TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

The first antibodies produced in a humoral immune response are IgM, but activated B cells subsequently undergo isotype switching or class switching to secrete antibodies of different isotypes : IgG [inmunoglobulin G], IgA, and IgE. Isotype switching does not affect antibody specificity significantly, but alters the effector functions that an antibody can engage. Isotype switching occurs by a site-specific recombination involving the deletion of the intervening DNA.  7, record 1, English, - isotype%20switching

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Processus par lequel une cellule B peut associer de nouveaux gènes de chaînes lourdes d'immunoglobulines à son gène V recombiné pour produire un anticorps de même spécificité mais de classe différente.  3, record 1, French, - commutation%20isotypique

Record number: 1, Textual support number: 1 OBS

Ce processus est aussi retrouvé dans la commutation isotypique générale que l'on observe au cours de la maturation d'une réponse immunitaire.  3, record 1, French, - commutation%20isotypique

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Proceso durante el cual una célula plasmática deja de producir anticuerpos de una clase y comienza a producirlos de otro distinta.  2, record 1, Spanish, - cambio%20de%20clase

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A procedure for quantifying serum IgE levels to an accuracy of 1 ng/ml without identifying antigenic specificity. The serum under test is exposed to a solid-phase material coated with rabbit anti-IgE, and the amount of human IgE bound to the rabbit antibody is measured by the addition and counting of radiolabeled rabbit anti-IgE in soluble form.  1, record 2, English, - radioimmunosorbent%20test

Record number: 2, Textual support number: 1 OBS

This test has been replaced by the paper radioimmunosorbent test.  2, record 2, English, - radioimmunosorbent%20test

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

C'est une méthode par compétition dans laquelle une quantité connue d'IgE humaine marquée à l'iode 125 et les IgE contenues dans le sérum à étudier vont se lier en fonction de leurs taux respectifs à des anticorps anti-IgE fixés sur un support.  2, record 2, French, - radio%2Dimmuno%2Dsorbent%20test

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

A primary immunodeficiency disorder characterized by recurrent staphylococcal abscesses of skin, lungs, joints, and other sites, pruritic dermatitis, very serum IgE levels, normal levels of IgG, IgA, and IgM, blood and sputum eosinophilia, low anamnestic antibody responses to booster immunization, and poor antibody and cell-mediated responses to neoantigens.  1, record 3, English, - hyperimmunoglobulinemia%20E%20syndrome

Record number: 3, Textual support number: 1 CONT

hyperimmunoglobulinemia E : extremely high levels of IgE in the serum, associated with cutaneous anergy and deficient antibody response, as occurs in Job's syndrome.  1, record 3, English, - hyperimmunoglobulinemia%20E%20syndrome

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Syndrome d'immunodéficience caractérisé par des infections staphylococciques à répétition, en particulier cutanées, et des taux nettement élevés d'IgE. L'infection staphylococciques peut atteindre la peau, les poumons, les articulations et d'autres localisations.  1, record 3, French, - hypergammaglobulin%C3%A9mie%20IgE

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

[A reaction which is] immune in nature and depends upon formation of IgE [immunoglobuline E] antibody, the immunoglobulin responsible for typical allergic reactions. The initial sensitization step induces formation of IgE specifically directed to the initiating substance.  2, record 4, English, - anaphylaxis

Record number: 4, Textual support number: 1 OBS

In anaphylaxis, the reaction is systemic in nature, occurs rapidly upon administration of minute concentrations of the offending material, and is potentially fatal.  2, record 4, English, - anaphylaxis

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

Certains auteurs englobent ces 3 entités [aphylaxie, réaction anaphylactique et réaction anaphylactoïde] sous le terme «anaphylaxie»; d'autres distinguent entre réaction anaphylactique et réaction anaphylactoïde, et dans ce cas, pour certains on parle d'anaphylaxie seulement si la réaction est médiée par les IgE[immunoglobuline E], pour d'autres ce terme englobe toutes les formes médiées par le système immunitaire, incluant aussi les réactions médiées par des complexes immuns. Pour palier à cette situation, on parle de «syndrome anaphylactique» pour englober toutes ces réactions.  2, record 4, French, - anaphylaxie

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Reacción de hipersensibilidad inmediata aguda, consecuente a la administración de un antígeno que, por su unión a las superficies celulares a través de un anticuerpo, provoca la liberación de aminas vasoactivas, principalmente de la histamina.  3, record 4, Spanish, - anafilaxis

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

(Gell and Coombs classification) : Type I reactions are initiated by antigens reacting with cell-bound antibody, usually IgE. Release of mediators, mainly from basophils and mast cells, provide the pathogenic mechanism.  1, record 5, English, - type%20I%20hypersensitivity%20reaction

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Réaction d'immunité humorale. La combinaison antigène-anticorps provoque la libération par les cellules basophiles ou les mastocytes d'histamine et de substances vaso-actives. Les anticorps sont des IgE. La réaction est précoce. En clinique, l'asthme franc, la pollinose, le choc anaphylactique, certaines urticaires sont dues à la réaction de type I.  1, record 5, French, - r%C3%A9action%20immunitaire%20de%20type%20I

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

An abnormal, immediate hypersensitivity to certain common allergens, such as house dusts, animal dander, and pollen, that is related to the production of the IgE antibody, reagin.  2, record 6, English, - atopy

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Tendance constitutionnelle ou héréditaire à présenter des réactions d'hypersensibilité immédiate (asthme allergique, ou rhume des foins par exemple), ou d'autres réactions allergiques à des allergènes qui ne provoquent aucune réaction chez les sujets normaux.  1, record 6, French, - atopie

Record 6,  Textual support,  Spanish

Record number: 6, Textual support number: 1 DEF

Proceso patológico en el que se desarrollan estados de hipersensibilidad inmediata.  2, record 6, Spanish, - atopia

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

An antibody, usually IgE, that binds to tissue cells that have surface receptors for the Fc fragment of the immunoglobulin. The bound antibody retains its capacity to combine with antigen and the occurrence of an antigen-antibody reaction stimulates the subjacent cell to release the contents of its granules or to engage in enhanced phagocytic activity.  1, record 7, English, - cytotropic%20antibody

Record number: 7, Textual support number: 1 CONT

homocytotropic antibodies, i.e. antibodies that bind to mast cells an basophil leukocytes.  4, record 7, English, - cytotropic%20antibody

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Anticorps susceptibles de se fixer sur la membrane de certaines cellules, pouvant ainsi conférer à ces dernières une activité contre l'antigène qu'elles ne possèdent pas par elles-mêmes.  1, record 7, French, - anticorps%20cytophile

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

The transfer of skin-sensitizing antibodies, now identified as IgE, from an individual to another of the same species. Following intradermal injection of serum, antigen is injected intravenously at the site at which circulating antigen combines with cell-fixed antibody exhibits a wheal and flare reaction. Evans blue dye has been used in animals as an indicator for location and size of the reacting area.  2, record 8, English, - passive%20cutaneous%20anaphylaxis

Record number: 8, Textual support number: 2 DEF

The technique used to detect antigen-specific IgE, in which the test animal is injected intravenously with the antigen and dye, the skin having been previously sensitized with antibody.  3, record 8, English, - passive%20cutaneous%20anaphylaxis

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

L'anaphylaxie cutanée passive est une réaction locale obtenue en injectant l'anticorps par voie locale puis, à 48 heures d'intervalle, l'antigène au même site ou par voie générale. La réaction se traduit par une augmentation de la vasoperméabilité attestée par la survenue d'un érythème et objectivée par la coloration de la peau par le bleu Evans injecté au site d'administration de l'anticorps.  2, record 8, French, - anaphylaxie%20cutan%C3%A9e%20passive

Record number: 8, Textual support number: 1 DEF

Technique utilisée pour détecter les anticorps IgE; antigène et colorant sont injectés par voie intraveineuse à un animal dont la peau a préalablement été sensibilisée par l'anticorps.  3, record 8, French, - anaphylaxie%20cutan%C3%A9e%20passive

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

The antibody that mediates immediate hypersensitivity reactions; in humans reagins are IgE antibodies.  4, record 9, English, - specialized%20IgE

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

Anticorps sérique, appartenant aux immunoglobulines E(IgE), apparaissant chez des sujets sensibilisés par un premier contact avec un antigène. Il va se fixer sur certaines cellules, surtout sur les mastocytes et les polynucléaires basophiles, où sa rencontre ultérieure avec le même antigène provoquera la libération de médiateurs chimiques (histamine, sérotonine, kinine, héparine) et l'apparition de manifestations d'hypersensibilité immédiate.  1, record 9, French, - IgE%20s%C3%A9rique

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

Antibody responsible for acute anaphylactic reactions(type 7 hypersensitivity reaction). It is usually of IgE class and its characteristic properties is to bind to IgE Fc receptors on most cells of their own species.  1, record 10, English, - reaginic%20antibody

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 DEF

Anticorps (chez l'homme de type IgE) responsable des réactions d'hypersensibilité immédiate.  3, record 10, French, - anticorps%20r%C3%A9aginique

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

... the "Human Basophil Degranulation Test, "... Basophils contain granules which are made of histamine and other chemicals which can elicit symptoms of allergy when they are released or degranulated. A substance to which a person is allergic causes degranulation of the basophils. There are certain substances which will cause anybody's basophils to degranulate. IgE is a special type of antibody which causes the release/degranulation of basophils, and "anti-IgE" is an artificial(man-made) antibody that can have a similar effect as IgE.  1, record 11, English, - basophil%20degranulation

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Les granulocytes basophiles sont impliqués essentiellement dans les phénomènes d'hypersensibilité immédiate, fonction liée aux substances chimiques contenues dans leurs granulations: la dégranulation des basophiles, après intervention d'immunoglobulines E (IgE), se produit par l'intermédiaire de vésicules d'exocytose, et s'accompagne d'une libération d'histamine et autres amines vasopressives responsables de réactions anaphylactiques.  1, record 11, French, - d%C3%A9granulation%20des%20basophiles

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

A quantitative technique to measure serum levels of an IgE antibody directed against a specific antigen.  1, record 12, English, - radioallergosorbent%20test

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 DEF

Dosage radio-immunologique des IgE spécifiques d'un antigène donné.  2, record 12, French, - technique%20RAST

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 CONT

... for the injected allergens there is no clear evidence that the production of IgE reflects an inherited predisposition.... The fact that atopy does not increase the incidence of IgE antibody to venom or penicillin adds further evidence that the specific inherited factor(s) in atopy is related to the conditions of inhalant allergy and is not a generalized control enhancing IgE production.  1, record 13, English, - inherited%20predisposition%20%28to%20allergy%29

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 DEF

Prédisposition constitutionnelle à développer des maladies allergiques.  1, record 13, French, - terrain%20allergique

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 DEF

Heterogenous particles shed from the surface of the skin of various animals, as of cats and dogs, and commonly a cause of allergic reactions in atopic individuals. Dander consists of microorganisms, desquamated epithelial cells, fragments of hair, and sebaceous material.  2, record 14, English, - dander

Record number: 14, Textual support number: 1 CONT

The IgE antibody which mediates positive immediate skin tests to pollen, dust mite and animal dander allergens forms part of an immune response that also includes IgG antibody, IgA antibody, and T cells.  3, record 14, English, - dander

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 DEF

Produits de dégradation de la peau, des poils et des cheveux des humains ou des animaux qui constituent des allergènes par eux-mêmes, par les antigènes dont ils sont porteurs (salive du chat) ou l'alimentation qu'ils apportent aux allergènes (acariens).  1, record 14, French, - phan%C3%A8re

Record number: 14, Textual support number: 1 OBS

Terme générique par lequel on désigne parfois les productions épidermiques apparentes, telles que poils, ongles, cornes, etc.  2, record 14, French, - phan%C3%A8re

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 DEF

A rapidly occurring(within 30 min) antibody-mediated reaction arising from the release of histamine and other vasoactive substances. The antibody(an immunoglobulin, usually of IgE type) fixes to cells, especially mast cells. On contact with antigen, the cell is disrupted and vasoactive substances are released and produce anaphylaxis.  2, record 15, English, - immediate%20hypersensitivity%20reaction

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 CONT

Classification des réactions allergiques selon le délai d'apparition [...] deux catégories : 1) les réactions d'hypersensibilité de type immédiat qui surviennent très rapidement après le contact avec l'allergène. L'anaphylaxie cutanée survient en quelques minutes. La réaction d'Arthus, [...] atteint son maximum en 3 à 6 heures après le contact avec l'allergène [...]; 2) les réactions d'hypersensibilité du type retardé [...]  1, record 15, French, - r%C3%A9action%20d%27hypersensibilit%C3%A9%20du%20type%20imm%C3%A9diat

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 CONT

... some human sera contained antibodies that were still able to sensitize the skin of monkeys after heating the serum for 2 hours at 56 degrees C. Moreover, maximal sensitization with these sera was accomplished approximately 2 hours after injection and persisted for less than 24 hours, whereas sensitization by IgE antibodies was optimal after 24 hours and persisted for several weeks. The heat-stable anaphylactic antibody was not removed from the serum by absorption with immunosorbent-bound anti-IgE. Accordingly, the name "short-term sensitization IgG, IgG(S-TS) was introduced to distinguish these antibodies from IgE antibodies.  1, record 16, English, - short%2Dterm%20sensitization%20immunoglobulin%20G

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 DEF

Les IgG STS (short term sensitizing) sont des anticorps spécifiques appartenant au sous-groupe des IgG 4. Pour Pepys, leur intervention devrait être soupçonnée chez l'homme lorsque les prick-tests sont négatifs et que seules les intradermoréactions sont positives.  1, record 16, French, - immunoglobuline%20G%20STS

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 DEF

An allergen rendered less allergenic but not less antigenic(formation of IgE but not of IgG blocking antibody is decreased) by formalin or glutaraldehyde treatment.  1, record 17, English, - allergoid

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 DEF

Extrait allergénique modifié par action du formol dans le but de réduire son pouvoir allergénique tout en conservant son pouvoir antigénique de manière à réaliser des désensibilisations spécifiques en réduisant le nombre d'injections et sans risque de réaction syndromique.  1, record 17, French, - allergoide

Record 17,  Textual support,  Spanish

Record 18,  Textual support,  English

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 OBS

Voir source pour contexte.  2, record 18, French, - anticorps%20IgE

Record 18,  Textual support,  Spanish