TERMIUM Plus^®

Record 1,  Textual support,  English

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A collection of computer files containing the operational data of an organization.  3, record 1, English, - database

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In the absence of a suitable crystal structure, computer methods must predict protein conformation from sequence. The most powerful approaches for structure prediction are based on sequence homology or a more general analogy with known crystal structures. Improvements in these methods will require access to data bases containing the basic motifs of protein architecture... The database will also enable us to extract and store tertiary motifs... These motifs can then be slotted into a model-building study when, for example, predicting the conformation of an homologous protein.  2, record 1, English, - database

Record number: 1, Textual support number: 1 OBS

The system includes not only the stored information but also the data sublanguage (DSL), a group of subroutines used to retrieve, update, insert, and delete information; and the administrator, the person responsible for the integrity of the data and programs.  3, record 1, English, - database

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Ensemble de données automatisées, renvoyant à des unités documentaires primaires.  1, record 1, French, - base%20de%20donn%C3%A9es

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L'ensemble des banques de données (séquences d'acides nucléiques, protéines, bibliographiques) actuellement en cours de développement est absolument hors de portée de microsystèmes distribués dans les laboratoires de recherche où la compétence informatique est généralement absente. [...] Des efforts importants sont en cours pour optimiser la structure des bases de données et rendre leur interrogation plus aisée et plus performante à terme.  2, record 1, French, - base%20de%20donn%C3%A9es

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Compilación ordenada de información, usualmente contenida en un sistema de computación.  2, record 1, Spanish, - base%20de%20datos

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

... Protein [that] is a central component of the bacterial system [and] mediates recombinational DNA repair and homologous genetic recombination.  1, record 2, English, - recA%20protein

Record number: 2, Textual support number: 1 CONT

Genomic DNA is maintained with high fidelity to guarantee the integrity of genetic information. Damaged DNA must be properly repaired by sophisticated DNA repair systems to sustain cell viability and genomic stability. Homologous recombination is the major pathway for repairing DNA double strand breaks and for re-initiating stalled replication forks in E. coli and eukaryotes. In E. coli, there are several important proteins involved in homologous recombination : RecA protein is essential for pairing homologous DNA, and for promoting the strand exchange process.  2, record 2, English, - recA%20protein

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

La protéine recA, expression du gène du même nom, joue un rôle essentiel dans le processus de recombinaison homologue, qui permet la réparation de l’ADN chez Escherichia coli. La protéine recA a pour effet de dissocier les deux brins d’un ADN normal pour permettre l’excision d’une séquence destinée à complèter une brèche d’un ADN dont les deux brins sont lésés irréversiblement. Ainsi au cours de la réplication si un des deux ADN produits est anormal et ne contient plus d’information, l’autre ADN, dissocié par recA, détachera un de ses brins pour le recombiner avec l’autre ADN : de sorte qu’il y aura de chaque côté un brin porteur de l’information et que les enzymes de réparation pourront complèter les deux doubles hélices avec la même information.  1, record 2, French, - prot%C3%A9ine%20recA

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Proteína que contienen la mayoría de las bacterias, esencial para la reparación y la recombinación del ADN.  1, record 2, Spanish, - prote%C3%ADna%20recA

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Dr. Robson's laboratory is studying some of the important house-keeping genes of P. falciparum which cause severe malaria in man. Her team has recently isolated and sequenced the parasite's calmodulin gene; discovered a new gene encoding a protein called thrombospondin-related anonymous protein which has many sequence motifs of particular interest, particularly those homologous to human properdin and thrombospondin; and has defined a family of ATPase-like genes in P. falciparum.  3, record 3, English, - thrombospondin%20related%20anonymous%20protein

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

[...] les LTC (lymphocytes T cytotoxiques) pourraient intervenir dans la résistance au paludisme en détruisant les cellules infectées avant que les manifestations cliniques apparaissent. Pour tester cette hypothèse, les chercheurs ont synthétisé 70 peptides longs de 8 à 10 acides aminés et correspondant à des fragments de quatre antigènes plasmodiaux: LSA-1 (liver stage antigen 1), TRAP (thrombospondin related anonymous protein) et STARP (sporozoite threonine and asparagine rich protein).  1, record 3, French, - TRAP

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

A 96-amino acid(14 kd) protein, which is incorporated into the virion. It interacts with the p6gag part of the Pr55gag precursor. Vpr detected in the cell is localized to the nucleus. Proposed functions for Vpr include the nuclear import of preintegration complexes, cell growth arrest, transactivation of cellular genes, and induction of cellular differentiation. Found in HIV-1, HIV-2, SIVmac and SIVmnd. It is homologous to VPX of SIVagm.  2, record 4, English, - viral%20protein%20u

Record number: 4, Textual support number: 1 OBS

Glossary in molecular biology (Portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  3, record 4, English, - viral%20protein%20u

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Une des protéines du rétrovirus HIV-1 qui participe avec la protéine Vif à la maturation du virus.  2, record 4, French, - prot%C3%A9ine%20virale%20u

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 OBS

Uno de los tres genes auxiliares del VIH [virus de la inmunodeficiencia humana].  1, record 4, Spanish, - vpu

Record 5,  Textual support,  English

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In meiotic cells, a protein with broad phyletic distribution and unique cellular localization which shows a high binding efficiency for single-stranded DNA and the property of catalyzing the renaturation of thermally denatured DNA. The protein is assumed to play a role in meiotic recombination and to promote chromosome pairing and crossing over between homologous chromosomes. It is absent from somatic tissues.  1, record 5, English, - DNA%2Dbinding%20protein

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Le déroulement des deux biens de la molécule de DNA entraîne la formation de zones monocoténaires. Ces zones simple brin doivent être stabilisées (suppression du réappariement des deux brins de la molécule de DNA) et protégées de l'action des DNases. Ces fonctions semblent être assurées par une protéine appelée «DNA binding protein» qui se lie spécifiquement au DNA simple chaîne [...]. C'est le complexe formé par l'association entre le DNA monocoténaire et la protéine de liaison au DNA qui constitue en fait le substrat de la DNA polymérase III et des autres protéines qui jouent un rôle dans la réplication.  1, record 5, French, - prot%C3%A9ine%20de%20liaison%20au%20DNA

Record number: 5, Textual support number: 2 CONT

La régulation de l'expression d'un gène passe, entre autres mécanismes, par l'association de protéines à certaines des séquences d'acides nucléiques qui le constituent. L'analyse de ces séquences et celles des protéines régulatrices qui s'y fixent est donc d'une importance capitale pour la compréhension des mécanismes de régulation de l'expression des gènes.  2, record 5, French, - prot%C3%A9ine%20de%20liaison%20au%20DNA

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  French

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Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

A very original set of experiments carried out by the Unit of Molecular Biology of Gene Expression concerns another protein essential for mouse development that is also a transcription factor. This factor known as KBF2 or RBP-Jk is homologous to a Drosophila gene product, Su(H)(Suppressor of Hairless), which belongs to the Notch signal transduction cascade involved in regulating the competence of a cell to respond to specific developmental cues. A likely function of the Su(H) protein is to serve as an anchor on DNA for non DNA-binding transcriptional activators. This function is conserved in the Notch pathway : the activation of this transmembrane receptor likely involves a proteolytic cleavage step which releases its intracellular domain; following nuclear translocation, it activates its target genes by binding to the Su(H) protein, which is already bound to several sites in the target promoters.  2, record 7, English, - Su%28H%29%20protein

Record 7,  Textual support,  French

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La protéine Su(H), impliquée dans l'activité de transmission de ce signal, semble capable de s'associer à la région intracellulaire de Notch. C'est un facteur de transcription qui se lie à certaines séquences localisées dans les promoteurs de plusieurs des gènes cibles de Notch.  1, record 7, French, - prot%C3%A9ine%20Su%28H%29

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

The most recent group of regulatory proteins to be described and the least well characterized are erythrocyte membrane proteins which inhibit the insertion of C8 and C9. A C8-binding protein of MWW 65 000(homologous restriction factor, HRF) in human erythrocyte membranes inhibits the lysis of human erythrocytes bearing C5B67 by C8 and C9.  1, record 8, English, - homologous%20restriction%20factor

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Très récemment, une protéine de membrane, le «homologous restriction factor» (HRF) a été isolée des globules rouges humains. Il inhibe le complexe lytique en liant le C8.  1, record 8, French, - facteur%20HRF

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

A 96-amino acid(14 kd) protein, which is incorporated into the virion. It interacts with the p6gag part of the Pr55gag precursor. the Vpr detected in the cell is localized to the nucleus. Proposed funtions for Vpr include the nuclear import of preintegration complexes, cell growth arrest, transactivation of cellular genes, and induction of cellular differentiation. Found in HIV-1, HIV-2, SIVmac and SIVmnd, It is homologous to VPX of SIVmgm.  2, record 9, English, - virus%2Dencoded%20protein

Record number: 9, Textual support number: 1 OBS

Glossary of molecular biology (portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  3, record 9, English, - virus%2Dencoded%20protein

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Le processus de transcription inverse commence pendant l'encapsidation de l'ARN. Il n'est pas initié par un ARN de transfert, comme chez les rétrovirus, mais par une protéine virale qui n'est autre que la polymérase.  3, record 9, French, - prot%C3%A9ine%20virale

Record number: 9, Textual support number: 1 OBS

Équivalents français approuvés par l'Unité de recherche en vaccinologie, Laboratoire et Service d'infectiologie, Centre hospitalier de l'université Laval (CHUL), Québec.  4, record 9, French, - prot%C3%A9ine%20virale

Record 9,  Textual support,  Spanish