TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

... the suprachoroidal injection approach delivers the gene therapy payload via the potential space between the sclera and the choroid(suprachoroidal space, or SCS). This is a potentially favored injection site for gene therapy because it may reduce the likelihood of eliciting an immunologic response due to its unique location with respect to the blood-retina barrier while simultaneously permitting adequate gene expression to control the nAMD [neovascular age-related macular degeneration] disease process. Surgical access to the SCS can be facilitated by creation of a sclerotomy, followed by introduction of a catheter or cannula. Separately, and potentially of greater interest, is for suprachoroidal gene therapy to be delivered in the clinic setting by utilizing hypodermic needles or hollow microneedles.  1, record 1, English, - suprachoroidal%20gene%20therapy

Record number: 1, Textual support number: 2 CONT

gene therapy: The treatment of certain medical disorders, especially those caused by genetic anomalies or deficiencies, by introducing specific engineered genes into a patient’s cells.  3, record 1, English, - suprachoroidal%20gene%20therapy

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

Thérapie qui consiste en l'injection de gènes dans la couche de la choroïde adhérant à la sclère dans le but de traiter une maladie rétinienne.  1, record 1, French, - th%C3%A9rapie%20g%C3%A9nique%20suprachoro%C3%AFdienne

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Latent tuberculosis is a clinical state in which a person has immunologic evidence of tuberculosis but lacks symptoms and signs of the disease. The immunologic evidence that makes the diagnosis is a positive tuberculin skin test or interferon gamma release assay.  5, record 2, English, - latent%20tuberculosis

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

L'ITL est la forme latente de l'infection, soit la présence de bacilles tuberculeux à l'intérieur de l'organisme sans manifestation de la maladie. La plupart du temps, elle se manifeste par une réaction au test cutané à la tuberculine (TCT) ou par un résultat positif au test de libération de l'interféron gamma (TLIG), 2 à 8 semaines après le contact.  4, record 2, French, - tuberculose%20latente

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

A clinical study in which participants are deliberately infected with a predetermined infectious agent under controlled conditions in order to generate scientific, immunologic and therapeutic data from analysis of the disease caused by the agent.  4, record 3, English, - controlled%20human%20infection%20model

Record number: 3, Textual support number: 1 OBS

A controlled human infection model may involve a human challenge trial.  4, record 3, English, - controlled%20human%20infection%20model

Record 3,  Textual support,  French

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

The prevention or diminution of the immune response, as by irradiation or by administration of antimetabolites, antilymphocyte serum, or specific antibody.  3, record 4, English, - immunosuppression

Record number: 4, Textual support number: 1 CONT

Immunosuppression... may reflect natural immunologic unresponsiveness(tolerance) [or] may be artificially induced by chemical, biological, or physical agents, or may be caused by disease.  3, record 4, English, - immunosuppression

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Diminution ou suppression des réponses immunitaires normales chez un individu.  3, record 4, French, - immunosuppression

Record number: 4, Textual support number: 1 CONT

[Le] traitement dit immunosuppresseur, [vise] à réduire les risques de réactions de rejet. Cette immunosuppression préalable peut être réalisée par irradiation corporelle totale (conduisant à détruire toutes les cellules de la moelle du receveur, et donc celles de son système immunitaire) ou par traitement médicamenteux au moyen par exemple de sérum anti-lymphocytaire.  4, record 4, French, - immunosuppression

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Tratamiento que consiste en la administración de sustancias que alteran la capacidad del sistema inmunitario para combatir infecciones o enfermedades.  2, record 4, Spanish, - inmunosupresi%C3%B3n

Record number: 4, Textual support number: 1 OBS

Puede ser de forma deliberada, como en la preparación de trasplantes, para evitar el rechazo por parte del huésped de los tejidos del donante; o de forma no intencionada, como resulta en el tratamiento de cáncer con quimioterapia.  2, record 4, Spanish, - inmunosupresi%C3%B3n

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

[The disorders] are associated with Epstein-Barr virus and monoclonal lymphoma with clonal cytogentic changes. Unlike other postallograft lymphoproliferative processes, B-cell lymphoproliferative disorders in these patients have not responded to antiviral therapy, immunologic therapy, or chemotherapy. The radiographic patterns of disease include diffuse or focal hepatic involvement; gallbladder wall thickening; and pulmonary, soft-tissue, and basal-ganglion masses. These radiologic findings are not specific and evaluation of tissue histology is required for diagnosis.  1, record 5, English, - monoclonal%20lymphoma

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

[...] on considère comme lymphome primitif du poumon les proliférations lymphoïdes monoclonales sans atteinte extra-pulmonaire ou avec une atteinte très limitée exclusivement histologique [...]  2, record 5, French, - lymphome%20%C3%A0%20cellules%20monoclonales

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

The condition [or disease] that results when the immune cells of a transplant (usually of bone marrow) from a donor attack the tissues of the person receiving the transplant.  2, record 6, English, - graft%20versus%20host%20disease

Record number: 6, Textual support number: 1 CONT

In 1955, Barnes and Loutit first described graft versus host disease(GVHD) in mice. Simonsen introduced the term graft-versus-host reaction in 1958 to describe the direction of the immunological damage caused by introduction of immunologically competent cells into an immunocompromised host. In 1966, Billingham proposed 3 conditions required for the development of GVHD, as follows :(1) the graft must contain immunologically competent cells,(2) the host must possess important transplant alloantigens that are lacking in the donor graft so that the host appears foreign to the graft, and(3) the host itself must be incapable of mounting an effective immunological reaction against the graft. According to the accepted definition, the immunologic assault itself and its consequences are referred to as GVHD.  3, record 6, English, - graft%20versus%20host%20disease

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

La principale complication, en cas d'allogreffe, est la maladie du greffon contre l'hôte. [...] Il s'agit d'une réaction immunitaire des cellules du greffon contre les organes du receveur. Cette réaction peut être aiguë, dans les trois premiers mois suivant la greffe, ou chronique et constituer une vraie maladie.  2, record 6, French, - maladie%20du%20greffon%20contre%20l%27h%C3%B4te

Record number: 6, Textual support number: 1 OBS

Ne pas confondre avec : réaction du greffon contre l'hôte.  3, record 6, French, - maladie%20du%20greffon%20contre%20l%27h%C3%B4te

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

Erythema multiforme is an immunologic reaction in the skin and mucous membranes often mediated by circulating immune complexes that evolve in response to a number of antigenic stimulae(infections, drugs, connective tissue disease). As the name implies, the skin reaction is characterized by a variety of lesions, namely, erythematous plaques, blisters, and target or bull' s-eye lesions. The mucous membranes of the mouth and eye may also be involved, and this is referred to as Stevens-Johnson syndrome.  1, record 7, English, - Stevens%2DJohnson%20syndrome

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Forme grave d'érythème polymorphe caractérisée par des lésions cutanées maculo-vésiculeuses ou bulleuses, avec atteinte simultanée des muqueuses (conjonctivite, stomatite, urétrite) et symptômes généraux (fièvre, anorexie).  3, record 7, French, - syndrome%20de%20Stevens%2DJohnson

Record 7,  Textual support,  Spanish

Record number: 7, Textual support number: 1 DEF

Forma de eritema multiforme que puede ser muy severo [...] y que se caracteriza por conjuntivitis que puede terminar en ceguera y por ulceraciones en los genitales y el ano.  1, record 7, Spanish, - s%C3%ADndrome%20de%20Stevens%20Johnson

Record 8,  Textual support,  French

Record 8,  Textual support,  Spanish