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IL-3 [2 records]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2011-05-09

English

Subject field(s)
  • Immunology
DEF

A lymphokine produced by antigen-or mitogen-activated T lymphocytes, which stimulates proliferation of hematopoietic as well as lymphoid stem cells; a colony-stimulating factor for all bone marrow progenitor cells. IL-3 supports the growth and differentiation of early hematopoietic and lymphoid stem cells as well as that of more mature hematopoietic cells, including granulocytes, macrophages, and mast cells.

French

Domaine(s)
  • Immunologie
DEF

Facteur de croissance granulocyto-monocytaire dont le poids moléculaire est compris entre 20 et 26 kDa. Elle est principalement produite par les lymphocytes T activés et elle favorise la croissance de colories de plusieurs types.

OBS

L'identité de l'IL-3 et de l'HCSF (facteur stimulant les cellules productrices d'histamine) est suspectée mais non démontrée.

Spanish

Save record 1

Record 2 1997-01-20

English

Subject field(s)
  • Genetics
CONT

Here we describe changes in dNTP metabolism that precede DNA fragmentation in a model of apoptosis driven by deprivation of the cytokine interleukin 3(IL-3). In haemopoietic BAF3 cells, IL-3 withdrawal leads to a rapid decrease in the size of dATP, dTTP and dGTP pools without affecting dCTP levels. This imbalance in dNTP pools precedes DNA fragmentation and is accompanied by down-regulation of enzymes controlling the de novo and salvage pathways of dNTP synthesis, ribonucleotide reductase and thymidine kinase(TK) respectively.

OBS

Biochemical Journal, Biochem. J. (1996) 316, 421 425 (Printed in Great Britain).

French

Domaine(s)
  • Génétique
OBS

Précurseur utilisé pour la synthèse de l'ADN.

Spanish

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