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ILLEGITIMATE RECOMBINATION [2 records]

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Alphabetical list of terms

Record 1 2026-02-13

English

Subject field(s)
  • Genetics
CONT

Illegitimate recombination, also known as non-homologous recombination, is much less well understood mechanistically than homologous recombination. It either involves recombination based on little sequence homology between recombining strands, or no sequence homology at all. Furthermore, rather than replacing alleles, illegitimate recombination results... in insertion of new DNA... Illegitimate recombination... is both very rare and results... in gains in the amount of DNA carried by an organism.

Key term(s)
  • non homologous recombination
  • nonhomologous recombination

French

Domaine(s)
  • Génétique
DEF

[...] recombinaison pouvant avoir lieu entre deux molécules d'ADN ayant peu ou pas d'homologies de séquences.

OBS

recombinaison hétérologue; recombinaison illégitime : désignations publiées au Journal officiel de la République française le 4 février 2021.

Spanish

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Record 2 2011-10-31

English

Subject field(s)
  • Biotechnology
CONT

Because recombination in yeast is primarily legitimate rather than illegitimate, it is relatively easy to replace a resident gene with whatever modified gene that you wish. For E. Coli and yeast, such replacement can be done with ease. With mouse, it is possible but very time consuming to do such replacement. For other organisms, it is not yet possible.

French

Domaine(s)
  • Biotechnologie
CONT

[...] des chercheurs de l'Inra ont introduit dans le tabac le gène de la nitrate réductase (NR) sous le contrôle du promoteur 35S, afin d'optimiser l'assimilation du nitrate absorbé dans la surexpression de cette enzyme. [...] Cette fois encore, il y a eu cosuppression du transgène et du gène résident de la NR.

Spanish

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