9, English, - agastaquinone

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 OBS

L'agastaquinone est un diterpénoïde qui a une activité inhibitrice de l'activité de la protéase du virus d'immunodéficience humaine de type 1 (HIV-1).  1, record 9, French, - agastaquinone

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

Two diterpenoid compounds, agastanol(1) and agastaquinone(2), were isolated from the roots of Agastache rugosa(Labiatae). Compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1(HIV-1) protease activity with IC50 values of 360 and 87 microM, respectively.  2, record 10, English, - agastanol

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 OBS

L'agastanol est un diterpénoïde qui a une activité inhibitrice de l'activité de la protéase du virus d'immunodéficience humaine de type 1 (HIV-1).  1, record 10, French, - agastanol

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

Injecting equipment includes needles, syringes, spoons and cookers, and washouts.  1, record 11, English, - washout

Record number: 11, Textual support number: 2 CONT

... attempted to replicate a real-world injection drug use situation. They used syringes containing... HIV-1 infected blood, rinsed them quickly(taking only the time to draw in and immediately expel rinse liquid) with water, diluted bleach(1 : 10) and/or undiluted bleach and then tested them for viable HIV-1.  2, record 11, English, - washout

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Pratiques à risque intermédiaire, mais non négligeable : utilisation du reste du matériel d'injection déjà utilisé (récipient, cuillère, liquide de rinçage ou de dilution, filtre ou coton).  2, record 11, French, - liquide%20de%20rin%C3%A7age

Record number: 11, Textual support number: 2 CONT

[...] et ses collaborateurs ont tenté de reproduire un cas réel d'injection de drogue. Ils ont utilisé des seringues contenant [...] de sang contaminé par le VIH-1; ils les ont rincées (juste le temps d'introduire le liquide de rinçage et de l'expulser aussitôt) à l'eau, à l'eau de Javel diluée (1:10) et/ou à l'eau de Javel non diluée.  3, record 11, French, - liquide%20de%20rin%C3%A7age

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition.  1, record 12, English, - human%20T%2Dlymphotropic%20virus%20type%20IV

Record number: 12, Textual support number: 1 OBS

It shares serologic reactivity and sequence homology with simian Lentivirus SIV and infects on T4-lymphocytes expressing the CD4 phenotypic marker.  1, record 12, English, - human%20T%2Dlymphotropic%20virus%20type%20IV

Record 12,  Textual support,  French

Record 12,  Textual support,  Spanish

Record number: 12, Textual support number: 1 OBS

HTLV por sus siglas en inglés Human T-Cell Lymphotropic Virus - IV.  1, record 12, Spanish, - virus%20linfotr%C3%B3pico%20humano%20tipo%20cuatro

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 DEF

A 96-amino acid(14 kd) protein, which is incorporated into the virion. It interacts with the p6gag part of the Pr55gag precursor. Vpr detected in the cell is localized to the nucleus. Proposed functions for Vpr include the nuclear import of preintegration complexes, cell growth arrest, transactivation of cellular genes, and induction of cellular differentiation. Found in HIV-1, HIV-2, SIVmac and SIVmnd. It is homologous to VPX of SIVagm.  2, record 13, English, - viral%20protein%20u

Record number: 13, Textual support number: 1 OBS

Glossary in molecular biology (Portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  3, record 13, English, - viral%20protein%20u

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 DEF

Une des protéines du rétrovirus HIV-1 qui participe avec la protéine Vif à la maturation du virus.  2, record 13, French, - prot%C3%A9ine%20virale%20u

Record 13,  Textual support,  Spanish

Record number: 13, Textual support number: 1 OBS

Uno de los tres genes auxiliares del VIH [virus de la inmunodeficiencia humana].  1, record 13, Spanish, - vpu

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 CONT

HIV-1 is an RNA-containing retrovirus that codes for a DNA intermediary that can integrate into the host genome and persist for the life of the cell.  2, record 14, English, - retrovirus

Record number: 14, Textual support number: 1 OBS

A second human retrovirus, genetically distinct from HTLV-I, termed HTLV-II, has been isolated from several patients with a syndrome resembling hairy cell leukemia.  2, record 14, English, - retrovirus

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 CONT

HIV ou VIH, virus appartenant à la famille des rétrovirus, de la sous-famille des lentivirus. [...] Les rétrovirus ont pour caractéristique de transcrire l'ARN de leur génome en ADN [...] en ayant recours à une enzyme présente dans leur noyau, la transcriptase inverse.  2, record 14, French, - r%C3%A9trovirus

Record 14,  Textual support,  Spanish

Record number: 14, Textual support number: 1 DEF

Virus de la familia Retroviridae cuyo genoma está constituido por ARN monocatenario que contiene cuatro genes.  2, record 14, Spanish, - retrovirus

Record number: 14, Textual support number: 1 OBS

Este virus posee la cualidad de transformar su ARN en ADN para de esta manera transmitir su código genético a la célula infectada y lograr así que cuando la célula intente reproducirse, en realidad produzca retrovirus. En la naturaleza lo común es ver como el ADN se transforma en ARN, pero no al contrario, por eso este tipo de virus, por la cualidad de realizar este proceso al revés, se llama retrovirus. El proceso de transcripción genética lo efectúa una enzima viral llamada transcriptasa inversa.  3, record 14, Spanish, - retrovirus

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 DEF

The spectrum of immunodeficiency and disease associated with HIV infection.  3, record 15, English, - HIV%20infection

Record number: 15, Textual support number: 1 OBS

Characterized by a gradual deterioration of immune function. During the course of infection, crucial immune cells called CD4+ T cells are disabled and killed, and their numbers progressively decline. CD4+ T cells play a crucial role in the immune response, signaling other cells in the immune system to perform their special functions.  4, record 15, English, - HIV%20infection

Record number: 15, Textual support number: 2 OBS

The term AIDS is used to indicate only the most severe diseases or clinical conditions(i. e., infections, neoplasm) observed in the continuum of illness related to infection with the retrovirus human immunodeficiency virus type 1(HIV-1). Infection with HIV and AIDS are not synonymous terms.  5, record 15, English, - HIV%20infection

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 OBS

Classification des infections à V.I.H. Les conséquences de l'infection par le V.I.H. ne se limitent pas à la forme majeure de cette infection : le S.I.D.A. Par le passé, des formes intermédiaires ont été décrites dénommées par des termes imparfaits de pré-S.I.D.A. ou de para-S.I.D.A.; celui qui s'est imposé le plus longtemps est celui d'A.R.C. (A.I.D.S. related complex).  1, record 15, French, - infection%20%C3%A0%20VIH

Record number: 15, Textual support number: 1 CONT

personne susceptible de contracter l'infection au VIH  2, record 15, French, - infection%20%C3%A0%20VIH

Record 15,  Textual support,  Spanish

Record number: 15, Textual support number: 1 OBS

La infección comienza cuando el virus encuentra a una célula CD4; entonces la glucoproteína 120 (Gp120) de la superficie del VIH se une estrechamente al receptor CD4 en la superficie de la célula; las membranas del virus y la célula se fusionan con la intervención de otra glucoproteína de la superficie del virus, llamada Gp41, para que las proteínas, enzimas y el corazón viral que contiene el RNA del VIH, sean introducidas en la célula ahora infectada.  1, record 15, Spanish, - infecci%C3%B3n%20por%20VIH

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 CONT

Abnormalities in numbers of CD4+ and CD8+ T-cell subsets and the helper/suppressor ratio(CD4/CD8) were used very early in the AIDS epidemic to help define persons affected with AIDS before a screening test for HIV-1 was available. A low number of CD4+ lymphocytes alone or in combination with a decreased CD4 : CD8 ratio and total lymphocyte count can be useful as a predictor of HIV-1 seropositivity and progression of disease.  1, record 16, English, - helper%2Fsuppressor%20ratio

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 CONT

Les CD4 ou T4 sont une sorte de globules blancs, des lymphocytes qui jouent un rôle capital dans le déclenchement d'une réaction immunitaire (de défense du corps) face à un "envahisseur". Ils sont aussi la cible privilégiée des VIH. [...] On utilise parfois [...] comme indicateur le rapport CD4/CD8, ces derniers étant les éléments qui assurent la clôture d'une réaction immunitaire.  1, record 16, French, - rapport%20CD4%2FCD8

Record 16,  Textual support,  Spanish

Record number: 16, Textual support number: 1 DEF

Correspondencia cuantitativa que se establece entre las células CD4 cooperadoras y las CD8 supresoras.  1, record 16, Spanish, - relaci%C3%B3n%20CD4%2FCD8

Record number: 16, Textual support number: 1 OBS

En condiciones normales, [la relación CD4/CD8] debe ser por arriba de uno, aproximadamente 2:1. En la mayoría de los casos de VIH, esta relación se encuentra invertida y es menor de uno.  1, record 16, Spanish, - relaci%C3%B3n%20CD4%2FCD8

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 DEF

A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.  1, record 17, English, - delavirdine

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 CONT

Rescriptor(R) (délavirdine) est un [anti-VIH] inhibiteur non nucléosidique de la transcriptase inverse ou plus simplement non nucléosidique.  1, record 17, French, - d%C3%A9lavirdine

Record 17,  Textual support,  Spanish

Record number: 17, Textual support number: 1 DEF

Antirretroviral, inhibidor de la transcriptasa inversa no nucleósido análogo.  1, record 17, Spanish, - delavidine

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 CONT

There are two types of HIV :HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. HIV-2, seen more often in western Africa, has a slower course than HIV-1. There are many strains of both types and the virus mutates rapidly, a trait that has made it especially difficult for researchers to find an effective treatment or vaccine.  1, record 18, English, - VIH%2D2

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 CONT

En 1985, a été découverte une seconde forme de virus [VIH1], le VIH2 présente surtout en Afrique Orientale.  1, record 18, French, - VIH2

Record 18,  Textual support,  Spanish

Record 19,  Textual support,  English

Record number: 19, Textual support number: 1 CONT

The mature MA protein remains associated with the inner side of the lipid envelope. In addition, MA plays a role in the transport of the preintegration complex to the nucleus. A nuclear localization signal(NLS) has been proposed within the MA protein, located between residues 14-36 and 107-116 of the HIV-1 p17MA protein.  3, record 19, English, - nuclear%20localization%20signal

Record 19,  Textual support,  French

Record number: 19, Textual support number: 1 CONT

L'une des bases moléculaires du transport nucléaire réside dans l'existence d'une signalétique particulière. De courts signaux peptidiques présents au sein des molécules à transporter sont reconnus par des récepteurs spécifiques et déterminent ainsi la nature de la molécule et sa destination finale au travers de la membrane nucléaire. Le signal de localisation nucléaire NLS (nuclear localization signal) est le mieux caractérisé. Composé d'acides aminés basiques, il permet aux protéines qui le possèdent d'être importées dans le noyau cellulaire.  1, record 19, French, - signal%20de%20localisation%20nucl%C3%A9aire

Record 19,  Textual support,  Spanish

Record 20,  Textual support,  English

Record number: 20, Textual support number: 1 DEF

A potential antiviral shown to work in both T-cells and macrophages infected with HIV-1 which does not affect HIV-2 or other viruses.  1, record 20, English, - hydroxyethethoxy%20methyl%20phenylthiothymine

Record number: 20, Textual support number: 1 OBS

It did not affect HIV-2 or other viruses.  1, record 20, English, - hydroxyethethoxy%20methyl%20phenylthiothymine

Record 20,  Textual support,  French

Record number: 20, Textual support number: 1 CONT

Un autre type de composés bloquant la transcriptase reverse a été découvert en 1990 par la firme Janssen qui criblait «à l'aveugle» des anti-HIV : il s'agit de dérivés des benzodiazépines. Ces composés (TIBO et apparentés, HEPT, PMEA, BI-RG 578), lointains cousins des tranquillisants sont très actifs in vitro.  1, record 20, French, - HEPT

Record 20,  Textual support,  Spanish

Record 21,  Textual support,  English

Record number: 21, Textual support number: 1 CONT

Nuclease footprinting has been used to probe features of binary complexes of type 1 human immunodeficiency virus reverse transcriptase(HIV-1 RT) with both natural and synthetic preparations of its cognate replication primer, tRNA(Lys-3). In addition to heterodimeric RT(p66/p51), ribonucleoprotein complexes containing either the p66 or p51 subunit were analyzed. Footprinting experiments employed both structure-and sequence-specific nucleases.  2, record 21, English, - nuclease%20footprinting

Record 21,  Textual support,  French

Record number: 21, Textual support number: 1 OBS

Visualisation d'une région de l'ADN spécifiquement liée à une protéine qui la protège contre l'action d'une nucléase.  1, record 21, French, - empreinte%20de%20la%20nucl%C3%A9ase

Record 21,  Textual support,  Spanish

Record 22,  Textual support,  English

Record number: 22, Textual support number: 1 CONT

7-chloro-5-(2-pyrryl)-3H-1, 4 benzodiazapin-2-(H)-one)(Ro 5-3335) and(7-chloro-5-(1H-pyrrol-2-yl)-3H-ben zo(e)(1, 4) diazepin-2-yl)-methylamine(Ro 24-7429), inhibit human immunodeficiency virus type 1(HIV-1) replication via a specific effect on the function of the transactivator protein, Tat.  1, record 22, English, - Ro%2024%2D7429

Record 22,  Textual support,  French

Record number: 22, Textual support number: 1 CONT

Hoffman-La Roche dispose d'ores et déjà d'un inhibiteur de Tat efficace in vitro, qui montre une faible toxicité, et une synergie d'action avec l'AZT. Ce composé, le RO 24-7429, est une benzodiazépine.  1, record 22, French, - RO%2024%2D7429

Record 22,  Textual support,  Spanish

Record 23,  Textual support,  English

Record number: 23, Textual support number: 1 CONT

7-chloro-5-(2-pyrryl)-3H-1, 4 benzodiazapin-2-(H)-one)(Ro 5-3335) and(7-chloro-5-(1H-pyrrol-2-yl)-3H-ben zo(e)(1, 4) diazepin-2-yl)-methylamine(Ro 24-7429), inhibit human immunodeficiency virus type 1(HIV-1) replication via a specific effect on the function of the transactivator protein, Tat.  1, record 23, English, - Ro%205%2D3335

Record 23,  Textual support,  French

Record number: 23, Textual support number: 1 CONT

Hoffman-La Roche dispose d'ores et déjà d'un inhibiteur de Tat efficace in vitro, qui montre une faible toxicité, et une synergie d'action avec l'AZT. Ce composé, le RO 24-7429, est une benzodiazépine. Une deuxième molécule, le RO 5-3335, est à l'étude.  1, record 23, French, - RO%205%2D3335

Record 23,  Textual support,  Spanish

Record 24,  Textual support,  English

Record number: 24, Textual support number: 1 DEF

A 96-amino acid(14 kd) protein, which is incorporated into the virion. It interacts with the p6gag part of the Pr55gag precursor. the Vpr detected in the cell is localized to the nucleus. Proposed funtions for Vpr include the nuclear import of preintegration complexes, cell growth arrest, transactivation of cellular genes, and induction of cellular differentiation. Found in HIV-1, HIV-2, SIVmac and SIVmnd, It is homologous to VPX of SIVmgm.  2, record 24, English, - virus%2Dencoded%20protein

Record number: 24, Textual support number: 1 OBS

Glossary of molecular biology (portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  3, record 24, English, - virus%2Dencoded%20protein

Record 24,  Textual support,  French

Record number: 24, Textual support number: 1 CONT

Le processus de transcription inverse commence pendant l'encapsidation de l'ARN. Il n'est pas initié par un ARN de transfert, comme chez les rétrovirus, mais par une protéine virale qui n'est autre que la polymérase.  3, record 24, French, - prot%C3%A9ine%20virale

Record number: 24, Textual support number: 1 OBS

Équivalents français approuvés par l'Unité de recherche en vaccinologie, Laboratoire et Service d'infectiologie, Centre hospitalier de l'université Laval (CHUL), Québec.  4, record 24, French, - prot%C3%A9ine%20virale

Record 24,  Textual support,  Spanish

Record 25,  Textual support,  English

Record number: 25, Textual support number: 1 CONT

TEV,(also named tnv), tripartite 28 kD viral phosphoprotein produced by some HIV-1 strains. Found primarily in the nucleolus/nucleus. Tev contains the first exon of Tat, a small part of Env and the second exon of Rev. It exhibits both Tat and Rev functions and can functionally replace both essential regulatory proteins of HIV-1. It is produced very early in infection.  1, record 25, English, - TEV

Record 25,  Textual support,  French

Record 25,  Textual support,  Spanish

Record 26,  Textual support,  English

Record number: 26, Textual support number: 1 DEF

Sequence postulated to inhibit structural protein expression in the absence of Rev. One such site was mapped within the pol region of HIV-1. The exact function has not been defined; splice sites have been postulated to act as CRS sequences.  1, record 26, English, - cis%2Dacting%20repressing%20sequence

Record number: 26, Textual support number: 1 OBS

Glossary in molecular biology (Portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  1, record 26, English, - cis%2Dacting%20repressing%20sequence

Record 26,  Textual support,  French

Record 26,  Textual support,  Spanish

Record 27,  Textual support,  English

Record number: 27, Textual support number: 1 DEF

Sequence found within the structural genes of HIV-1 and of other complex retroviruses. Multiple INS elements exist within the genome and can act independently; one of the best characterized elements spans nucleotides 414 to 631 in the gag region of HIV-1. The INS elements have been defined by functional assays as elements that inhibit expression posttranscriptionally. Mutation of the RNA elements was shown to lead to INS inactivation and up regulation of gene expression.  1, record 27, English, - inhibitory%20RNA%20sequence

Record number: 27, Textual support number: 1 OBS

In plural in the text.  2, record 27, English, - inhibitory%20RNA%20sequence

Record number: 27, Textual support number: 2 OBS

Glossary in molecular biology (Portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  2, record 27, English, - inhibitory%20RNA%20sequence

Record 27,  Textual support,  French

Record 27,  Textual support,  Spanish

Record 28,  Textual support,  English

Record number: 28, Textual support number: 1 CONT

The silent period that follows infection by the human immunodeficiency virus(HIV-1) and precedes seroconversion remains a problem for the screening of blood supply, and knowledge about the mechanism involved in the maintenance of latency is only fragmentary. Using purified nef recombinant protein and six synthetic nef peptides, antibodies to the product of an HIV-1 regulatory gene, the negative regulatory factor(nef) involved in maintenance of proviral latency, were detected by Western blot and radioimmunoassay techniques in HIV-1-seronegative, viral antigen-negative, and virus culture-negative individuals at risk for HIV infection.  2, record 28, English, - negative%2Dregulatory%20factor

Record number: 28, Textual support number: 1 OBS

Tiré de la base de donnée: Index Medicus.  2, record 28, English, - negative%2Dregulatory%20factor

Record 28,  Textual support,  French

Record number: 28, Textual support number: 1 CONT

Le virus de l'immunodéficience humaine (HIV) présente une organisation génomique complexe, avec l'identification à ce jour de dix gènes codant pour des protéines structurales et régulatrices de l'expression génique virale. Parmi les protéines de régulation, Nef ou negative-regulatory factor (précédemment nommée 3'orf, orf-B, E' ou F) ne semble pas indispensable à la réplication et aux effets cytopathogènes du HIV.  1, record 28, French, - prot%C3%A9ine%20de%20r%C3%A9gulation%20NEF

Record 28,  Textual support,  Spanish