TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

... the Taiwan Food and Drug Administration(TFDA) designed a pathway to EUA [emergency use authorization] for all local vaccine candidates [against severe acute respiratory syndrome coronavirus 2] based on immunobridging, which compares the immune response of a vaccine candidate with an approved vaccine... It is assumed that a part of the immune response—such as binding or neutralizing antibodies—will correlate with other important components of the immune response... In the absence of efficacy data, immunobridging can be adopted as an approach to infer the likelihood of a vaccine's protective effect by translating immunogenicity to vaccine efficacy. The inference is based on the comparison of immunogenicity of a new vaccine with a comparator vaccine with an established protective effect...  2, record 1, English, - immunobridging

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Procédure de mise au point d'un vaccin qui est fondée sur l'évaluation de la production d'anticorps.  2, record 1, French, - %C3%A9valuation%20immunologique

Record number: 1, Textual support number: 1 OBS

évaluation immunologique : désignation et définition publiées au Journal officiel de la République française le 19 juin 2024.  3, record 1, French, - %C3%A9valuation%20immunologique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

The process of covalent attachment of polyethylene glycol (PEG) polymer chains to another molecule, normally a drug or therapeutic protein.  3, record 2, English, - PEGylation

Record number: 2, Textual support number: 1 OBS

An appropriately sized and shaped nano-object decorated with polyethylene glycol (a process called PEGylation) can avoid detection.  4, record 2, English, - PEGylation

Record number: 2, Textual support number: 2 OBS

Many PEG-coupled biomolecules are reported to have increased plasma half-lives as well as improved solubility, increased resistance to proteolysis and reducedtoxicity and immunogenicity.  2, record 2, English, - PEGylation

Record number: 2, Textual support number: 3 OBS

"PEG" stands for "polyethylene glycol."  4, record 2, English, - PEGylation

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Procédé [...] qui consiste à attacher (conjuguer) des chaînes de polyéthylène glycol à des molécules biologiquement actives [...]  2, record 2, French, - p%C3%A9gylation

Record number: 2, Textual support number: 1 OBS

[On entend par «molécules biologiquement actives»] des molécules telles que des protéines ou des médicaments peptidiques. [La pégylation] peut augmenter la masse moléculaire des protéines et des peptides et leur solubilité et ainsi mieux les protéger des enzymes protéolytiques. La pégylation d'une protéine peut aussi diminuer ses propriétés allergènes. Le procédé peut inactiver certaines enzymes face à un produit pégylé, mais il peut aussi allonger la durée de présence d'une enzyme si cette dernière est une molécule qui a été pégylée puis injectée dans l'organisme.  2, record 2, French, - p%C3%A9gylation

Record number: 2, Textual support number: 2 OBS

La pégylation de nano-objets de dimensions et de forme appropriées (par greffage avec du polyéthylène glycol) leur permet de ne pas être détectés.  3, record 2, French, - p%C3%A9gylation

Record number: 2, Textual support number: 3 OBS

pégylation : nom dérivé de l'abréviation anglaise «PEG», qui signifie «polyethylene glycol».  4, record 2, French, - p%C3%A9gylation

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

The ability of a substance to induce an immune response.  2, record 3, English, - immunogenicity

Record number: 3, Textual support number: 1 OBS

Not to be confused with "antigenicity," which refers to the capacity of an antigen to bind to immune response products.  3, record 3, English, - immunogenicity

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Capacité d'une substance de déclencher une réponse immunitaire.  2, record 3, French, - immunog%C3%A9nicit%C3%A9

Record number: 3, Textual support number: 1 OBS

Ne pas confondre avec «antigénicité», qui fait référence à la capacité d'un antigène de se combiner avec les produits d'une réaction immunitaire.  3, record 3, French, - immunog%C3%A9nicit%C3%A9

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

Capacidad de una sustancia para generar una respuesta inmune.  2, record 3, Spanish, - inmunogenicidad

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

A vaccine containing whole infectious agents or infectious agent particles that have been treated to eliminate their pathogenicity without affecting their immunogenicity.  5, record 4, English, - inactivated%20vaccine

Record number: 4, Textual support number: 1 OBS

Inactivated vaccines are contrasted with attenuated vaccines, or live vaccines.  6, record 4, English, - inactivated%20vaccine

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Vaccin contenant des agents infectieux entiers ou des particules d'agents infectieux qui ont été traités pour éliminer leur pathogénicité sans affecter leur immunogénicité.  4, record 4, French, - vaccin%20inactiv%C3%A9

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

... the ability of a foreign material (antigen) to bind to, or interact with, the products of the final cell-mediated response such as B-cell or T-cell receptors.  2, record 5, English, - antigenicity

Record number: 5, Textual support number: 1 OBS

Not to be confused with "immunogenicity, "which refers to the ability of an antigen to induce an immune response.  3, record 5, English, - antigenicity

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 OBS

Ne pas confondre avec «immunogénicité», qui fait référence à la capacité d'un antigène d'induire une réponse immunitaire.  2, record 5, French, - antig%C3%A9nicit%C3%A9

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

A recombinant or genetically engineered antibody(e. g. a mouse monoclonal) which contains polypeptides or domains from a different species(e. g. humans) often introduced to reduce the antibody's immunogenicity.  3, record 6, English, - chimeric%20monoclonal%20antibody

Record number: 6, Textual support number: 1 CONT

A chimeric antibody is one of which both chain types are chimeric as a result of antibody engineering. A chimeric chain is a chain that contains a foreign variable domain (V-D-J-region) (originating from one species other than human, or synthetic) linked to a constant region (C-region) of human origin.  4, record 6, English, - chimeric%20monoclonal%20antibody

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

[...] le développement de l’ingénierie génétique des anticorps [...] a permis de transformer progressivement les anticorps murins en anticorps humains. Cette transformation a d’abord conduit à la construction d’anticorps chimériques, dans lesquels les régions constantes des chaînes lourdes et légères des immunoglobulines murines sont remplacées par des régions constantes humaines [...] Cette chimérisation conduit à une diminution importante des réponses immunes dirigées contre les régions murines [...]  4, record 6, French, - anticorps%20monoclonal%20chim%C3%A9rique

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

A water-in-oil emulsion that lacks the mycobacteria present in Freund's complete adjuvant but nonetheless has moderate capacity to potentiate immunogenicity when administered with a soluble antigen.  1, record 7, English, - Freund%26rsquo%3Bs%20incomplete%20adjuvant

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Émulsion d'eau dans l'huile sans mycobactéries.  1, record 7, French, - adjuvant%20incomplet%20de%20Freund

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 DEF

A water-in oil emulsion that contains killed mycobacteria, administered along with an antigen to enhance immunogenicity of the antigen. The mechanism of action is not clear, but it appears to potentiate macrophages activity and may slow the disappearance of soluble antigen from immunologically active tissue sites.  2, record 8, English, - complete%20Freund%26rsquo%3Bs%20adjuvant

Record number: 8, Textual support number: 2 DEF

An emulsified preparation of heat-killed tubercle bacilli in mineral oil. It is used in experimental immunology to promote the formation of antibodies against weakly antigenic substance, and in pharmacology to produce an animal model of arthritis (adjuvant arthritis).  3, record 8, English, - complete%20Freund%26rsquo%3Bs%20adjuvant

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Émulsion d'eau dans l'huile contenant des mycobactéries tuées dans la phase huileuse.  2, record 8, French, - adjuvant%20complet%20de%20Freund

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Ockenhouse, C. F. [...] et al. Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum Malaria. "Journal of Infectious Diseases, June 1998;177(6) : 1664-1673. According to the authors’ abstract of an article published in Journal of Infectious Diseases, "Candidate malaria vaccines have failed to elicit consistently protective immune responses against challenge with Plasmodium falciparum. NYVAC-Pf7, a highly attenuated vaccinia virus with 7 P. falciparum genes inserted into its genome, was tested in a Phase I/IIa safety, immunogenicity, and efficacy vaccine trial in human volunteers. Malaria genes inserted into the NYVAC genome encoded proteins from all stages of the parasite's life cycle.  1, record 9, English, - multiantigen%20vaccine

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 CONT

Grâce aux vaccins multi-antigènes, une piqûre «six-en-un» et le tour est joué.  1, record 9, French, - vaccin%20multi%2Dantig%C3%A8nes

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 OBS

Dr. Emini described the production of the second generation vaccine from yeast cells, and evidence was reviewed showing that the vaccine is similar in immunogenicity to plasma-derived vaccine.  1, record 10, English, - yeast%20cell

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 OBS

Le Dr Emini décrit la production du vaccin de seconde génération à partir de cellules de levure et passe en revue les preuves selon lesquelles le vaccin présente une immunogénicité semblable au vaccin dérivé du plasma.  1, record 10, French, - cellule%20de%20levure

Record 10,  Textual support,  Spanish

Record number: 10, Textual support number: 1 DEF

Hongo ascomiceto que se desarrolla sobre sustancias azucaradas, produciendo fermentaciones alcohólicas.  2, record 10, Spanish, - levadura

Record number: 10, Textual support number: 1 CONT

En 1938, [René Jules Dubos] obtuvo y purificó parcialmente una enzima que degradaba de forma selectiva el ácido nucleico en levaduras y pneumococos.  3, record 10, Spanish, - levadura

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 CONT

An analysis of the amino acid sequences of variable regions of human and mouse antibody molecules was performed. It involved comparison of their constituent tetrapeptides with those found in a reference set(the somatic self) built with non-immunological proteins found in a protein data base. It appeared that hypervariable regions, particularly CDR1 and CDR3, are often made up of rare tetrapeptides not present in the reference set. As assessed by simple statistical tests, this bias was significant. We discuss its possible connection with the problem of antibody immunogenicity. This result provides indirect support for the existence of idiopeptides predicted by the "peptidic self model".  2, record 11, English, - peptidic%20self%20model

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 CONT

[...] la tolérance d'un hôte à ses propres protéines (le soi) s'exerce au niveau peptidique, par la délétion fonctionnelle des lymphocytes T capables d'en reconnaître les peptides constitutifs : c'est le modèle du «soi peptidique». En premier lieu, ce modèle permet de donner son véritable sens à la présence de molécules du CMH de classe I à la surface de toutes les cellules.  1, record 11, French, - mod%C3%A8le%20du%20soi%20peptidique

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

Immunogenicity of Haemophilus influenzae type b polysaccharide-Neisseria meningitidis outer membrane protein conjugate vaccine in 2-to 6-month-old infants(Pediatrics 1987; 80 : 283-7).  1, record 12, English, - outer%20membrane%20protein

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

Les principales préparations de ce type disponibles actuellement sont (4, 13-17, 23, 27, 29, 30) : PRP couplé à une protéine de membrane externe de Neisseria meningitidis (PRP-OMP), PRP couplé à l'anatoxine diphtérique (PRP-D) ou à l'anatoxine tétanique (PRP-T), et des oligosaccharides de PRP couplés à la toxine diphtérique d'un mutant non toxique (OS-D).  1, record 12, French, - prot%C3%A9ine%20de%20membrane%20externe

Record 12,  Textual support,  Spanish