TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

[A] large pentameric immunoglobulin [molecule] (five linked subunits), largely confined to plasma [that is] produced early in response to infecting organisms ...  4, record 1, English, - immunoglobulin%20M

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Les IgM sont des immunoglobulines sécrétées lors du premier contact de l'organisme avec un antigène. Leur affinité pour l'antigène est plus faible que celle des IgG.  4, record 1, French, - immunoglobuline%20M

Record number: 1, Textual support number: 2 CONT

La principale caractéristique structurale des IgM réside dans l'existence de 2 formes moléculaires distinctes : 1) une forme monomère [...] 2) une forme pentamère [...]  5, record 1, French, - immunoglobuline%20M

Record number: 1, Textual support number: 3 CONT

La présence d'anticorps IgM [dirigés] contre le virus de l'hépatite A (anti-VHA), qui peut durer trois mois, permet de diagnostiquer une infection aiguë.  6, record 1, French, - immunoglobuline%20M

Record number: 1, Textual support number: 1 OBS

IgM: Ce terme figure dans l'article «immunoglobuline» du Larousse médical.  7, record 1, French, - immunoglobuline%20M

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 DEF

Clase de anticuerpos producidos por el cuerpo como respuesta inicial a un antígeno.  1, record 1, Spanish, - inmunoglobulina%20M

Record number: 1, Textual support number: 1 OBS

Si la IgM se produce en respuesta a una vacuna, una vacuna de refuerzo producirá un "cambio" de IgM sobre todo a [la] inmunoglobulina G.  1, record 1, Spanish, - inmunoglobulina%20M

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

The first antibodies produced in a humoral immune response are IgM, but activated B cells subsequently undergo isotype switching or class switching to secrete antibodies of different isotypes : IgG [inmunoglobulin G], IgA, and IgE. Isotype switching does not affect antibody specificity significantly, but alters the effector functions that an antibody can engage. Isotype switching occurs by a site-specific recombination involving the deletion of the intervening DNA.  7, record 2, English, - isotype%20switching

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Processus par lequel une cellule B peut associer de nouveaux gènes de chaînes lourdes d'immunoglobulines à son gène V recombiné pour produire un anticorps de même spécificité mais de classe différente.  3, record 2, French, - commutation%20isotypique

Record number: 2, Textual support number: 1 OBS

Ce processus est aussi retrouvé dans la commutation isotypique générale que l'on observe au cours de la maturation d'une réponse immunitaire.  3, record 2, French, - commutation%20isotypique

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 DEF

Proceso durante el cual una célula plasmática deja de producir anticuerpos de una clase y comienza a producirlos de otro distinta.  2, record 2, Spanish, - cambio%20de%20clase

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

The Bartels PRIMA SystemTM Cytomegalovirus IgM Enzyme Immunoassay is a rapid, qualitative method for the detection of IgM Antibody to cytomegalovirus in human serum. Patient serum is diluted with specimen diluent that contains an absorbent to remove IgG. The absorbent prevents IgG/rheumatoid factor complexes from forming and prevents interfering competition from IgG during the test procedure. The treated serum is incubated with purified CMV antigens bound to EIA plate wells. If antibodies to CMV are present, they bind to the antigen and do not rinse off. Subsequently, when enzyme labeled anti-human IgM is added to the reaction site, it binds to the immobilized antibodies. After washing and the addition of a chromogenic substrate and stop solution, specimens containing antibodies to CMV produce a color endpoint reaction which is measured and compared to negative and positive controls, and may be measured spectrophotometrically.  1, record 3, English, - chromogenic%20substrate

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Dans ce cas, les dNTP (2-désoxyribonucléotides triphosphates peuvent être marqués par la biotine [...] Les produits d'amplification sont ensuite détectés directement par l'avidine ou la streptavidine couplée à la phosphatase alcaline ou à la peroxydase et le substrat chromogène correspondant.  1, record 3, French, - substrat%20chromog%C3%A8ne

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

Compuesto o sustancia que contiene un grupo que produce color.  1, record 3, Spanish, - sustrato%20cromog%C3%A9nico

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 OBS

Term(s) taken from a Canadian laboratory-equipment company’s catalogue.  1, record 4, English, - EBV%20IgM%20heterophile%20antibody

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

Terme(s) tiré(s) du catalogue d'une compagnie canadienne d'équipement de laboratoire.  1, record 4, French, - anticorps%20h%C3%A9t%C3%A9rophile%20EBV%20IgM

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

A primary immunodeficiency disorder characterized by recurrent staphylococcal abscesses of skin, lungs, joints, and other sites, pruritic dermatitis, very serum IgE levels, normal levels of IgG, IgA, and IgM, blood and sputum eosinophilia, low anamnestic antibody responses to booster immunization, and poor antibody and cell-mediated responses to neoantigens.  1, record 5, English, - hyperimmunoglobulinemia%20E%20syndrome

Record number: 5, Textual support number: 1 CONT

hyperimmunoglobulinemia E: extremely high levels of IgE in the serum, associated with cutaneous anergy and deficient antibody response, as occurs in Job’s syndrome.  1, record 5, English, - hyperimmunoglobulinemia%20E%20syndrome

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

Syndrome d'immunodéficience caractérisé par des infections staphylococciques à répétition, en particulier cutanées, et des taux nettement élevés d'IgE. L'infection staphylococciques peut atteindre la peau, les poumons, les articulations et d'autres localisations.  1, record 5, French, - hypergammaglobulin%C3%A9mie%20IgE

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

Antibody, usually IgM but occasionally IgG, that reacts less efficiently with antigen at 37 ° C than at lower temperatures.  1, record 6, English, - cold%20antibody

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Anticorps dont la mise en évidence in vitro n'est franche qu'à basse température.  2, record 6, French, - anticorps%20froid

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

Antibody that binds to erythrocytes or bacteria but does not produce agglutination.  1, record 7, English, - incomplete%20antibody

Record number: 7, Textual support number: 1 CONT

The nonagglutinating antibody is detectable with the antiglobulin(Coombs) test. For example, IgG anti-Rh antibodies do not agglutinate erythrocytes in physiologic saline whereas IgM antibodies do(the large IgM molecule can cross-link the erythrocytes at a wider separation so that there is less electrostatic repulsion due to the zeta potential).  1, record 7, English, - incomplete%20antibody

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

Un anticorps est dit «agglutinant» (les hématies) quand il entraîne l'hémagglutination en milieu salin (CINa 0,15 mol/l). Dans le cas contraire, on parle d'anticorps «non agglutinant».  1, record 7, French, - anticorps%20non%20agglutinant

Record number: 7, Textual support number: 2 CONT

En raison du faible nombre de site antigénique Rhésus [...], le nombre de molécules d'IgG anti-Rhésus fixées sur chaque hématie est insuffisant pour agglutiner les globules rouges : ces anticorps sont improprement appelés «incomplets» par opposition aux IgM anti-Rhésus qui sont agglutinants (anticorps complets).  2, record 7, French, - anticorps%20non%20agglutinant

Record number: 7, Textual support number: 1 OBS

anticorps incomplet (impropre). Source : J.-F. Bach, P. Lesavre, Op, Cit., p. 50.  2, record 7, French, - anticorps%20non%20agglutinant

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

EAC rosette assay. An assay for human B lymphocytes using complement receptors, a B cell marker. Peripheral blood cell are mixed with ox red blood cells, IgM antierythrocyte antibody, and complement deficient in C5(to prevent red cell lysis). The antibody-and-complement-coated erythrocytes(EAC) form rosettes with B cells, which are counted using a hemocytometer.  1, record 8, English, - EAC%20rosette

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

De nombreuses cellules présentent sur leur membrane des récepteurs pour certains facteurs du complément, notamment le C3b, le C4b et peut-être le C1q. Ces récepteurs peuvent être objectivés par la formation de rosettes EAC avec des hématies recouvertes d'anticorps IgM anti-érythrocytaires et de complément à concentration non hémolytique. Ces récepteurs sont retrouvés sur la majorité des lymphocytes B, mais aussi sur les monocytes et les polynucléaires [...]  1, record 8, French, - rosette%20EAC

Record number: 8, Textual support number: 1 OBS

EAC = érythrocyte-anticorps-complément.  2, record 8, French, - rosette%20EAC

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

EA Rosettes. Cells which have Fc receptors for IgM or IgG can be isolated by mixing with red cells sensitized with antibody(EA) of the appropriate class. The antibody crosslinks the red cell to the Fc receptor and the rosettes are then isolated.  1, record 9, English, - EA%20rosette

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Ces récepteurs sont mis en évidence par fixation d'IgG agrégées préalablement rendues fluorescentes, ou mieux par formation de rosettes EA («érythrocytes-anticorps») avec des érythrocytes sensibilisés par des anticorps anti-érythrocytaires, à des concentrations non agglutinantes.  1, record 9, French, - rosette%20EA

Record number: 9, Textual support number: 1 OBS

EA = érythrocytes recouverts d'anticorps.  2, record 9, French, - rosette%20EA

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

Antibody to the Rh group of antigens found on human erythrocytes. Anti Rh antibodies may be synthesized either by a Rh+ mother with an Rh-fetus or an Rh+ patient who receives a transfusion of Rh-blood. Agglutinating anti-Rh antibodies are of IgM class. IgG anti-Rh antibodies can cross the placenta and cause hemolytic disease of the newborn.  1, record 10, English, - anti%2DRh%20antibody

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

Si une unité de sang D-positif est transfusée à un sujet Rhésus-négatif, des anticorps anti-D sont produits dans 60 à 80 p. cent des cas, alors que des anticorps anti-c et anti E n'apparaissent que dans 2 p. cent des cas de transfusions incompatibles. [...] Il n'existe pas d'anticorps naturels anti-Rhésus. Les anticorps anti-Rhésus apparaissent après une grossesse ou une transfusion incompatible; ils ont presque toujours de classe IgG. [...] ces anticorps sont improprement appelés "incomplets" par opposition aux IgM anti-Rhésus qui sont agglutinantes (anticorps complets).  1, record 10, French, - anticorps%20anti%2DRh%C3%A9sus

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 DEF

Antibody that reacts with red cells carrying the A antigen, causing agglutination. Agglutinating anti-A antibodies are usually of the IgM class. Anti-A antibodies are found in the sera of subjects of blood group O and B.  1, record 11, English, - anti%2DA%20antibody

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

Système ABO. Landsteiner conclut : 1. à l'existence de deux antigènes ou substances de groupes sanguins différents : A et B [...]; 2. à la présence d'alloanticorps anti-A et anti-B chez les sujets qui n'ont pas l'antigène correspondant. [...] Tout sujet possède dans son sérum des agglutinines anti-A ou anti-B quand l'antigène correspondant est absent. [...] ce sont des anticorps naturels. [...] Par opposition, il existe de façon irrégulière chez certains sujets des anticorps anti-A ou anti-B immuns apparus à la suite d'une immunisation.  1, record 11, French, - alloanticorps%20anti%2DA

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 DEF

Antibody that reacts with red cells carrying the B antigen, causing agglutination. Agglutinating anti-B antibodies are usually of the IgM class. Anti-B antibodies are found in the sera of subjects of blood group O and A.  1, record 12, English, - anti%2DB%20antibody

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

Système ABO. Landsteiner conclut : 1) à l'existence de deux antigènes ou substances de groupes sanguins différents : A et B (...); 2) à la présence d'alloanticorps anti-A et anti-B chez les sujets qui n'ont pas l'antigène correspondant. (...) Tout sujet possède dans son sérum des agglutinines anti-A ou anti-B quand l'antigène correspondant est absent. (...) ce sont des anticorps naturels. (...) Par opposition, il existe de façon irrégulière chez certains sujets des anticorps anti-A ou anti-B immuns apparus à la suite d'une immunisation.  1, record 12, French, - alloanticorps%20anti%2DB

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 OBS

Canada Diseases Weekly Report.  2, record 13, English, - IgM%20antibody%20response

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 OBS

Rapport hebdomadaire des maladies au Canada.  2, record 13, French, - %C3%A9laboration%20d%27anticorps%20IgM

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 OBS

Canada Diseases Weekly Report.  2, record 14, English, - rubella%20IgM%20antibody%20testing

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 OBS

Rapport hebdomadaire des maladies au Canada.  2, record 14, French, - d%C3%A9pistage%20des%20anticorps%20IgM%20antirub%C3%A9oliques

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 OBS

Canada Diseases Weekly Report.  2, record 15, English, - rubella%20IgM%20antibody

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 OBS

Rapport hebdomadaire des maladies au Canada.  2, record 15, French, - anticorps%20IgM%20antirub%C3%A9olique

Record 15,  Textual support,  Spanish

Record 16,  Textual support,  English

Record number: 16, Textual support number: 1 OBS

Canada Diseases Weekly Report.  2, record 16, English, - rubella%20IgM%20antibody%20positivity

Record 16,  Textual support,  French

Record number: 16, Textual support number: 1 OBS

Rapport hebdomadaire des maladies au Canada.  2, record 16, French, - positivit%C3%A9%20%C3%A0%20l%27%C3%A9gard%20de%20l%27anticorps%20IgM%20antirub%C3%A9olique

Record 16,  Textual support,  Spanish

Record 17,  Textual support,  English

Record number: 17, Textual support number: 1 OBS

Canada Diseases Weekly Report.  2, record 17, English, - rubella%20IgM%20antibody%20test

Record 17,  Textual support,  French

Record number: 17, Textual support number: 1 OBS

Rapport hebdomadaire des maladies au Canada.  2, record 17, French, - analyse%20de%20d%C3%A9tection%20de%20l%27anticorps%20IgM%20antirub%C3%A9olique

Record 17,  Textual support,  Spanish

Record 18,  Textual support,  English

Record number: 18, Textual support number: 1 DEF

A method used to detect and enumerate antibody producing cells. Cells obtained from, e. g. the spleen of an animal that has been immunized against sheep erythrocytes, are mixed into molten Agarose containing sheep erythrocytes. The agarose is poured into a Petri dish, allowed to set and then incubated at 37 ° C. Later, complement is poured into the dish, and any cells that have secreted antibody are revealed by the appearance of a zone of haemolysis round each of them. The agarose layer can be dried and stained so that the cells may be identified. The technique described reveals IgM secreting cells forming direct plaques. By the addition of an anti-IgG serum before the complement, indirect plaques due to IgG secreting cells can be revealed. Cells producing antibodies to antigens other than erythrocytes can be detected by coating the rythrocytes with the antigen as in passive haemolysis.  1, record 18, English, - balmolytic%20plaque%20test

Record 18,  Textual support,  French

Record number: 18, Textual support number: 1 CONT

La méthode de numération par la technique des plages de lyse est utilisée dans certains laboratoires [...] pour le titrage de suspensions de cultures pures.  2, record 18, French, - technique%20des%20plages%20de%20lyse

Record 18,  Textual support,  Spanish