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IMMUNOGLOBULIN GLOMERULONEPHRITIS [3 records]

Record 1 2013-07-18

English

Subject field(s)
  • Urinary Tract
DEF

A chronic form [of glomerulonephritis] marked by hematuria and proteinuria and by deposits of [immunoglobulin A] in the mesangial areas of the renal glomeruli, with subsequent hyperplasia of mesangial cells.

Key term(s)
  • immunoglobulin A glomerulonephritis
  • immunoglobulin A nephropathy
  • immunoglobulin A nephritis

French

Domaine(s)
  • Appareil urinaire
CONT

La maladie de Berger, également appelée glomérulonéphrite à dépôts mésangiaux d'IgA, ou simplement néphropathie à IgA est une maladie auto-immune atteignant les reins.

Key term(s)
  • glomérulonéphrite à dépôts mésangiaux d'immunoglobuline A
  • néphropathie à immunoglobuline A

Spanish

Save record 1

Record 2 2006-05-05

English

Subject field(s)
  • Immunology
DEF

Glomerulonephritis, usually of a generalized proliferative crescent-forming histologic type with a rapidly progressive course, marked by circulating anti-GBM antibodies and linear deposits of immunoglobulin and complement along the glomerular basement membrane. When associated with pulmonary hemorrhage, the condition is called Goodpasture's syndrome.

OBS

In the Merck Manual, these two diseases are synonymous.

French

Domaine(s)
  • Immunologie
CONT

Glomérulonéphrites auto-immunes. La plupart des glomérulonéphrites ont une origine immunitaire. Si le dépôt ou la formation locale de complexes immuns représente le mécanisme le plus fréquemment en cause, l'action néphrotoxique d'autoanticorps dirigés contre la membrane basale glomérulaire (GBM) a été bien démontrée chez certains malades.

Spanish

Campo(s) temático(s)
  • Inmunología
Save record 2

Record 3 2006-02-27

English

Subject field(s)
  • Immunology
DEF

An autoantibody found in high concentrations in some kidney diseases which binds to, and stabilizes C3b,Bb, thus potentiating alternative pathway activity.

CONT

Nephritic factor is an immunoglobulin found in patients with partial lipodystrophy and/or mesangiocapillary glomerulonephritis. It binds to the alternative pathway convertase enzyme C3bBd and stabilizes it by inhibiting release of Bb.

French

Domaine(s)
  • Immunologie
DEF

Auto-anticorps dirigé contre la C3-convertase de la voie alterne. Cette spécifique explique sa fonction d'activateur de la voie alterne du complément.

CONT

Certaines protéines peuvent activer la voie alterne : 1) le facteur du venin de cobra [...]; le facteur néphritique, qui est un autoanticorps (IgG) dirigé contre la C3 convertase C3bBb; se fixant à elle, il stabilise le complexe qui résiste à l'action du (facteur) H; 3) la properdine [...]

Spanish

Campo(s) temático(s)
  • Inmunología
Save record 3

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