TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Thinking about how cancer medicine has evolved, we’ve had surgery, chemotherapy, and radiation. CAR [chimeric antigen receptor] T cell therapy is a highly targeted immunotherapy, and is now being used worldwide to treat blood cancers.  1, record 1, English, - highly%20targeted%20immunotherapy

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

Cibler spécifiquement les cellules cancéreuses et les détruire sans endommager les cellules saines : telle est la promesse des nouvelles immunothérapies ultraciblées.  1, record 1, French, - immunoth%C3%A9rapie%20ultracibl%C3%A9e

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Immune checkpoints are a normal part of the immune system. Their role is to prevent an immune response from being so strong that it destroys healthy cells in the body. Immune checkpoints engage when proteins on the surface of immune cells called T cells recognize and bind to partner proteins on other cells, such as some tumor cells. These proteins are called immune checkpoint proteins. When the checkpoint and partner proteins bind together, they send an "off" signal to the T cells. This can prevent the immune system from destroying the cancer. Immunotherapy drugs called immune checkpoint inhibitors work by blocking checkpoint proteins from binding with their partner proteins. This prevents the "off" signal from being sent, allowing the T cells to kill cancer cells.  3, record 2, English, - immune%20checkpoint%20inhibitor

Record number: 2, Textual support number: 2 CONT

Monoclonal antibodies (mAbs) are ... available as immune checkpoint inhibitors (ICIs). These ICIs target specific immune checkpoints, including cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death protein 1 (PD-1).  4, record 2, English, - immune%20checkpoint%20inhibitor

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Les inhibiteurs de points de contrôle sont des anticorps monoclonaux dirigés contre les signaux inhibiteurs de la réponse immunitaire que les cellules anticancéreuses mettent en place, en particulier en inactivant les lymphocytes T.  3, record 2, French, - inhibiteur%20de%20point%20de%20contr%C3%B4le%20immunitaire

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Immune checkpoints are a normal part of the immune system. Their role is to prevent an immune response from being so strong that it destroys healthy cells in the body. Immune checkpoints engage when proteins on the surface of immune cells called T cells recognize and bind to partner proteins on other cells, such as some tumor cells. These proteins are called immune checkpoint proteins. When the checkpoint and partner proteins bind together, they send an "off" signal to the T cells. This can prevent the immune system from destroying the cancer. Immunotherapy drugs called immune checkpoint inhibitors work by blocking checkpoint proteins from binding with their partner proteins. This prevents the "off" signal from being sent, allowing the T cells to kill cancer cells.  2, record 3, English, - immune%20checkpoint%20protein

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Les protéines nommées protéines de point de contrôle immunitaire permettent de moduler la force et la durée des réponses immunitaires pour éviter d'éliminer les cellules saines. Ces protéines réduisent la réponse immune naturelle ou thérapeutique contre le cancer. L'une des stratégies d'immunothérapie consiste à inhiber l'activité de ces protéines de point de contrôle immunitaire pour restaurer ou augmenter une réponse immunitaire.  1, record 3, French, - prot%C3%A9ine%20de%20point%20de%20contr%C3%B4le%20immunitaire

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

A new protein that forms on cancer cells when certain mutations occur in tumor DNA.  3, record 4, English, - neoantigen

Record number: 4, Textual support number: 1 OBS

Neoantigens may play an important role in helping the body make an immune response against cancer cells. Neoantigens used in vaccines and other types of immunotherapy are being studied in the treatment of many types of cancer.  3, record 4, English, - neoantigen

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Durant la formation des cellules néoplasiques, celles-ci accumulent généralement un nombre élevé d'altérations génétiques en raison de leur instabilité chromosomique et du haut taux de réplication cellulaire. Ces altérations conduisent à la production de protéines mutantes, appelées des néoantigènes, qui peuvent être reconnues par le système immunitaire de l'hôte pour produire une réponse immunitaire ciblée contre la tumeur [...]  3, record 4, French, - n%C3%A9oantig%C3%A8ne

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

... immunotherapy that uses a person's own immune cells(T cells) to identify and attack cancer cells.  1, record 5, English, - chimeric%20antigen%20receptor%20T%2Dcell%20therapy

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 DEF

[...] immunothérapie qui utilise les cellules immunitaires du patient (lymphocytes T) pour reconnaître et attaquer les cellules cancéreuses.  1, record 5, French, - th%C3%A9rapie%20par%20lymphocytes%20T%20%C3%A0%20r%C3%A9cepteur%20antig%C3%A9nique%20chim%C3%A9rique

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

A new class of cancer treatment that works to harness the innate powers of the immune system to fight cancer.  3, record 6, English, - cancer%20immunotherapy

Record number: 6, Textual support number: 1 OBS

Because of the immune system’s unique properties, these therapies may hold greater potential than current treatment approaches to fight cancer more powerfully, to offer longer-term protection against the disease, to come with fewer side effects, and to benefit more patients with more cancer types.  3, record 6, English, - cancer%20immunotherapy

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 OBS

L'immunothérapie permet de renforcer les défenses immunitaires de l’organisme de sorte qu’il puisse lutter et détruire lui-même les cellules cancéreuses.  2, record 6, French, - immunoth%C3%A9rapie%20du%20cancer

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

In terms of treatment, scientists have for more than three decades tried to find ways to sic the immune system on cancer-a tactic termed immunotherapy or vaccine therapy. And for good reason. Because immunity is a systemic reaction, it could potentially eliminate all cancer cells in patient's body-even when they migrate away from the original tumor site or reappear after years of clinical remission.  2, record 7, English, - genetic%20vaccination

Record number: 7, Textual support number: 1 OBS

Gene therapy for cancer.  3, record 7, English, - genetic%20vaccination

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

Vaccination par injection de l'ADN codant les principales protéines virales, par voie intramusculaire.  1, record 7, French, - vaccination%20g%C3%A9n%C3%A9tique

Record number: 7, Textual support number: 1 CONT

Helicobacter pylori, une bactérie non invasive qui survit dans l'estomac grâce à une uréase capable de neutraliser l'acidité gastrique, est responsable d'une inflammation chronique conduisant à la maladie ulcéreuse ou éventuellement aux cancers de l'estomac. Un vaccin oral contenant l'uréase recombinante et la toxine labile d'E. Coli ou la toxine du cholera comme adjuvants permet d'éliminer une infection préexistante chez la souris[...] Nous développons des vaccins de deuxième génération, basés sur une meilleure compréhension des mécanismes immunologiques responsables de l'élimination de l'infection. Pour ce faire nous utilisons des souris déficientes dans l'une ou l'autre composante du système immunitaire et nous testons le potentiel thérapeutique des nouveaux vaccins. Dans la souris normale, la vaccination génique avec l'ADN codant pour l'uréase entraîne une élimination partielle de l'infection et l'effet thérapeutique d'un vaccin Salmonelle dépend du niveau d'expression de l'uréase.  3, record 7, French, - vaccination%20g%C3%A9n%C3%A9tique

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

The goal of [the] research study is to find out if patients receiving an anti-cancer vaccine made from their own kidney tumor after removal of the kidney helps to keep them alive longer than patients who receive no vaccine.  2, record 8, English, - anticancer%20vaccine

Record number: 8, Textual support number: 1 OBS

anticancer vaccine; anti-cancer vaccine; cancer vaccine :[In these terms, the word] "vaccine" is slightly misleading, because the experimental medicine does not prevent cancer. Rather, patients receive vaccines after cancer is diagnosed.... Using monoclonal antibodies is an immunotherapy technique but not a vaccine.  3, record 8, English, - anticancer%20vaccine

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 CONT

Les vaccins anticancéreux utilisent le système immunitaire du patient pour interrompre la croissance et la propagation d'une tumeur.  6, record 8, French, - vaccin%20anticanc%C3%A9reux

Record number: 8, Textual support number: 1 OBS

vaccin anti-cancéreux; vaccin anti-cancer : En règle générale, les mots composés qui commencent par le préfixe «anti» s'écrivent sans trait d'union.  7, record 8, French, - vaccin%20anticanc%C3%A9reux

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

Active immunotherapy provides a valuable strategy for treatment of cancer patients. Human gliomas and carcinomas of the breast, lung and ovary, but not a variety of normal tissues, express mEGF-R. Therefore, mEGF-R is a suitable target for active immunotherapy against these tumors.  2, record 9, English, - active%20immunotherapy

Record number: 9, Textual support number: 1 OBS

Extrait électronique de : PROC. AMERI. ASSOC. CANCER RES. 40, March 1999] Copyright © 1999 by the American Association for Cancer Research.  3, record 9, English, - active%20immunotherapy

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 OBS

immunothérapie : méthode de traitement fondée sur l'utilisation des réactions immunitaires.  2, record 9, French, - immunoth%C3%A9rapie%20active

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 CONT

An enzyme-linked immunosorbent assay(ELISA) was developed to monitor the antibody response to corynebacterium parvum during cancer immunotherapy.  1, record 10, English, - corynebacterium%20parvum

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

L'activité antitumorale de corynebacterium parvum est très faible chez les souris jeunes [...]  2, record 10, French, - corynebacterium

Record 10,  Textual support,  Spanish