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HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE [2 records]
Record 1 - internal organization data 2006-05-08
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- HAT medium
1, record 1, English, HAT%20medium
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- HAT 2, record 1, English, HAT
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
A tissue culture medium containing hypoxanthine, aminopterin, and thymidine, used in somatic cell fusion experiments. Aminopterin(an antifolate) blocks de novo synthesis of purine and thymine nucleotides, but these compounds can be produced from hypoxanthine and thymidine by normal cells possessing the enzymes hypoxanthine phosphoribosyltransferase(HPRT) and thymidine kinase(TK). 1, record 1, English, - HAT%20medium
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- milieu HAT
1, record 1, French, milieu%20HAT
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Milieu sélectif contenant de l'hypoxanthine, de l'aminoptérine et de la thymidine. La synthèse de l'ADN à partir des sucres et des acides aminés est bloquée par l'aminoptérine. Une autre voie de biosynthèse possible utilise des nucléotides préformés (les précurseurs de l'ADN) et deux enzymes : la thymidine-kinase (TK) et l'hypoxanthine guanine phosphoriboxyl transférase (HGPRT). Les cellules qui possèdent ces enzymes peuvent croître sur un milieu contenant l'aminoptérine et les nucléosides. 2, record 1, French, - milieu%20HAT
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Genética
Record 1, Main entry term, Spanish
- medio HAT
1, record 1, Spanish, medio%20HAT
correct, masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 1991-09-12
Record 2, English
Record 2, Subject field(s)
- Biochemistry
- Biophysics
Record 2, Main entry term, English
- hypoxanthine phosphoribosyltransférase
1, record 2, English, hypoxanthine%20phosphoribosyltransf%C3%A9rase
correct
Record 2, Abbreviations, English
- HPRT 1, record 2, English, HPRT
correct
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 DEF
An enzyme of the transferase class that catalyzes the reaction hypoxanthine (of guanine) + 5 - phospho - alpha - Delta - ribose I - disphosphate = inosine 5’ - monophosphate (or guanasine 5’ - monoiphosphate) + pyrophosphate. 1, record 2, English, - hypoxanthine%20phosphoribosyltransf%C3%A9rase
Record 2, French
Record 2, Domaine(s)
- Biochimie
- Biophysique
Record 2, Main entry term, French
- hypoxanthine phosphoribosyltransférase
1, record 2, French, hypoxanthine%20phosphoribosyltransf%C3%A9rase
correct, feminine noun
Record 2, Abbreviations, French
- Hprt 2, record 2, French, Hprt
correct, feminine noun
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Une modification directe du gène Hprt (hypoxanthine phosphoribosyltransférase), pour lequel il est possible de sélectionner les cellules possédant cette fonction (avec le milieu HAT : hypoxanthine-aminoptérine-thymidine) ou au contraire les cellules qui l'ont perdue (avec la 6-TG : 6-thioguanine) peut aussi être obtenue. 1, record 2, French, - hypoxanthine%20phosphoribosyltransf%C3%A9rase
Record 2, Spanish
Record 2, Textual support, Spanish
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