TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Immune checkpoints are a normal part of the immune system. Their role is to prevent an immune response from being so strong that it destroys healthy cells in the body. Immune checkpoints engage when proteins on the surface of immune cells called T cells recognize and bind to partner proteins on other cells, such as some tumor cells. These proteins are called immune checkpoint proteins. When the checkpoint and partner proteins bind together, they send an "off" signal to the T cells. This can prevent the immune system from destroying the cancer. Immunotherapy drugs called immune checkpoint inhibitors work by blocking checkpoint proteins from binding with their partner proteins. This prevents the "off" signal from being sent, allowing the T cells to kill cancer cells.  3, record 1, English, - immune%20checkpoint%20inhibitor

Record number: 1, Textual support number: 2 CONT

Monoclonal antibodies(mAbs) are... available as immune checkpoint inhibitors(ICIs). These ICIs target specific immune checkpoints, including cytotoxic T-lymphocyte-associated antigen-4(CTLA-4) and programmed cell death protein 1(PD-1).  4, record 1, English, - immune%20checkpoint%20inhibitor

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Les inhibiteurs de points de contrôle sont des anticorps monoclonaux dirigés contre les signaux inhibiteurs de la réponse immunitaire que les cellules anticancéreuses mettent en place, en particulier en inactivant les lymphocytes T.  3, record 1, French, - inhibiteur%20de%20point%20de%20contr%C3%B4le%20immunitaire

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Immune checkpoints are a normal part of the immune system. Their role is to prevent an immune response from being so strong that it destroys healthy cells in the body. Immune checkpoints engage when proteins on the surface of immune cells called T cells recognize and bind to partner proteins on other cells, such as some tumor cells. These proteins are called immune checkpoint proteins. When the checkpoint and partner proteins bind together, they send an "off" signal to the T cells. This can prevent the immune system from destroying the cancer. Immunotherapy drugs called immune checkpoint inhibitors work by blocking checkpoint proteins from binding with their partner proteins. This prevents the "off" signal from being sent, allowing the T cells to kill cancer cells.  2, record 2, English, - immune%20checkpoint%20protein

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Les protéines nommées protéines de point de contrôle immunitaire permettent de moduler la force et la durée des réponses immunitaires pour éviter d'éliminer les cellules saines. Ces protéines réduisent la réponse immune naturelle ou thérapeutique contre le cancer. L'une des stratégies d'immunothérapie consiste à inhiber l'activité de ces protéines de point de contrôle immunitaire pour restaurer ou augmenter une réponse immunitaire.  1, record 2, French, - prot%C3%A9ine%20de%20point%20de%20contr%C3%B4le%20immunitaire

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

An immune checkpoint is a regulator of the immune system that is important for maintaining self-tolerance(the ability of the immune system to recognize self antigens as harmless while appropriately mounting a response to foreign entities) and preventing random attacks on health cells. Several tumors hijack this mechanism to protect themselves against tumoricidal responses elicited by T cells by activating immune checkpoints.  2, record 3, English, - immune%20checkpoint

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Les points de contrôle immunitaire sont des systèmes de régulation, inhibiteurs et activateurs, du système immunitaire, garantissant la tolérance du Soi. Dans le contexte du cancer, ces points de contrôle jouent un rôle-clé dans la reconnaissance des cellules cancéreuses qui ont développé une capacité à déjouer l'immunité antitumorale et échapper à la surveillance immunitaire.  2, record 3, French, - point%20de%20contr%C3%B4le%20immunitaire

Record number: 3, Textual support number: 1 OBS

point de contrôle immunitaire : désignation publiée au Journal officiel de la République française le 7 août 2022.  3, record 3, French, - point%20de%20contr%C3%B4le%20immunitaire

Record 3,  Textual support,  Spanish