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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

Any of a group of chemical compounds of which purine is the base, including adenine, guanine, xanthine and hypoxanthine which are constituents of nucleic acids, nucleotides and coenzymes.  2, record 1, English, - purine%20base

Record number: 1, Textual support number: 1 OBS

The term purine is often used as a synonym for purine base.  2, record 1, English, - purine%20base

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Substance azotée dérivant du noyau purine, qui entre dans la constitution des nucléotides, des acides nucléiques et de certaines coenzymes. Suivant la substitution du noyau purine, on distingue l'adénine, la guanine, la xanthine et l'hypoxanthine.  2, record 1, French, - base%20purique

Record number: 1, Textual support number: 1 OBS

Le terme purine est souvent employé comme synonyme de base purique.  3, record 1, French, - base%20purique

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Base nitrogenada derivada de la purina, que forma parte de los nucleótidos, de los ácidos nucleicos y de muchas coenzimas.  1, record 1, Spanish, - base%20p%C3%BArica

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

An enzyme of the transferase class that catalyzes the phosphorylation of hypoxanthine or guanine to its corresponding nucleoside monophosphate, a salvage mechanism for recovery of preformed purines, especially in the central nervous system.  3, record 2, English, - hypoxanthine%2Dguanine%2Dphosphoribosyltransferase

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Enzyme catalysant le transfert du radical phosphoribosyle du phosphoribosyl-pyrophosphate sur l'hypoxanthine ou sur la guanine, qu'il transforme respectivement en acide inosinique ou guanylique.  1, record 2, French, - hypoxanthine%2Dguanine%2Dphosphoribosyl%2Dtransf%C3%A9rase

Record number: 2, Textual support number: 1 OBS

Cet enzyme joue un rôle important dans le métabolisme des bases puriques dans le foie en permettant la récupération de ces bases libérées lors de la dégradation des nucléotides et d'éviter leur transformation en acide urique.  1, record 2, French, - hypoxanthine%2Dguanine%2Dphosphoribosyl%2Dtransf%C3%A9rase

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

A chemical compound which appears under the form of odourless, colourless or white crystals, of a white crystalline powder or of a syrupy liquid, is derived from the biosynthesis of purine bases, is freely soluble in water, slightly soluble in ethanol, and is used as a flavour enhancer.  5, record 3, English, - inosinic%20acid

Record number: 3, Textual support number: 1 OBS

Chemical formula: C₁₀H₁₃N₄O₈P  5, record 3, English, - inosinic%20acid

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Liquide sirupeux dérivé de la biosynthèse des bases puriques, miscible à l'eau, [que l'on utilise] comme exhausteur de goût.  4, record 3, French, - acide%20inosinique

Record number: 3, Textual support number: 1 OBS

Formule chimique : C₁₀H₁₃N₄O₈P  5, record 3, French, - acide%20inosinique

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 OBS

A hypoxanthine and adenine analogue that serves as a purine antagonist. It is utilized primarily as an antineoplastic agent since it is a potent inhibitor of DNA synthesis.  3, record 4, English, - mercaptopurine

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

La mercaptopurine (6-MP) ne s'administre que per os, à des doses ne dépassant pas 100 mg/j, et souvent moins. C'est le seul produit qui ait résisté à la vogue des cures discontinues; des enfants atteints de leucémie aigue lymphoblastique en absorbent quotidiennement pendant plusieurs années.  2, record 4, French, - mercaptopurine

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Base purínica que contiene azufre y que no se encuentra en las nucleoproteínas animales. Polvo amarillo cristalino insoluble en agua y soluble en alcohol [...]  2, record 4, Spanish, - mercaptopurina

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 OBS

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules.  2, record 5, English, - inosine

Record number: 5, Textual support number: 2 OBS

Chemical formula: C₁₀H₁₂N₄O₅  3, record 5, English, - inosine

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 OBS

Formule chimique : C₁₀H₁₂N₄O₅  2, record 5, French, - inosine

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

A tissue culture medium containing hypoxanthine, aminopterin, and thymidine, used in somatic cell fusion experiments. Aminopterin(an antifolate) blocks de novo synthesis of purine and thymine nucleotides, but these compounds can be produced from hypoxanthine and thymidine by normal cells possessing the enzymes hypoxanthine phosphoribosyltransferase(HPRT) and thymidine kinase(TK).  1, record 6, English, - HAT%20medium

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Milieu sélectif contenant de l'hypoxanthine, de l'aminoptérine et de la thymidine. La synthèse de l'ADN à partir des sucres et des acides aminés est bloquée par l'aminoptérine. Une autre voie de biosynthèse possible utilise des nucléotides préformés (les précurseurs de l'ADN) et deux enzymes : la thymidine-kinase (TK) et l'hypoxanthine guanine phosphoriboxyl transférase (HGPRT). Les cellules qui possèdent ces enzymes peuvent croître sur un milieu contenant l'aminoptérine et les nucléosides.  2, record 6, French, - milieu%20HAT

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

Hereditary metabolic disorder affecting the central nervous system and characterized by incoordination, mental retardation, aggressive behaviour, and compulsive biting. The cause of the syndrome is a defective organic catalyst or enzyme, hypoxanthine-guanine-phosphoribosyl transferase, which normally is particularly active in brain cells and is involved in the metabolism of purines.  1, record 7, English, - Lesch%2DNyhan%20syndrome

Record number: 7, Textual support number: 1 OBS

Lesch-Nyhan syndrome is transmitted by a recessive sex-linked gene and generally affects males.  2, record 7, English, - Lesch%2DNyhan%20syndrome

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

Le syndrome est causé par une absence d'enzyme : l'hypoxanthine - guanine - phospho - ribosyl - transférase.  2, record 7, French, - syndrome%20de%20Lesch%2DNyhan

Record 7,  Textual support,  Spanish

Record number: 7, Textual support number: 1 CONT

El síndrome de Lesch-Nyhan es una enfermedad metabólica hereditaria caracterizada por la carencia total de la HPRT (hidroxantina fosforibosil transferasa), enzima que cataliza la conversión de la hipoxantina a inosina-5-monofosfato.  1, record 7, Spanish, - s%C3%ADndrome%20de%20Lesch%2DNyhan

Record number: 7, Textual support number: 1 OBS

La enfermedad se caracteriza por hiperuricemia y gota en niños varones.  1, record 7, Spanish, - s%C3%ADndrome%20de%20Lesch%2DNyhan

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

A white, amorphous base, 2, 6-dioxypurine..., from most of the body tissues and fluids, urinary calculi, and certain plants. It is formed by the oxidation of hypoxanthine and may be oxidized to uric acid.  2, record 8, English, - xanthine

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Sous médication par l'allopurinol, la formation d'acide urique est [...] remplacée par celle d'hypoxanthine et de xanthine ("oxypurines"), qui sont cependant excrétées par les reins plus rapidement que l'acide urique.  2, record 8, French, - xanthine

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 OBS

Canada Diseases Weekly Report.  3, record 9, English, - hypoxanthine

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 OBS

Rapport hebdomadaire des maladies au Canada.  3, record 9, French, - hypoxanthine

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

An enzyme that catalyzes the hydrolysis of adenine to hypoxanthine and ammonia.  1, record 10, English, - adenase

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 DEF

Ferment agissant comme désaminase, transformant l'adénine en hypoxanthine.  1, record 10, French, - ad%C3%A9nase

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 DEF

An enzyme of the transferase class that catalyzes the reaction hypoxanthine(of guanine) + 5-phospho-alpha-Delta-ribose I-disphosphate=inosine 5’-monophosphate(or guanasine 5’-monoiphosphate) + pyrophosphate.  1, record 11, English, - hypoxanthine%20phosphoribosyltransf%C3%A9rase

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Une modification directe du gène Hprt (hypoxanthine phosphoribosyltransférase), pour lequel il est possible de sélectionner les cellules possédant cette fonction (avec le milieu HAT : hypoxanthine-aminoptérine-thymidine) ou au contraire les cellules qui l'ont perdue (avec la 6-TG : 6-thioguanine) peut aussi être obtenue.  1, record 11, French, - hypoxanthine%20phosphoribosyltransf%C3%A9rase

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 OBS

After three or four days the spleen is removed and a suspension of mouse lymphocytes is fused in the presence of polyethylene glycol with mouse myeloma cells grown in culture and deficient in the enzyme hypoxanthine guanine ribosyltransferase.  1, record 12, English, - myeloma%20cell

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 OBS

Trois ou quatre jours après, on prélève la rate et on fait fusionner, en présence de polyéthylène glycol, une suspension de lymphocytes de souris avec des cellules de myélome de souris. (...) Les cellules fusionnées que l'on nomme hétérocaryons sont placées dans un milieu de culture qui inhibe la croissance des cellules myélomateuses.  1, record 12, French, - cellule%20de%20my%C3%A9lome

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 OBS

After three or four days the spleen is removed and a suspension of mouse lymphocytes is fused in the presence of polyethylene glycol with mouse myeloma cells grown in culture and deficient in the enzyme hypoxanthine guanine ribosyltransferase.  1, record 13, English, - hypoxanthine%20guanine%20ribosyltransferase

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 OBS

Ces [cellules de myélome], obtenues à partir de culture cellulaire, sont déficientes en une enzyme, l'hypoxanthine guanine ribosyltransférase.  1, record 13, French, - hypoxanthine%20guanine%20ribosyltranf%C3%A9rase

Record 13,  Textual support,  Spanish