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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase(HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir(GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes.  1, record 1, English, - herpes%20simplex%20virus%20thymidine%20kinase

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Traitement du glioblastome multiforme - une tumeur létale du cerveau - par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex (HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique.  1, record 1, French, - thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A structural gene in the MHC that exerts a regulatory role on the immune response.  5, record 2, English, - immune%2Dresponse%20gene

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Le processus par lequel les gènes interfèrent, pour provoquer ou prévenir le diabète, est loin d'être clair. L'une des hypothèses avancées provient des travaux de Hugh McDevitt, de l'Université de Stanford et de Baruj Benacerraf, de la Faculté de médecine de Harvard. Ils ont découvert que chez la souris, des gènes spécifiques contrôlent les gènes de la réponse immunitaire (RI) et que ces gènes sont localisés dans la même portion du chromosome que ceux correspondant aux principaux antigènes d'histocompatibilité de la souris.  1, record 2, French, - g%C3%A8ne%20de%20la%20r%C3%A9ponse%20immunitaire

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Activation of macrophages by bacterial lipopolysaccharide(LPS) induces transcription of genes that encode for proinflammatory regulators of the immune response. Previous work has suggested that activation of the transcription factor activator protein 1(AP-1) is one LPS-induced event that mediates this response. Consistent with this notion, we found that LPS stimulated AP-1-mediated transcription of a transfected reporter gene in the murine macrophage cell line RAW 264. 7. As AP-1 activity is regulated in part by activation of the c-Jun N-terminal kinase(JNK), which phosphorylates and subsequently increases the transcriptional activity of c-Jun, we examined whether LPS treatment of macrophages resulted in activation of this kinase.  3, record 3, English, - jun%20N%2Dterminal%20kinase

Record number: 3, Textual support number: 1 OBS

PNAS Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-sti. Proceedings of the National Academy of Sciences Volume 93, Number 07; Pages: 2774-2778 Immunology.  4, record 3, English, - jun%20N%2Dterminal%20kinase

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 OBS

JNK  2, record 3, French, - prot%C3%A9ine%20JNK

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

... there may be two major genetic mechanisms governing IgE antibodies in atopy. One is a specific immune response(Ir) or immune suppressor(Is) gene associated with HLA on chromosome 6. A second gene is for total serum IgE level that is not linked to HLA.  1, record 4, English, - immune%20suppressor%20gene

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

(...) il existe (...) des gènes codant pour la régulation positive (helper) et négative (suppressive) opérée par les cellules T sur les réactions immunitaires; ces gènes, appelés selon le cas Ir ou Is, sont en grande majorité localisés dans le complexe majeur d'histocompatibilité (CMH); chacun est spécifique d'un antigène, chaque déterminant antigénique étant sous la dépendance d'un seul de ces gènes; (...)  1, record 4, French, - g%C3%A8ne%20Is

Record 4,  Textual support,  Spanish